FlyBase Allele Report: Dmel\Trim9[UAS.cMa]

General Information

Symbol

Dmel\Trim9^UAS.cMa

Species

D. melanogaster

Name

FlyBase ID

FBal0266855

Feature type

allele

Associated gene

Dmel\Trim9

Associated Insertion(s)

Carried in Construct

P{UAS-Trim9.M}

Key Links

Transgenic product class

wild_type

(Morikawa et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Morikawa et al., 2011)

Mutagen

in vitro construct

(Morikawa et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-Trim9.M}

Cytology

Description

UAS regulatory sequences drive expression of Trim9.

(Morikawa et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Trim9

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | somatic clone, with Scer\GAL4^ppk.PU

(Yang et al., 2014)

Phenotype Manifest In

larval ventral multidendritic neuron vdaB | somatic clone, with Scer\GAL4^ppk.PU

(Yang et al., 2014)

Detailed Description

Statement

Reference

Expression of Trim9^Scer\UAS.cMa under the control of Scer\GAL4^ppk.PU in class IV v'ada dendritic arborization neurons results in 11.8% of them developing contralateral projections, a phenotype not seen in wild type. The v'ada neurons show a ventral shift in the position of their presynaptic terminals compared to controls.

(Yang et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Ham et al., 2021)

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor of decreased cell number | adult stage phenotype of Pink1^B9

(Ham et al., 2021)

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor of abnormal locomotor behavior | adult stage phenotype of park¹

(Ham et al., 2021)

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor of decreased cell number | adult stage phenotype of park¹

(Ham et al., 2021)

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor | partially of increased cell death | adult stage phenotype of park¹

(Ham et al., 2021)

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor | partially of increased cell death | adult stage phenotype of Pink1^B9

(Ham et al., 2021)

Phenotype Manifest In

Suppressor of

Statement

Reference

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor | partially of mitochondrion | adult stage phenotype of park¹

(Ham et al., 2021)

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor | partially of flight muscle cell | adult stage phenotype of park¹

(Ham et al., 2021)

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor of dopaminergic PPL1 neuron | decreased number phenotype of park¹

(Ham et al., 2021)

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor of dopaminergic PPM2 neuron | decreased number phenotype of Pink1^B9

(Ham et al., 2021)

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor of dopaminergic PPM1 neuron | decreased number phenotype of Pink1^B9

(Ham et al., 2021)

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor | partially of mitochondrion | adult stage phenotype of Pink1^B9

(Ham et al., 2021)

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor | partially of flight muscle cell | adult stage phenotype of Pink1^B9

(Ham et al., 2021)

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor of dopaminergic PPL1 neuron | decreased number phenotype of Pink1^B9

(Ham et al., 2021)

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor of dopaminergic PPM1 neuron | decreased number phenotype of park¹

(Ham et al., 2021)

Trim9^UAS.cMa/Scer\GAL4^hs.PB is a suppressor of dopaminergic PPM2 neuron | decreased number phenotype of park¹

(Ham et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Trim9^UAS.cMa/Scer\GAL4^ppk.PG partially rescues Trim9⁹¹

(Morikawa et al., 2011)

Trim9^UAS.cMa/Scer\GAL4^ppk.PG partially rescues Trim9⁹¹/Df(2L)Exel8026

(Morikawa et al., 2011)

Comments

C4da neuron-specific expression of Trim9^Scer\UAS.cMa under the control of Scer\GAL4^ppk.PG largely rescues the axonal defects seen in Trim9⁹¹/Df(2L)Exel8026 mutants.

Expression of Trim9^Scer\UAS.cMa under the control of Scer\GAL4^ppk.PG significantly rescues the crawling behavior defects seen in Trim9⁹¹ mutants.

(Morikawa et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Trim9^Scer\UAS.cMa

Trim9^UAS.cMa

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close