FlyBase Allele Report: Dmel\α-Cat[HMS00317]

FB2024_03 , released June 25, 2024

FB2024_03 , released June 25, 2024

Allele: Dmel\α-Cat^HMS00317

General Information

Symbol

Dmel\α-Cat^HMS00317

Species

D. melanogaster

Name

FlyBase ID

FBal0257207

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00317}

Also Known As

α-catenin RNAi, α-Cat RNAi, HMS00317, UAS-α-Cat^RNAi

Key Links

Genomic Maps

Transgenic product class

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00317}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult gut, with Scer\GAL4^klu-G410

(Bohere et al., 2022)

adult gut, with Scer\GAL4^NP7397

(Bohere et al., 2022)

adult gut, with α-Cat^{ΔM1a.UAS.Tag:V5}, Scer\GAL4^klu-G410

(Bohere et al., 2022)

adult gut, with α-Cat^{ΔM1a.UAS.Tag:V5}, Scer\GAL4^NP7397, Scer\GAL80^Su(H).GBE

(Bohere et al., 2022)

border follicle cell, with Scer\GAL4^slbo.2.6

(Raza et al., 2019)

cephalic furrow | embryonic stage 6, with Scer\GAL4^{VP16.mat.αTub67C}

(Eritano et al., 2020)

ectoderm, with Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

embryonic/first instar larval cuticle | embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

embryonic/first instar larval cuticle | embryonic stage, with α-Cat^{UASp.ΔVH2.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

embryonic/first instar larval cuticle | embryonic stage, with α-Cat^{UASp.ΔVH2N.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

embryonic/first instar larval cuticle | embryonic stage, with α-Cat^{ΔM1.UASp.R.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

embryonic/first instar larval cuticle | embryonic stage, with α-Cat^{ΔM3.UASp.R.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

embryonic/first instar larval cuticle | embryonic stage, with α-Cat^{ΔM.UASp.R.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

embryonic head, with α-Cat^{UASp.R.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

embryonic head, with α-Cat^{UASp.ΔVH2.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

embryonic head, with α-Cat^{ΔM1.UASp.R.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

embryonic head, with α-Cat^{ΔM3.UASp.R.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

embryonic head, with α-Cat^{ΔM.UASp.R.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

eye, with Scer\GAL4^ey.PU

(Nagarkar-Jaiswal et al., 2015)

mesoderm, with Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

ventral denticle belt | embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

ventral denticle belt | embryonic stage, with α-Cat^{UASp.ΔVH2.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

ventral denticle belt | embryonic stage, with α-Cat^{UASp.ΔVH2N.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

ventral denticle belt | embryonic stage, with α-Cat^{ΔM3.UASp.R.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

ventral denticle belt | embryonic stage, with α-Cat^{ΔM.UASp.R.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

Detailed Description

Statement

Reference

Stage 6 embryos expressing α-Cat^HMS00317 under the control of Scer\GAL4^{VP16.mat.αTub67C} show decreased cephalic furrow initiation linearity, increased cleft depth and decreased cephalic furrow alignment.

(Eritano et al., 2020)

The expression of α-Cat^HMS00317 under the control of Scer\GAL4^slbo.2.6 frequently leads to border cell migration failure or delay, as well as a border cell cluster disassociation phenotype, where one or more cells are separated from the cluster.

(Raza et al., 2019)

Expression of α-Cat^HMS00317 under the control of Scer\GAL4^ey.PU at 28[o]C results in a rough eye phenotype.

(Nagarkar-Jaiswal et al., 2015)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^fat/α-Cat^HMS00317 is an enhancer of visible | larval stage phenotype of Axn¹²⁷

(Zhang et al., 2017)

Phenotype Manifest In

Enhanced by

Statement

Reference

α-Cat^HMS00317, α-Cat^{UASp.ΔVH2N.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C} has embryonic/first instar larval cuticle | embryonic stage phenotype, enhanceable by cno^TRiP.cUa, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^HMS00317, Scer\GAL4^{VP16.mat.αTub67C} has embryonic/first instar larval cuticle | embryonic stage phenotype, enhanceable by cno^TRiP.cUa, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^HMS00317, α-Cat^{UASp.ΔVH2.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C} has ventral denticle belt | embryonic stage phenotype, enhanceable by Vinc^{CO.UASp.TagRFP}, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^{ΔM.UASp.R.Tag:HA}, α-Cat^HMS00317, Scer\GAL4^{VP16.mat.αTub67C} has ventral denticle belt | embryonic stage phenotype, enhanceable by jub^HMS00714, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^{ΔM.UASp.R.Tag:HA}, α-Cat^HMS00317, Scer\GAL4^{VP16.mat.αTub67C} has embryonic/first instar larval cuticle | embryonic stage phenotype, enhanceable by cno^TRiP.cUa, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^{ΔM.UASp.R.Tag:HA}, α-Cat^HMS00317, Scer\GAL4^{VP16.mat.αTub67C} has ventral denticle belt | embryonic stage phenotype, enhanceable by Rap1^HMJ21898, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^{ΔM1.UASp.R.Tag:HA}, α-Cat^HMS00317, Scer\GAL4^{VP16.mat.αTub67C} has embryonic/first instar larval cuticle | embryonic stage phenotype, enhanceable by cno^TRiP.cUa, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^{ΔM3.UASp.R.Tag:HA}, α-Cat^HMS00317, Scer\GAL4^{VP16.mat.αTub67C} has embryonic/first instar larval cuticle | embryonic stage phenotype, enhanceable by cno^TRiP.cUa, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^HMS00317, α-Cat^{UASp.R.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C} has embryonic head phenotype, enhanceable by cno^TRiP.cUa, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^HMS00317, α-Cat^{UASp.ΔVH2.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C} has embryonic/first instar larval cuticle | embryonic stage phenotype, enhanceable by cno^TRiP.cUa, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

NOT Enhanced by

Statement

Reference

α-Cat^{ΔM.UASp.R.Tag:HA}, α-Cat^HMS00317, Scer\GAL4^{VP16.mat.αTub67C} has ventral denticle belt | embryonic stage phenotype, non-enhanceable by ed^GD79, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

Suppressed by

Statement

Reference

α-Cat^{ΔM.UASp.R.Tag:HA}, α-Cat^HMS00317, Scer\GAL4^{VP16.mat.αTub67C} has ventral denticle belt | embryonic stage phenotype, suppressible | partially by cno^UASp.GFP, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^{ΔM3.UASp.R.Tag:HA}, α-Cat^HMS00317, Scer\GAL4^{VP16.mat.αTub67C} has ventral denticle belt | embryonic stage phenotype, suppressible | partially by cno^UASp.GFP, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^HMS00317, Scer\GAL4^{VP16.mat.αTub67C} has embryonic/first instar larval cuticle | embryonic stage phenotype, suppressible | partially by cno^UASp.GFP, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^HMS00317, α-Cat^{UASp.ΔVH2N.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C} has ventral denticle belt | embryonic stage phenotype, suppressible | partially by cno^UASp.GFP, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^HMS00317, α-Cat^{UASp.ΔVH2.Tag:HA}, Scer\GAL4^{VP16.mat.αTub67C} has ventral denticle belt | embryonic stage phenotype, suppressible | partially by cno^UASp.GFP, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

NOT suppressed by

Statement

Reference

α-Cat^{ΔM.UASp.R.Tag:HA}, α-Cat^HMS00317, Scer\GAL4^{VP16.mat.αTub67C} has ventral denticle belt | embryonic stage phenotype, non-suppressible by ed^GD79, Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

Enhancer of

Statement

Reference

Scer\GAL4^fat/α-Cat^HMS00317 is an enhancer of larval abdomen phenotype of Axn¹²⁷

(Zhang et al., 2017)

Other

Statement

Reference

α-Cat^HMS00317, α-Cat^{UASp.R.Tag:HA}, Rap1^HMJ21898, Scer\GAL4^{VP16.mat.αTub67C} has ventral denticle belt | embryonic stage phenotype

(Sheppard et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

α-Cat^HMS00317 is rescued by α-Cat^{ΔM1.UASp.R.Tag:HA}/Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^HMS00317 is rescued by α-Cat^{UASp.R.Tag:HA}/Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^HMS00317 is rescued by α-Cat^{ΔM2.UAS.Tag:V5}/Scer\GAL4^NP7397

(Bohere et al., 2022)

α-Cat^HMS00317 is rescued by α-Cat^{UAS.FL.Tag:V5}/Scer\GAL4^NP7397

(Bohere et al., 2022)

Partially rescued by

α-Cat^HMS00317 is partially rescued by α-Cat^{ΔM.UASp.R.Tag:HA}/Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^HMS00317 is partially rescued by α-Cat^{ΔM3.UASp.R.Tag:HA}/Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^HMS00317 is partially rescued by α-Cat^{UASp.ΔVH2N.Tag:HA}/Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

Not rescued by

α-Cat^HMS00317 is not rescued by α-Cat^{UASp.ΔVH2.Tag:HA}/Scer\GAL4^{VP16.mat.αTub67C}

(Sheppard et al., 2023)

α-Cat^HMS00317 is not rescued by α-Cat^{ΔM1a.UAS.Tag:V5}/Scer\GAL4^NP7397

(Bohere et al., 2022)

α-Cat^HMS00317 is not rescued by Scer\GAL4^NP7397/α-Cat^{ΔM1b.UAS.Tag:V5}

(Bohere et al., 2022)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

33430

y¹ v¹; P{TRiP.HMS00317}attP2

HMS00317

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00317}attP2/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

α-Cat^HMS00317

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections