SMC4, DmSMC4, l(2)k08819
condensin subunit SMC4 - involved in mitotic chromatin condensation
Please see the JBrowse view of Dmel\glu for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\glu using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally supplied; enriched at posterior pole where pole cells are forming
Comment: mitotic neuroblasts
Comment: mitotic neuroblasts
glu has a typical "mitotic" expression pattern
JBrowse - Visual display of RNA-Seq signals
View Dmel\glu in JBrowse2-52
2-51.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in defects in chromosome condensation and chromosome misalignment on the metaphase spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
Area matching Drosophila EST AA940865. This EST has sequence similarity to Xenopus chromosomal assembly protein, U1367.
glu is critically important for the resolution of sister chromatids during mitosis prior to anaphase onset.
Source for merge of: glu anon-WO0118547.156
Source for merge of glu anon-WO0118547.156 was sequence comparison ( date:051113 ).