FlyBase Allele Report: Dmel\COX4[KK107510]

General Information

Symbol

Dmel\COX4^KK107510

Species

D. melanogaster

Name

FlyBase ID

FBal0259522

Feature type

allele

Associated gene

Dmel\COX4

Associated Insertion(s)

Carried in Construct

P{KK107510}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK107510}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK107510

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cytochrome-c oxidase deficiency disease

CEA

(Kemppainen et al., 2014)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of cytochrome-c oxidase deficiency disease

is ameliorated by Zzzz\AOX^Scer\UAS.cFa

(Kemppainen et al., 2014)

is ameliorated by Cint\AOX^UAS.cFa

(Kemppainen et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

neuroblast | pupal stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

(Homem et al., 2014)

Detailed Description

Statement

Reference

Expression via Scer\GAL4^wor.PA and Scer\GAL80^ase.PN does not prevent proliferation of larval neuroblasts (NBs), and increases the size and extends the lifespan of pupal NBs.

(Homem et al., 2014)

Expression of COX4^KK107510 driven by Scer\GAL4^da.PU leads to early larval lethality; larvae survive at least 15 days but do not progress beyond morphologically abnormal L1 or L2 stage.

Expression of COX4^KK107510 driven by Scer\GAL4^elav-C155 leads to almost complete lethality, with males more affected than heterozygous females; weak eclosing adults soon die in food, particularly males. Expression of COX4^KK107510 driven by Scer\GAL4^elav.PLu leads to a shortened lifespan and locomotor impairments (in males), but no obvious anatomical defects.

(Kemppainen et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

COX4^KK107510, Scer\GAL4^elav.PLu has short lived phenotype, enhanceable by Scer\NDI1^UAS.cSa, Scer\GAL4^elav.PLu

(Kemppainen et al., 2014)

Suppressed by

Statement

Reference

COX4^KK107510, Scer\GAL4^da.PU has lethal - all die during larval stage phenotype, suppressible | partially by Cint\AOX^UAS.cFa, Scer\GAL4^da.PU

(Kemppainen et al., 2014)

COX4^KK107510, Scer\GAL4^da.PU has abnormal developmental rate | larval stage phenotype, suppressible | partially by Cint\AOX^UAS.cFa, Scer\GAL4^da.PU

(Kemppainen et al., 2014)

COX4^KK107510, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, suppressible | partially by Cint\AOX^UAS.cFa, Scer\GAL4^elav-C155

(Kemppainen et al., 2014)

COX4^KK107510, Scer\GAL4^elav.PLu has short lived phenotype, suppressible by Cint\AOX^UAS.cFa, Scer\GAL4^elav.PLu

(Kemppainen et al., 2014)

NOT suppressed by

Statement

Reference

COX4^KK107510, Scer\GAL4^da.PU has lethal - all die during larval stage phenotype, non-suppressible by Scer\NDI1^UAS.cSa, Scer\GAL4^da.PU

(Kemppainen et al., 2014)

COX4^KK107510, Scer\GAL4^da.PU has abnormal developmental rate | larval stage phenotype, non-suppressible by Scer\NDI1^UAS.cSa, Scer\GAL4^da.PU

(Kemppainen et al., 2014)

COX4^KK107510, Scer\GAL4^elav-C155 has partially lethal - majority die phenotype, non-suppressible by Scer\NDI1^UAS.cSa, Scer\GAL4^elav-C155

(Kemppainen et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Zzzz\AOX^Scer\UAS.cFa (but not Scer\NDI1^Scer\UAS.cSa) enables development to proceed to the pupal stage (and a few flies eclose) in flies with expression of COX4^KK107510 driven by Scer\GAL4^da.PU. Co-expression of Zzzz\AOX^Scer\UAS.cFa (but not Scer\NDI1^Scer\UAS.cSa) partially rescues lethality in flies with expression of COX4^KK107510 driven by Scer\GAL4^elav-C155. Co-expression of Zzzz\AOX^Scer\UAS.cFa suppresses shortened lifespan in males with expression of COX4^KK107510 driven by Scer\GAL4^elav.PLu; co-expression of Scer\NDI1^Scer\UAS.cSa enhances the phenotype.

(Kemppainen et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v109338

P{KK107510}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG10664^KK107510

COX4^KK107510

COX4^RNAi

(Bonnay et al., 2020)

CoIV^KK107510

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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