l(2)k15914
zinc finger transcription factor - required in males for the maintenance of pairing between homologs at meiosis - required for the localization of the product of mod(mdg4) to paired autosomal bivalents - promotes alternative homolog conjunction during male meiosis without being part of the final physical linkage between chromosomes
Please see the JBrowse view of Dmel\tef for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tef using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\tef in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
tef expression is required in the male germline prior to spermatocyte stage S4 for the proper segregation of the autosomes during meiosis.
tef is required for maintenance of pairing between autosomal bivalents until their separation at anaphase I.
Mutations in tef cause meiosis-I specific nondisjunction of the autosomes in males.
Mutations cause high rates of fourth chromosome nondisjunction and also nondisjunction of the major autosomes in male meiosis. The mutant phenotype is male-specific.
Source for merge of: tef l(2)k15914
It is possible that "mei-S8" and "tef" identify the same complementation group, but lack of extant "mei-S8" mutant stocks precludes complementation tests.
Source for identity of: tef CG8961