FB2024_03 , released June 25, 2024
Allele: Dmel\AP-2σUAS.cCa
Open Close
General Information
Symbol
Dmel\AP-2σUAS.cCa
Species
D. melanogaster
Name
UAS construct of Choudhury
FlyBase ID
FBal0344947
Feature type
allele
Associated gene
Dmel\AP-2σ
Associated Insertion(s)
Carried in Construct
P{UAS-AP-2σ.C}
Key Links
Transgenic product class
wild_type
(Choudhury et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Choudhury et al., 2016)
Mutagen
in vitro construct
(Choudhury et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-AP-2σ.C}
Cytology
Description

UASt regulatory sequences drive expression of the AP-2σ open reading frame.

(Choudhury et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
AP-2σ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Act5C.PU/AP-2σUAS.cCa rescues AP-2σang-7/AP-2σKG02457

      (Choudhury et al., 2016)

      Scer\GAL4Act5C.PU/AP-2σUAS.cCa rescues AP-2σKG02457

      (Choudhury et al., 2016)
      Partially rescues

      Scer\GAL4elav-C155/AP-2σUAS.cCa partially rescues AP-2σKG02457

      (Choudhury et al., 2016)

      Scer\GAL4Act5C.PU/AP-2σUAS.cCa partially rescues AP-2σang-7/AP-2σang-5

      (Choudhury et al., 2016)

      Scer\GAL4elav-C155/AP-2σUAS.cCa partially rescues AP-2σang-7/AP-2σang-5

      (Choudhury et al., 2016)

      AP-2σUAS.cCa/Scer\GAL4ey.PU partially rescues AP-2σang-7

      (Choudhury et al., 2016)

      Scer\GAL4elav-C155/AP-2σUAS.cCa partially rescues AP-2σang-7/AP-2σKG02457

      (Choudhury et al., 2016)
      Comments

      The expression of AP-2σUAS.cCa under the control of Scer\GAL4elav-C155 rescues the larval synaptic phenotypes but not the lethality observed in AP-2σKG02457 homozygotes and in AP-2σKG02457/AP-2σang-7 or AP-2σang-5/AP-2σang-7 transheterozygotes. Expression under the control of Scer\GAL4Act5C.PU rescues both lethality and larval synaptic phenotypes in AP-2σKG02457 homozygotes and in AP-2σKG02457/AP-2σang-7 transheterozygotes.

      The expression of AP-2σUAS.cCa under the control of Scer\GAL4ey.PU partially rescues the eye morphology and ERG defects induced by AP-2σang-7 whole-eye clones; it fully rescues the photoreceptor cell loss.

      (Choudhury et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AP-2σUAS.cCa
      Name Synonyms
      UAS construct of Choudhury
      Secondary FlyBase IDs
        References (1)