FB2024_03 , released June 25, 2024
Allele: Dmel\varif00033
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General Information
Symbol
Dmel\varif00033
Species
D. melanogaster
Name
FlyBase ID
FBal0184623
Feature type
allele
Associated gene
Dmel\vari
Associated Insertion(s)
PBac{WH}varif00033
Carried in Construct
Also Known As
variF033
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Wu et al., 2007)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{WH}varif00033
    Cytology
    Description

    PBac{WH} insertion in the first common intron.

    (Wu et al., 2007)
    Allele components
    Component
    Use(s)
    Inserted element
    PBac{WH}
    Regulatory region(s)
    UAS
    Also carries
    FRT
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The tracheal dorsal trunk is long and tortuous in mutant embryos compared to wild type.

        (Swanson et al., 2009)

        Trachea are longer than normal and are missing lumenal segments of the ganglionic branches in mutant embryos.

        Mutants show defects in septate junction barrier function (as tested using a dye exclusion assay).

        (Wu et al., 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhanced by
        NOT Enhanced by
        Statement
        Reference

        varif00033 has presumptive embryonic/larval tracheal system phenotype, non-enhanceable by shgg119

        (Swanson et al., 2009)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The tracheal tube length defects caused by varif00033 are enhanced if the embryos are also mutant for dpov1, but are not enhanced if the embryos are also mutant for shgg119.

        (Swanson et al., 2009)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (5)
        Reported As
        Symbol Synonym
        CG9326f00033
        F033
        (Wu et al., 2007)
        szarf00033
        variF033
        (Swanson et al., 2009, Bachmann et al., 2008)
        varif00033
        Name Synonyms
        Secondary FlyBase IDs
          References (4)