Imprecise excision of P{SUPor-P}NcKG02994 has deleted about 2.8 kb of genomic sequence, including the most of the sequence encoding Nc and CG6685.
neuroblast & larval abdominal segment 3 | late third instar larval stage
neuroblast & larval abdominal segment 4 | late third instar larval stage
neuroblast & larval abdominal segment 5 | late third instar larval stage
neuroblast & larval abdominal segment 6 | late third instar larval stage
neuroblast & larval abdominal segment 7 | late third instar larval stage
Dendrites of Nc11 mutant C4da neuron clones appear normal at larval stages. However, unlike wild-type, these neurons fail to properly prune their larval dendrites during metamorphosis and most display relatively intact primary and secondary larval dendritic arbors at 18 hours after puparium formation.
Nc11 homozygous embryos hatch at the normal time, but the larvae develop more slowly than wild-type. These larvae fail to pupariate, but continue to grow for some time after controls pupariate. The resulting giant larvae die at 10-12 days after wild-type larvae pupariate. Unlike wild-type larvae, these larvae are not induced to pupariate early by feeding with ecdysone at the mid-third instar.
Nc11 homozygous larvae fail to exhibit cell death in the larval midgut ,as wild-type larvae do, at end of the third larval instar (assayed by Tunel staining) or in response to feeding with ecdysone at mid-third instar (assayed by acridine orange staining).
In Nc11 homozygous larvae, most of the abdominal neuroblasts in segments A3-A7 that normally die during the late third instar persist.
Dronc11/Nc[+] is a suppressor of eye phenotype of grimGMR.PH
Nc11/+ partially suppresses the small, rough eye phenotype caused by rprGMR.PH or grimGMR.PH but not that caused by WGMR.PG.
Dronc11 is partially rescued by DroncUAS.EGFP/Scer\GAL4hs.PB
Dronc11 is not rescued by DroncC318S.UAS/Scer\GAL4hs.PB