FB2024_03 , released June 25, 2024
Allele: Dmel\Dronc11
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General Information
Symbol
Dmel\Dronc11
Species
D. melanogaster
Name
FlyBase ID
FBal0239864
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Caused by aberration
Cytology
Description

Imprecise excision of P{SUPor-P}NcKG02994 has deleted about 2.8 kb of genomic sequence, including the most of the sequence encoding Nc and CG6685.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

neuroblast & larval abdominal segment 3 | late third instar larval stage

neuroblast & larval abdominal segment 4 | late third instar larval stage

neuroblast & larval abdominal segment 5 | late third instar larval stage

neuroblast & larval abdominal segment 6 | late third instar larval stage

neuroblast & larval abdominal segment 7 | late third instar larval stage

Detailed Description
Statement
Reference

Dendrites of Nc11 mutant C4da neuron clones appear normal at larval stages. However, unlike wild-type, these neurons fail to properly prune their larval dendrites during metamorphosis and most display relatively intact primary and secondary larval dendritic arbors at 18 hours after puparium formation.

Nc11 homozygous embryos hatch at the normal time, but the larvae develop more slowly than wild-type. These larvae fail to pupariate, but continue to grow for some time after controls pupariate. The resulting giant larvae die at 10-12 days after wild-type larvae pupariate. Unlike wild-type larvae, these larvae are not induced to pupariate early by feeding with ecdysone at the mid-third instar.

Nc11 homozygous larvae fail to exhibit cell death in the larval midgut ,as wild-type larvae do, at end of the third larval instar (assayed by Tunel staining) or in response to feeding with ecdysone at mid-third instar (assayed by acridine orange staining).

In Nc11 homozygous larvae, most of the abdominal neuroblasts in segments A3-A7 that normally die during the late third instar persist.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

Dronc11/Nc[+] is a suppressor of eye phenotype of grimGMR.PH

Dronc11/Nc[+] is a suppressor of eye phenotype of rprGMR.PH

NOT Suppressor of
Statement
Reference

Dronc11/Nc[+] is a non-suppressor of eye phenotype of hidGMR.PG

Additional Comments
Genetic Interactions
Statement
Reference

Nc11/+ partially suppresses the small, rough eye phenotype caused by rprGMR.PH or grimGMR.PH but not that caused by WGMR.PG.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)