Imprecise excision of the progenitor insertion, resulting in a 2972bp deletion (coordinates 2R:6190378..6193350 , release 5 genome) that removes the first two SH3 domain-coding exons.
2973 kb deletion resulting from the imprecise excision of P{PTT-GA}CAPCA06924.
Homozygous and hemizygous larvae do not show a significant hunching response to vibration, in contrast to wild-type controls.
The electrophysiological response of the auditory nerve to mating songs is significantly reduced in homozygous adults compared to wild type.
Mutant scolopale cells of the Johnston's organ are dysmorphic and appear collapsed and ruptured. In addition the Johnston's organ sensory neurons often show accumulation of vacuolar structures.
Actin organisation at the muscle attachment site (MAS) between lateral-ventral somatic muscles 6 and 7 in abdominal segments is severely disrupted in mutant larvae, resulting in a jagged boundary. There is a significantly enlarged gap between actin filaments from adjacent muscles at most MASs. Larger junctional invaginations are seen at the mutant MAS than in wild type and integrin distribution is broader than normal. Aberrant muscle structure, with Z-lines oriented perpendicular to the MAS, is seen in approximately 30% of larvae. The parallel arrangement of actomyosin filaments is disrupted close to the muscle membrane in approximately 15% of larvae. MASs of lateral transverse muscles appear normal.
CAP49e, Msp300sz75 has increased cell number | embryonic stage phenotype
CAP49e, rhea1 has abnormal cell number | embryonic stage phenotype
CAP49e, scb2 has abnormal cell number | embryonic stage phenotype
CAP49e, Msp300sz75 has embryonic cardioblast | increased number phenotype
CAP49e, rhea1 has embryonic cardioblast phenotype
CAP49e, scb2 has embryonic cardioblast phenotype
CAP49e is rescued by CAPC.UAS.Tag:MYC/Scer\GAL4Mef2.PR
CAP49e is rescued by Scer\GAL4Mef2.PR/CAPΔSoHo.C.UAS.Tag:MYC
CAP49e is partially rescued by CAPC.UAS.Tag:MYC/Scer\GAL4tin.CΔ4
CAP49e is not rescued by CAPE.UAS.Tag:MYC/Scer\GAL4Mef2.PR
Expression of CAPC.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Mef2.PR fully rescues the muscle attachment defects of CAP49e mutant larvae.
Expression of CAPΔSoHo.C.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Mef2.PR rescues the muscle attachment defects of CAP49e mutant larvae.
Expression of CAPE.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Mef2.PR fails to rescue the muscle attachment defects of CAP49e mutant larvae.