FB2024_03 , released June 25, 2024
Allele: Dmel\FdhUAS.cHa
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General Information
Symbol
Dmel\FdhUAS.cHa
Species
D. melanogaster
Name
FlyBase ID
FBal0258615
Feature type
allele
Associated gene
Dmel\Fdh
Associated Insertion(s)
Carried in Construct
P{UAS-Fdh.H}
Key Links
Transgenic product class
wild_type
(Hou et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Hou et al., 2011)
Mutagen
in vitro construct
(Hou et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Fdh.H}
Cytology
Description

UASt regulatory sequences drive expression of the 1.1kb Fdh coding region.

(Hou et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Fdh
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Over-expression of FdhScer\UAS.cHa in pan neurons under the control of Scer\GAL4elav.PU results in flies presenting with visual pattern memory defects.

      Expression of FdhScer\UAS.cHa in the fan-shaped body neurons under the control of Scer\GAL4c205 results in a visual pattern memory defect whereas expression in the mushroom body under the control of Scer\GAL4Mef2.247 does not affect visual pattern memory.

      Expression of FdhScer\UAS.cHa under the control of both Scer\GAL4elav.PU and Scer\GAL80ts.αTub84B in flies raised at 19[o]C (permissive temperature) and then maintained at 30[o]C (restrictive temperature) in adulthood show memory defects that are significantly different compared to the same fly strains constitutively maintained at 19[o]C.

      Expression of FdhScer\UAS.cHa under the control of both Scer\GAL4c205 and Scer\GAL80ts.αTub84B in flies raised at 19[o]C (permissive temperature) and then maintained at 30[o]C (restrictive temperature) in adulthood show memory defects that are significantly different compared to the same fly strains constitutively maintained at 19[o]C.

      (Hou et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      FdhUAS.cHa, Scer\GAL4elav.PU has abnormal memory phenotype, suppressible by forUAS.cWa, Scer\GAL4elav.PU

      (Hou et al., 2011)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Scer\GAL4elav.PU-driven expression of forScer\UAS.cWa pan-neuronally suppresses the defects in visual pattern memory found upon expression of FdhScer\UAS.cHa neuronally (also under the control of Scer\GAL4elav.PU).

      (Hou et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      FdhScer\UAS.cHa
      FdhUAS.cHa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)