FlyBase Allele Report: Scer\GAL4[Mz19]

ScerGAL4^Mz19 drives expression in around 14 uniglomerular antennal lobe projection neurons. The cell bodies of around 6 of these neurons are positioned in the anterior-dorsal part of the antennal lobe and around 8 cell bodies are found in the lateral part. These neurons project to three different antennal lobe glomeruli.

(Tanaka et al., 2012)

ScerGAL4^Mz19 expresses in ~6 neurons that innervate the VA1d and DC3 glomeruli, and in approximately 7 neurons innervating the dorsolateral DA1 glomerulus.

(Berdnik et al., 2008)

Adult expression is seen in projection neurons the adNb lineage in antennal glomeruli VA1d and DC3, and of the lNb lineage in antennal glomerulus DA1

(Zhu and Luo, 2004)

Expression is observed in 12-15 projection neurons in antennal glomeruli DA1, VA1d and DC3.

(Tanaka et al., 2004)

Adult expression is observed in a cluster of neurons with cell bodies in the dorsolateral region of the anterior cortex of the brain. Labelled neurons, which include inner antennocerebral tract neurons between the antennal lobe and lateral horn, and mushroom body extrinsic neurons between the γ lobe and the inferior medial protocerebrum, arborize in the γ lobe of the mushroom body and in the medial and lateral 1 regions of the inferior medial protocerebrum. Representative images can be seen in Figures 4 and 5 of FBrf0105251.

(Ito et al., 1998)

Marker for

adult antennal lobe projection neuron DC3 adPN

(Tanaka et al., 2004)

adult antennal lobe projection neuron VA1d adPN

(Tanaka et al., 2004)

antennal lobe glomerulus DA1

(Jefferis et al., 2004, Tanaka et al., 2004)

antennal lobe glomerulus DC3

(Jefferis et al., 2004, Zhu and Luo, 2004)

antennal lobe glomerulus VA1d

(Jefferis et al., 2004)

medial antennal lobe tract projection neuron

(Ito et al., 1998)

mushroom body

(Ito et al., 1998)

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory | heat sensitive, with Scer\GAL80^Mef2.mb247, TrpA1^UAS.(B).cKa

(Aso et al., 2012)

abnormal neuroanatomy, with caps^GS10839

(Hong et al., 2009)

abnormal neuroanatomy, with caps^UAS.cSa

(Hong et al., 2009)

abnormal neuroanatomy, with Cbeta\DT^A-I.UAS

(Berdnik et al., 2006)

abnormal neuroanatomy, with Cbeta\DT^A-I.UAS, Scer\GAL4^Or88a.PW

(Berdnik et al., 2006)

abnormal neuroanatomy, with Ctet\tetX^TNT-LC.UAS

(Kremer et al., 2010)

abnormal neuroanatomy, with Ork1^{Δ-C.UAS.EGFP}

(Kremer et al., 2010)

abnormal neuroanatomy, with Rcom\RT^A.UAS

(Berdnik et al., 2006)

abnormal neuroanatomy, with Ten-a^GE1914

(Hong et al., 2012)

abnormal neuroanatomy, with Ten-m^GS9267

(Hong et al., 2012)

abnormal neuroanatomy | adult stage, with Lrp4^GD14320

(Mosca et al., 2017)

abnormal neuroanatomy | adult stage, with Lrp4^KK101962

(Mosca et al., 2017)

abnormal neuroanatomy | adult stage, with Ten-m^GD3620

(Mosca and Luo, 2014)

abnormal neuroanatomy | adult stage | somatic clone, with Wnt5^UAS.cFa

(Wu et al., 2014)

abnormal neuroanatomy | pupal stage, with Dscam1^{UAS.1.30.30.1}

(Zhu et al., 2006)

abnormal neuroanatomy | somatic clone, with Ncra\QF^Mz19.PH, Ten-m^GS9267, Ten-m^QUAS.cHa

(Hong et al., 2012)

abnormal neuroanatomy | somatic clone, with Ten-a^GD8834

(Hong et al., 2012)

abnormal neuroanatomy | somatic clone, with Ten-a^GE1914

(Hong et al., 2012)

abnormal neuroanatomy | somatic clone, with Ten-m^GS9267

(Hong et al., 2012)

abnormal neurophysiology, with Ork1^{Δ-C.UAS.EGFP}

(Kremer et al., 2010)

increased cell number | P-stage, with ths^UAS.cUa

(Wu et al., 2017)

Phenotype Manifest In

adult antennal lobe, with Dscam1^{UAS.1.30.30.1}

(Zhu et al., 2006)

adult antennal lobe projection neuron, with Lrp4^GD14320

(Mosca et al., 2017)

adult antennal lobe projection neuron, with Lrp4^KK101962

(Mosca et al., 2017)

adult antennal lobe projection neuron DA1 lPN, with Ten-m^GD3620

(Mosca and Luo, 2014)

adult antennal lobe projection neuron DA1 lPN, with Wnt5^UAS.cFa

(Wu et al., 2014)

adult antennal lobe projection neuron DC3 adPN, with Wnt5^UAS.cFa

(Wu et al., 2014)

adult antennal lobe projection neuron VA1d adPN, with Ten-m^GD3620

(Mosca and Luo, 2014)

adult antennal lobe projection neuron VA1d adPN, with Wnt5^UAS.cFa

(Wu et al., 2014)

adult ensheathing glial cell | P-stage | increased number, with ths^UAS.cUa

(Wu et al., 2017)

adult olfactory receptor neuron Or67d, with Ten-m^GD3620

(Mosca and Luo, 2014)

antennal lobe glomerulus DA1 | P-stage, with ths^UAS.cUa

(Wu et al., 2017)

antennal lobe glomerulus DA1 | pupal stage, with Dscam1^{UAS.1.30.30.1}

(Zhu et al., 2006)

antennal lobe glomerulus VA1, with Cbeta\DT^A-I.UAS, Scer\GAL4^Or88a.PW

(Berdnik et al., 2006)

antennal lobe glomerulus VA1d, with Dscam1^{UAS.1.30.30.1}

(Zhu et al., 2006)

antennal lobe glomerulus VA1d | ectopic, with Dscam1^{UAS.1.30.30.1}

(Zhu et al., 2006)

antennal lobe glomerulus VA1d | P-stage, with ths^UAS.cUa

(Wu et al., 2017)

antennal lobe glomerulus VA1d | pupal stage, with Dscam1^{UAS.1.30.30.1}

(Zhu et al., 2006)

antennal lobe projection neuron, with caps^UAS.cSa

(Hong et al., 2009)

dendrite, with caps^GS10839

(Hong et al., 2009)

dendrite, with caps^UAS.cSa

(Hong et al., 2009)

dendrite | adult stage, with Wnt5^UAS.cFa

(Wu et al., 2014)

Kenyon cell, with Ctet\tetX^TNT-LC.UAS

(Kremer et al., 2010)

Kenyon cell, with Ork1^{Δ-C.UAS.EGFP}

(Kremer et al., 2010)

neuron & antennal glomerulus, with Cbeta\DT^A-I.UAS

(Berdnik et al., 2006)

neuron & antennal glomerulus, with Rcom\RT^A.UAS

(Berdnik et al., 2006)

neuron & antennal glomerulus DA1, with Rcom\RT^A.UAS

(Berdnik et al., 2006)

neuron & antennal glomerulus VA1, with Cbeta\DT^A-I.UAS, Scer\GAL4^Or88a.PW

(Berdnik et al., 2006)

neuron & antennal glomerulus VA1, with Rcom\RT^A.UAS

(Berdnik et al., 2006)

olfactory neuron & antennal glomerulus VA1, with Cbeta\DT^A-I.UAS, Scer\GAL4^Or88a.PW

(Berdnik et al., 2006)

presynaptic active zone, with Ork1^{Δ-C.UAS.EGFP}

(Kremer et al., 2010)

presynaptic active zone | adult stage, with Lrp4^GD14320

(Mosca et al., 2017)

presynaptic active zone | adult stage, with Lrp4^KK101962

(Mosca et al., 2017)

presynaptic active zone | adult stage, with Ten-m^GD3620

(Mosca and Luo, 2014)

projection neuron, with caps^GS10839

(Hong et al., 2009)

projection neuron, with Ctet\tetX^TNT-LC.UAS

(Kremer et al., 2010)

projection neuron, with Ork1^{Δ-C.UAS.EGFP}

(Kremer et al., 2010)

synapse | adult stage, with Lrp4^GD14320

(Mosca et al., 2017)

synapse | adult stage, with Lrp4^KK101962

(Mosca et al., 2017)

synapse | adult stage, with Ten-m^GD3620

(Mosca and Luo, 2014)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^Mz19, Ten-m^GD3620 has abnormal neuroanatomy | adult stage phenotype, non-enhanceable by Df(1)Ten-a/Df(1)Ten-a

(Mosca and Luo, 2014)

Suppressor of

Statement

Reference

Toll-7^UAS.cYa/Scer\GAL4^Mz19 is a suppressor of abnormal neuroanatomy | adult stage phenotype of Toll-6^ex13

(Ward et al., 2015)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^Mz19, Ten-m^GD3620 has adult antennal lobe projection neuron VA1d adPN phenotype, non-enhanceable by Df(1)Ten-a/Df(1)Ten-a

(Mosca and Luo, 2014)

Scer\GAL4^Mz19, Ten-m^GD3620 has adult antennal lobe projection neuron DA1 lPN phenotype, non-enhanceable by Df(1)Ten-a/Df(1)Ten-a

(Mosca and Luo, 2014)

Scer\GAL4^Mz19, Ten-m^GD3620 has synapse | adult stage phenotype, non-enhanceable by Df(1)Ten-a/Df(1)Ten-a

(Mosca and Luo, 2014)

Suppressor of

Statement

Reference

Toll-7^UAS.cYa/Scer\GAL4^Mz19 is a suppressor of adult olfactory receptor neuron Or88a phenotype of Toll-6^ex13

(Ward et al., 2015)

Toll-7^UAS.cYa/Scer\GAL4^Mz19 is a suppressor of adult antennal lobe projection neuron VA1d adPN | somatic clone phenotype of Toll-6^ex13

(Ward et al., 2015)

Toll-7^UAS.cYa/Scer\GAL4^Mz19 is a suppressor of adult antennal lobe projection neuron DC3 adPN | somatic clone phenotype of Toll-6^ex13

(Ward et al., 2015)

Toll-7^UAS.cYa/Scer\GAL4^Mz19 is a suppressor of dendrite | somatic clone phenotype of Toll-6^ex13

(Ward et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Toll-6^{Δcyto.UAS.GFP}/Scer\GAL4^Mz19 rescues Toll-6^ex13

(Ward et al., 2015)

Toll-6^{TIR-dead.UAS.Tag:FLAG,Tag:HA,Tag:polyHis}/Scer\GAL4^Mz19 rescues Toll-6^ex13

(Ward et al., 2015)

Toll-6^UAS.cYa/Scer\GAL4^Mz19 rescues Toll-6^ex13

(Ward et al., 2015)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

34497

y¹ w¹; P{GawB}Mz19

64070

y¹ w^*; P{GawB}Mz19, P{UAS-mCD8::GFP.L}LL5, P{Or88a-myr-tdTomato}2; Df(3L)spz5^AW18 P+PBac{XP3.WH3}spz5-AW18/TM6B, Tb¹

Notes on Origin

Discoverer

Ito

(Jefferis et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Scer\GAL4^Mz19

Name Synonyms

Secondary FlyBase IDs

References (63)

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