FB2024_03 , released June 25, 2024
Allele: Scer\GAL4DvirPdf.1.9
Open Close
General Information
Symbol
Scer\GAL4Dvir\Pdf.1.9
Species
S. cerevisiae
Name
FlyBase ID
FBal0279528
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{DvPdf-GAL4.1.9}
Also Known As
DvPdf-GAL4, dvpdfgal4
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Bahn et al., 2009)
Progenitor genotype
Carried in construct
P{DvPdf-GAL4.1.9}
Cytology
Description

An approximately 1.9kb KpnI-XcmI genomic fragment from upstream of Dvir\Pdf is fused upstream of sequence encoding a GAL4 driver.

(Bahn et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
Dvir\Pdf
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      wandering third instar larval stage
      larval Pdf neuron
      (Nair et al., 2020)
      adult stage
      Pdf neuron
      (Schubert et al., 2018)
      Pdf negative s-LNv neuron
      (Schubert et al., 2018)
      CRY negative LNd neuron
      (Li et al., 2018, Schubert et al., 2018)
      ITP and CRY expressing LNd neuron
      (Li et al., 2018, Schubert et al., 2018)
      s-LNv Pdf neuron
      (Li et al., 2018, Luo et al., 2018, Guo et al., 2016)
      adult s-LNv neuron
      (Li et al., 2018, Guo et al., 2016)
      LNd neuron
      (Guo et al., 2016)
      l-LNv neuron
      (Li et al., 2018)
      adult evening cell
      (Luo et al., 2018)
      LNd neuron | subset
      (Meiselman et al., 2022)
      Additional Information
      Statement
      Reference

      ScerGAL4DvirPdf.1.9 is expressed in Pdf neurons, the Pdf negative s-LNv neuron and three CRY negative LNd neurons and one cry and ITP positive LITP and CRY expressing LNd neuron.

      (Schubert et al., 2018)

      ScerGAL4DvirPdf.1.9 drives expression in morning and evening oscillating neurons.

      (Luo et al., 2018)

      Drives expression in Pdf neurons, including LNv and LNd neurons, and morning and evening cells.

      (FlyBase Curators, 2017)

      ScerGAL4DvirPdf.1.9 drives expression in four circadian morning (M) cells (s-LNv Pdf neuron), and in four evening (E) cells, three cry-expressing dorsolateral neurons (LNd neuron), and the fifth s-LNv neuron.

      (Guo et al., 2016)
       
      Marker for
      LNd neuron
      (Meiselman et al., 2022)
      Reflects expression of
      Dvir\Pdf
      (Meiselman et al., 2022, Li et al., 2018, Guo et al., 2016)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Elimination of molecular clock function (using cycΔ.UAS.Tag:MYC) in a subset of Scer\GAL4Dvir\Pdf.1.9 cells (restricted using Scer\GAL80Pdf.PS) in adults does not affect the strength of the circadian rhythm of sleep-wake cycles, compared to controls. Elimination of clock function in a subset of the combined set of Scer\GAL4GMR78G02 and Scer\GAL4Dvir\Pdf.1.9 cells (restricted using Scer\GAL80Pdf.PS) in adults significantly reduces the strength of the circadian rhythm of sleep-wake cycles, compared to controls.

      Inhibition (using Hsap\KCNJ2UAS.EGFP) of a subset of Scer\GAL4Dvir\Pdf.1.9 cells (restricted using Scer\GAL80Pdf.PS) significantly reduces the strength of the circadian rhythm of sleep-wake cycles, compared to controls.

      (Bulthuis et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL4Dvir\Pdf.1.9
      Name Synonyms
      Secondary FlyBase IDs
        References (33)