FB2024_03 , released June 25, 2024
Allele: Scer\GAL4CCAP.PP
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General Information
Symbol
Scer\GAL4CCAP.PP
Species
S. cerevisiae
Name
Cardioacceleratory peptide promoter construct of Park
FlyBase ID
FBal0150627
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
CCAP-GAL4, CCAPGAL4
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

CCAP sequences from -516 to +39bp regulate expression of a GAL4 driver.

Allele components
Component
Use(s)
Regulatory region(s)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Information
Statement
Reference

ScerGAL4CCAP.PP drives expression in adult CCAP neurons as well as two CCAP negative EH neuroscretory neurons.

Drives expression in CCAP neurons.

ScerGAL4CCAP.PP drives expression in a subset of peptidergic neurons in the larval ventral nerve cord and in one pair of peptidergic neurons in the embryonic/larval protocerebrum. In the adult labeled neurons are detected in the posterior part of the thoracico-abdominal ganglion and in the subesophageal ganglion only at 0-6h after eclosion. Expression in the superior protocerebrum persists until at least 3-4 days after eclosion.

ScerGAL4Ccap.PP drives expression in a subset of CCAP neurons in the adult brain, including neurons in the subesophageal ganglion that extend their axons along the midline to the anterior brain.

ScerGAL4Ccap.PP drives expression in a subset of neurons in the ventral nerve cord, including: one pair of laterally located neurons in each of the first two thoracic neuromeres (T1-T2), two pairs in the third thoracic and first four abdominal neuromeres (T3, A1-A4), one pair in the next three abdominal neuromeres (A5-A8), and weak expression in the three pairs in the last two abdominal neuromeres (A8-A9). The neurites also showed strong expression of ScerGAL4Ccap.PP.

Larval expression is observed in CCAP-positive neurons: 2 pairs of neurons in the brain, 5 pairs in the subesophageal ganglion, 1-2 pairs in each of eight ganglia in the ventral nervous system.

 
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Activation of Scer\GAL4CCAP.PP-positive neurons (by the expression of TrpA1UAS.(B).cKa under the control of Scer\GAL4CCAP.PP) leads to decreased female fecundity.

One copy of Scer\GAL4CCAP.PP suppresses the normal bursCCAP neuron apoptosis seen in wild type flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Enhancer of
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Enhanced by
Suppressed by
Statement
Reference

OsbpUAS.cMa, Scer\GAL4CCAP.PP has wing phenotype, suppressible | partially by CG3329844-5/CG33298[+]

OsbpUAS.cMa, Scer\GAL4CCAP.PP has Golgi apparatus phenotype, suppressible by CG3329844-5/CG33298[+]

OsbpUAS.cMa, Scer\GAL4CCAP.PP has wing phenotype, suppressible by Df(2R)ED3181/+

NOT suppressed by
Enhancer of
Suppressor of
Statement
Reference
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Scer\GAL4CCAP.PP
Scer\GAL4Ccap.PP
Name Synonyms
Cardioacceleratory peptide promoter construct of Park
Secondary FlyBase IDs
    References (81)