FlyBase Allele Report: Dmel\H[1]

General Information

Symbol

Dmel\H¹

Species

D. melanogaster

Name

FlyBase ID

FBal0005292

Feature type

allele

Associated gene

Dmel\H

Associated Insertion(s)

copia{}H¹

Carried in Construct

Also Known As

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Nagel et al., 2000)

loss of function allele

(Long et al., 1996)

Mutagen

spontaneous

(Maier et al., 1992, Ashburner, 1982)

Progenitor genotype

Associated Insertion(s)

copia{}H¹

Cytology

Description

Insertion of a copia element in the second intron. The insertion occurs in between the T/A at 314/315 base pairs counting from the 5' splice junction.

(Harding-Theobald et al., 2007.2.6)

Insertion whose restriction map matches copia inserted into the 2nd intron.

(Maier et al., 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Diaz-Benjumea and Garcia-Bellido, 1990)

visible

(Apidianakis et al., 1999, Steinberg, 1937)

visible (with H³)

(Nagel et al., 2000)

visible | dominant

(Verheyen et al., 2001, Fostier et al., 1998, Maier et al., 1992)

Phenotype Manifest In

adult head bristle

(Verheyen et al., 2001)

eo neuron (with H³)

(Nagel et al., 2000)

eo neuron (with H^P8)

(Nagel et al., 2000)

intestinal stem cell | somatic clone

(Bardin et al., 2010)

larval dorsal hair

(Dickinson and Thatcher, 1997)

macrochaeta

(Fostier et al., 1998)

macrochaeta & scutum

(Lyman and Yedvobnick, 1995)

mechanosensory chaeta | adult stage

(Shukla et al., 2017)

mesothoracic tergum & macrochaeta

(Verheyen et al., 2001)

microchaeta

(Fostier et al., 1998)

microchaeta & scutum

(Lyman and Yedvobnick, 1995)

(Steinberg, 1937)

(Apidianakis et al., 1999)

sensory mother cell (with H³)

(Nagel et al., 2000)

supracervical bristle

thecogen cell (with H^P8)

(Nagel et al., 2000)

thecogen cell | ectopic (with H³)

(Nagel et al., 2000)

tormogen cell | ectopic (with H³)

(Nagel et al., 2000)

wing vein L2

(Steinberg, 1937)

wing vein L4

(Steinberg, 1937)

wing vein L5

(Verheyen et al., 2001, Fostier et al., 1998, Steinberg, 1937)

Detailed Description

Statement

Reference

H¹ heterozygous adults display loss of one or more thoracic sensory bristles, as compared o controls.

(Shukla et al., 2017)

Homozygous intestinal stem cell clones lose self-renewing capacity over time, and fail to form large clones at 14 days after clone induction, in contrast to wild-type controls.

(Bardin et al., 2010)

Mutant embryos show normal boundary cell differentiation in the hindgut.

(Takashima et al., 2002)

Heterozygotes show shortening of wing vein L5.

(Verheyen et al., 2001)

H³/H¹ flies have a loss of Sensory Organ Precursors (SOP), and thus in nearly bald pharate adults. Remaining SOPs mainly give rise to quadruple sockets. In H¹/H^P8 flies a complete transformation of all external sensory organ neurons into sheath cells.

(Nagel et al., 2000)

H¹/H² flies produce nota that are bald.

(Apidianakis et al., 1999)

Small L5 gap phenotype at low penetrance in heterozygotes.

(Fostier et al., 1998)

Dorsal hairs are sparse compared to wild type. Denticle belts are normal.

(Dickinson and Thatcher, 1997)

Terminal gaps in LIV and LV and occasionally short terminal gaps in LII and LIII.

(Diaz-Benjumea and Garcia-Bellido, 1990)

Strongly enhanced expression of "N^Ax" alleles.

(Siren and Portin, 1989)

Mutant flies show shortening of at least one and sometimes more of: wing veins L2, L4 and L5 and the posterior crossvein.

(Steinberg, 1937)

Bristles, especially postverticals and abdominals, missing in heterozygous H¹ flies. Bristle sockets present at some sites, not at others. Expressed most distinctly on head; occipital; postvertical and ocellar bristles affected. Veins L4 and L5 do not reach wing margin; occasionally true of L2 also. Recessive lethal. Homozygotes die during larval and pupal stages Animals surviving to pharate adult are completely devoid of macrochaetes and microchaetes on the head and notum, with occasional 'double sockets' remaining on the abdominal tergites. Bristles on the legs significantly resistant to loss of H⁺ function.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

H¹ has visible | dominant phenotype, enhanceable by nmo^adk2/nmo^adk1

(Verheyen et al., 2001)

H¹ has visible | dominant phenotype, enhanceable by nmo^adk1/nmo^adk1

(Verheyen et al., 2001)

Enhancer of

Statement

Reference

H¹ is an enhancer of visible phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

NOT Enhancer of

Statement

Reference

H¹ is a non-enhancer of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Suppressor of

Statement

Reference

H[+]/H¹ is a suppressor of visible phenotype of Caf1-105^NIG.12892R, Scer\GAL4^ey.PH

(Yu et al., 2013)

H[+]/H¹ is a suppressor of visible phenotype of Caf1-105^NIG.12892R, Scer\GAL4^sd.PU

(Yu et al., 2013)

H¹ is a suppressor of lethal phenotype of N^nd-p, e(r)^p2

(Tsubota et al., 2011)

H[+]/H¹ is a suppressor of visible phenotype of Scer\GAL4^en-e16E, pzg^RNAi.UAS

(Kugler and Nagel, 2007)

H¹ is a suppressor of visible | recessive phenotype of nmo^adk2

(Verheyen et al., 2001)

H¹ is a suppressor of visible phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

H¹ is a suppressor | partially of lethal phenotype of Delta¹, RpS3[+]/RpS3¹

(Schultz, 1929)

H¹ is a suppressor | partially of lethal phenotype of Dl[+]/Delta¹, RpS3¹

(Schultz, 1929)

NOT Suppressor of

Statement

Reference

H¹ is a non-suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Other

Statement

Reference

H¹, N^nd-p, e(r)^p2 has viable phenotype

(Tsubota et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

H¹ has mechanosensory chaeta | adult stage phenotype, enhanceable by Rbfox1^RNAi.UAS/Scer\GAL4^sca-109-68

(Shukla et al., 2017)

H¹ has adult head bristle phenotype, enhanceable by nmo^adk2/nmo^adk1

(Verheyen et al., 2001)

H¹ has mesothoracic tergum & macrochaeta phenotype, enhanceable by nmo^adk2/nmo^adk1

(Verheyen et al., 2001)

H¹ has adult head bristle phenotype, enhanceable by nmo^adk1/nmo^adk1

(Verheyen et al., 2001)

H¹ has mesothoracic tergum & macrochaeta phenotype, enhanceable by nmo^adk1/nmo^adk1

(Verheyen et al., 2001)

H¹ has wing vein L5 phenotype, enhanceable by Su(dx)^sp

(Fostier et al., 1998)

H¹ has macrochaeta phenotype, enhanceable by Su(dx)^sp

(Fostier et al., 1998)

H¹ has microchaeta phenotype, enhanceable by Su(dx)^sp

(Fostier et al., 1998)

H¹ has phenotype, enhanceable by Su(H)^eBC11

(Verheyen et al., 1996)

H¹ has phenotype, enhanceable by Su(H)^O5

(Fortini and Artavanis-Tsakonas, 1994)

H¹ has phenotype, enhanceable by Su(H)^T4

(Fortini and Artavanis-Tsakonas, 1994)

H¹ has phenotype, enhanceable by Su(H)^E(H)

Suppressed by

Statement

Reference

H¹ has phenotype, suppressible by Su(H)^sA21

(Verheyen et al., 1996)

H¹ has phenotype, suppressible by Su(H)^sK2

(Verheyen et al., 1996)

H¹ has phenotype, suppressible by Su(H)^sO10

(Verheyen et al., 1996)

H¹ has phenotype, suppressible by Su(H)¹²

(Furukawa et al., 1992)

H¹ has phenotype, suppressible by Su(H)¹³

(Furukawa et al., 1992)

H¹ has phenotype, suppressible by Su(H)¹⁴

(Furukawa et al., 1992)

H¹ has phenotype, suppressible by Su(H)⁶

(Furukawa et al., 1992)

H¹ has phenotype, suppressible by Su(H)⁸

(Furukawa et al., 1992)

H¹ has phenotype, suppressible by Su(H)^AM1

(Furukawa et al., 1992)

H¹ has phenotype, suppressible by Su(H)^IB115

(Furukawa et al., 1992)

H¹ has phenotype, suppressible by Su(H)¹¹

(O'Donnell et al., 1977)

NOT suppressed by

Statement

Reference

H¹ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

H¹ is an enhancer of presutural bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

H¹ is an enhancer of posterior scutellar bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

H¹ is an enhancer of anterior notopleural bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

H¹ is an enhancer of posterior notopleural bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

H¹ is an enhancer of anterior supraalar bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

H¹ is an enhancer of posterior supraalar bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

H¹ is an enhancer of posterior postalar bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

H¹ is an enhancer of anterior dorsocentral bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

H¹ is an enhancer of posterior dorsocentral bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

H¹ is an enhancer of anterior scutellar bristle & trichogen cell phenotype of Delta^UAS.cJa, Scer\GAL4^{l(3)31-1-31-1}

(Jacobsen et al., 1998)

H¹ is an enhancer of microchaeta & scutum phenotype of N^60g11

(Lyman and Yedvobnick, 1995)

H¹ is an enhancer of phenotype of N^l1N-B

(Lyman and Yedvobnick, 1995)

H¹ is an enhancer of microchaeta & scutum phenotype of N^l1N-B

(Lyman and Yedvobnick, 1995)

NOT Enhancer of

Statement

Reference

H¹ is a non-enhancer of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Suppressor of

Statement

Reference

H[+]/H¹ is a suppressor of eye phenotype of Caf1-105^NIG.12892R, Scer\GAL4^ey.PH

(Yu et al., 2013)

H[+]/H¹ is a suppressor of wing phenotype of Caf1-105^NIG.12892R, Scer\GAL4^sd.PU

(Yu et al., 2013)

H[+]/H¹ is a suppressor of wing phenotype of Scer\GAL4^en-e16E, pzg^RNAi.UAS

(Kugler and Nagel, 2007)

H¹ is a suppressor of chemosensory ventral triple row & microchaeta | ectopic phenotype of ed^4.12

(Rawlins et al., 2003)

H¹ is a suppressor of dorsal triple row & microchaeta | ectopic phenotype of ed^4.12

(Rawlins et al., 2003)

H¹ is a suppressor of dorsocentral bristle | ectopic phenotype of ed^4.12

(Rawlins et al., 2003)

H¹ is a suppressor of scutellar bristle | ectopic phenotype of ed^4.12

(Rawlins et al., 2003)

H¹ is a suppressor of wing vein | ectopic phenotype of nmo^adk2

(Verheyen et al., 2001)

H¹ is a suppressor of phenotype of Delta^TM.sev

(Sun and Artavanis-Tsakonas, 1996)

H¹ is a suppressor of phenotype of Ser^{TM.sev.Tag:VSV-G}

(Sun and Artavanis-Tsakonas, 1996)

H¹ is a suppressor of microchaeta phenotype of N^Ax-9/N^l1N-B

(Lyman and Yedvobnick, 1995)

H¹ is a suppressor of phenotype of Delta¹

H¹ is a suppressor of phenotype of NX¹

NOT Suppressor of

Statement

Reference

H¹ is a non-suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Other

Statement

Reference

H¹, Rbfox1^RNAi.UAS, Scer\GAL4^sca-109-68 has tormogen cell | adult stage phenotype

(Shukla et al., 2017)

Delta^UAS.cJa, H¹, Scer\GAL4^{l(3)31-1-31-1} has microchaeta phenotype

(Jacobsen et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

H¹ heterozygous adults also expressing Rbfox1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^sca-109-68 exhibit an enhanced loss of thoracic sensory bristles and exhibit a significant amount of sockets instead of bristles, as compared to H¹ heterozygotes.

(Shukla et al., 2017)

One copy of H¹ fully suppresses the small eye phenotype seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^ey.PH.

One copy of H¹ suppresses the wing phenotypes seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^sd.PU. Instead the flies have interruption to longitudinal vein 5 in the distal part.

(Yu et al., 2013)

The reduction in wing area seen in flies expressing pzg^{dsRNA.Scer\UAS} under the control of Scer\GAL4^en-e16E is suppressed by N^Ax-M1/+ or H¹/+.

(Kugler and Nagel, 2007)

The ectopic wing veins seen in nmo^adk2 flies are completely suppressed by H¹. The loss of bristles on the head and notum seen in H¹/+ flies is dramatically enhanced by nmo^adk1/nmo^adk1 or nmo^adk1/nmo^adk2.

(Verheyen et al., 2001)

The addition of H¹ suppresses the wing nicking phenotype seen in mam^N.Scer\UAS, Scer\GAL4^C96 flies producing a range of phenotypes.

(Helms et al., 1999)

Heterozygous vein L5 gap phenotype is enhanced by hetero- and homozygotes for Su(dx)^sp which also enhances the bristle loss phenotype of H¹.

(Fostier et al., 1998)

Enhances the transformation of the trichogen to a tormogen fate in the notal macrochaetae caused by Dl^Scer\UAS.cJa expressed under the control of Scer\GAL4^{l(3)31-1-31-1}. Widespread transformation of microchaetae is also seen in this background.

(Jacobsen et al., 1998)

Enhances the microchaetae and macrochaetae loss phenotype of N gain of function heterozygotes.

(Lyman and Yedvobnick, 1995)

The lethality of Dl¹ RpS3¹ heterozygotes is partially suppressed by H¹.

(Schultz, 1929)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (22)

5440

515

1698

516

1927

w^*; Delta¹ H¹ r-l^K1/TM2

108236

106459

105955

101666

In(3R)C, cd¹ / Sb¹ H¹

106581

w^*; Delta¹ H¹ r-l^K1/TM2

105956

H¹ Pri¹/In(3R)C, sprd¹ e¹

107634

DCTN1-p150^Gl-1 Sb¹ H¹/In(3L)P, In(3R)P

More stocks available...

Notes on Origin

Discoverer

Bridges, 4th March 1916.

Comments

Phenotypic series of H alleles, progressing from strongest (amorphic) to weakest mutant phenotype: H^B79 = H⁸¹ >> H¹ = H⁹⁹ > H^bob > H^94a > H^88d > H^B8 > H² >= H³ > H^A120.

(Maier et al., 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

(Tsubota et al., 2011, Steinberg, 1937, Schultz, 1929)

(Simonova et al., 1998)

H¹

(Gagliani et al., 2022, Kuang et al., 2020, Bala Tannan et al., 2018, Gomez-Lamarca et al., 2018, Chan et al., 2017, Shukla et al., 2017, Morimoto et al., 2016, Yu et al., 2013, Domanitskaya and Schüpbach, 2012, Duan et al., 2011, Pilgram et al., 2011, Walrad et al., 2011, Bardin et al., 2010, Kugler and Nagel, 2007)

Name Synonyms

Secondary FlyBase IDs

References (49)

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