FlyBase Allele Report: Dmel\ato[UAS.cJa]

General Information

Symbol

Dmel\ato^UAS.cJa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Jarman

FlyBase ID

FBal0030530

Feature type

allele

Associated gene

Dmel\ato

Associated Insertion(s)

Carried in Construct

P{UAS-ato.J}

Also Known As

UAS-ato

Key Links

Transgenic product class

cDNA

(Jarman et al., 1993)

wild_type

(Jarman et al., 1993)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Jarman et al., 1993)

wild_type

(Jarman et al., 1993)

Mutagen

in vitro construct

(Jarman et al., 1993)

Progenitor genotype

Carried in construct

P{UAS-ato.J}

Cytology

Description

UASt regulatory sequences drive expression of an ato cDNA fragment that includes 48bp of sequence 5' to the predicted initiation codon, the open reading frame and 8bp of sequence 3' to the predicted stop codon.

(Jarman et al., 1993)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

ato

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Delta^UAS.cDa, lola^GS88A8, psq^GS88A8

(Bossuyt et al., 2009)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity | somatic clone | third instar larval stage, with Scer\GAL4^αTub84B.PL

(Mora et al., 2018)

abnormal neuroanatomy | somatic clone | third instar larval stage, with Scer\GAL4^αTub84B.PL

(Mora et al., 2018)

decreased cell size | somatic clone | third instar larval stage, with Scer\GAL4^αTub84B.PL

(Mora et al., 2018)

lethal - all die before end of P-stage, with Scer\GAL4^ptc-559.1

(Jarman and Ahmed, 1998)

some die during pharate adult stage, with Scer\GAL4^ptc-559.1

(Jarman and Ahmed, 1998)

visible, with Scer\GAL4¹⁰⁹

(Jarman and Ahmed, 1998)

visible, with Scer\GAL4³⁸⁴

(Gupta and Rodrigues, 1997)

visible, with Scer\GAL4^dpp.blk1

(Li et al., 2009)

visible, with Scer\GAL4^ey.PH

(Jiao et al., 2001)

visible, with Scer\GAL4^hs.PB

(Huang et al., 2000)

visible, with Scer\GAL4^ptc-559.1

(Jarman and Ahmed, 1998)

visible, with Scer\GAL4^sca-109-68

(Powell et al., 2012, Rawlins et al., 2003, White and Jarman, 2000)

Phenotype Manifest In

abdominal basiconical sensillum dbd & larva & nerve terminal, with Scer\GAL4^sca.PC

(Zlatic et al., 2003)

abdominal sternite bristle, with Scer\GAL4¹⁰⁹

(Jarman and Ahmed, 1998)

adult head, with Scer\GAL4^ey.PH

(Jiao et al., 2001)

adult thorax & macrochaeta, with Scer\GAL4¹⁰⁹

(Jarman and Ahmed, 1998)

basiconic sensillum, with Scer\GAL4^{neur-GAL4-A101}

(Jhaveri et al., 2000)

basiconic sensillum of antennal segment 3, with Scer\GAL4^{neur-GAL4-A101}

(Jhaveri et al., 2000)

campaniform sensillum of anterior crossvein, with Scer\GAL4¹⁰⁹

(Jarman and Ahmed, 1998)

chordotonal neuron | ectopic, with Scer\GAL4^sca-537.4

(Huang et al., 2000)

chordotonal organ, with Scer\GAL4¹⁰⁹

(Jarman and Ahmed, 1998)

chordotonal organ & wing | ectopic, with Scer\GAL4^dpp.blk1

(Quan et al., 2004)

chordotonal organ | ectopic, with Scer\GAL4¹⁰⁹

(Jarman and Ahmed, 1998)

chordotonal organ | ectopic, with Scer\GAL4^h-1J3

(Goulding et al., 2000)

chordotonal organ | ectopic, with Scer\GAL4^hs.PB

(Jarman and Ahmed, 1998, Jarman et al., 1993)

chordotonal organ | ectopic, with Scer\GAL4^sca-109-68

(Goulding et al., 2000)

coeloconic sensillum | ectopic, with Scer\GAL4^{neur-GAL4-A101}

(Jhaveri et al., 2000)

coeloconic sensillum of antennal segment 3 | increased number, with Scer\GAL4^{neur-GAL4-A101}

(Jhaveri et al., 2000)

eye, with Scer\GAL4^ey.PH

(Jiao et al., 2001)

eye, with Scer\GAL4^sca-109-68

(White and Jarman, 2000)

eye disc morphogenetic furrow | somatic clone, with Scer\GAL4^GMR.PF

(Brown et al., 2006)

eye photoreceptor cell, with Scer\GAL4^sca-109-68

(White and Jarman, 2000)

eye photoreceptor cell | ectopic, with Scer\GAL4^sca-109-68

(White and Jarman, 2000)

inner optic anlage neuroblast | somatic clone | third instar larval stage, with Scer\GAL4^αTub84B.PL

(Mora et al., 2018)

lobula, with Scer\GAL4^ato.3.6

(Hassan et al., 2000)

macrochaeta, with Scer\GAL4^hs.PB

(Jarman and Ahmed, 1998)

macrochaeta & wing | ectopic, with Scer\GAL4^dpp.blk1

(Quan et al., 2004)

medulla, with Scer\GAL4^ato.3.6

(Hassan et al., 2000)

multidendritic neuron | ectopic, with Scer\GAL4^sca-537.4

(Huang et al., 2000)

ommatidial precursor cluster | somatic clone, with Scer\GAL4^GMR.PF

(Brown et al., 2006)

ommatidium, with Scer\GAL4^sca-109-68

(Rawlins et al., 2003, White and Jarman, 2000)

optic chiasma, with Scer\GAL4^ato.3.6

(Hassan et al., 2000)

photoreceptor cell R7 | ectopic, with Scer\GAL4^sca-109-68

(White and Jarman, 2000)

photoreceptor cell R8, with Scer\GAL4^hs.PB

(Dokucu et al., 1996)

photoreceptor cell R8, with Scer\GAL4^sca-109-68

(White and Jarman, 2000)

photoreceptor cell R8 | ectopic, with Scer\GAL4^hs.PB

(Dokucu et al., 1996)

photoreceptor cell R8 | increased number, with Scer\GAL4^sca-109-68

(Rawlins et al., 2003)

sacculus | ectopic, with Scer\GAL4³⁸⁴

(Gupta and Rodrigues, 1997)

scutellar bristle, with Scer\GAL4^sca-109-68

(Powell et al., 2012)

scutellar bristle | ectopic, with Scer\GAL4¹⁰⁹

(Jarman and Ahmed, 1998)

scutellar bristle | ectopic, with Scer\GAL4^dpp.blk1

(Li et al., 2009)

scutum, with Scer\GAL4¹⁰⁹

(Jarman and Ahmed, 1998)

sensory mother cell & dorsal mesothoracic disc, with Scer\GAL4¹⁰⁹

(Jarman and Ahmed, 1998)

sensory mother cell & dorsal mesothoracic disc, with Scer\GAL4^ptc-559.1

(Jarman and Ahmed, 1998)

sensory mother cell | ectopic, with Scer\GAL4^ptc-559.1

(Jarman and Ahmed, 1998)

sensory mother cell | ectopic | third instar larval stage, with Scer\GAL4^dpp.blk1

(Yuan et al., 2016)

sternopleural bristle | ectopic, with Scer\GAL4^dpp.blk1

(Li et al., 2009)

trichoid sensillum, with Scer\GAL4^{neur-GAL4-A101}

(Jhaveri et al., 2000)

wing, with Scer\GAL4^ptc-559.1

(Jarman and Ahmed, 1998)

wing sensillum, with Scer\GAL4¹⁰⁹

(Jarman and Ahmed, 1998)

wing sensillum | ectopic, with Scer\GAL4^hs.PB

(Huang et al., 2000)

wing vein L3, with Scer\GAL4¹⁰⁹

(Jarman and Ahmed, 1998)

Detailed Description

Statement

Reference

Somatic clones of type I neuroblasts expressing ato^UAS.cJa under the control of Scer\GAL4^αTub84B.PL exhibit symmetric cell divisions (indicating altered cell polarity) and a reduction in cell size in the optic lobe of third instar larvae.

(Mora et al., 2018)

Expression of ato^Scer\UAS.cJa driven by Scer\GAL4^dpp.blk1 leads to neurogenesis (presence of ectopic sensory organ precursors) in third instar larval wing discs.

(Yuan et al., 2016)

Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68 results in loss of scutellar bristles.

(Powell et al., 2012)

Ectopic expression of ato^Scer\UAS.cJa anterior to the morphogenetic furrow, under the control of Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} does not lead to premature differentiation.

(Bhattacharya and Baker, 2011)

Expression of ato^Scer\UAS.cJa with Scer\GAL4^sca-109-68 does not elicit overt eye/R8 defects at 24[o]C.

(Kahali et al., 2009)

Flies expressing ato^Scer\UAS.cJa under the control of Scer\GAL4^dpp.blk1 have ectopic sternopleural and scutellar bristles.

(Li et al., 2009)

Clones that express ato^Scer\UAS.cJa behind the morphogenetic furrow of the eye disc, driven by Scer\GAL4^GMR.PF, leads to disorganised clusters with many cells having upregulated adherens junction components.

(Brown et al., 2006)

ato^Scer\UAS.cJa; Scer\GAL4^dpp.blk1 flies have large numbers of ectopic sensory bristles around the A-P compartment boundary of their wings, along with ectopic chordotonal organs.

(Quan et al., 2004)

Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68 results in a rough eye phenotype. Some R8 twinning is seen in the mutant ommatidia.

(Rawlins et al., 2003)

When expression is driven in the PNS by Scer\GAL4^sca.PC, the larval dbd neuron projection is shifted ventrally and from the medial to the intermediate longitudinal fascicle and, in pronounced cases, the dbd-characteristic ventral extension no longer occurs. Late remodelling of the dbd terminal also does not occur. The major CNS axon fascicles are wild type and the larvae hatch.

(Zlatic et al., 2003)

Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^SG18.1 or Scer\GAL4^{neur-GAL4-A101} does not affect the formation of the antennal glomeruli.

(Jhaveri and Rodrigues, 2002)

Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^ey.PH gives rise to animals in which most of the head and one or both eyes of reduced size are present.

(Jiao et al., 2001)

Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68 produce densely packed arrays of ectopic chordotonal organs. Misexpression of ato^Scer\UAS.cJa driven by Scer\GAL4^h-1J3 results in expansion of lateral chordotonal organ clusters (usually 6-10 neurons instead of 5) but the neurons are of normal morphology.

(Goulding et al., 2000)

Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^unspecified results in no or very few ectopic olfactory-like sensilla.

(Goulding et al., 2000)

Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^ato.3.6 results in excessive branching in the lobula and the medulla as compared to wild type. The organisation of the ato-expressing dorsal cluster, its size and its position are unaffected in third larval instar and adult brains. The number of axons crossing the optic chiasma, but not their morphology, is wild type.

(Hassan et al., 2000)

Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-537.4 slightly induces the formation of multiple dendritic neurons in embryos. A slight increase in the number of chordotonal neurons in the lateral region is also seen. Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^hs.PB using a 10 minute heat shock just after puparium formation results in ectopic bristles in the wing.

(Huang et al., 2000)

When ato^Scer\UAS.cJa is driven by Scer\GAL4^{neur-GAL4-A101}, Many of the basiconic and trichoid sensilla of the antenna are converted to a coeloconic lineage, leading to an increase in the latter type of sense organs. Glial cell number is significantly increased and these cells now appear at ectopic positions on the antenna.

(Jhaveri et al., 2000)

When ato^Scer\UAS.cJa is driven by Scer\GAL4^{neur-GAL4-A101} a reduction is seen in basiconica and trichoidea and a concomitant increase in coeloconic sensilla. This appears to be a conversion of other sensilla to "ectopic coeloconica".

(Jhaveri et al., 2000)

Flies expressing ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68 have rough eyes, with many ommatidia containing inappropriate complements of photoreceptors and support cells (there can be an increase or a decrease in any specific cell type). This phenotype results from a combination of recruitment and R8 spacing defects. Ommatidial spacing is abnormal and there appear to be fused ommatidia. R8 cells are more dense, frequently juxtaposed (twinned) and unevenly spaced relative to one another. The phenotype is non-autonomous; the presence of supernumerary cells is not always correlated with ectopic ato expression within them. The ommatidia are no longer arranged in straight rows and ectopic photoreceptors infrequently differentiate in the interommatidial spaces. Supernumerary R7 photoreceptors are frequently seen in these flies.

(White and Jarman, 2000)

Flies expressing low levels of ato^Scer\UAS.cJa under the control of Scer\GAL4¹⁰⁹ have ectopic bristles on the scutellum, on the dorsocentral notum and wing vein L3. A small number of ectopic chordotonal organs are detected under the cuticle of the scutellum and vein L3. The wild-type chordotonal organs are hyperplastic, consisting of more aligned scolopidia or individual chordotonal unit organs. Flies expressing higher levels of ato^Scer\UAS.cJa under the control of Scer\GAL4^hs.PB show only the ectopic chordotonal organ phenotype. In many places the formation of ectopic chordotonal organs coincides with bristle loss in these flies. In some cases, when expression is driven by Scer\GAL4¹⁰⁹, external sense organs are malformed and are associated with scolopales, suggesting an incomplete transformation to chordotonal organs. External sense organs affected in this way include the sternitals of the ventral abdomen, the wing sense organs ACV and TSM1+2 and in extreme cases all other thoracic macrochaetae. Extra sensory organ precursors are seen in the wing discs of flies expressing ato^Scer\UAS.cJa under the control of Scer\GAL4¹⁰⁹. Flies expressing ato^Scer\UAS.cJa under the control of Scer\GAL4^ptc-559.1 are not viable and die as pharate adults with deformed wings and appendages. Ectopic sensory organ precursors are seen in the wing discs of these animals.

(Jarman and Ahmed, 1998)

Scer\GAL4³⁸⁴-mediated expression causes duplication of the antenna sacculus in a position near to the normal sacculus.

(Gupta and Rodrigues, 1997)

Scer\GAL4^hs.PB mediated expression causes a slightly irregular ommatidial pattern: ectopic R8 cells in several ommatidia due to transformation of all 2-3 cells within the R8 equivalence group. Multiple R8 cells are observed in ommatidia that were within the morphogenetic furrow at the time of heat shock.

(Dokucu et al., 1996)

Fifteen minute heat shock pulse during larval development allows spatially restricted rescue of ommatidia. A row of ommatidia is formed within the pigment cell patch, ommatidia are of variable size. Longer or multiple heat shocks result in pupal death.

(Jarman et al., 1994)

When ato is ectopically expressed, large numbers of ectopic chordotonal organs develop.

(Jarman et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^sca-109-68, ato^UAS.cJa has visible phenotype, enhanceable by Sumo^{UASp.Tag:FLAG.Tag:polyHis}/Scer\GAL4^sca-109-68

(Powell et al., 2012)

Scer\GAL4^sca-109-68, ato^UAS.cJa has visible phenotype, enhanceable by ed[+]/ed^4.12

(Rawlins et al., 2003)

Scer\GAL4^sca-109-68, ato^UAS.cJa has visible phenotype, enhanceable by Delta^9P

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has visible phenotype, enhanceable by ro¹

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has visible phenotype, enhanceable by hry^unspecified

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has visible phenotype, enhanceable by hh^UAS.cSa

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has visible phenotype, enhanceable by ptc⁵

(White and Jarman, 2000)

Suppressed by

Statement

Reference

Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, ato^UAS.cJa has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype, suppressible by ase^UAS.cBa/Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Mora et al., 2018)

Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, ato^UAS.cJa has abnormal cell polarity | somatic clone | third instar larval stage phenotype, suppressible by ase^UAS.cBa/Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Mora et al., 2018)

Scer\GAL4^sca-109-68, ato^UAS.cJa has visible phenotype, suppressible by Ras85D^e2F

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has visible phenotype, suppressible by ci^unspecified/ci[+]

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has visible phenotype, suppressible by dos^unspecified

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has visible phenotype, suppressible by hh[+]/hh^AC

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has visible phenotype, suppressible | partially by Egfr^f3

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has visible phenotype, suppressible by Raf¹

(White and Jarman, 2000)

Suppressor of

Statement

Reference

ato^UAS.cJa, Scer\GAL4^ey.PH is a suppressor of neoplasia phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Bossuyt et al., 2009)

ato^UAS.cJa/Scer\GAL4^h-H10 is a suppressor of visible phenotype of ro^DOM

(Chanut et al., 2000)

Other

Statement

Reference

Delta^UAS.cDa, Scer\GAL4^ey.PH, ato^UAS.cJa, lola^GS88A8, psq^GS88A8 has increased cell death | third instar larval stage phenotype

(Bossuyt et al., 2009)

Delta^UAS.cDa, Scer\GAL4^ey.PH, ato^UAS.cJa, bsk^DN.UAS, lola^GS88A8, psq^GS88A8 has neoplasia phenotype

(Bossuyt et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^sca-109-68, ato^UAS.cJa has scutellar bristle phenotype, enhanceable by Sumo^{UASp.Tag:FLAG.Tag:polyHis}/Scer\GAL4^sca-109-68

(Powell et al., 2012)

Scer\GAL4^sca-109-68, ato^UAS.cJa has ommatidium phenotype, enhanceable by ed[+]/ed^4.12

(Rawlins et al., 2003)

Scer\GAL4^sca-109-68, ato^UAS.cJa has photoreceptor cell R8 | increased number phenotype, enhanceable by ed[+]/ed^4.12

(Rawlins et al., 2003)

Scer\GAL4^sca-109-68, ato^UAS.cJa has eye phenotype, enhanceable by Delta^9P

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has ommatidium phenotype, enhanceable by ptc⁵

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has eye phenotype, enhanceable by ro¹

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has ommatidium phenotype, enhanceable by ro¹

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa, sev¹⁴ has photoreceptor cell R7 phenotype, enhanceable by Egfr^f3

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has ommatidium phenotype, enhanceable by Delta^9P

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has eye phenotype, enhanceable by hry^unspecified

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has ommatidium phenotype, enhanceable by hry^unspecified

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has eye phenotype, enhanceable by hh^UAS.cSa

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has eye phenotype, enhanceable by ptc⁵

(White and Jarman, 2000)

Suppressed by

Statement

Reference

Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, ato^UAS.cJa has inner optic anlage neuroblast | somatic clone | third instar larval stage phenotype, suppressible by ase^UAS.cBa/Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Mora et al., 2018)

Scer\GAL4^sca-109-68, ato^UAS.cJa has eye phenotype, suppressible by Ras85D^e2F

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has eye phenotype, suppressible by ci^unspecified/ci[+]

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has eye phenotype, suppressible by dos^unspecified

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has eye phenotype, suppressible by hh[+]/hh^AC

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has eye phenotype, suppressible by Raf¹

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has eye phenotype, suppressible | partially by Egfr^f3

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has ommatidium phenotype, suppressible by ci^unspecified/ci[+]

(White and Jarman, 2000)

Scer\GAL4^sca-109-68, ato^UAS.cJa has ommatidium phenotype, suppressible by hh[+]/hh^AC

(White and Jarman, 2000)

Enhancer of

Statement

Reference

Scer\GAL4^{FRT.Rnor\Cd2.Act5C}/ato^UAS.cJa is an enhancer of eye disc | somatic clone phenotype of Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, da^Δex1.UAS

(Bhattacharya and Baker, 2011)

Scer\GAL4^{FRT.Rnor\Cd2.Act5C}/ato^UAS.cJa is an enhancer of eye disc anterior to the morphogenetic furrow | somatic clone phenotype of Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, da^Δex1.UAS

(Bhattacharya and Baker, 2011)

Scer\GAL4^{FRT.Rnor\Cd2.Act5C}/ato^UAS.cJa is an enhancer of eye disc morphogenetic furrow | somatic clone phenotype of Scer\GAL4^{FRT.Rnor\Cd2.Act5C}, da^Δex1.UAS

(Bhattacharya and Baker, 2011)

NOT Enhancer of

Statement

Reference

ato^UAS.cJa, Scer\GAL4^ato.3.6 is a non-enhancer of lobula phenotype of N^intra.GS.UAS, Scer\GAL4^ato.3.6

(Hassan et al., 2000)

ato^UAS.cJa, Scer\GAL4^ato.3.6 is a non-enhancer of medulla phenotype of N^intra.GS.UAS, Scer\GAL4^ato.3.6

(Hassan et al., 2000)

Suppressor of

Statement

Reference

ato^UAS.cJa, Scer\GAL4^ey.PH is a suppressor of eye phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Bossuyt et al., 2009)

ato^UAS.cJa, Scer\GAL4^ey.PH is a suppressor of eye disc | third instar larval stage phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Bossuyt et al., 2009)

ato^UAS.cJa, Scer\GAL4^sca-109-68 is a suppressor of eye phenotype of E(spl)m8-HLH^SD.UAS, Scer\GAL4^sca-109-68

(Kahali et al., 2009)

ato^UAS.cJa, Scer\GAL4^sca-109-68 is a suppressor of eye photoreceptor cell phenotype of E(spl)m8-HLH^SD.UAS, Scer\GAL4^sca-109-68

(Kahali et al., 2009)

ato^UAS.cJa/Scer\GAL4^h-H10 is a suppressor of eye phenotype of ro^DOM

(Chanut et al., 2000)

ato^UAS.cJa/Scer\GAL4^sca-109-68 is a suppressor of photoreceptor cell R7 phenotype of sev¹⁴

(White and Jarman, 2000)

NOT Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/ato^UAS.cJa is a non-suppressor of ommatidial precursor cluster | somatic clone phenotype of Ras85D^ΔC40B

(Brown et al., 2006)

ato^UAS.cJa is a non-suppressor of basiconic sensillum phenotype of Scer\GAL4^hs.PB, lz³

(Goulding et al., 2000)

ato^UAS.cJa, Scer\GAL4^ato.3.6 is a non-suppressor of lobula phenotype of N^intra.GS.UAS, Scer\GAL4^ato.3.6

(Hassan et al., 2000)

ato^UAS.cJa, Scer\GAL4^ato.3.6 is a non-suppressor of medulla phenotype of N^intra.GS.UAS, Scer\GAL4^ato.3.6

(Hassan et al., 2000)

Other

Statement

Reference

Delta^UAS.cDa, Scer\GAL4^ey.PH, ato^UAS.cJa, lola^GS88A8, psq^GS88A8 has eye disc | third instar larval stage phenotype

(Bossuyt et al., 2009)

Delta^UAS.cDa, Scer\GAL4^ey.PH, ato^UAS.cJa, bsk^DN.UAS, lola^GS88A8, psq^GS88A8 has eye phenotype

(Bossuyt et al., 2009)

Scer\GAL4^hs.PB, ato^UAS.cJa, lz³ has coeloconic sensillum phenotype

(Goulding et al., 2000)

Egfr^f3, Scer\GAL4^sca-109-68, ato^UAS.cJa, sev¹⁴ has photoreceptor cell R7 phenotype

(White and Jarman, 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of smt3^{Scer\UAS.P\T.T:Zzzz\FLAG.T:Zzzz\His6} enhances the loss of scutellar bristles caused by expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68.

(Powell et al., 2012)

Approximately 81% of cells overexpressing both ato^Scer\UAS.cJa and da^{Δex1.Scer\UAS} ahead of the morphogenetic furrow (under the control of Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C}) differentiate into neurons.

(Bhattacharya and Baker, 2011)

Co-expression of ato^Scer\UAS.cJa almost completely suppresses the formation of eye tumours seen in 'eyeful' (Scer\GAL4^ey.PH, Dl^Scer\UAS.cDa, psq^GS88A8, lola^GS88A8) flies.

Co-expression of ato^Scer\UAS.cJa in 'eyeful' third instar eye discs (Scer\GAL4^ey.PH, Dl^Scer\UAS.cDa, psq^GS88A8, lola^GS88A8) results in dramatically increased apoptosis, as measured by decay staining.

Co-expression of ato^Scer\UAS.cJa reduces ectopic proliferation in "eyeful" (Scer\GAL4^ey.PH Dl^Scer\UAS.cDa, psq^GS88A8 and lola^GS88A8) third instar eye discs.

Co-expression of ato^Scer\UAS.cJa restores the size and organization of "eyeful" (Scer\GAL4^ey.PH Dl^Scer\UAS.cDa, psq^GS88A8 and lola^GS88A8) third instar eye discs.

Co-expression of bsk^DN.Scer\UAS in a ato^Scer\UAS.cJa 'eyeful' (Scer\GAL4^ey.PH, Dl^Scer\UAS.cDa, psq^GS88A8, lola^GS88A8) background leads to a suppression of the inhibitory effects of ato^Scer\UAS.cJa on the 'eyeful' tumor phenotype, restoring tumor formation and enhancing metastasis.

(Bossuyt et al., 2009)

The eye and photoreceptor defects caused by expression of E(spl)m8-HLH^SD.Scer\UAS with Scer\GAL4^sca-109-68 are suppressed by co-expression of ato^Scer\UAS.cJa.

(Kahali et al., 2009)

Expressing ato^Scer\UAS.cJa under the control of Scer\GAL4^GMR.PF fails to suppress the morphogenetic furrow phenotype of Ras85D^ΔC40B clones.

(Brown et al., 2006)

The rough eye phenotype and R8 twinning phenotype caused by expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68 is dominantly enhanced by ed^4.12.

(Rawlins et al., 2003)

When expression is driven by Scer\GAL4^h-H10 in an ro^DOM mutant, the stop-furrow phenotype of ro^DOM is suppressed.

(Chanut et al., 2000)

The reduction in number of sensilla basiconica seen in lz³ flies is not rescued by expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^hs.PB even though the number of sensilla coeloconica is increased.

(Goulding et al., 2000)

Expression of N^{intra.GS.Scer\UAS} under the control of Scer\GAL4^ato.3.6 results in a severe inhibition of axonal branching over the lobula and a complete failure of innervation of the medulla. This phenotype is not altered by coexpression of ato^Scer\UAS.cJa.

(Hassan et al., 2000)

Egfr^f3 suppresses the recruitment defects in the eye caused by expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68, although abnormal pattern formation still occurs. ro¹, ptc⁵, h^unspecified or Dl^9P enhance the rough eye phenotype caused by expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68. hh^AC or ci^unspecified suppress the rough eye phenotype caused by expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68. The eye is extremely disorganised when both ato^Scer\UAS.cJa and hh^Scer\UAS.cSa are expressed under the control of Scer\GAL4^sca-109-68. Many R7 cells differentiate in sev¹⁴ flies expressing ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68 (in contrast to sev¹⁴ flies which lack R7 photoreceptors). This rescue of R7 formation by ato^Scer\UAS.cJa expressed under the control of Scer\GAL4^sca-109-68 is strongly suppressed if the flies are also carrying Egfr^f3.

(White and Jarman, 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

ato^UAS.cJa/Scer\GAL4^ato.3.6 rescues ato¹/Df(3R)p13

(Hassan et al., 2000)

Fails to rescue

Scer\GAL4^SG18.1/ato^UAS.cJa fails to rescue ato¹/Df(3R)p13

(Jhaveri and Rodrigues, 2002)

Comments

Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4⁷ restores the formation of R8 photoreceptor cells and numerous ommatidia in ato¹ flies.

(Sun et al., 2003)

Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^SG18.1 does not rescue the lack of antennal glomeruli seen in ato¹/Df(3R)p13 mutants.

(Jhaveri and Rodrigues, 2002)

The lobular innervation pattern defect of ato¹/Df(3R)p13 flies is rescued by ato^Scer\UAS.cJa expressed under the control of Scer\GAL4^ato.3.6.

(Hassan et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

39679

w^*; P{UAS-ato.J}8/TM3, Sb¹

Notes on Origin

Discoverer

Comments

Used to ectopically express ato via a heat shock Scer\GAL4 construct.

(Jarman et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ato^Scer\UAS.cJa

ato^UAS.cJa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Jarman

Secondary FlyBase IDs

References (48)

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