l(2)br36, l(2)35Dc, br36, anon- EST:Posey289 , SPT
encodes Serine Palmitoyl-transferase (SPT), the first enzymatic step for synthesis of sphingolipids - neuromuscular junction, enriched in lipid rafts - facilitates glial ensheathment of peripheral nerves - suppresses dystrophic muscle phenotypes in a model of Duchenne muscular dystrophy
Please see the JBrowse view of Dmel\lace for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.52
597 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lace using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: rapidly degraded
lace transcripts are observed in most tissues assayed. Elevated transcript levels are observed in the embryonic midgut and in head sensory organs.
JBrowse - Visual display of RNA-Seq signals
View Dmel\lace in JBrowse2-51
2-48.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Notch accumulates abnormally in endocytic compartments in lace mutant wing disc cells.
9 additional alleles are discussed but are not named.
Strong alleles lethal; weak alleles viable with supernumerary fragments of wing veins.
Source for merge of: lace anon- EST:Posey289
Source for identity of: lace CG4162