FB2024_03 , released June 25, 2024
Allele: Dmel\Pink1HMC04160
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General Information
Symbol
Dmel\Pink1HMC04160
Species
D. melanogaster
Name
FlyBase ID
FBal0299205
Feature type
allele
Associated gene
Dmel\Pink1
Associated Insertion(s)
Carried in Construct
P{TRiP.HMC04160}
Also Known As
HMC04160
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMC04160}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMC04160
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease 6
      CEA
      (Gumeni et al., 2021)
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Pink1HMC04160 under the control of Scer\GAL4Mef2.PR leads to increased lysosome number in adult muscles, and disrupts the mitochondrial network, with increased mitochondrial aggregates and increased number of mitolysosomes, in both adult and larval muscles, and wing posture defects.

      Expression under the control of Scer\GAL4αTub84B.Switch.PK (induced by RU486 treatment) results in wing posture defects, decreased adult climbing activity and disorganization of muscle intestine fibers.

      Expression under the control of Scer\GAL4elav.PLu leads to a decrease in the number of PPL1 neurons; there is decreased climbing activity.

      (Gumeni et al., 2021)

      Females heterozygous for Pink1HMC04160 and Scer\GAL4mat.αTub67C.T:Hsim\VP16 crossed to Pink1HMC04160 males results in: 52% hatching; non-maternal effect.

      (Sopko et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Suppressed by
      Suppressor of
      Statement
      Reference

      Pink1HMC04160, Scer\GAL4GMR.PU is a suppressor of eye phenotype of Chchd2S81L.UAS, Scer\GAL4GMR.PU

      (Baek et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Pink1HMC04160
      Name Synonyms
      Secondary FlyBase IDs
        References (9)