FlyBase Allele Report: Dmel\Delta[DN.UAS]

Expression of Dl^D.Scer\UAS under the control of Scer\GAL4^ato.3.6 results in clustering of dorsal cluster neuron axons. There is a significant increase in the number of axons targeting the medulla compared to wild type.

(Langen et al., 2013)

Expression of Dl^D.Scer\UAS under the control of Scer\GAL4^sca-109-68 results in extra scutellar bristles.

(Xie et al., 2012)

Expression of Dl^D.Scer\UAS under the control of Scer\GAL4^tin.CΔ4 post-development (by co-expression of Scer\GAL80^ts.αTub84B, inactivated post-embryonically by shifting the flies to 26[o]C) results in deterioration of cardiac function, and this can be corrected by a second temperature shift back to 18[o]C. Animals show dilated cardiomyopathy, with enlarged end-diastolic and end-systolic dimensions, and impaired fractional shortening.

(Kim et al., 2010)

Expression of Dl^D.Scer\UAS using Scer\GAL4^34B causes the development of thickened wing veins.

Expression of Dl^D.Scer\UAS using Scer\GAL4^bbg-C96 results in notches in the wing margin.

(Shalaby et al., 2009)

The number of cap cells and germline stem cells in the ovaries of 2 day old females expressing Dl^{ΔICD.Scer\UAS} under the control of Scer\GAL4^C587 is significantly reduced compared to wild type.

(Song et al., 2007)

Border cell migration is severely impaired following expression of Dl^D.Scer\UAS in the border cells using Scer\GAL4^slbo.2.6.

(Wang et al., 2007)

Expression of Dl^{ΔICD.Scer\UAS} under the control of Scer\GAL4^bs-1348 results in wing vein thickening.

Expression of Dl^{ΔICD.Scer\UAS} under the control of Scer\GAL4^{l(3)31-1-31-1} does not result in a mutant phenotype.

Expression of Dl^{ΔICD.Scer\UAS} under the control of Scer\GAL4^dpp.blk1 results in thickening of wing vein 3 and severe wing notching.

(Parks et al., 2006)

Expression of Dl^D.Scer\UAS under the control of Scer\GAL4^bi-omb-Gal4 results in a reduction of the eye disc on both the dorsal and ventral margins.

(Singh et al., 2004)

Embryos expressing Dl^D.Scer\UAS under the control of Scer\GAL4^byn-Gal4 completely lack hindgut boundary cell rows and rings.

(Iwaki and Lengyel, 2002)

Boundary cells of the hindgut do not form in embryos expressing Dl^D.Scer\UAS under the control of Scer\GAL4^byn-Gal4.

(Takashima et al., 2002)

When expression is driven by Scer\GAL4^sca-C253 many macrochaetae develop from proneural clusters.

(Culi et al., 2001)

Expression of Dl^D.Scer\UAS under the control of Scer\GAL4^ey.PB can result in homeotic transformation of the eye to antenna.

(Kumar and Moses, 2001)

Expression of Dl^D.Scer\UAS under the control of Scer\GAL4^dpp.blk1 inhibits furrow reincarnation but not birth in the eye disc.

(Kumar and Moses, 2001)

Neuronal patterning in the ommatidial preclusters is maintained in flies expressing Dl^D.Scer\UAS under the control of Scer\GAL4^lz-gal4.

(Flores et al., 2000)

When expression is driven by Scer\GAL4^bs-1348 all wing veins are thickened.

(Huppert et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Delta^DN.UAS, Scer\GAL4^sca-109-68 has visible phenotype, enhanceable by uif^asterisk.UAS, Scer\GAL4^sca-109-68

(Xie et al., 2012)

Delta^DN.UAS, Scer\GAL4^sca-537.4 has visible phenotype, enhanceable by ed^ΔECD.UAS, Scer\GAL4^sca-537.4

(Escudero et al., 2003)

Suppressed by

Statement

Reference

Delta^DN.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible | partially by Mnr^EP555, Scer\GAL4^GMR.PU

(Nagel et al., 2021)

Delta^DN.UAS, Scer\GAL4^GMR.PU has decreased size | adult stage phenotype, suppressible | partially by Mnr^EP555, Scer\GAL4^GMR.PU

(Nagel et al., 2021)

Delta^DN.UAS, Scer\GAL4^sca-C253 has visible phenotype, suppressible by aos^UAS.cHa, Scer\GAL4^sca-C253

(Culi et al., 2001)

Enhancer of

Statement

Reference

Delta^DN.UAS, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Dcp-1^UAS.cKa, Scer\GAL4^GMR.PF

(Kim et al., 2010)

Suppressor of

Statement

Reference

Delta^DN.UAS, Scer\GAL4^insc-Mz1407 is a suppressor of increased cell number | third instar larval stage phenotype of Scer\GAL4^insc-Mz1407, Su(Tpl)^{UAS.SR.Tag:MYC}, lilli^{UAS.SR.Tag:FLAG}

(Liu et al., 2017)

Delta^DN.UAS, Scer\GAL4^insc-Mz1407 is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^insc-Mz1407, Su(Tpl)^{UAS.SR.Tag:MYC}, lilli^{UAS.SR.Tag:FLAG}

(Liu et al., 2017)

NOT Suppressor of

Statement

Reference

Delta^DN.UAS, Scer\GAL4^dpp.blk1 is a non-suppressor of neoplasia phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

Delta^DN.UAS, Scer\GAL4^dpp.blk1 is a non-suppressor of abnormal cell migration | larval stage phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

Other

Statement

Reference

Delta^DN.UAS, Hr38[+]/Hr38^d10593, Scer\GAL4^34B has lethal phenotype

(Shalaby et al., 2009)

Delta^DN.UAS, Scer\GAL4^sca-537.4, ed^ΔECD.UAS has visible phenotype

(Escudero et al., 2003)

Delta^DN.UAS, Scer\GAL4^sca-C253, aos^UAS.cHa has visible phenotype

(Culi et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

Delta^DN.UAS, Scer\GAL4^sca-109-68 has scutellar bristle | increased number phenotype, enhanceable by uif^asterisk.UAS, Scer\GAL4^sca-109-68

(Xie et al., 2012)

Delta^DN.UAS, Scer\GAL4^34B has wing vein phenotype, enhanceable by kst[+]/kst^d11183, Scer\GAL4^34B

(Shalaby et al., 2009)

Delta^DN.UAS, Scer\GAL4^bbg-C96 has wing margin phenotype, enhanceable by Hr38[+]/Hr38^d10593, Scer\GAL4^bbg-C96

(Shalaby et al., 2009)

Delta^DN.UAS, Scer\GAL4^bbg-C96 has wing margin phenotype, enhanceable by Amun[+]/Amun^d03329, Scer\GAL4^bbg-C96

(Shalaby et al., 2009)

Delta^DN.UAS, Scer\GAL4^bi-omb-Gal4 has eye disc | ventral phenotype, enhanceable by tsh^UAS.cGa, Scer\GAL4^bi-omb-Gal4

(Singh et al., 2004)

Delta^DN.UAS, Scer\GAL4^bi-omb-Gal4 has eye disc | dorsal phenotype, enhanceable by tsh^UAS.cGa, Scer\GAL4^bi-omb-Gal4

(Singh et al., 2004)

Delta^DN.UAS, Scer\GAL4^sca-537.4 has macrochaeta | ectopic phenotype, enhanceable by ed^ΔECD.UAS, Scer\GAL4^sca-537.4

(Escudero et al., 2003)

Delta^DN.UAS, Scer\GAL4^sca-537.4 has microchaeta | ectopic phenotype, enhanceable by ed^ΔECD.UAS, Scer\GAL4^sca-537.4

(Escudero et al., 2003)

Suppressed by

Statement

Reference

Delta^DN.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Mnr^EP555, Scer\GAL4^GMR.PU

(Nagel et al., 2021)

Delta^DN.UAS, Scer\GAL4^34B has wing vein phenotype, suppressible | partially by Amun[+]/Amun^d03329, Scer\GAL4^34B

(Shalaby et al., 2009)

Delta^DN.UAS, Scer\GAL4^bbg-C96 has wing margin phenotype, suppressible | partially by Csp[+]/Csp^d07162, Scer\GAL4^bbg-C96

(Shalaby et al., 2009)

Delta^DN.UAS, Scer\GAL4^bbg-C96 has wing margin phenotype, suppressible by Vha68-2^d04859/Vha68-2[+], Scer\GAL4^bbg-C96

(Shalaby et al., 2009)

Delta^DN.UAS, Scer\GAL4^sca-C253 has mesothoracic tergum & macrochaeta phenotype, suppressible by aos^UAS.cHa, Scer\GAL4^sca-C253

(Culi et al., 2001)

Enhancer of

Statement

Reference

Delta^DN.UAS, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Dcp-1^UAS.cKa, Scer\GAL4^GMR.PF

(Kim et al., 2010)

Suppressor of

Statement

Reference

Delta^DN.UAS, Scer\GAL4^insc-Mz1407 is a suppressor of type II neuroblast | third instar larval stage phenotype of Scer\GAL4^insc-Mz1407, Su(Tpl)^{UAS.SR.Tag:MYC}, lilli^{UAS.SR.Tag:FLAG}

(Liu et al., 2017)

Delta^DN.UAS, Scer\GAL4^insc-Mz1407 is a suppressor of embryonic/larval brain | third instar larval stage phenotype of Scer\GAL4^insc-Mz1407, Su(Tpl)^{UAS.SR.Tag:MYC}, lilli^{UAS.SR.Tag:FLAG}

(Liu et al., 2017)

NOT Suppressor of

Statement

Reference

Delta^DN.UAS, Scer\GAL4^dpp.blk1 is a non-suppressor of wing disc phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

Other

Statement

Reference

Delta^DN.UAS, Scer\GAL4^Act5C.PI, tsh^UAS.cGa has eye disc | somatic clone phenotype

(Singh et al., 2004)

Delta^DN.UAS, Scer\GAL4^sca-537.4, ed^ΔECD.UAS has macrochaeta | ectopic phenotype

(Escudero et al., 2003)

Delta^DN.UAS, Scer\GAL4^sca-537.4, ed^ΔECD.UAS has microchaeta | ectopic phenotype

(Escudero et al., 2003)

Delta^DN.UAS, Scer\GAL4^sca-C253, aos^UAS.cHa has mesothoracic tergum & macrochaeta phenotype

(Culi et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The additional co-expression of Dl^D.Scer\UAS suppresses the increased number of type II neuroblasts resulting from the Scer\GAL4^insc-Mz1407-driven co-expression of lilli^{Scer\UAS.SR.T:Zzzz\FLAG} and Su(Tpl)^{Scer\UAS.SR.T:Hsap\MYC} in third instar larval brains, to the point of near absence of type II neuroblasts as compared to controls.

(Liu et al., 2017)

The scutellar bristle phenotype resulting from the expression of Dl^D.Scer\UAS under the control of Scer\GAL4^sca-109-68 is enhanced by co-expression of uif^{asterisk.Scer\UAS}.

(Xie et al., 2012)

Expression of Dl^D.Scer\UAS enhances the rough eye phenotype seen when Dcp-1^Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) is expressed under the control of Scer\GAL4^GMR.PF.

(Kim et al., 2010)

kst^d11183/+ results in enhancement, whereas Amun^d03329/+ results in suppression of the Scer\GAL4^34B, Dl^D.Scer\UAS wing vein-thickening phenotype.

Hr38^d10593/+ or Amun^d03329/+ results in enhancement, whereas Csp^d07162/+ or Vha68-2^d04859/+ results in suppression of the Scer\GAL4^bbg-C96, Dl^D.Scer\UAS wing notching phenotype.

(Shalaby et al., 2009)

Co-expression of tsh^Scer\UAS.cGa further enhances the suppression of eye development at the dorsal and ventral margins of the eye disc which is seen in animals expressing Dl^D.Scer\UAS under the control of Scer\GAL4^bi-omb-Gal4. Clones in the dorsal part of the eye disc which are co-expressing tsh^Scer\UAS.cGa and Dl^D.Scer\UAS under the control of Scer\GAL4^Act5C.PI cause autonomous overgrowth in the posterior margin of the dorsal eye, but photoreceptor differentiation is suppressed within the clone. The overall size of the eye disc is also reduced.

(Singh et al., 2004)

The neurogenic phenotype caused by expression of Dl^D.Scer\UAS under the control of Scer\GAL4^sca-537.4 is potentiated by co-expression of ed^{ΔECD.Scer\UAS}, resulting in large tufts of macrochaetae and an increased density of microchaetae in the notum.

(Escudero et al., 2003)

Microchaetae and macrochaetae of the notum caused by expression of Dl^D.Scer\UAS driven by Scer\GAL4^sca-C253 are eliminated by co-expression of argos^Scer\UAS.cHa.

(Culi et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Delta^DN.UAS/Scer\GAL4^tin.CΔ4 rescues Df(2L)Exel7007

(Kim et al., 2010)

Comments

Expression of Dl^D.Scer\UAS under the control of Scer\GAL4^tin.CΔ4 rescues the abnormal cardiac function of Df(2L)Exel7007 flies.

(Kim et al., 2010)

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