FB2024_03 , released June 25, 2024
Allele: Dmel\E(spl)m8-HLHUAS.cUa
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General Information
Symbol
Dmel\E(spl)m8-HLHUAS.cUa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Unknown
FlyBase ID
FBal0244018
Feature type
allele
Associated gene
Dmel\E(spl)m8-HLH
Associated Insertion(s)
Carried in Construct
P{UAS-E(spl)m8-HLH.U}
Also Known As
UAS-E(spl)m8, UAS-m8
Key Links
Transgenic product class
wild_type
(Ayyar et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Ayyar et al., 2007)
Mutagen
in vitro construct
(Ayyar et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-E(spl)m8-HLH.U}
Cytology
Description

UAS regulatory sequences drive expression of E(spl)m8-HLH.

(Ayyar et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
E(spl)m8-HLH
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of E(spl)m8-HLHScer\UAS.cUa under the control of Scer\GAL4sca-109-68 results in adults exhibiting a virtually complete loss of thoracic sensory macrochaeta and microchaeta, leading to a 'bald appearance', as compared to controls.

      (Shukla et al., 2017)

      The gl-positive corpora cardiaca precursor cells are missing in stage 12 embryos expressing E(spl)Scer\UAS.cUa under the control of Scer\GAL4twi.2PE.

      (Park et al., 2011)

      No extra neuroblasts are seen when E(spl)m8-HLHScer\UAS.cUa is expressed under the control of Scer\GAL4wor.PA or Scer\GAL4elav.PU.

      (San-Juán and Baonza, 2011)

      Expression of E(spl)m8-HLHScer\UAS.cUa with Scer\GAL4sca-537.4 has no effect on the eye, but elicits loss of the scutellar macrochaetes and interommatidial bristles.

      Expression of E(spl)m8-HLHScer\UAS.cUa with Scer\GAL4455.2 results in potent loss of scutellar macrochaetes.

      (Kahali et al., 2009)

      Expression of E(spl)Scer\UAS.cUa under the control of Scer\GAL4neur-GAL4-A101 results in a complete loss of bristles on the notum.

      Expression of E(spl)Scer\UAS.cUa under the control of Scer\GAL4Tollo-MD806 has no effect on the bristles of the notum.

      (Ayyar et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The complete loss of thoracic sensory macrochaeta and microchaeta that results from the expression of E(spl)m8-HLHScer\UAS.cUa under the control of Scer\GAL4sca-109-68 is not suppressed by the co-expression of Rbfox1dsRNA.Scer\UAS.

      (Shukla et al., 2017)

      The potent loss of scutellar macrochaetes in E(spl)m8-HLHScer\UAS.cUa Scer\GAL4455.2 flies is not affected by Df(3R)Espl22/+.

      The loss of the scutellar macrochaetes and interommatidial bristles resulting from expression of E(spl)m8-HLHScer\UAS.cUa with Scer\GAL4sca-537.4 is suppressed by co-expression of CkIIαdsRNA.Scer\UAS or CkIIαScer\UAS.Tik.

      (Kahali et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      E(spl)m8-HLHUAS.cUa is rescued by Scer\GAL4455.2/E(spl)m8-HLHSD.Δgro.UAS

      (Kahali et al., 2009)
      Not rescued by

      E(spl)m8-HLHUAS.cUa is not rescued by Scer\GAL4455.2/E(spl)m8-HLHΔgro.UAS

      (Kahali et al., 2009)
      Comments

      Co-expression of E(spl)m8-HLHSD.Δgro.Scer\UAS fully attenuates the potent loss of scutellar bristles seen in E(spl)m8-HLHScer\UAS.cUa Scer\GAL4455.2 flies.

      Co-expression of E(spl)m8-HLHΔgro.Scer\UAS does not attenuate the potent loss of scutellar bristles seen in E(spl)m8-HLHScer\UAS.cUa Scer\GAL4455.2 flies.

      (Kahali et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      E(spl)Scer\UAS.cUa
      E(spl)m8-HLHScer\UAS.cUa
      E(spl)m8-HLHUAS.cUa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Unknown
      Secondary FlyBase IDs
        References (8)