FlyBase Allele Report: Dmel\Myt1[KK102559]

General Information

Symbol

Dmel\Myt1^KK102559

Species

D. melanogaster

Name

FlyBase ID

FBal0231863

Feature type

allele

Associated gene

Dmel\Myt1

Associated Insertion(s)

Carried in Construct

P{KK102559}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102559}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102559

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult enterocyte | decreased number | somatic clone, with Scer\GAL4^esg.PU

(Willms et al., 2020)

adult midgut, with Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

(Willms et al., 2020)

adult midgut, with Scer\GAL4^GMR28E03

(Willms et al., 2020)

adult midgut, with Scer\GAL4^Su(H).GBE

(Willms et al., 2020)

enteroblast, with Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

(Willms et al., 2020)

enteroblast, with Scer\GAL4^GMR28E03

(Willms et al., 2020)

enteroblast, with Scer\GAL4^Su(H).GBE

(Willms et al., 2020)

enteroblast | increased number, with Scer\GAL4^esg.PU

(Willms et al., 2020)

intestinal stem cell, with Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

(Willms et al., 2020)

intestinal stem cell | decreased number, with Scer\GAL4^esg.PU

(Willms et al., 2020)

Detailed Description

Statement

Reference

Expression of Myt1^KK102559 (in combination with tub-GAL80[ts]) under the control of Scer\GAL4^esg.PU (also in combination with Scer\GAL80[Su(H).GBE]), Scer\GAL4^Su(H).GBE or Scer\GAL4^GMR28E03 leads to increased number of dividing cells (both intestinal stem cells and enteroblasts) in adult midgut.

Expression of Myt1^KK102559 under the control of Scer\GAL4^esg.PU (in combination with tub-GAL80[ts]) leads to an increase in the proportion of G1 phase cells relative to G2 phase cells and a decrease in the number of endocycling enteroblasts in adult gut. It also leads to an increase in the number of enteroblasts while it leads to a decrease in the number of intestinal stem cells.

Clones expressing Myt1^KK102559 under the control of Scer\GAL4^esg.PU exhibit decreased number of enterocytes in adult gut.

(Willms et al., 2020)

Expression of Myt1^KK102559 under the control of Scer\GAL4^en-e16E does not affect the size of the adult wing posterior compartment, as compared to controls.

(Ibar and Glavic, 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Myt1^KK102559, Scer\GAL4^GMR28E03 has increased occurrence of cell division | adult stage phenotype, suppressible | partially by CycA^GLV21059, Scer\GAL4^GMR28E03

(Willms et al., 2020)

Myt1^KK102559, Scer\GAL4^GMR28E03 has increased occurrence of cell division | adult stage phenotype, suppressible | partially by CycB^HMS01015, Scer\GAL4^GMR28E03

(Willms et al., 2020)

Myt1^KK102559, Scer\GAL4^Su(H).GBE has increased occurrence of cell division | adult stage phenotype, suppressible by Incenp^GL00279, Scer\GAL4^Su(H).GBE

(Willms et al., 2020)

Myt1^KK102559, Scer\GAL4^Su(H).GBE has increased occurrence of cell division | adult stage phenotype, suppressible | partially by cid^HMS02160, Scer\GAL4^Su(H).GBE

(Willms et al., 2020)

Myt1^KK102559, Scer\GAL4^Su(H).GBE has increased occurrence of cell division | adult stage phenotype, suppressible | partially by Mgtor^HMS00735, Scer\GAL4^Su(H).GBE

(Willms et al., 2020)

NOT Enhancer of

Statement

Reference

Myt1^KK102559, Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE is a non-enhancer of decreased occurrence of cell division | adult stage phenotype of CycA^GLV21059, Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

(Willms et al., 2020)

Suppressor of

Statement

Reference

Myt1^KK102559, Scer\GAL4^en-e16E is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^en-e16E, p115^KK100066

(Ibar and Glavic, 2017)

Myt1^KK102559, Scer\GAL4^en-e16E is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^en-e16E, p115^KK100066

(Ibar and Glavic, 2017)

NOT Suppressor of

Statement

Reference

Myt1^KK102559, Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE is a non-suppressor of decreased occurrence of cell division | adult stage phenotype of CycA^GLV21059, Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

(Willms et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

Myt1^KK102559, Scer\GAL4^Su(H).GBE has adult midgut phenotype, suppressible | partially by Mgtor^HMS00735, Scer\GAL4^Su(H).GBE

(Willms et al., 2020)

Myt1^KK102559, Scer\GAL4^Su(H).GBE has enteroblast phenotype, suppressible | partially by Incenp^GL00279, Scer\GAL4^Su(H).GBE

(Willms et al., 2020)

Myt1^KK102559, Scer\GAL4^Su(H).GBE has enteroblast phenotype, suppressible | partially by cid^HMS02160, Scer\GAL4^Su(H).GBE

(Willms et al., 2020)

Myt1^KK102559, Scer\GAL4^GMR28E03 has adult gut phenotype, suppressible | partially by CycA^GLV21059, Scer\GAL4^GMR28E03

(Willms et al., 2020)

Myt1^KK102559, Scer\GAL4^GMR28E03 has adult gut phenotype, suppressible | partially by CycB^HMS01015, Scer\GAL4^GMR28E03

(Willms et al., 2020)

Myt1^KK102559, Scer\GAL4^GMR28E03 has enteroblast phenotype, suppressible by CycA^GLV21059, Scer\GAL4^GMR28E03

(Willms et al., 2020)

Myt1^KK102559, Scer\GAL4^Su(H).GBE has adult midgut phenotype, suppressible by Incenp^GL00279, Scer\GAL4^Su(H).GBE

(Willms et al., 2020)

Myt1^KK102559, Scer\GAL4^Su(H).GBE has adult midgut phenotype, suppressible | partially by cid^HMS02160, Scer\GAL4^Su(H).GBE

(Willms et al., 2020)

NOT Enhancer of

Statement

Reference

Myt1^KK102559, Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE is a non-enhancer of adult midgut phenotype of CycA^GLV21059, Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

(Willms et al., 2020)

Suppressor of

Statement

Reference

Myt1^KK102559, Scer\GAL4^en-e16E is a suppressor | partially of wing posterior compartment | adult stage phenotype of Scer\GAL4^en-e16E, p115^KK100066

(Ibar and Glavic, 2017)

NOT Suppressor of

Statement

Reference

Myt1^KK102559, Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE is a non-suppressor of adult midgut phenotype of CycA^GLV21059, Scer\GAL4^esg.PU, Scer\GAL80^Su(H).GBE

(Willms et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

The wing posterior compartment size reduction seen in flies expressing p115^KK100066 under the control of Scer\GAL4^en-e16E is partially suppressed when Myt1^KK102559 is co-expressed.

(Ibar and Glavic, 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v105157

P{KK102559}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Myt1^KK102559

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections