FB2024_03 , released June 25, 2024
Allele: Dmel\fs(1)K10LM00
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General Information
Symbol
Dmel\fs(1)K10LM00
Species
D. melanogaster
Name
FlyBase ID
FBal0039349
Feature type
allele
Associated gene
Dmel\fs(1)K10
Associated Insertion(s)
Carried in Construct
Also Known As
K10LM00
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Cheung et al., 1992)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Possesses wild type activity in trangenic flies.

        (Serano and Cohen, 1995)

        Female fertility is restored with two copies of P{K-bcd} or P{K-osk}.

        (Serano and Cohen, 1995)

        Eggs produced by fs(1)K10LM00 grkED22 double mutant females are more ventralised than eggs produced by grkED22 single mutant females. Most double mutant eggs contain no or only a node of dorsal appendage material positioned on the dorsal midline, whereas grkED22 single mutant eggs have at least one dorsal appendage that usually extends anteriorly beyond the anterior tip of the egg. Expression of fs(1)K10hs.PS restores near complete fertility (greater than 95% egg hatching) to fs(1)K10LM00 females. Maximal rescue occurs with heat shocks applied at any time between the middle of stage 7 and the middle of stage 8. Heat shocks applied at any time between the middle of stage 8 to the end of stage 8 can restore up to 35% fertility. No fertility is restored if heat shocks are applied during or after the end of stage 8.

        (Serano et al., 1995)

        Strong dorsalisation of embryos.

        (Christerson and McKearin, 1994)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        K10LM00
        (Cohen et al., 2005, Saunders and Cohen, 1999, Karlin-Mcginness et al., 1996, Serano and Cohen, 1995, Cheung et al., 1992)
        fs(1)K10LM00
        fs(1)K10LMOO
        (Doerflinger et al., 1999)
        Name Synonyms
        Secondary FlyBase IDs
          References (11)