FlyBase Allele Report: Dmel\raptor[HMS00124]

General Information

Symbol

Dmel\raptor^HMS00124

Species

D. melanogaster

Name

FlyBase ID

FBal0263126

Feature type

allele

Associated gene

Dmel\raptor

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00124}

Also Known As

UAS-Raptor RNAi, Raptor RNAi, HMS00124, UAS-Raptor^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS00124}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00124

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell cycle | oogenesis, with Scer\GAL4^nanos.PG

(Taslim et al., 2023)

abnormal locomotor behavior | adult stage, with Scer\GAL4^c179

(Hatfield et al., 2015)

abnormal neuroanatomy | adult stage, with Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

abnormal size | adult stage, with Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

abnormal stress response | oogenesis, with Scer\GAL4^nanos.PG

(Taslim et al., 2023)

female sterile, with Scer\GAL4^{VP16.nanos.UTR}

(Wei and Lilly, 2014)

female sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

lethal - all die before end of pupal stage, with Scer\GAL4^how-24B

(Hatfield et al., 2015)

majority die during pupal stage, with Scer\GAL4^c179

(Hatfield et al., 2015)

partially lethal - majority die, with Scer\GAL4^c179

(Hatfield et al., 2015)

short lived, with Scer\GAL4^Mhc.F3-580

(Hatfield et al., 2015)

some die during pharate adult stage, with Scer\GAL4^c179

(Hatfield et al., 2015)

visible | adult stage, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression under the control of Scer\GAL4^eya.enh1+E+2 results in a misshapen eye phenotype.

(Pletcher et al., 2019)

Posterior dorsocentral bristle neurons expressing raptor^HMS00124 under the control of Scer\GAL4^pnr-MD237 show a significantly decreased terminal arbor territory and significantly fewer synapses (Syt1 puncta) on the contralateral collateral branch, as compared to controls.

(Urwyler et al., 2019)

Expression of raptor^HMS00124 in cardiac muscle under the control of Scer\GAL4^GMR88D05 has no effect on pupal eclosion rates.

Expression of raptor^HMS00124 in skeletal muscle under the control of Scer\GAL4^how-24B results in lethality.

Expression of raptor^HMS00124 under the control of Scer\GAL4^c179 causes partial lethality. The number of pupae formed does not differ from controls. Many of the surviving flies have a reduced climbing rate compared with controls.

Expression of raptor^HMS00124 under the control of Scer\GAL4^Mhc.F3-580 has no effect on pupal eclosion rates and the adult flies do not exhibit any significant climbing defects. Lifespan is reduced compared with controls.

(Hatfield et al., 2015)

Females heterozygous for raptor^HMS00124 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to raptor^HMS00124 males results in: no eggs; egg/embryonic phenotype: no vitellogenic egg chambers; oogenesis defect.

(Sopko et al., 2014)

Scer\GAL4^{nos.UTR.T:Hsim\VP16}-mediated expression of raptor^HMS00124 results in a block to oogenesis with females containing extremely small ovaries.

(Wei and Lilly, 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^unspecified/raptor^HMS00124 is a suppressor of increased cell death | somatic clone phenotype of Axn^S044230, Rbf^15aΔ

(Zhang et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^unspecified/raptor^HMS00124 is a suppressor of eye disc | somatic clone phenotype of Axn^S044230, Rbf^15aΔ

(Zhang et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

34814

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00124}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

raptor^HMS00124

(Kim et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (21)

Report Sections

Open Close