FlyBase Allele Report: Dmel\N[UAS.cSb]

General Information

Symbol

Dmel\N^UAS.cSb

Species

D. melanogaster

Name

FlyBase ID

FBal0123133

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

P{UAS-N⁺.Sb}

Also Known As

UAS-Notch, UAS-N^FL

Key Links

Transgenic product class

wild_type

(Struhl and Greenwald, 2001)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Struhl and Greenwald, 2001)

Mutagen

in vitro construct

(Struhl and Greenwald, 2001)

Progenitor genotype

Carried in construct

P{UAS-N⁺.Sb}

Cytology

Description

UAS sequences drive expression of wild-type N.

(Struhl and Greenwald, 2001)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

male genitalia, with Scer\GAL4^Abd-B-LDN

(Lee et al., 2011)

Detailed Description

Statement

Reference

Expression of N^Scer\UAS.cSb under the control of Scer\GAL4^c768 has no effect on neuroepithelium growth in the developing optic lobe in larvae.

(Zhou and Luo, 2013)

~54% of males expressing N^Scer\UAS.cSb under the control of Scer\GAL4^Abd-B-LDN show incomplete genitalia rotation.

(Lee et al., 2011)

N^{Scer\FRT.Scer\UAS.T:Ivir\HA1} when driven by Scer\GAL4^{F442A.αTub84B.T:Hsim\VP16} has little or no effect on neuroblast segregation.

(Struhl and Greenwald, 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^Act5C.PU/N^UAS.cSb is a suppressor | partially of abnormal cell polarity | recessive | somatic clone phenotype of flw^FP41

(Sun et al., 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

N^UAS.cSb, Scer\GAL4^c768 is a suppressor of larval optic anlage phenotype of RPA3^GD4799, Scer\GAL4^c768

(Zhou and Luo, 2013)

Scer\GAL4^Act5C.PU/N^UAS.cSb is a suppressor | partially of oocyte | somatic clone phenotype of flw^FP41

(Sun et al., 2011)

NOT Suppressor of

Statement

Reference

Scer\GAL4^{VP16.F442A.αTub84B}/N^UAS.cSb is a non-suppressor of embryonic neuroblast | increased number phenotype of Psn^C2

(Struhl and Greenwald, 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of N^Scer\UAS.cSb significantly rescues the loss of neuroepithelium cells seen in the optic lobe of third instar larvae expressing RPA3^GD4799 under the control of Scer\GAL4^c768.

(Zhou and Luo, 2013)

Expression of N^Scer\UAS.cSb under the control of Scer\GAL4^Act5C.PU partially suppresses the oocyte polarity defect seen when the posterior follicle cells are mutant for flw^FP41.

(Sun et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

N^Scer\UAS.cSb

N^UAS.cSb

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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