FlyBase Allele Report: Hsap\HTT[Q128.UAS]

General Information

Symbol

Hsap\HTT^Q128.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0156385

Feature type

allele

Associated gene

Hsap\HTT

Associated Insertion(s)

Carried in Construct

P{UAS-HTT.Q128}

Also Known As

UAS-Htt-Q128, UAS-HttQ128, Htt-Q128, HttQ128, UAS-Htt^548aa-128Q, UAS-HTT-548-128Q

Key Links

Transgenic product class

inframe_deletion

(Lee et al., 2004)

trinucleotide_repeat_expansion

(Lee et al., 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Lee et al., 2004)

trinucleotide_repeat_expansion

(Lee et al., 2004)

Mutagen

in vitro construct

(Lee et al., 2004)

Progenitor genotype

Carried in construct

P{UAS-HTT.Q128}

Cytology

Description

UASt sequences drive expression of the N terminal 548 aa of the Q128 Hsap\HTT cDNA, which encodes the pathogenic protein.

(Lee et al., 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\HTT

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Huntington's disease

CEA

(Dubey et al., 2024, Nitta et al., 2023, Martin et al., 2021, Xu et al., 2019, Coelho et al., 2018, Akbergenova and Littleton, 2017, Gregory et al., 2017, Prakash et al., 2017, Arribat et al., 2013, Gohil et al., 2011, Rana et al., 2010, Ryoo et al., 2007, Lee et al., 2004)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neurodegenerative disease

modeled by dsh^Q108.UAS

(Lee et al., 2004)

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Lee et al., 2004)

model of Huntington's disease

is ameliorated by Atx2^HMS01392

(Xu et al., 2019)

is ameliorated by Atx2^HMS02726

(Xu et al., 2019)

is ameliorated by Atx2^KK100423

(Xu et al., 2019)

is exacerbated by Atx2^UAS.Tag:FLAG

(Xu et al., 2019)

is ameliorated by CrebA^JF02189

(Xu et al., 2019)

is ameliorated by Fmr1^GL00075

(Xu et al., 2019)

is ameliorated by Fmr1^HMS00248

(Xu et al., 2019)

is ameliorated by Hsap\HTT^P42.UAS.GFP

(Arribat et al., 2013)

is ameliorated by Hsap\HTT^{P42.UAS.Tag:MYC}

(Arribat et al., 2013)

is ameliorated by Pyk^GL00099

(Martin et al., 2021)

is ameliorated by nej^HMS01507

(Martin et al., 2021)

is ameliorated by nej^KK113191

(Martin et al., 2021)

is ameliorated by nej^RNAi.UAS.cSa

(Martin et al., 2021)

is ameliorated by pan^ΔN.UAS

(Martin et al., 2021)

is ameliorated by pygo^KK108114

(Martin et al., 2021)

is ameliorated by srl^EY05931

(Martin et al., 2021)

is ameliorated by CG42306^GD11667

(Martin et al., 2021)

is exacerbated by CrebB^JF02494

(Martin et al., 2021)

is ameliorated by Hsap\DNAJB1^UAS.cKa

(Martin et al., 2021)

is ameliorated by Hsp110^UAS.cKa

(Martin et al., 2021)

is ameliorated by Hsp68^UAS.cUa

(Martin et al., 2021)

is ameliorated by InR^K1409A.UAS

(Martin et al., 2021)

is ameliorated by Itpr^JF01957

(Martin et al., 2021)

is ameliorated by Pten^UAS.cUa

(Martin et al., 2021)

is exacerbated by Rab5^KK102895

(Martin et al., 2021)

is ameliorated by Rab5^UAS.EGFP

(Martin et al., 2021)

is ameliorated by SERCA^HMS02878

(Martin et al., 2021)

is ameliorated by SERCA^JF01948

(Martin et al., 2021)

is ameliorated by foxo^TM.UAS

(Martin et al., 2021)

is ameliorated by foxo^UAS.cUa

(Martin et al., 2021)

is ameliorated by kto^HMS01062

(Martin et al., 2021)

is ameliorated by nej^GD8975

(Martin et al., 2021)

is ameliorated by rho-5^UAS.cZa

(Lee et al., 2015)

is exacerbated by rho-5^KO1

(Lee et al., 2015)

is ameliorated by Hsap\RHBDF1^UAS.cLa

(Lee et al., 2015)

is ameliorated by slmb^UAS.cGa

(Godin et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Lee et al., 2004)

HTT:p.Gln18[128]

(FlyBase curators, 2019-)

Variants Synonym(s)

HTT:p.Gln18[128Gln]

HTT, (CAG)n REPEAT EXPANSION

Associated human disease model(s)

Huntington disease

External database links

ClinVar: HTT_409

Comments concerning this variant

Phenotypic Data

Phenotypic Class

abnormal behavior, with Scer\GAL4^elav.PLu

(Lee et al., 2004)

abnormal circadian rhythm | adult stage, with Scer\GAL4^P2.4.Pdf

(Xu et al., 2019, Prakash et al., 2017)

abnormal eye color, with Scer\GAL4^GMR.PU

(Godin et al., 2010)

abnormal locomotor behavior, with Scer\GAL4^elav-C155

(Lee et al., 2004)

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PLu

(Lee et al., 2004)

abnormal locomotor behavior | adult stage, with Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

abnormal locomotor behavior | larval stage, with Scer\GAL4^elav-C155

(Lee et al., 2004)

abnormal locomotor rhythm | adult stage, with Scer\GAL4^P2.4.Pdf

(Prakash et al., 2017)

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR.PF

(Fujikake et al., 2008)

abnormal neuroanatomy | adult stage, with Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^elav.PLu

(Gohil et al., 2011)

abnormal neurophysiology, with Scer\GAL4^GMR.PF

(Lee et al., 2004)

decreased cell number | adult stage, with Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

increased cell death | larval stage, with Scer\GAL4^GMR.PF

(Coelho et al., 2018)

lethal, with Scer\GAL4^elav-C155

(Lee et al., 2004)

short lived, with Scer\GAL4^elav.PU

(Godin et al., 2010)

short lived, with Scer\GAL4^unspecified

(Rana et al., 2010)

short lived | RU486 conditional, with Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

some die during immature adult stage | recessive, with Scer\GAL4^elav-C155

(Lee et al., 2004)

visible, with Scer\GAL4^GMR.PU

(Lee et al., 2015, Godin et al., 2010)

visible | adult stage, with Scer\GAL4^GMR.PU

(Qurashi et al., 2012)

Phenotype Manifest In

adult s-LNv neuron, with Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

adult s-LNv neuron | adult stage

(Prakash et al., 2017)

eye, with Scer\GAL4^GMR.PF

(Lee et al., 2004)

eye, with Scer\GAL4^GMR.PU

(Lee et al., 2015, Qurashi et al., 2012, Godin et al., 2010)

eye disc, with Scer\GAL4^GMR.PF

(Coelho et al., 2018)

eye photoreceptor cell, with Scer\GAL4^GMR.PF

(Lee et al., 2004)

interommatidial bristle, with Scer\GAL4^GMR.PF

(Lee et al., 2004)

ommatidium, with Scer\GAL4^GMR.PF

(Fujikake et al., 2008)

ommatidium, with Scer\GAL4^GMR.PU

(Lee et al., 2015, Godin et al., 2010)

pigment cell, with Scer\GAL4^GMR.PF

(Lee et al., 2004)

rhabdomere | adult stage, with Scer\GAL4^GMR.PF

(Fujikake et al., 2008)

rhabdomere | progressive, with Scer\GAL4^elav.PLu

(Gohil et al., 2011)

Detailed Description

Statement

Reference

The expression of Hsap\HTT^Q128.UAS under the control of Scer\GAL4^{repo.Switch.2301} from day 1 of adulthood (induced by feeding of RU486) leads to decreased lifespan and decreased climbing ability.

(Martin et al., 2021)

The expression of Hsap\HTT^Q128.UAS under the control of Scer\GAL4^P2.4.Pdf severely impairs circadian behavior, and leads to a severe decrease in the number of sLNv nurons in 10-days old adults.

(Xu et al., 2019)

Expressing Hsap\HTT^Q128.UAS under the control of Scer\GAL4^GMR.PF induces significant apoptosis (cleaved DCP1 labelling) in the eye disc, as compared to controls.

(Coelho et al., 2018)

Most of the adult flies expressing Hsap\HTT^{Q128.Scer\UAS} under the control of Scer\GAL4^P2.4.Pdf show arrhythmic locomotor activity from the first day in constant darkness (DD) as well as poor consolidation of daily activity, whereas all control flies are rhythmic. The Hsap\HTT^{Q128.Scer\UAS}-expressing flies have significantly fewer s-LNv somas that label positive for either Pdf or per, in contrast the number of Pdf-positive l-LNv neurons is comparable to controls but only about half of these is also positive for per. However, there is no significant difference in the number of Pdf+ s-LNv neurons between Hsap\HTT^{Q128.Scer\UAS}-expressing flies that are (weakly) rhythmic and those completely arrhythmic and both these groups show Pdf immunoreactivity in the dorsal projections of s-LNv neurons. The Pdf levels in these dorsal projections oscillate after transfer to DD and while the peak coincides with the timing observed in control flies but the rise and fall of Pdf in Hsap\HTT^{Q128.Scer\UAS} flies occurs earlier than in controls. per protein levels in the somas of l-LNv neurons do not oscillate and are very low relative to flies expressing Hsap\HTT^Q0.Scer\UAS, whereas they oscillate with similar phase and overall intensity in other (Pdf-negative) neuronal groups (LNd, DN1, DN2 or the 5th s-LNv).

Adult flies expressing Hsap\HTT^{Q128.Scer\UAS} continue to show anticipation of the dark-light transition even under low light intensity LD (light-dark) cycles and, like controls, show a clear oscillation in Pdf levels in s-LNv dorsal projections. On average, fewer per+ s-LNv somas are found in Hsap\HTT^{Q128.Scer\UAS} expressing flies compared to Hsap\HTT^Q0.Scer\UAS flies. The number of Pdf and per positive l-LNv somas are comparable between the two genotypes and in these neurons the per protein shows clear oscillation under LD although the amplitude is dampened in Hsap\HTT^{Q128.Scer\UAS} flies compared to Hsap\HTT^Q0.Scer\UAS.

Hsap\HTT^{Q128.Scer\UAS};Scer\GAL4^P2.4.Pdf flies raised and maintained in constant light (LL) show a progressive loss of Pdf from s-LNv neurons' dorsal projections, flies maintained in LL, transferred to LD and then DD (the LL-LD regimen) show no Pdf+ s-LNv somas at age 23 and 28 days, not even after experiencing 5 days in LD. The numbers of Pdf+ l-LNv somas is comparable between regimens. Both LL-LD and LD-LD flies Scer\GAL4^P2.4.Pdf>Hsap\HTT^{Q128.Scer\UAS} flies exhibit activity profiles similar to their in-regimen controls and also show no differences in their morning and evening anticipation behavior relative to controls and across regimens.

(Prakash et al., 2017)

Flies with expression of Hsap\HTT^{Q128.Scer\UAS} driven by Scer\GAL4^GMR.PU display a rough eye phenotype, with reduced numbers of ommatidia.

(Lee et al., 2015)

Expression of Hsap\HTT^{Q128.Scer\UAS} under the control of Scer\GAL4^GMR.PU results in a rough eye phenotype.

(Qurashi et al., 2012)

Expression of Hsap\HTT^{Q128.Scer\UAS} under the control of Scer\GAL4^elav.PLu results in time-dependent neurodegeneration. Newly eclosed flies have the normal complement of seven visible rhabdomeres per ommatidium, but this is reduced by day 10 post-eclosion. Treatment with meclizine partially rescues this phenotype.

(Gohil et al., 2011)

Expression of Hsap\HTT^{Q128.Scer\UAS} under the control of Scer\GAL4^GMR.PU results in a loss of eye pigmentation, a rough eye phenotype and defects in the ommatidial array.

The loss of eye pigmentation seen in flies expressing Hsap\HTT^{Q128.Scer\UAS} under the control of Scer\GAL4^GMR.PU is significantly reduced by feeding with indomethacin.

Feeding with indomethacin increases the mean lifespan of flies expressing Hsap\HTT^{Q128.Scer\UAS} under the control of Scer\GAL4^elav.PU.

(Godin et al., 2010)

Expression of Hsap\HTT^{Q128.Scer\UAS} under the control of an unknown Gal4 driver severely reduces adult survival rates.

(Rana et al., 2010)

One day old flies expressing Hsap\HTT^{Q128.Scer\UAS} under the control of Scer\GAL4^GMR.PF show photoreceptor degeneration, resulting in loss of rhabdomeres in each ommatidium. This photoreceptor degeneration is suppressed upon treatment with the HSF1-activating compound 17-AAG. Treatment with GA and RA modestly increases the number of rhabdomeres, as does the histone deacetylase inhibitor SB.

(Fujikake et al., 2008)

When Hsap\HD^{Q128.Scer\UAS} is driven by Scer\GAL4^GMR.PF a rough eye phenotype is seen. A loss of pigmentation is seen in the eye as well as abnormal bristle pattern and photoreceptor degeneration. A neurophysiological phenotype is also seen; mutant animals show reduced photoreceptor depolarisation and complete abolishment of synaptic transmission in response to light. Cytoplasmic Hsap\HD aggregates are seen in neurons, aggregates are transported in larval motor axons and accumulate in presynaptic neuromuscular junction terminals When Hsap\HD^{Q128.Scer\UAS} is driven by Scer\GAL4^elav-C155, larvae show a significant reduction in locomotor speed of about 25% from 1.23 mm/s to 0.92 mm/s. In adults expression of Hsap\HD^{Q128.Scer\UAS} by Scer\GAL4^elav-C155 cause adult lethality. When driven by Scer\GAL4^elav.PLu adults are fully viable, however, several days after eclosion, mutant adults begin to exhibit uncoordinated movement and abnormal grooming behaviour. These behaviours worsen with age, resulting in premature death. When Hsap\HD^{Q128.Scer\UAS} is driven by Scer\GAL4^elav-C155, Hsap\HD cytoplasmic aggregates are seen in neurons. When driven by Scer\GAL4^αTub84B.PL cytoplasmic aggregates are seen in both neuronal and non-neuronal tissues. No nuclear aggregates are seen.

(Lee et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, enhanceable by CrebB^JF02494, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, enhanceable by gro^HMS01506, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, enhanceable by Rab5^KK102895, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal circadian rhythm | adult stage phenotype, enhanceable by Atx2^{ΔLsm.UAS.Tag:FLAG}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by rho-5[+]/rho-5^KO1

(Lee et al., 2015)

NOT Enhanced by

Statement

Reference

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-enhanceable by v^KK108195, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-enhanceable by HDAC1^GD4513, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-enhanceable by Itpr^JF01957, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-enhanceable by CrebA^HMJ02218, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-enhanceable by nej^UAS.Tag:V5, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-enhanceable by nej^EP1179, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-enhanceable by p53^5A-1-4/p53^5A-1-4

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-enhanceable by foxo^Δ94/foxo^Δ94

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-enhanceable by nej^GD8975, Scer\GAL4^{repo.Switch.2301}/foxo^Δ94/foxo^Δ94

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-enhanceable by cn^KK101938, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal circadian rhythm | adult stage phenotype, non-enhanceable by Atx2^KK100423, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal neuroanatomy | adult stage phenotype, non-enhanceable by tyf^e00614

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has decreased cell number | adult stage phenotype, non-enhanceable by tyf^e00614

(Xu et al., 2019)

Suppressed by

Statement

Reference

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by Rab5^UAS.EGFP, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by Hsp110^UAS.cKa, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by Hsp68^UAS.cUa, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by SERCA^JF01948, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by SERCA^HMS02878, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by nej^RNAi.UAS.cSa, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by nej^GD8975, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by nej^HMS01507, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by nej^KK113191, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has abnormal locomotor behavior | adult stage phenotype, suppressible by nej^GD8975, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has abnormal locomotor behavior | adult stage phenotype, suppressible by nej^HMS01507, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has abnormal locomotor behavior | adult stage phenotype, suppressible by nej^KK113191, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by nej^GD8975, p53^5A-1-4/p53^5A-1-4/Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by p53^5A-1-4/nej^GD8975, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by nej^GD8975/foxo[+]/foxo^Δ94, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by InR^K1409A.UAS, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by foxo^UAS.cUa, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by foxo^TM.UAS, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by Pten^UAS.cUa, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by arm^KK102545, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by Axn^UAS.GFP, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by pan^ΔN.UAS, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by pygo^KK108114, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by CG42306^GD11667, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by kto^HMS01062, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by skd^HMS01305, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, suppressible | partially by Hsap\DNAJB1^UAS.cKa, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal circadian rhythm | adult stage phenotype, suppressible by Atx2^HMS02726, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal circadian rhythm | adult stage phenotype, suppressible by Atx2^HMS01392, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal neuroanatomy | adult stage phenotype, suppressible by Atx2^{ΔPAM2.UAS.Tag:FLAG}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal circadian rhythm | adult stage phenotype, suppressible by Atx2^{ΔPAM2.UAS.Tag:FLAG}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal circadian rhythm | adult stage phenotype, suppressible by Fmr1^GL00075, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal circadian rhythm | adult stage phenotype, suppressible by Fmr1^HMS00248, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal neuroanatomy | adult stage phenotype, suppressible by Fmr1^HMS00248, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has decreased cell number | adult stage phenotype, suppressible by Fmr1^HMS00248, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has decreased cell number | adult stage phenotype, suppressible by Atx2^{ΔPAM2.UAS.Tag:FLAG}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal circadian rhythm | adult stage phenotype, suppressible by CrebA^JF02189, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal neuroanatomy | adult stage phenotype, suppressible by CrebA^JF02189, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has decreased cell number | adult stage phenotype, suppressible by CrebA^JF02189, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible | partially by Hsap\RHBDF1^UAS.cLa, Scer\GAL4^GMR.PU

(Lee et al., 2015)

Hsap\HTT^Q128.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible | partially by rho-5^UAS.cZa, Scer\GAL4^GMR.PU

(Lee et al., 2015)

Hsap\HTT^Q128.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible | partially by slmb^UAS.cGa, Scer\GAL4^GMR.PU

(Godin et al., 2010)

Hsap\HTT^Q128.UAS, Scer\GAL4^GMR.PU has abnormal eye color phenotype, suppressible | partially by slmb^UAS.cGa, Scer\GAL4^GMR.PU

(Godin et al., 2010)

NOT suppressed by

Statement

Reference

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-suppressible by foxo^Δ94/foxo^Δ94

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-suppressible by nej^GD8975, Scer\GAL4^{repo.Switch.2301}/foxo^Δ94/foxo^Δ94

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-suppressible by cn^KK101938, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-suppressible by v^KK108195, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-suppressible by HDAC1^GD4513, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-suppressible by Itpr^JF01957, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-suppressible by CrebA^HMJ02218, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-suppressible by nej^UAS.Tag:V5, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-suppressible by nej^EP1179, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301} has short lived | RU486 conditional phenotype, non-suppressible by p53^5A-1-4/p53^5A-1-4

(Martin et al., 2021)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal neuroanatomy | adult stage phenotype, non-suppressible by Atx2^HMS02726, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal circadian rhythm | adult stage phenotype, non-suppressible by Atx2^KK100423, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal neuroanatomy | adult stage phenotype, non-suppressible by tyf^e00614

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal neuroanatomy | adult stage phenotype, non-suppressible by Fmr1^GL00075, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has decreased cell number | adult stage phenotype, non-suppressible by Fmr1^GL00075, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has decreased cell number | adult stage phenotype, non-suppressible by tyf^e00614

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has decreased cell number | adult stage phenotype, non-suppressible by Atx2^HMS02726, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal circadian rhythm | adult stage phenotype, non-suppressible by Fmr1^HMS00248/Atx2^HMS02726, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal circadian rhythm | adult stage phenotype, non-suppressible by Fmr1^GL00075/Atx2^HMS02726, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal circadian rhythm | adult stage phenotype, non-suppressible by CrebA^UAS.cRa/CrebA^JF02189, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has abnormal circadian rhythm | adult stage phenotype, non-suppressible by CrebA^UAS.cRa/Atx2^HMS01392, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by GIIIspla2^EP1516/GIIIspla2[+]

(Qurashi et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\HTT^Q128.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by rho-5[+]/rho-5^KO1

(Lee et al., 2015)

Hsap\HTT^Q128.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, enhanceable by rho-5[+]/rho-5^KO1

(Lee et al., 2015)

NOT Enhanced by

Statement

Reference

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has adult s-LNv neuron phenotype, non-enhanceable by tyf^e00614

(Xu et al., 2019)

Suppressed by

Statement

Reference

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has adult s-LNv neuron phenotype, suppressible by Atx2^{ΔPAM2.UAS.Tag:FLAG}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has adult s-LNv neuron phenotype, suppressible by Fmr1^HMS00248, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has adult s-LNv neuron phenotype, suppressible by CrebA^JF02189, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Hsap\RHBDF1^UAS.cLa, Scer\GAL4^GMR.PU

(Lee et al., 2015)

Hsap\HTT^Q128.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, suppressible | partially by Hsap\RHBDF1^UAS.cLa, Scer\GAL4^GMR.PU

(Lee et al., 2015)

Hsap\HTT^Q128.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by rho-5^UAS.cZa, Scer\GAL4^GMR.PU

(Lee et al., 2015)

Hsap\HTT^Q128.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, suppressible | partially by rho-5^UAS.cZa, Scer\GAL4^GMR.PU

(Lee et al., 2015)

Hsap\HTT^Q128.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by slmb^UAS.cGa, Scer\GAL4^GMR.PU

(Godin et al., 2010)

Hsap\HTT^Q128.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, suppressible | partially by slmb^UAS.cGa, Scer\GAL4^GMR.PU

(Godin et al., 2010)

NOT suppressed by

Statement

Reference

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has adult s-LNv neuron phenotype, non-suppressible by Atx2^HMS02726, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has adult s-LNv neuron phenotype, non-suppressible by tyf^e00614

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^P2.4.Pdf has adult s-LNv neuron phenotype, non-suppressible by Fmr1^GL00075, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\HTT^Q128.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by GIIIspla2^EP1516/GIIIspla2[+]

(Qurashi et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of rho-5^Scer\UAS.cZa or Hsap\RHBDF1^Scer\UAS.cLa partially suppresses the rough eye phenotype and reduced numbers of ommatidia seen in flies with Hsap\HTT^{Q128.Scer\UAS} driven by Scer\GAL4^GMR.PU.

rho-5^KO1/+ enhances the rough eye phenotype and reduced numbers of ommatidia seen in flies with Hsap\HTT^{Q128.Scer\UAS} driven by Scer\GAL4^GMR.PU.

(Lee et al., 2015)

One copy of GIIIspla2^EP1516 does not suppress the rough eye phenotype seen when Hsap\HTT^{Q128.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

(Qurashi et al., 2012)

Co-expression of slmb^Scer\UAS.cGa decreases the loss of eye pigmentation and improves ommatidial morphology in flies expressing Hsap\HTT^{Q128.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Godin et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Hsap\HD^{Q128.Scer\UAS}

Hsap\HTT^{Q128.Scer\UAS}

Hsap\HTT^Q128.UAS

HttQ128

(Rana et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (25)

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