FB2024_03 , released June 25, 2024
Allele: Dmel\eyaE7.UAS
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General Information
Symbol
Dmel\eyaE7.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0117565
Feature type
allele
Associated gene
Dmel\eya
Associated Insertion(s)
Carried in Construct
P{UAS-eya.E7}
Key Links
Transgenic product class
missense_variant
(Bui et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Bui et al., 2000)
Mutagen
in vitro construct
(Bui et al., 2000)
Progenitor genotype
eyaE7
(Bui et al., 2000)
Carried in construct
P{UAS-eya.E7}
Cytology
Description

UASt regulatory sequences drive expression of eyaE7.

(Bui et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
eya
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of eyaE7.Scer\UAS under the control of Scer\GAL4dpp.blk1 does not cause ectopic eye development, abnormal leg development or a reduced eye phenotype.

      (Bui et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      eyaE7.UAS/Scer\GAL4dpp.blk1 is an enhancer of visible phenotype of Scer\GAL4dpp.blk1, dacUAS.cSa

      (Bui et al., 2000)
      Other
      Statement
      Reference

      Scer\GAL4dpp.blk1, eyaE7.UAS, soUAS.cPa has visible phenotype

      (Bui et al., 2000)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      eyaE7.Scer\UAS shows a synergy in ectopic eye formation when coexpressed under the control of Scer\GAL4dpp.blk1 with dacScer\UAS.cSa. Co-expression of eyaE7.Scer\UAS and soScer\UAS.cPa under the control of Scer\GAL4dpp.blk1 results in ectopic retinal tissue in 19% of cases. The ectopic retinal tissue consists of discernible ommatidia and is limited to the antennal region. Abnormal leg development is seen in 100% of cases, and in 12% of cases a reduced eye phenotype is seen.

      (Bui et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4ey.PB/eyaE7.UAS partially rescues eya2

      (Bui et al., 2000)
      Comments

      The ability of eyaE7.Scer\UAS to rescue the eya2 mutant phenotype when expressed under the control of Scer\GAL4ey.PB is approximately one-fourth as strong as that of eyaScer\UAS.cBa (a wild-type transgene).

      (Bui et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      cliE7.Scer\UAS
      eyaE7.Scer\UAS
      eyaE7.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)