BG:DS05639.1
Please see the JBrowse view of Dmel\yuri for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.55
Gene model includes transcripts encoding non-overlapping portions of the full CDS.
Gene model reviewed during 5.43
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.48
Gene model reviewed during 6.04
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\yuri using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
Western blot analysis reveals that different yuri protein isoforms are developmentally distributed. Only the 30 kDa isoform is maternally loaded into eggs. The 65 kDa isoforms are the most abundant in other tissues and in embryos. All isoform classes are observed in testis and in the thorax. Immunocytochemisty reveals that yuri protein present at all stages of spermatogenesis, peaking around meiosis, with most staining being cytoplasmic and diffuse. In post-meiotic spermatids, yuri protein accumulates in a cap over one hemisphere of each spermatid nucleus. As the nucleus elongates from the initial spherical shape, the yuri cap elongates into a stripe along the long axis of the nucleus; there is also a dot of immunoreactivity at the apical tip of the nucleus. In the final stages of spermatid nuclear maturation, the stripe disappears, leaving only the apical dot. By onset of actin cone formation, all yuri immunoreactivity is lost.
Comment: in axons that extend from antennal neurons to AMMC
Comment: in axons that extend from antennal neurons to AMMC
JBrowse - Visual display of RNA-Seq signals
View Dmel\yuri in JBrowse2-51
2-48.2
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: BG:DS05639.1 CG12635
Source for merge of: BG:DS05639.1 BG:DS07851.11
Annotations CG11860 and CG12635 merged as CG31732 in release 3 of the genome annotation.
Source for identity of: yuri CG31732
Termed 'yuri gagarin' because this gravitaxis defective mutant was identified on the 40th anniversary of the first manned space flight.
Called 'yuri' because a single amino acid polymorphism in this gene is uniquely present in strains showing strong negative gravitaxis and "this polymorphism was confirmed on the 40th anniversary of Gagarin's historic space flight, leading to the naming of the gene yuri, in his honour".