a nuclear factor that physically interacts with Suppressor of Hairless and inhibits Notch signalling during peripheral nervous system development
Please see the JBrowse view of Dmel\insv for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Gene model reviewed during 5.55
Homodimer. Interacts (via BEN domain) with Su(H). Interacts with Cp190.
The BEN domain mediates DNA-binding.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\insv using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
JBrowse - Visual display of RNA-Seq signals
View Dmel\insv in JBrowse2-7
2-5.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Mutations in insv were originally reported to be lethal and to show Notch gain-of-function phenotypes in notum clones (FBrf0183881). FBrf0207678 showed that these phenotypes were confounded by the mutation of the Notch agonist l(2)gl on the mutant chromosomes. FBrf0214638 uses cleaned up insv stocks to show that viable insv mutants maintain detectable Notch gain-of-function phenotypes in the peripheral nervous system that are fully rescued by insv genomic DNA.
The sensory organ defects previously reported for insv mutant clones (FBrf0183881) can in fact be accounted for by a second-site mutation in l(2)gl that is also present on the mutant chromosomes.
dsRNA has been made from templates generated with primers directed against this gene.
Source for merge of: CG3227 BcDNA:RE55538
Source for merge of CG3227 BcDNA:RE55538 was a shared cDNA ( date:030728 ).
Source for identity of: insv CG3227
The gene is named "insensitive" because of the severe defects in the specification and differentiation of sensory organ cells in the adult peripheral nervous system in mosaic clones. FlyBase curator comment: it has subsequently been shown (FBrf0207678) that the strong sensory organ defects reported for insv mutant clones can in fact be accounted for by a second-site mutation in l(2)gl that is also present on the mutant chromosome, although FBrf0214638 uses cleaned up insv stocks to show that the mutants do have detectable mild Notch gain-of-function phenotypes in the peripheral nervous system.