FlyBase Gene Report: Dmel\Sod1

CEC

(Cacciottolo et al., 2019)

Sod1^UAS.cWa

DOES NOT model amyotrophic lateral sclerosis

CEA

(Watson et al., 2008)

Sod1^GD7385

CEC

(Cacciottolo et al., 2019)

Sod1^KK102426

CEC

(Cacciottolo et al., 2019)

Sod1^G37R

CEA

(Şahin et al., 2017)

Sod1^H48R

CEA

(Agudelo et al., 2020, Şahin et al., 2017)

Sod1^H71Y

CEA

(Agudelo et al., 2020, Şahin et al., 2017)

Sod1^G85R

CEA

(Nemtsova et al., 2023, Agudelo et al., 2020, Held et al., 2019, Şahin et al., 2017)

Sod1^null

CEA

(Agudelo et al., 2020)

Sod1^G85R-cr

SOD1; superoxide dismutase 1

CEA

(Nemtsova et al., 2023)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 12 )

Allele

Disease

Interaction

References

Sod1^HMS01291

exacerbates amyotrophic lateral sclerosis type 21

modeled by Hsap\MATR3^{S85C.UAS.cZa.Tag:FLAG}

(Zhao et al., 2020)

modeled by Hsap\MATR3^{UAS.cZa.Tag:FLAG}

(Zhao et al., 2020)

modeled by Hsap\MATR3^{F115C.UAS.cZa.Tag:FLAG}

(Zhao et al., 2020)

modeled by Hsap\MATR3^{T622A.UAS.cZa.Tag:FLAG}

(Zhao et al., 2020)

exacerbates amyotrophic lateral sclerosis type 8

modeled by Vap33^Δ166, Vap33^P58S.cRa.UAS

(Tendulkar et al., 2022)

Sod1^UAS.cAa

DOES NOT ameliorate Parkinson's disease

modeled by Chchd2^null

(Meng et al., 2017)

ameliorates epilepsy

modeled by pk^sple-1

(Nukala et al., 2023)

exacerbates neurodegenerative disease

modeled by Zzzz\CAG^{Q48.UAS.Tag:MYC,Tag:FLAG}

(Underwood et al., 2010)

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Rival et al., 2009)

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}

(Rival et al., 2009)

exacerbates mucopolysaccharidosis type IIIA

modeled by Sgsh^GD1578

(Webber et al., 2018)

ameliorates cancer

modeled by Ras85D^Q13.UAS

(Tamamouna et al., 2021)

exacerbates amyotrophic lateral sclerosis type 8

modeled by Vap33^Δ166, Vap33^P58S.cRa.UAS

(Tendulkar et al., 2022)

Sod1^X-39

model of amyotrophic lateral sclerosis

is ameliorated by Hsap\SOD1^UAS.cPa

(Parkes et al., 1998)

Sod1^RNAi.UAS.cHa

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Rival et al., 2009)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^Aβ42.lexAop

(Stapper and Jahn, 2018)

Sod1ⁿ¹

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Rival et al., 2009)

exacerbates Alexander disease

modeled by Hsap\GFAP^R79H.UAS

(Wang et al., 2011)

is exacerbated by Gem3^ΔN.UAS

(Cacciottolo et al., 2019)

Sod1^GL01016

ameliorates amyotrophic lateral sclerosis type 8

modeled by Vap33^P58S.cRa.UAS

(Chaplot et al., 2019)

Sod1^UAS.cWa

ameliorates cardiomyopathy

modeled by park^HMS01651

(Bhandari et al., 2014)

modeled by park^HMS01800

(Bhandari et al., 2014)

ameliorates Parkinson's disease

modeled by Pgk^KK102941

(Shimizu et al., 2020)

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.2N4R.cSb

(Saito et al., 2021)

modeled by Hsap\MAPT^{C291A.UAS.2N4R}, Hsap\MAPT^{C322A.UAS.2N4R}

(Saito et al., 2021)

ameliorates neurodegenerative disease

modeled by ifc^KO

(Tzou et al., 2021)

Sod1^GD7385

exacerbates amyotrophic lateral sclerosis type 1

modeled by Sod1^GD7385

(Cacciottolo et al., 2019)

is exacerbated by Sod1^GD7385

(Cacciottolo et al., 2019)

Sod1^KK102426

exacerbates amyotrophic lateral sclerosis type 1

modeled by Sod1^KK102426

(Cacciottolo et al., 2019)

is exacerbated by Sod1^KK102426

(Cacciottolo et al., 2019)

Sod1^JF03321

ameliorates amyotrophic lateral sclerosis type 8

modeled by Vap33^P58S.cRa.UAS

(Chaplot et al., 2019)

Sod1^UAS.cUa

ameliorates Parkinson's disease 6

modeled by Pink1^RNAi.UAS.cYa

(Liu and Lu, 2010)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Arctic.Aβ42.lexAop.Tag:SS(nec)}

(Hsieh and Chiang, 2023)

Sod1^G85R

SOD1; superoxide dismutase 1

is ameliorated by COX6AL2^HMC03530

(Nemtsova et al., 2023)

is ameliorated by Drp1^KG03815

(Nemtsova et al., 2023)

is ameliorated by ND-51L1^HMS02423

(Nemtsova et al., 2023)

is ameliorated by SdhBL^HMJ22015

(Nemtsova et al., 2023)

is ameliorated by gbb^UAS.cKa

(Held et al., 2019)

is ameliorated by sax^CA.UAS.cUa

(Held et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

13 of 14

147450

amyotrophic lateral sclerosis type 1

CCS; copper chaperone for superoxide dismutase

3 of 14

603864

SOD3; superoxide dismutase 3

3 of 14

185490

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

View in Interactions Browser

Hsap\SOD1

(Missirlis et al., 2003, Mockett et al., 2003, Elia et al., 1999)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

comigration in non denaturing gel electrophoresis, molecular weight estimation by staining

(Phillips et al., 1995)

Sod1 - AnxB10

(Guruharsha et al., 2011)

Sod1 - Art8

(Guruharsha et al., 2011)

Sod1 - CG10214

(Guruharsha et al., 2011)

Sod1 - CG10638

(Guruharsha et al., 2011)

Sod1 - CG14715

(Guruharsha et al., 2011)

Sod1 - CG1532

(Guruharsha et al., 2011)

Sod1 - CG2852

(Guruharsha et al., 2011)

Sod1 - CG3630

(Guruharsha et al., 2011)

Sod1 - CG4278

(Guruharsha et al., 2011)

Sod1 - CG4570

(Guruharsha et al., 2011)

Sod1 - CG7492

(Guruharsha et al., 2011)

Sod1 - CG7737

(Guruharsha et al., 2011)

Sod1 - CG8993

(Guruharsha et al., 2011)

Sod1 - Calr

(Guruharsha et al., 2011)

Sod1 - Chd64

(Guruharsha et al., 2011)

Sod1 - Cyp1

(Guruharsha et al., 2011)

Sod1 - DUBAI

(Guruharsha et al., 2011)

Sod1 - Df31

anti tag coimmunoprecipitation, peptide massfingerprinting

(Guruharsha et al., 2011)

Sod1 - Dredd

(Fukuyama et al., 2012)

Sod1 - Eno

(Guruharsha et al., 2011)

Sod1 - Fkbp12

(Guruharsha et al., 2011)

Sod1 - Got1

(Guruharsha et al., 2011)

Sod1 - HINT1

(Guruharsha et al., 2011)

Sod1 - Nlp

(Guruharsha et al., 2011)

Sod1 - Ntf-2

(Guruharsha et al., 2011)

Sod1 - Pdi

(Guruharsha et al., 2011)

Sod1 - RpS21

(Guruharsha et al., 2011)

Sod1 - Sh3β

(Guruharsha et al., 2011)

Sod1 - Sumo

(Guruharsha et al., 2011)

Sod1 - Taf5

(Guruharsha et al., 2011)

Sod1 - Tango2

(Guruharsha et al., 2011)

Sod1 - Treh

(Guruharsha et al., 2011)

Sod1 - Trx2

(Guruharsha et al., 2011)

Sod1 - Trxr1

(Guruharsha et al., 2011)

Sod1 - Zpr1

(Guruharsha et al., 2011)

Sod1 - awd

(Guruharsha et al., 2011)

Sod1 - cib

(Guruharsha et al., 2011)

Sod1 - fabp

(Guruharsha et al., 2011)

Sod1 - mtSSB

(Guruharsha et al., 2011)

Sod1 - regucalcin

View in Interactions Browser

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

COX6AL2

(Nemtsova et al., 2023)

suppressible

Drp1

(Nemtsova et al., 2023)

suppressible

Lsd-1

(Wang et al., 2021)

suppressible

Miro

(Nemtsova et al., 2023)

suppressible

ND-51L1

(Nemtsova et al., 2023)

suppressible

SdhBL

(Nemtsova et al., 2023)

enhanceable

(Lim et al., 2014)

enhanceable

(O'Keefe et al., 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Adck1

suppressible

(Yoon et al., 2019)

Cln3

suppressible

(Tuxworth et al., 2011)

Creld

suppressible

(Paradis et al., 2022)

Drp1

suppressible

(Nemtsova et al., 2023)

fbl

suppressible

Sod1|Cat|Trxr1

(Bosveld et al., 2008)

htl

suppressible

(Dong et al., 2021)

Marf

suppressible

(Dorn et al., 2011)

ND-42

suppressible

(Choo et al., 2015)

ND-42

enhanceable

(Choo et al., 2015)

park

suppressible

(Bhandari et al., 2014)

Pgk

suppressible

(Shimizu et al., 2020)

suppressible

(Xia et al., 2024)

suppressible

(Bosveld et al., 2008)

Sgsh

enhanceable

(Webber et al., 2018)

enhanceable

(Sen et al., 2013)

enhanceable

(Lim et al., 2014)

suppressible

(Muliyil et al., 2020)

TrpA1

suppressible

(Vaccaro et al., 2020)

Trxr1

enhanceable

(Missirlis et al., 2001)

Vap33

suppressible

(Deivasigamani et al., 2014)

YME1L

suppressible