Gene Group: PHOSPHATASES

General Information

Name

PHOSPHATASES

Species

D. melanogaster

Symbol

PHOSASE

FlyBase ID

FBgg0000268

Date last reviewed

2015-06-08

Number of members

178

Description

Phosphatases are enzymes that catalyse the hydrolysis of a phosphate group from a substrate.

Notes on Group

The PHOSPHATASES gene group only includes catalytic subunits only. Regulatory or other non-catalytic subunits have not been included.

Source Material

The PHOSPHATASES Gene Group has been compiled using the following publication(s): Li et al., 2022, Singgih et al., 2021, Allen et al., 2020, Lee et al., 2020, Balakrishnan et al., 2015, Cheng and Andrew, 2015, Hatzihristidis et al., 2015, Pogson et al., 2014, Attrill and Antonazzo, 2013.6.25, Fuhrmann et al., 2013, Cao et al., 2011, Miskei et al., 2011, Zhang et al., 2011, Imai et al., 2010, Valente et al., 2010, Cao et al., 2009, Pan and Zhang, 2009, Hudson et al., 2007, Burroughs et al., 2006, Garcia-Murillas et al., 2006, Andersen et al., 2004, Pagliarini et al., 2004, Seeds et al., 2004, Renault et al., 2002, Miller et al., 2000, Morrison et al., 2000, Walchli et al., 2000, Chi et al., 1999, and Acharya et al., 1998 .

Key Gene Ontology (GO) terms

Molecular Function

phosphatase activity

Biological Process

dephosphorylation

Cellular Component

Enzymatic activity

Enzyme name (EC)

3.1.3.-

Related Gene Groups

Parent group(s)

ESTER BOND HYDROLASES

Component group(s)

ACID PHOSPHATASES

ALKALINE PHOSPHATASES

CARBOHYDRATE PHOSPHATASES

HAD FAMILY NON-PROTEIN PHOSPHATASES

LIPID PHOSPHATE PHOSPHATASES

NUCLEOTIDASES

PHOSPHATIDYLINOSITOL PHOSPHATE AND INOSITOL PHOSPHATE PHOSPHATASES

PROTEIN PHOSPHATASES

UNCLASSIFIED PHOSPHATASES

Other related group(s)

PSEUDOPHOSPHATASES

Members (178)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

ACID PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Acph-1

Acid phosphatase 1

Acph

(Attrill and Antonazzo, 2013.6.25)

CG1637

(Pogson et al., 2014)

CG6656

(Attrill and Antonazzo, 2013.6.25)

CG9449

(Attrill and Antonazzo, 2013.6.25)

CG9451

(Attrill and Antonazzo, 2013.6.25)

CG9452

(Attrill and Antonazzo, 2013.6.25)

Mipp1

Multiple inositol polyphosphate phosphatase 1

(FlyBase, 2017-, Cheng and Andrew, 2015)

Mipp2

Multiple inositol polyphosphate phosphatase 2

l(1)G0050, l(1)G0303

(FlyBase, 2017-, Cheng and Andrew, 2015)

primo-1

(FlyBase, 2017-, Miller et al., 2000)

primo-2

(FlyBase, 2017-, Miller et al., 2000)

ALKALINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Alp1

Alkaline phosphatase 1

Aph, Aph-1

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp2

Alkaline phosphatase 2

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp4

Alkaline phosphatase 4

Aph-4, l(3)07028

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp5

Alkaline phosphatase 5

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp6

Alkaline phosphatase 6

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp7

Alkaline phosphatase 7

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp8

Alkaline phosphatase 8

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp9

Alkaline phosphatase 9

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp10

Alkaline phosphatase 10

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp11

Alkaline phosphatase 11

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp12

Alkaline phosphatase 12

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp13

Alkaline phosphatase 13

(Attrill and Antonazzo, 2013.6.25)

phu

phurba tashi

BEST:LD38109

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

CARBOHYDRATE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5171

(FlyBase, 2017-)

Fbp

Fructose bisphosphatase

fructose-1,6-bisphosphatase

(FlyBase, 2017-)

G6P

Glucose-6-Phosphatase

G6pase

(FlyBase, 2017-)

Pfrx

6-phosphofructo-2-kinase

Pfk2

(FlyBase, 2017-)

Tps1

Trehalose-6-phosphate synthase 1

l(2)k08903, jf5, BcDNA:GH08860, trehalose synthase, trehalose-6-phosphate synthase

(FlyBase, 2017-)

CDC25 FAMILY PROTEIN PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

stg

string

cdc25, cdc25^string, l(3)01235, Cdc25^stg, stg^cdc25

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

twe

twine

Cdc25, twn, mat(2)synHB5, l(2)35Fh, mat(2)syn^HB5

(Hatzihristidis et al., 2015, Morrison et al., 2000)

CTD FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG8584

(Burroughs et al., 2006)

CG12078

(Burroughs et al., 2006)

Dullard

l(1)G0269, ddd

(Burroughs et al., 2006)

Fcp1

TFIIF-interacting CTD phosphatase

(Burroughs et al., 2006)

hzg

herzog

(Burroughs et al., 2006)

ttm2

tiny tim 2

(Burroughs et al., 2006)

ttm3

tiny tim 3

(Pan and Zhang, 2009)

ttm50

tiny tim 50

EG:95B7.3, Gp99

(Burroughs et al., 2006)

Ublcp1

Ubiquitin-like domain-containing C-terminal domain phosphatase 1

BcDNA:LD21504

(Burroughs et al., 2006)

CYTOSOLIC PROTEIN TYROSINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG14297

(Hatzihristidis et al., 2015, Morrison et al., 2000)

csw

corkscrew

E(sev)1A, EG:BACN25G24.2, l(1)csw, l(1)2Db, l(1)G0170

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000, Walchli et al., 2000)

primo-1

(Lee et al., 2020, Morrison et al., 2000)

primo-2

(Morrison et al., 2000)

Ptp61F

Protein tyrosine phosphatase 61F

DPTP61F, protein tyrosine phosphatase

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000, Walchli et al., 2000)

PTP-ER

Protein tyrosine phosphatase-ERK/Enhancer of Ras1

ER2-5

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000)

Ptpmeg

Protein tyrosine phosphatase Meg

Meg

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000, Walchli et al., 2000)

Ptpmeg2

Protein tyrosine phosphatase Meg2

l(1)G0232

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000, Walchli et al., 2000)

DUAL SPECIFICITY PROTEIN PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cdc14

Cell division cycle 14

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

CG3632

(Hatzihristidis et al., 2015, Morrison et al., 2000)

CG7378

MKP-like

(Hatzihristidis et al., 2015, Morrison et al., 2000)

CG10089

(Hatzihristidis et al., 2015, Morrison et al., 2000)

CG13197

(Hatzihristidis et al., 2015, Morrison et al., 2000)

CG15528

(Hatzihristidis et al., 2015, Morrison et al., 2000)

EDTP

Egg-derived tyrosine phosphatase

(Hatzihristidis et al., 2015)

Mkp

MAP kinase-specific phosphatase

DMKP

(Hatzihristidis et al., 2015)

Mkp3

Mitogen-activated protein kinase phosphatase 3

DMKP-3, MAP Kinase Phosphatase 3

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

MKP-4

MAPK Phosphatase 4

MAPK

(Hatzihristidis et al., 2015, Morrison et al., 2000)

mtm

myotubularin

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

Mtmr6

Myotubularin related protein 6

BcDNA:GH04637

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

PRL-1

PRL-1 phosphatase

BG:DS07473.3, PRL

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

Pten

Phosphatase and tensin homolog

dPTEN

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

PTPMT1

Protein tyrosine phosphatase, mitochondrial 1

Plip

(Hatzihristidis et al., 2015, Morrison et al., 2000)

puc

puckered

hrt, l(3)84Eh, vco, hearty

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

ssh

slingshot

l(3)01207, Mkph, MKP

(Hatzihristidis et al., 2015, Morrison et al., 2000)

EYA FAMILY PROTEIN TYROSINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

eya

eyes absent

cli, clift, ey-2

(Hatzihristidis et al., 2015, Burroughs et al., 2006)

HAD FAMILY NON-PROTEIN PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

aay

astray

(Burroughs et al., 2006)

CG2680

EG:100G10.4

(Cao et al., 2009, Burroughs et al., 2006)

CG5171

(FlyBase, 2017-)

CG5567

(Cao et al., 2009, Burroughs et al., 2006)

CG5577

(Burroughs et al., 2006)

CG10352

(Cao et al., 2009)

CG11291

(Cao et al., 2009)

CG12237

(Burroughs et al., 2006)

CG14212

(Burroughs et al., 2006)

CG15739

(Burroughs et al., 2006)

CG15771

(Burroughs et al., 2006)

CG17294

(Cao et al., 2009, Burroughs et al., 2006)

CG32487

(Cao et al., 2009, Burroughs et al., 2006)

CG32488

(Cao et al., 2009, Burroughs et al., 2006)

cN-IIIB

cytosolic 5'-nucleotidase IIIB

cytosolic nucleotidase III-like, cNIII-like

(Burroughs et al., 2006)

Enoph

Enolase-phosphatase

(Burroughs et al., 2006)

Nt5a

5' nucleotidase A

(Burroughs et al., 2006)

Nt5b

5' nucleotidase B

(Burroughs et al., 2006)

Nt5c

5' nucleotidase C

(Burroughs et al., 2006)

PNKP

Polynucleotide kinase 3'-phosphatase

(Burroughs et al., 2006)

Tps1

Trehalose-6-phosphate synthase 1

l(2)k08903, jf5, BcDNA:GH08860, trehalose synthase, trehalose-6-phosphate synthase

(Burroughs et al., 2006)

LIPID PHOSPHATE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG11425

(Garcia-Murillas et al., 2006, Renault et al., 2002, Morrison et al., 2000)

CG11426

LPP

(Garcia-Murillas et al., 2006, Renault et al., 2002, Morrison et al., 2000)

CG11437

(Garcia-Murillas et al., 2006, Renault et al., 2002, Morrison et al., 2000)

CG11438

(Garcia-Murillas et al., 2006, Renault et al., 2002, Morrison et al., 2000)

CG12746

(Renault et al., 2002, Morrison et al., 2000)

CG31717

(FlyBase, 2017-)

laza

lazaro

(Garcia-Murillas et al., 2006, Renault et al., 2002, Morrison et al., 2000)

Lpin

Lipin

dLipin, DmLpin, DmLipin, EP2431

(Valente et al., 2010)

wun

wunen

l(2)k16806

(Garcia-Murillas et al., 2006, Renault et al., 2002, Morrison et al., 2000)

wun2

wunen-2

wun-2, N14, Tunen, Pap2G

(Garcia-Murillas et al., 2006, Renault et al., 2002, Morrison et al., 2000)

NUCLEOTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

cytosolic 5'-nucleotidase IIIB

cytosolic nucleotidase III-like, cNIII-like

(FlyBase, 2017-)

Nt5a

5' nucleotidase A

(Singgih et al., 2021, FlyBase, 2017-)

Nt5b

5' nucleotidase B

(Singgih et al., 2021, FlyBase, 2017-)

Nt5c

5' nucleotidase C

(Singgih et al., 2021, FlyBase, 2017-)

NT5E-2

Ecto-5'-nucleotidase 2

(FlyBase, 2017-)

veil

NT5E-1

(FlyBase, 2017-)

PHOSPHATIDYLINOSITOL PHOSPHATE AND INOSITOL PHOSPHATE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

5PtaseI

Inositol polyphosphate-5-phosphatase type I

(Allen et al., 2020, Seeds et al., 2004, Morrison et al., 2000)

CG3632

(Allen et al., 2020, Balakrishnan et al., 2015, Morrison et al., 2000)

CG6707

(Allen et al., 2020, Balakrishnan et al., 2015)

CG6805

(Allen et al., 2020, Seeds et al., 2004)

CG9389

(Allen et al., 2020, Morrison et al., 2000)

CG9391

(Allen et al., 2020, Morrison et al., 2000)

CG9784

lincRNA.S9473

(Allen et al., 2020, Balakrishnan et al., 2015, Seeds et al., 2004)

CG17026

(Allen et al., 2020, Morrison et al., 2000)

CG17027

(Allen et al., 2020, Morrison et al., 2000)

CG17028

(Allen et al., 2020, Morrison et al., 2000)

CG17029

(Allen et al., 2020, Morrison et al., 2000)

CG42271

(Allen et al., 2020, Balakrishnan et al., 2015)

EDTP

Egg-derived tyrosine phosphatase

(Allen et al., 2020)

FIG4

FIG4 phosphoinositide 5-phosphatase

dFIG4

(Allen et al., 2020, Balakrishnan et al., 2015)

INPP5E

Inositol polyphosphate 5-phosphatase E

pharbin-like

(Allen et al., 2020, Balakrishnan et al., 2015, Seeds et al., 2004, Morrison et al., 2000)

Ipp

Inositol polyphosphate 1-phosphatase

(Allen et al., 2020, Acharya et al., 1998)

Mipp1

Multiple inositol polyphosphate phosphatase 1

(Allen et al., 2020, Chi et al., 1999)

Mipp2

Multiple inositol polyphosphate phosphatase 2

l(1)G0050, l(1)G0303

(Allen et al., 2020, Chi et al., 1999)

mtm

myotubularin

(Allen et al., 2020, Balakrishnan et al., 2015, Morrison et al., 2000)

Mtmr6

Myotubularin related protein 6

BcDNA:GH04637

(Allen et al., 2020, Balakrishnan et al., 2015, Morrison et al., 2000)

Ocrl

Oculocerebrorenal syndrome of Lowe

dOCRL, EG:86E4.5

(Allen et al., 2020, Balakrishnan et al., 2015)

Pten

Phosphatase and tensin homolog

dPTEN

(Allen et al., 2020, Pagliarini et al., 2004)

PTPMT1

Protein tyrosine phosphatase, mitochondrial 1

Plip

(Allen et al., 2020, Balakrishnan et al., 2015, Pagliarini et al., 2004, Morrison et al., 2000)

Sac1

Sac1 phosphatase

impatent

(Allen et al., 2020, Balakrishnan et al., 2015)

sp3

spermathreecae

(Allen et al., 2020, Balakrishnan et al., 2015)

Synj

Synaptojanin

(Allen et al., 2020, Balakrishnan et al., 2015, Seeds et al., 2004, Morrison et al., 2000)

PPM FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

alph

alphabet

SK3-1, pp2c99B

(Morrison et al., 2000)

CG7115

BcDNA:LD21794

(Morrison et al., 2000)

CG10376

(Morrison et al., 2000)

CG10417

(Morrison et al., 2000)

CG12091

(Hudson et al., 2007)

CG15035

(Hudson et al., 2007)

CG17598

(Morrison et al., 2000)

CG17746

(Morrison et al., 2000)

fig

fos intronic gene

(Hudson et al., 2007)

Mppe

Metallophosphoesterase

dmppe

(Cao et al., 2011)

Nil

Nilkantha

(Morrison et al., 2000)

Pdp

Pyruvate dehydrogenase phosphatase

(Morrison et al., 2000)

Phlpp

PH domain leucine-rich repeat protein phosphatase

(Morrison et al., 2000)

Pp2C1

Protein phosphatase 2C

PP2C, dpp2c1

(Morrison et al., 2000)

Ppm1

(Morrison et al., 2000)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CanA1

Calcineurin A1

calcineurin, CaN, PP2B 21EF

(Miskei et al., 2011, Morrison et al., 2000)

CanA-14F

Calcineurin A at 14F

MRE12, Calcineurin

(Miskei et al., 2011, Morrison et al., 2000)

CG11597

PP4-like

(Miskei et al., 2011, Morrison et al., 2000)

flw

flapwing

PP1β9C, PP1, PP1β, PP1 9C, PP1c

(Miskei et al., 2011, Morrison et al., 2000)

mts

microtubule star

PP2A, PP2A-C, PP2Ac, PP2A catalytic subunit, protein phosphatase 2A

(Miskei et al., 2011, Morrison et al., 2000)

Pp1-13C

Protein phosphatase 1 at 13C

PP1α13C, PP1, PP1 13C, PP1c, 13C

(Miskei et al., 2011, Morrison et al., 2000)

Pp1-87B

Protein phosphatase 1 at 87B

Su(var)3-6, PP1α87B, PP1, PP1 87B, Su-var(3)6

(Miskei et al., 2011, Morrison et al., 2000)

Pp1α-96A

Protein phosphatase 1α at 96A

PP1α96A, Pp1-96A, PP1, PP1 96A, PP1c

(Miskei et al., 2011, Morrison et al., 2000)

Pp1-Y1

Protein phosphatase 1, Y-linked 1

(Miskei et al., 2011)

Pp1-Y2

Protein phosphatase 1, Y-linked 2

Pp1Y2

(Miskei et al., 2011)

Pp2B-14D

Protein phosphatase 2B at 14D

CnnA14D, canA, calcineurin, PP2B 14D, CaN

(Miskei et al., 2011, Morrison et al., 2000)

Pp4-19C

Protein phosphatase 19C

PP4, PP4c

(Miskei et al., 2011, Morrison et al., 2000)

PpD3

Protein phosphatase D3

PP5, Pp5-85E

(Miskei et al., 2011, Morrison et al., 2000)

PpD5

Protein phosphatase D5

(Miskei et al., 2011, Morrison et al., 2000)

PpD6

Protein phosphatase D6

PP1-like

(Miskei et al., 2011, Morrison et al., 2000)

PpN58A

Protein phosphatase N at 58A

PPN 58A

(Miskei et al., 2011, Morrison et al., 2000)

PpV

Protein phosphatase V

(Miskei et al., 2011, Morrison et al., 2000)

PpY-55A

Protein phosphatase Y at 55A

PPY, PPY 55A

(Miskei et al., 2011, Morrison et al., 2000)

rdgC

retinal degeneration C

(Miskei et al., 2011, Morrison et al., 2000)

PROTEIN ARGININE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Argp

Arginine phosphatase

(Lee et al., 2020, Fuhrmann et al., 2013)

PROTEIN HISTIDINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG18662

(FlyBase, 2017-)

janA

janus A

janus, Y

(FlyBase, 2017-)

janB

janus B

janus

(FlyBase, 2017-)

ocn

ocnus

BcDNA:GH02250

(FlyBase, 2017-)

RECEPTOR PROTEIN TYROSINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG42327

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000)

Lar

Leukocyte-antigen-related-like

Dlar, bypass

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000)

Ptp4E

Protein tyrosine phosphatase 4E

DPTP4E

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000)

Ptp10D

Protein tyrosine phosphatase 10D

DPTP10D

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000, Walchli et al., 2000)

Ptp52F

Protein tyrosine phosphatase 52F

DPTP52F

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000)

Ptp69D

Protein tyrosine phosphatase 69D

DPTP69D, DPTP

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000)

Ptp99A

Protein tyrosine phosphatase 99A

DPTP99A

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000, Walchli et al., 2000)

UNCLASSIFIED PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2921

(FlyBase, 2017-)

CG4161

BG:DS03023.2

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(Attrill and Antonazzo, 2013.6.25)

CG31924

(FlyBase, 2017-)

curled

nocturnin, nocturin

(FlyBase, 2017-)

Epp

Ecdysteroid phosphate phosphatase

(FlyBase, 2017-)

Gs1l

GS1-like

(FlyBase, 2017-)

UNCLASSIFIED PROTEIN SERINE/THREONINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG34183

(FlyBase, 2017-)

Pgam5

Phosphoglycerate mutase 5

EG:63B12.4, dPGAM5

(Imai et al., 2010)

Pgam5-2

Phosphoglycerate mutase 5-2

(Imai et al., 2010)

Ssu72

Ssu72 CTD phosphatase

(Zhang et al., 2011)

External Data

Equivalent Group(s)

Human Phosphatases (HGNC)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

PHOSASE

PHOSPHATASES

Secondary FlyBase ID(s)

References (31)

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