FlyBase Allele Report: Dmel\upd3[HMS00646]

General Information

Symbol

Dmel\upd3^HMS00646

Species

D. melanogaster

Name

FlyBase ID

FBal0257330

Feature type

allele

Associated gene

Dmel\upd3

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00646}

Also Known As

upd3 RNAi, UAS-upd3^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00646}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00646

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Bub3^GD9924

(Barrio et al., 2023)

modeled by yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Ding et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | adult stage | somatic clone, with Scer\GAL4^R42A07.-FRT

(Harris et al., 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of upd3^HMS00646 under the control of Scer\GAL4^elav.PU no effect on attraction to food cues or food in adult flies although the body weight is slightly increased relative to controls.

(Beshel et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

upd3^HMS00646/Scer\GAL4^R42A07.-FRT is an enhancer of visible | adult stage | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

upd3^HMS00646/Scer\GAL4^R42A07.-FRT is an enhancer of decreased size | adult stage | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

Suppressor of

Statement

Reference

upd3^HMS00646, Scer\GAL4^NP0001 is a suppressor of increased occurrence of cell division | adult stage phenotype of Rab21^KK115582, Scer\GAL4^NP0001

(Nassari et al., 2022)

upd3^HMS00646, Scer\GAL4^NP0001 is a suppressor of increased occurrence of cell division | adult stage phenotype of Rab21^GD9402, Scer\GAL4^NP0001

(Nassari et al., 2022)

Scer\GAL4^Su(H).GBE/upd3^HMS00646 is a suppressor | partially of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^Su(H).GBE, Xbp1^GD4745

(Wang et al., 2015)

upd3^HMS00646, Scer\GAL4^ptc-559.1 is a suppressor | partially of hyperplasia phenotype of N^UAS.icd, Scer\GAL4^ptc-559.1

(Djiane et al., 2013)

NOT Suppressor of

Statement

Reference

upd3^HMS00646/Scer\GAL4^esg.PU is a non-suppressor of increased cell number | adult stage phenotype of Scer\GAL4^esg.PU, botv^GD2083

(Ma et al., 2019)

upd3^HMS00646, upd2^HMS00901, Scer\GAL4^esg.PU is a non-suppressor of increased cell number | adult stage phenotype of Scer\GAL4^esg.PU, botv^GD2083

(Ma et al., 2019)

Phenotype Manifest In

Enhancer of

Statement

Reference

upd3^HMS00646/Scer\GAL4^R42A07.-FRT is an enhancer of wing | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

Suppressor of

Statement

Reference

upd3^HMS00646, Scer\GAL4^NP0001 is a suppressor of adult gut phenotype of Rab21^GD9402, Scer\GAL4^NP0001

(Nassari et al., 2022)

upd3^HMS00646, Scer\GAL4^NP0001 is a suppressor of adult gut phenotype of Rab21^KK115582, Scer\GAL4^NP0001

(Nassari et al., 2022)

Scer\GAL4^Su(H).GBE/upd3^HMS00646 is a suppressor | partially of adult gut phenotype of Scer\GAL4^Su(H).GBE, Xbp1^GD4745

(Wang et al., 2015)

NOT Suppressor of

Statement

Reference

upd3^HMS00646, upd2^HMS00901, Scer\GAL4^esg.PU is a non-suppressor of adult posterior midgut epithelium phenotype of Scer\GAL4^esg.PU, botv^GD2083

(Ma et al., 2019)

upd3^HMS00646/Scer\GAL4^esg.PU is a non-suppressor of adult posterior midgut epithelium phenotype of Scer\GAL4^esg.PU, botv^GD2083

(Ma et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

The increased cell proliferation in the adult gut characteristic for flies expressing Xbp1^GD4745 under the control of Scer\GAL4^Su(H).GBE (using tub-Gal80[ts] to limit the time of expression) is partially inhibited by co-expression of upd3^HMS00646.

(Wang et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

32859

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00646}attP2

NIG-Fly

HMS00646

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00646}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Upd3^RNAi32859

(Wang et al., 2015)

Upd3^RNAi

(Ma et al., 2019)

upd3^HMS00646

upd3^RNAi2

(Chen et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

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