Gene Group: GTPASES

General Information

Name

GTPASES

Species

D. melanogaster

Symbol

GTPASE

FlyBase ID

FBgg0001569

Date last reviewed

2020-07-16

Number of members

146

Description

GTPases are proteins that bind and hydrolyse GTP and act as bimodal switchs that alternates between inactive GDP-bound, and active GTP-bound confirmation to trigger a cellular response. They regulate numerous cellular processes, including signal transduction, cell growth and differentiation, ribosome assembly and protein synthesis, cytoskeletal organization, nuclear transport and spindle assembly, and intracellular protein transport. (Adapted from PMID:2122258).

Notes on Group

Source Material

The GTPASES Gene Group has been compiled using the following publication(s): Shuman and Momany, 2021, Zeledon et al., 2019, Fu et al., 2017, O'Neill and Clark, 2016, Im et al., 2015, Krishnan et al., 2015, Findeisen et al., 2014, Puhl et al., 2014, Sandoval et al., 2014, Neisch et al., 2013, Rojas et al., 2012, Diez et al., 2011, Noguchi et al., 2011, Boto et al., 2010, Katanayeva et al., 2010, Nielsen et al., 2010, Tracy et al., 2010, Deng et al., 2008, Kim et al., 2008, Pan et al., 2007, Zhang et al., 2007, Kollmar and Odronitz, 2006, Colicelli, 2004, Hwa et al., 2002, Pasqualato et al., 2002, Koizumi et al., 2001, and Goldstein and Gunawardena, 2000 .

Key Gene Ontology (GO) terms

Molecular Function

GTPase activity

Biological Process

Cellular Component

Related Gene Groups

Parent group(s)

NUCLEOSIDE TRIPHOSPHATE PHOSPHATASES

Component group(s)

BETA TUBULINS

DYNAMIN-LIKE GTPASES

HETEROTRIMERIC G-PROTEIN ALPHA SUBUNITS

MITOFUSINS

RAS GTPASE SUPERFAMILY

SEPTINS

SIGNAL RECOGNITION PARTICLE GTPASES

TRANSLATIONAL GTPASES

UNCLASSIFIED GTPASES

YLQF/YAWG GTPASES

Members (146)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

ARF GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Arf1

ADP ribosylation factor 1

Arf79F, ADP ribosylation factor 79F, dArf1, ADP ribosylation factor at 79F, Arf

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arf4

ADP ribosylation factor 4

Arf102F, ADP ribosylation factor 102F

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arf6

ADP ribosylation factor 6

Arf51F, dArf6

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arfrp1

ADP-ribosylation factor related protein 1

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arl1

ADP ribosylation factor-like 1

Arf72A, arl, l(3)72Ae, Arflike at 72A

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arl2

ADP ribosylation factor-like 2

Arf84F, Arl84F, Q06849

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arl4

ADP ribosylation factor-like 4

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arl5

ADP-ribosylation factor-like 5

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arl6

ADP ribosylation factor-like 6

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arl8

ADP ribosylation factor-like 8

Gie, GTPase indispensable for equal segregation of chromosomes

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

CG4789

(Rojas et al., 2012)

CG11356

(FlyBase, 2017-)

CG13692

(Zeledon et al., 2019)

CG17819

(Zeledon et al., 2019)

dnd

dead end

Arl3

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Sar1

Secretion-associated Ras-related 1

l(3)05712, bro5

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

BETA TUBULINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

βTub56D

β-Tubulin at 56D

β-tubulin, β1-tubulin, β1, β1 tubulin, tubulin

(Findeisen et al., 2014, Nielsen et al., 2010, Kollmar and Odronitz, 2006, Goldstein and Gunawardena, 2000)

βTub60D

β-Tubulin at 60D

β3-tubulin, β-tubulin, β3 tubulin, β3, Pin

(Findeisen et al., 2014, Nielsen et al., 2010, Kollmar and Odronitz, 2006, Goldstein and Gunawardena, 2000)

βTub65B

β-Tubulin at 65B

CT42364, Tub2B

(Findeisen et al., 2014, Kollmar and Odronitz, 2006, Goldstein and Gunawardena, 2000)

βTub85D

β-Tubulin at 85D

β-tubulin, β2-tubulin, β2 tubulin, B2t, β2

(Findeisen et al., 2014, Nielsen et al., 2010, Kollmar and Odronitz, 2006, Goldstein and Gunawardena, 2000)

βTub97EF

β-Tubulin at 97EF

β-tubulin, tubulin, β tubulin, βtubulin, βTub98C

(Findeisen et al., 2014, Nielsen et al., 2010, Kollmar and Odronitz, 2006, Goldstein and Gunawardena, 2000)

DYNAMIN-LIKE GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Drp1

Dynamin related protein 1

dynamin-2, l(2)ND2, l(2)ND3, noodle, Drp-1

(FlyBase, 2017-)

Opa1

Optic atrophy 1

dOpa1, Opa1-like, optic atrophy 1-like, l(2)s3475

(FlyBase, 2017-)

shi

shibire

dynamin, shibere, Dyn

(FlyBase, 2017-)

HETEROTRIMERIC G-PROTEIN ALPHA SUBUNITS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG17760

(Im et al., 2015, Krishnan et al., 2015, Colicelli, 2004)

CG30054

(Im et al., 2015, Krishnan et al., 2015, Colicelli, 2004)

cta

concertina

Gα, conc, Gα_12/13

(Im et al., 2015, Krishnan et al., 2015, Boto et al., 2010, Katanayeva et al., 2010, Colicelli, 2004)

Gαf

G protein alpha subunit f

Gα73B, Galpha73B, Gfα, Gf

(Im et al., 2015, Krishnan et al., 2015, Boto et al., 2010, Katanayeva et al., 2010, Colicelli, 2004)

Gαi

G protein alpha subunit i

G-iα65A, Gα_i, G-ialpha65A, Giα, Gai

(Krishnan et al., 2015, Boto et al., 2010, Katanayeva et al., 2010, Colicelli, 2004)

Gαo

G protein alpha subunit o

G-oα47A, G-oalpha47A, Go, Goα, Gα_o

(Im et al., 2015, Krishnan et al., 2015, Boto et al., 2010, Katanayeva et al., 2010, Colicelli, 2004)

Gαq

G protein alpha subunit q

dgq, Gqα, Gq, Gα49B, Galpha49B

(Im et al., 2015, Krishnan et al., 2015, Boto et al., 2010, Katanayeva et al., 2010, Colicelli, 2004)

Gαs

G protein alpha subunit s

Gα_s, Gs, dgs, Gsα, G-sα60A

(Im et al., 2015, Krishnan et al., 2015, Boto et al., 2010, Katanayeva et al., 2010, Colicelli, 2004)

MITOFUSINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

fzo

fuzzy onions

(Noguchi et al., 2011, Deng et al., 2008, Hwa et al., 2002)

Marf

Mitochondrial assembly regulatory factor

dMfn, Mfn, mitofusin, Mfn2

(Sandoval et al., 2014, Deng et al., 2008, Hwa et al., 2002)

RAB GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Rab1

Rab-protein 1, omt, omelette, dRab1, DmRab1

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab2

Drab2, Rab-protein 2, DmRab2

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab3

drab3, dm-Rab3, DmRab3, Rab3A

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab4

Rab-protein 4, DmRab4

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab5

DRab5, l(2)k08232, Rab-protein 5, DmRab5

(Fu et al., 2017, Zhang et al., 2007, Colicelli, 2004)

Rab6

l(2)08323, wrt, warthog, DmRab6

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab7

DmRab7, DRab7, Rab-protein 7

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab8

l(3)76BDu, DmRab8, dm-Rab8

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab9

DmRab9

(Zhang et al., 2007)

Rab9D

Rab at 9D

(Fu et al., 2017, Zhang et al., 2007, Colicelli, 2004)

Rab9Db

Rab at 9Db

(Fu et al., 2017, Zhang et al., 2007, Colicelli, 2004)

Rab9E

Rab at 9E

(Fu et al., 2017, Zhang et al., 2007)

Rab9Fa

Rab at 9Fa

DmRabX3

(Fu et al., 2017, Zhang et al., 2007)

Rab9Fb

Rab at 9Fb

DmRabX3, RabX3

(Zhang et al., 2007, Colicelli, 2004)

Rab10

Rab-protein 10, DRab10, DmRab10

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab11

l(3)j2D1, Drab11, Rab-protein 11, DmRab11, l(3)93Bi

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab14

BG:DS01068.7, ESTS:57H4T, DmRab14

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab18

Rab-RP4, DmRab18, Rab-related protein 4

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab19

Rab-RP3, DmRab19

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab21

DmRab21

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab23

DmRab23

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab26

DmRab26

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab27

EG:80H7.4, DmRab27, dm-Rab27

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab30

DmRab30

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab32

ltd, lightoid, Rab-RP1, RabRP1, DmRab32

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab35

dRab35, DmRab35

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab39

DmRab39

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab40

DmRab40

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

RabX1

chrw, chrowded, DmRabX1

(Fu et al., 2017, Zhang et al., 2007, Colicelli, 2004)

RabX2

DmRabX2

(Zhang et al., 2007, Colicelli, 2004)

RabX4

DmRabX4

(Fu et al., 2017, Zhang et al., 2007, Colicelli, 2004)

RabX5

DmRabX5

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

RabX6

DmRabX6

(Fu et al., 2017, Zhang et al., 2007, Colicelli, 2004)

RAN GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ran

l(1)G0075, Ran GTPase

(Rojas et al., 2012, Tracy et al., 2010, Koizumi et al., 2001)

Ran-like

(Tracy et al., 2010, Colicelli, 2004, Koizumi et al., 2001)

RAS GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5160

(Diez et al., 2011, Colicelli, 2004)

CG8500

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

CG8519

(Diez et al., 2011, Colicelli, 2004)

CG8641

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

CG13375

EG:BACR37P7.8

(Diez et al., 2011, Colicelli, 2004)

CG14669

(Rojas et al., 2012)

CG30158

(Diez et al., 2011)

CG42541

(Diez et al., 2011)

Rala

Ras-like protein A

Ral, dRal, Ras-related protein, l(1)G0174, l(1)G0373

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

Rap1

Rap1 GTPase

R, Roughened, Dras3, Rap, l(3)62Bf

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

Rap2l

Ras-associated protein 2-like

Rap21

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

Ras64B

Ras oncogene at 64B

Ras, Ras2, Dras2, Dmras64B, ras-2

(Diez et al., 2011, Colicelli, 2004)

Ras85D

Ras oncogene at 85D

Ras, Ras1, Dras1, RasV12, dRas

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

Rheb

Ras homolog enriched in brain

dRheb, Ras homologue enriched in brain

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

Ric

Ras-related protein interacting with calmodulin

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

RAS-RELATED GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

RagA-B

Ras-related GTP binding A/B

RagA, dRagB

(Kim et al., 2008)

RagC-D

Ras-related GTP binding C/D

RagC, dRagC

(Kim et al., 2008)

RGK GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Rgk1

Rad, Gem/Kir family member 1

(Puhl et al., 2014, Diez et al., 2011, Colicelli, 2004)

Rgk2

Rad, Gem/Kir family member 2

(Puhl et al., 2014, Diez et al., 2011)

Rgk3

Rad, Gem/Kir family member 3

(Puhl et al., 2014, Diez et al., 2011)

RHO GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cdc42

Cell division cycle 42

Dcdc42, DmCDC42

(Neisch et al., 2013, Rojas et al., 2012, Colicelli, 2004)

Miro

Mitochondrial Rho

dmiro

(Rojas et al., 2012, Colicelli, 2004)

Mtl

Mig-2-like

Rac, Rac GTPase

(Neisch et al., 2013, Colicelli, 2004)

Rac1

Rac, Drac1, Drac, Rac GTPase, D-Rac1

(Neisch et al., 2013, Rojas et al., 2012, Colicelli, 2004)

Rac2

Rac, Rac1, Drac2, Rac GTPase, DRacB

(Neisch et al., 2013, Rojas et al., 2012, Colicelli, 2004)

Rho1

RhoA, Rho, Rho GTPase, DrhoA, Rho kinase

(Neisch et al., 2013, Rojas et al., 2012, Colicelli, 2004)

RhoBTB

Rho-related BTB domain containing

RhoGTPase, RhoX

(Neisch et al., 2013, Rojas et al., 2012, Colicelli, 2004)

RhoL

Rho-like

Mes1, Drac3, DRhoL

(Neisch et al., 2013, Colicelli, 2004)

RhoU

(Neisch et al., 2013, Colicelli, 2004)

SEPTINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

pnut

peanut

dSEPT7, septin

(Shuman and Momany, 2021, O'Neill and Clark, 2016, Pan et al., 2007, Goldstein and Gunawardena, 2000)

Septin1

Septin 1

Sep1, septin, iby, dSEPT1

(Shuman and Momany, 2021, O'Neill and Clark, 2016, Pan et al., 2007, Goldstein and Gunawardena, 2000)

Septin2

Septin 2

Sep2, septin

(Shuman and Momany, 2021, O'Neill and Clark, 2016, Pan et al., 2007, Goldstein and Gunawardena, 2000)

Septin4

Septin 4

Sep4, septin, dSEPT4

(Shuman and Momany, 2021, O'Neill and Clark, 2016, Pan et al., 2007, Goldstein and Gunawardena, 2000)

Septin5

Septin 5

Sep5, septin

(Shuman and Momany, 2021, O'Neill and Clark, 2016, Pan et al., 2007, Goldstein and Gunawardena, 2000)

SIGNAL RECOGNITION PARTICLE GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Srp54k

Signal recognition particle 54k

l(3)01418, Srp54

(FlyBase, 2017-)

SrpRα

Signal recognition particle receptor α

Gtp-bp, GTP-binding protein

(FlyBase, 2017-)

SrpRβ

Signal recognition particle receptor β

l(3)rK561, l(3)rL537

(FlyBase, 2017-)

TRANSLATIONAL GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG4849

eEF2

(FlyBase, 2017-)

CG33158

(FlyBase, 2017-)

eEF1α1

eukaryotic translation elongation factor 1 alpha 1

Ef1alpha48D, EF-1α, Ef1α48D, EF1α, Elongation factor 1α48D

(FlyBase, 2017-)

eEF1α2

eukaryotic translation elongation factor 1 alpha 2

Ef1alpha100E, EF-1α, F2, Ef1α100E, EF1α

(FlyBase, 2017-)

eEF2

eukaryotic translation elongation factor 2

Ef2b, EF2, Elongation factor 2b, Elongation factor 2

(FlyBase, 2017-)

eEFSec

eukaryotic translation elongation factor, selenocysteine-specific

EfSec

(FlyBase, 2017-)

eIF2γ

eukaryotic translation initiation factor 2 subunit gamma

eIF-2γ, eIF-2gamma, eIF2G, eIF-2G

(FlyBase, 2017-)

eIF5B

eukaryotic translation initiation factor 5B

cIF2, dIF2, IF2, eukaryotic initiation factor 5B, cytoplasmic Initiation Factor 2

(FlyBase, 2017-)

eRF3

eukaryotic translation release factor 3

Elf, delf, Dsup35

(FlyBase, 2017-)

Gtpbp1

GTP binding protein 1

Dgp-1

(FlyBase, 2017-)

Gtpbp2

GTP binding protein 2

CG 2017, GP-1 related

(FlyBase, 2017-)

HBS1

(FlyBase, 2017-)

mEFG1

mitochondrial translation elongation factor G 1

ico, iconoclast, l(2)27Ea, G

(FlyBase, 2017-)

mEFTu1

mitochondrial translation elongation factor Tu 1

EfTuM, Elongation factor Tu mitochondrial, l(3)L4569

(FlyBase, 2017-)

mEFTu2

mitochondrial translation elongation factor Tu 2

(FlyBase, 2017-)

mIF2

mitochondrial translation initiation factor 2

(FlyBase, 2017-)

mRRF2

mitochondrial ribosome recycling factor 2

EF-G2

(FlyBase, 2017-)

waw

waclaw

(FlyBase, 2017-)

UNCLASSIFIED GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

128up

upstream of RpIII128

(FlyBase, 2017-)

atl

atlastin

D-atlastin, dAtl

(FlyBase, 2017-)

CenG1A

Centaurin gamma 1A

BG:DS08220.1

(FlyBase, 2017-)

CG2656

(FlyBase, 2017-)

CG3704

EG:BACR7A4.17

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Guanylyl cyclase at 88E

Gyc-88E

(FlyBase, 2017-)

Non1

Novel nucleolar protein 1

BcDNA:LD23830

(FlyBase, 2017-)

RecQ5

RecQ5 helicase

RECQE, Q1, DQ1, RECQ5/QE

(FlyBase, 2017-)

Scp2

Sarcoplasmic calcium-binding protein 2

Calexcitin, JHDK, dSCP2

(FlyBase, 2017-)

Tsr1

Tsr1 ribosome assembly factor

(FlyBase, 2017-)

YLQF/YAWG GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ns1

Nucleostemin 1

(FlyBase, 2017-)

Ns2

Nucleostemin 2

Ngp

(FlyBase, 2017-)

Ns3

Nucleostemin 3

l(1)BA11, EG:BACN32G11.5, l(1)G0431, l(1)2Ad

(FlyBase, 2017-)

Ns4

Nucleostemin 4

38E.14

(FlyBase, 2017-)

External Data

Equivalent Group(s)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

GTPASE

GTPASES

Secondary FlyBase ID(s)

References (29)

Report Sections

Open Close