FlyBase Gene Report: Dmel\Rgl

General Information

Symbol

Dmel\Rgl

Species

D. melanogaster

Name

Ral guanine nucleotide dissociation stimulator-like

Annotation Symbol

CG8865

Feature Type

protein_coding_gene

FlyBase ID

FBgn0026376

Gene Model Status

Current

Stock Availability

15 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

dRGL, Ral guanine nucleotide exchange factor, Ral guanine nucleotide exchange factor 2

Key Links

Genomic Location

Cytogenetic map

70C5-70C5

Sequence location

3L:13,906,897..13,925,335 [-]

Recombination map

3-41

RefSeq locus

NT_037436 REGION:13906897..13925335

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables guanyl-nucleotide exchange factor activity

inferred from mutant phenotype

(Nászai et al., 2021)

inferred from genetic interaction with FLYBASE:Rala; FB:FBgn0015286

(Mirey et al., 2003)

enables small GTPase binding

inferred from physical interaction with FLYBASE:Ras85D; FB:FBgn0003205,FLYBASE:Ras64B; FB:FBgn0003206,FLYBASE:Rap1; FB:FBgn0004636

(Mirey et al., 2003)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables guanyl-nucleotide exchange factor activity

inferred from electronic annotation with InterPro:IPR001895, InterPro:IPR008937, InterPro:IPR019804, InterPro:IPR036964

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN007734601

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in positive regulation of epidermal growth factor receptor signaling pathway

inferred from mutant phenotype

(Nászai et al., 2021)

involved_in positive regulation of stem cell proliferation

inferred from mutant phenotype

(Nászai et al., 2021)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in Ras protein signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN007734601

(GO Reference Genome Project, 2011-)

involved_in regulation of Ras protein signal transduction

inferred by curator from GO:0005085

(Mirey et al., 2003)

involved_in small GTPase-mediated signal transduction

inferred from electronic annotation with InterPro:IPR001895, InterPro:IPR008937, InterPro:IPR019804, InterPro:IPR036964

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN007734601

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS

Pathway (FlyBase)

Positive Regulators of EGFR Signaling Pathway

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS -: RasGEFs are Guanine Nucleotide Exchange Factors (GEFs) for Ras family GTPases. The RasGEFs are characterized by a CDC25 homology domain. (Adapted from FBrf0220530).

Pathway (FlyBase)

Positive Regulators of EGFR Signaling Pathway -: Positive regulators of Epidermal Growth Factor Receptor signaling up-regulate the pathway, enhancing the activation of ERK kinase (rl) or acting on downstream effectors.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Rgl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9PCE9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UAG) postulated; FBrf0216884.

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Rgl-RA

FBtr0075793

NM_079958

4564

954

Rgl-RB

FBtr0075794

NM_176325

3939

774

Rgl-RC

FBtr0075796

NM_176326

3754

774

Rgl-RD

FBtr0075795

NM_176327

3865

774

Rgl-RE

FBtr0330186

NM_001274885

4564

973

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Rgl-PA

FBpp0075535

108.1

954

9.17

FBpp0075536

87.2

774

7.15

FBpp0075538

87.2

774

7.15

FBpp0075537

87.2

774

7.15

FBpp0303219

110.1

973

8.88

M9PCE9

NP_001261814

AGB94507

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

774 aa isoforms: Rgl-PB, Rgl-PC, Rgl-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rgl using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.08

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | ubiquitous

(Mirey et al., 2003)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

(Mirey et al., 2003)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rgl in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Rgl

View exonic expression by tissue for Dmel\Rgl

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026376

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44115/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026376

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026376

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026376

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8865

Flygut - An atlas of the Drosophila adult midgut

FBgn0026376

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 22 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Rgl

Transgenic constructs containing regulatory region of Rgl

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | embryonic stage, with Scer\GAL4^da.G32

Rgl^2FL.UAS

lethal | larval stage, with Scer\GAL4^da.G32

Rgl^2FL.UAS

viable

Rgl^EY02700

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Rgl^GD14051

viable, with Scer\GAL4^Mef2.PR

Rgl^GD14051

viable, with Scer\GAL4^pnr-MD237

Rgl^GD14051

viable, with Scer\GAL4^tin.CΔ4

Rgl^GD14051

Sterility

Allele

fertile

Rgl^EY02700

Other Phenotypes

Allele

visible, with Scer\GAL4^Bx-MS1096

visible, with Scer\GAL4^GMR.PF

visible, with Scer\GAL4^pnr-MD237

Rgl^GD14051

visible, with Scer\GAL4^sca.PU

Rgl^{2.UAS.Tag:PM(hKRAS)}

Phenotype manifest in

Allele

eye, with Scer\GAL4^GMR.PF

macrochaeta, with Scer\GAL4^sca.PU

Rgl^{2.UAS.Tag:PM(hKRAS)}

ommatidium, with Scer\GAL4^GMR.PF

tormogen cell, with Scer\GAL4^pnr-MD237

Rgl^GD14051

wing, with Scer\GAL4^Bx-MS1096

wing vein, with Scer\GAL4^Bx-MS1096

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (26)

Hsap\RGL1

13 of 14

Yes

Hsap\RALGDS

12 of 14

Yes

Hsap\RGL3

7 of 14

Yes

Hsap\RGL2

6 of 14

Yes

Hsap\RGL4

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (32)

Rnor\Rgl1

13 of 14

Yes

Rnor\Ralgds

12 of 14

Yes

Rnor\Rgl3

7 of 14

Yes

Rnor\Rgl2

6 of 14

Yes

Rnor\LOC102552619

2 of 14

Yes

Rnor\Rapgef5

2 of 14

Rnor\RGD1564129

2 of 14

Yes

Rnor\LOC100911649

1 of 14

Yes

Rnor\LOC102552882

1 of 14

Yes

Rnor\LOC102553110

1 of 14

Yes

Rnor\LOC120093097

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Rasgrf2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\RGD1559804

1 of 14

Yes

Rnor\RGD1561114

1 of 14

Yes

Rnor\RGD1562508

1 of 14

Yes

Rnor\RGD1563356

1 of 14

Yes

Rnor\Sos1

1 of 14

Rnor\Sos2

1 of 14

Mus musculus (laboratory mouse) (40)

Mmus\Ralgds

12 of 14

Yes

Mmus\Rgl1

12 of 14

Yes

Mmus\Rgl3

9 of 14

Yes

Mmus\Rgl2

6 of 14

Yes

Mmus\1700001J03Rik

2 of 14

Yes

Mmus\1700018F24Rik

2 of 14

Yes

Mmus\1700123K08Rik

2 of 14

Yes

Mmus\4930449I24Rik

2 of 14

Yes

Mmus\4930596D02Rik

2 of 14

Yes

Mmus\4933421I07Rik

2 of 14

Yes

Mmus\Gm3402

2 of 14

Yes

Mmus\Gm3404

2 of 14

Yes

Mmus\Gm3409

2 of 14

Yes

Mmus\Gm3415

2 of 14

Yes

Mmus\Gm4871

2 of 14

Yes

Mmus\Gm6309

2 of 14

Yes

Mmus\Gm6370

2 of 14

Yes

Mmus\Gm6408

2 of 14

Yes

Mmus\Rapgef3

2 of 14

Mmus\Rapgef5

2 of 14

Mmus\4930474N05Rik

1 of 14

Yes

Mmus\Gm5565

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Sos1

1 of 14

Mmus\Sos2

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\ralgds

10 of 13

Yes

Xtro\rgl3

8 of 13

Yes

Xtro\rgl2

6 of 13

Yes

Xtro\zbtb22

5 of 13

Yes

Xtro\atp5mk

1 of 13

Xtro\LOC100487632

1 of 13

Xtro\prex1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\rasgrp1

1 of 13

Yes

Xtro\sos2

1 of 13

Danio rerio (Zebrafish) (29)

Drer\rgl1

13 of 14

Yes

Drer\ralgds

12 of 14

Yes

Drer\rgl3a

10 of 14

Yes

Drer\rgl2

6 of 14

Yes

Drer\rapgef2b

2 of 14

Drer\rapgef5a

2 of 14

Drer\LOC797658

1 of 14

Yes

Drer\LOC101884125

1 of 14

Yes

Drer\LOC101885008

1 of 14

Yes

Drer\LOC103909384

1 of 14

Yes

Drer\LOC110438234

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\rasgrp3

1 of 14

Yes

Drer\rasgrp4

1 of 14

Yes

Drer\rgl3b

1 of 14

Yes

Drer\sos1

1 of 14

Drer\sos2

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\rgl-1

13 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\sos-1

1 of 14

Cele\Y34B4A.4

1 of 14

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP010782

12 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP004853

1 of 12

Agam\AgaP_AGAP008775

1 of 12

Agam\AgaP_AGAP009180

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\BUD5

2 of 13

Yes

Scer\CDC25

2 of 13

Yes

Scer\LTE1

2 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\efc25

2 of 12

Yes

Spom\ste6

2 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Rgl. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (8)

Epac

4 of 13

PDZ-GEF

4 of 13

C3G

3 of 13

CG4853

3 of 13

CG7369

3 of 13

RalGPS

3 of 13

Sos

3 of 13

CG34393

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Rgl^d03208

ameliorates amyotrophic lateral sclerosis type 10

modeled by TBPH^N493D.UAS

(Kankel et al., 2020)

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^{R521C.UAS.Tag:HA}

(Kankel et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RGL1; ral guanine nucleotide dissociation stimulator like 1

13 of 14

605667

RALGDS; ral guanine nucleotide dissociation stimulator

12 of 14

601619

RGL3; ral guanine nucleotide dissociation stimulator like 3

7 of 14

616743

RGL2; ral guanine nucleotide dissociation stimulator like 2

6 of 14

602306

RGL4; ral guanine nucleotide dissociation stimulator like 4

4 of 14

612214

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Rgl - Rap1

two hybrid

(Mirey et al., 2003)

Rgl - Ras64B

two hybrid

(Mirey et al., 2003)

Rgl - Ras85D

two hybrid

(Mirey et al., 2003)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Rala

suppressible

Rgl

(Mirey et al., 2003)

Rap1

enhanceable

Rgl

(Mirey et al., 2003)

Rap1

suppressible

Rgl

(Mirey et al., 2003)

Ras85D

enhanceable

Rgl

(Mirey et al., 2003)

Ras85D|Rala

suppressible

Rgl

(Mirey et al., 2003)

TBPH

suppressible

Rgl

(Kankel et al., 2020)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68839

DroID - A comprehensive database of gene and protein interactions.

FBgn0026376

MIST (genetic) - An integrated Molecular Interaction Database

44115

MIST (protein-protein) - An integrated Molecular Interaction Database

44115

Pathways

Signaling Pathways (FlyBase)

Positive Regulators of EGFR Signaling Pathway -: Positive regulators of Epidermal Growth Factor Receptor signaling up-regulate the pathway, enhancing the activation of ERK kinase (rl) or acting on downstream effectors.

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-41

Cytogenetic map

70C5-70C5

Sequence location

3L:13,906,897..13,925,335 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

70C5-70C5

Limits computationally determined from genome sequence between P{lacW}l(3)L5212^L5212&P{PZ}l(3)05871⁰⁵⁸⁷¹ and P{EP}EP3561^EP3561

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

70C-70C

(determined by in situ hybridisation)

(Mirey et al., 2003)

70C2-70C5

(Camonis, 1999.4.6, Mirey, 1999.4.6)

Experimentally Determined Recombination Data

Location

3-41

(FlyBase, 2016)

3-35.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (15)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

85057

w¹¹¹⁸; PBac{PB}Rgl^c04979

20984

w¹¹¹⁸; P{GT1}Rgl^GT-000359

28938

y¹ v¹; P{TRiP.HM05149}attP2

62698

w¹¹¹⁸; PBac{IT.GAL4}Rgl^0007-G4

63942

w¹¹¹⁸; PBac{IT.GAL4}Rgl^0988-G4

65668

w¹¹¹⁸; PBac{IT.GAL4}Rgl^1316-G4

37080

y¹ w^*; Mi{MIC}Rgl^MI03736

44711

y¹ w^*; Mi{MIC}Rgl^MI07874

19655

y¹ w^67c23; P{EPgy2}Rgl^EY02700

Kyoto

125766

w¹¹¹⁸; P{RS5}Rgl^5-HA-3008

VDRC

v106468

P{KK102742}VIE-260B

v23639

w¹¹¹⁸; P{GD14051}v23639

More stocks available...

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (64)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0026376

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0026376

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Identification: Two hybrid screen using Rala protein as a bait.

(Mirey et al., 1999)

Relationship to Other Genes

Source for database merge of

Source for merge of: Rgl CG8865

(Bayraktaroglu, 2000.8.7)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Named "Rgl" after the mouse ortholog.

(FlyBase, 2009-)

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG8865

(Hosono et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, van Dam et al., 2009, Ryder, 2004.9.23, Mirey et al., 2003)

DRgl

(Balakireva et al., 2001)

RalGDS

(Mirey, 1997.10.31)

RasGDS

(van Dam et al., 2009)

Rgl

(Kankel et al., 2020, Clandinin and Owens, 2016-, Terriente-Felix et al., 2013, Cingolani et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kelsom and Lu, 2012, Diez et al., 2011, Guan et al., 2011, Jungreis et al., 2011, Edwards and Mackay, 2009, van Dam et al., 2009, Walker et al., 2006, Mirey et al., 2003)

dRGL

(Camonis, 1999.4.6, Mirey et al., 1999, Mirey et al., 1999)

rgl

(Tracy et al., 2016, Liebl et al., 2006)

Name Synonyms

Ral guanine nucleotide dissociation stimulator-like

Ral guanine nucleotide dissociation stimulator-like ortholog

Ral guanine nucleotide exchange factor

(Guan et al., 2011)

Ral guanine nucleotide exchange factor 2

(Edwards and Mackay, 2009, Mirey, 1999.4.6)

Secondary FlyBase IDs

FBgn0036385

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 72 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44115

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PCE9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PCE9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026376

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44115/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026376

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026376

FlyMine - An integrated database for Drosophila genomics

FBgn0026376

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8865

MARRVEL_MODEL - MARRVEL (model organism gene)

44115

Linkouts

BioGRID - A database of protein and genetic interactions.

68839

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0026376

DroID - A comprehensive database of gene and protein interactions.

FBgn0026376

DRSC - Results frm RNAi screens

FBgn0026376

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026376

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0026376

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8865

Flygut - An atlas of the Drosophila adult midgut

FBgn0026376

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0026376

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003754

MIST (genetic) - An integrated Molecular Interaction Database

44115

MIST (protein-protein) - An integrated Molecular Interaction Database

44115

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (65)

The following external sites may use different assemblies or annotations than FlyBase.

-1.08

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