FB2024_03 , released June 25, 2024
Allele: Dmel\DroncC318S.UAS
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General Information
Symbol
Dmel\DroncC318S.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0176065
Feature type
allele
Associated gene
Dmel\Dronc
Associated Insertion(s)
Carried in Construct
P{UAS-Dronc.C318S}
Key Links
Transgenic product class
dominant_negative_variant
(Huh et al., 2004)
missense_variant
(Huh et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Huh et al., 2004)
missense_variant
(Huh et al., 2004)
Mutagen
in vitro construct
(Huh et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-Dronc.C318S}
Cytology
Description

UAS regulatory sequences drive expression of a dominant negative form of Dronc.

(Huh et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Dronc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      NOT Suppressor of
      Phenotype Manifest In
      NOT Enhancer of
      NOT Suppressor of
      Statement
      Reference

      DroncC318S.UAS, Scer\GAL4rn-GAL4-5 is a non-suppressor of wing | ectopic phenotype of CtBP334Δ4, Scer\GAL4rn-GAL4-5, egrUAS.cUa

      (Worley et al., 2018)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of egrUAS.cUa and DroncC318S.UAS under the control of Scer\GAL4rn-GAL4-5 (with tub-Gal80[ts] restricting expression to third instar larvae) does not lead to ectopic wings compared to controls.

      (Worley et al., 2018)

      The increased cell proliferation seen in the posterior compartment of wing discs and in adult wings coexpressing BacA\p35Scer\UAS.cHa and WScer\UAS.cYa under the control of Scer\GAL4en-e16E is suppressed if they are also coexpressing NcC318S.Scer\UAS.

      (Huh et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference

      The increased cell proliferation seen in the posterior compartment of wing discs and in adult wings coexpressing BacA\p35Scer\UAS.cHa and hidScer\UAS.cYa under the control of Scer\GAL4en-e16E is suppressed if they are also coexpressing DroncC318S.Scer\UAS.

      (Huh et al., 2004)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DroncC318S.Scer\UAS
      DroncC318S.UAS
      NcC318S.Scer\UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)