Gene Group: HYDROLASES

General Information

Name

HYDROLASES

Species

D. melanogaster

Symbol

HYD

FlyBase ID

FBgg0001302

Date last reviewed

2020-02-05

Number of members

1415

Description

Hydrolases are hydrolytic enzymes that catalyze the hydrolysis of various bonds including C-O, C-N, C-C phosphoric anhydride bonds, etc.

Notes on Group

Source Material

The HYDROLASES Gene Group has been compiled using the following publication(s): Zhang et al., 2024, Fontana et al., 2023, Borovsky et al., 2022, Chen et al., 2022, Erven et al., 2022, Kaneko, 2022, Li et al., 2022, Liu et al., 2022, Páhi et al., 2022, Badmos et al., 2021, Feller et al., 2021, Meyer et al., 2021, Shuman and Momany, 2021, Singgih et al., 2021, Allen et al., 2020, Behr and Riedel, 2020, Lee et al., 2020, Andreyeva et al., 2019, He et al., 2019, Inomata et al., 2019, Kawaguchi et al., 2019, Laurinyecz et al., 2019, Metwally et al., 2019, Naba et al., 2019.7.9, Schmidt et al., 2019, Tao et al., 2019, Zeledon et al., 2019, Cao and Jiang, 2018, Marelja et al., 2018, Meyer et al., 2018.7.18, Pareek et al., 2018, Bellendir et al., 2017, Fu et al., 2017, Gáliková et al., 2017, LaFever et al., 2017, Matsushima et al., 2017, Raut et al., 2017, Sekelsky, 2017, Tang et al., 2017, Azlan et al., 2016, Claisse et al., 2016, Kim et al., 2016, Maor et al., 2016, Morrow et al., 2016, O'Neill and Clark, 2016, Pesch et al., 2016, Small and Crawford, 2016, Yoshida et al., 2016, Balakrishnan et al., 2015, Ben-David et al., 2015, Cheng and Andrew, 2015, Feller et al., 2015, Hatzihristidis et al., 2015, Im et al., 2015, Jang et al., 2015, Krishnan et al., 2015, Louis et al., 2015, Wünsch et al., 2015, Xie and Dubrovsky, 2015, Barclay et al., 2014, Delabaere et al., 2014, Dermauw and Van Leeuwen, 2014, Engel et al., 2014, Findeisen et al., 2014, Guio et al., 2014, Kunduri et al., 2014, Logan-Garbisch et al., 2014, Pogson et al., 2014, Puhl et al., 2014, Rosenbaum et al., 2014, Sandoval et al., 2014, Sitnik et al., 2014, Temme et al., 2014, Attrill and Antonazzo, 2013.6.25, Clague et al., 2013, Fuhrmann et al., 2013, Ismat et al., 2013, Kumar et al., 2013, Lombard et al., 2013, Maor et al., 2013, Neisch et al., 2013, Nemčovičová et al., 2013, Pantzartzi et al., 2013, Adolphsen et al., 2012, Berdnik et al., 2012, Birner-Gruenberger et al., 2012, Carter and Sjögren, 2012, Casso et al., 2012, Mandilaras and Missirlis, 2012, Mortimer et al., 2012, Ratheesh et al., 2012, Rojas et al., 2012, Tsou et al., 2012, Zhang et al., 2012, Arboleda-Bustos and Segarra, 2011, Cao et al., 2011, Diez et al., 2011, Dorus et al., 2011, Fenckova et al., 2011, Gabriško and Janeček, 2011, Meyer et al., 2011, Miskei et al., 2011, Morawe et al., 2011, Noguchi et al., 2011, Zaidman-Rémy et al., 2011, Zhang et al., 2011, Zhang et al., 2011, Boto et al., 2010, Imai et al., 2010, Katanayeva et al., 2010, Monzo et al., 2010, Nielsen et al., 2010, Takahashi et al., 2010, Tracy et al., 2010, Valente et al., 2010, Belote and Zhong, 2009, Cao et al., 2009, Horne et al., 2009, Pan and Zhang, 2009, Schneiderman et al., 2009, Xu et al., 2009, Bannan et al., 2008, Bland et al., 2008, Chan et al., 2008, Deng et al., 2008, Dixit et al., 2008, Kim et al., 2008, Lim et al., 2008, Wei et al., 2008, Zhu et al., 2008, Arya et al., 2007, Funkhouser and Aronson, 2007, Hudson et al., 2007, Kang et al., 2007, Kanno et al., 2007, Narayanan et al., 2007, Pan et al., 2007, Tsuchiya et al., 2007, Zhang et al., 2007, Burroughs et al., 2006, Cattaneo et al., 2006, Chen et al., 2006, Garcia-Murillas et al., 2006, Kollmar and Odronitz, 2006, Kupsco et al., 2006, Leonard et al., 2006, Seong et al., 2006, Walker et al., 2006, Chihara et al., 2005, Day, 2005, Li et al., 2005, Luo and Kaguni, 2005, Nicholson et al., 2005, Sarkar and Lakhotia, 2005, True et al., 2005, Andersen et al., 2004, Colicelli, 2004, Friedrich et al., 2004, Ishikawa et al., 2004, Lee et al., 2004, Nikolaidis and Nei, 2004, Oshige et al., 2004, Pagliarini et al., 2004, Seeds et al., 2004, Zhu et al., 2004, Campbell et al., 2003, Degl'Innocenti et al., 2003, Doronkin et al., 2003, Hsieh et al., 2003, Kocks et al., 2003, Mazzocco et al., 2003, Mellroth et al., 2003, Cope et al., 2002, Harvey et al., 2002, Hwa et al., 2002, Ma et al., 2002, Marti et al., 2002, Pandey et al., 2002, Pasqualato et al., 2002, Ponting et al., 2002, Renault et al., 2002, Renault et al., 2002, Urban et al., 2002, Zurovec et al., 2002, Bernstein et al., 2001, Dean et al., 2001, Golby et al., 2001, Harvey et al., 2001, Jager et al., 2001, Koizumi et al., 2001, Krause et al., 2001, Maier et al., 2001, Schulz et al., 2001, Coates et al., 2000, Easton et al., 2000, Frye, 2000, Giglione et al., 2000, Goldstein and Gunawardena, 2000, Guichard et al., 2000, Juhola et al., 2000, Miller et al., 2000, Morrison et al., 2000, Sekelsky et al., 2000, Walchli et al., 2000, Wasserman et al., 2000, Chi et al., 1999, Acharya et al., 1998, Regel et al., 1998, Filippov et al., 1997, Da Lage et al., 1996, Hultmark, 1996, Rawlings and Barrett, 1996-, Aoyagi et al., 1994, Daffre et al., 1994, Nugent et al., 1993, Reyland et al., 1988, and Fuerst et al., 1987 .

Key Gene Ontology (GO) terms

Molecular Function

hydrolase activity

Biological Process

Cellular Component

Enzymatic activity

Enzyme name (EC)

3.-.-.-

Related Gene Groups

Parent group(s)

ENZYMES

Component group(s)

ACID ANHYDRIDE HYDROLASES

ACID CARBON-CARBON HYDROLASES

ACID SULFUR-NITROGEN HYDROLASES

BETA-ALANYL-DOPAMINE/HISTAMINE HYDROLASES

CARBON-NITROGEN HYDROLASES (NON-PEPTIDASE)

CARBON-SULFUR HYDROLASES

ESTER BOND HYDROLASES

GLYCOSIDE HYDROLASES

HYDROLASES ACTING ON ETHER BONDS

PEPTIDASES

Members (1415)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

3'-5' DNA EXONUCLEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

XPG-like endonuclease

mus324, DmGEN, BcDNA:GM10765

(FlyBase, 2017-, Ishikawa et al., 2004)

hdm

hold'em

(FlyBase, 2017-)

mre11

meiotic recombination 11

(FlyBase, 2017-)

PolA1

DNA polymerase alpha subunit 1

DNApol-alpha180, DNA polymerase α, DNApol-α, DNApol-α180, POLA

(FlyBase, 2017-, Reyland et al., 1988)

PolD1

DNA polymerase delta subunit 1

DNApol-delta, DNApol-δ, Polδ, DNA polymerase delta, l(3)72Ac

(FlyBase, 2017-, Aoyagi et al., 1994)

PolE1

DNA polymerase epsilon subunit 1

DNApol-epsilon, DNApol-ε, DNApol-ε255, DNA polymerase ε, Polε

(FlyBase, 2017-, Oshige et al., 2004)

PolG1

DNA polymerase gamma subunit 1

tamas, tam, DNApol-γ125, pol γ-α, l(2)34Dc

(FlyBase, 2017-, Luo and Kaguni, 2005)

Rrp1

Recombination repair protein 1

APEX1

(FlyBase, 2017-)

Snp

Snipper

(FlyBase, 2017-, Kupsco et al., 2006)

WRNexo

WRN exonuclease

DmWRNexo

(FlyBase, 2017-)

3'-5' RNA EXONUCLEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

angel

DmAngel

(FlyBase, 2017-, Temme et al., 2014)

CG10214

(FlyBase, 2017-)

CG16790

(FlyBase, 2017-)

CG31759

3635

(FlyBase, 2017-, Temme et al., 2014)

curled

nocturnin, nocturin

(FlyBase, 2017-, Temme et al., 2014)

Dis3

dDis3, Tazman

(FlyBase, 2017-)

Dis3l2

Dis3 like 3'-5' exoribonuclease 2

(FlyBase, 2017-)

Exd2

Exonuclease 3'-5' domain-containing 2

(FlyBase, 2017-)

Nbr

Nibbler

(FlyBase, 2017-)

PAN2

Poly(A)-binding protein-dependent poly(A) ribonuclease 2

(FlyBase, 2017-)

PNPase

Polynucleotide phosphorylase

dmpnpase

(FlyBase, 2017-)

PolrMT

RNA polymerase mitochondrial

mtRNApol, mitochondrial RNA polymerase

(Liu et al., 2022)

Pop2

CAF1

(FlyBase, 2017-, Temme et al., 2014)

Rexo5

RNA exonuclease 5

(FlyBase, 2017-)

Rrp6

dRrp6

(FlyBase, 2017-)

Snp

Snipper

(FlyBase, 2017-)

twin

CCR4

(FlyBase, 2017-, Temme et al., 2014)

3'-TRNA PROCESSING ENDORIBONUCLEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

RNaseZ

Ribonuclease Z

JhI-1, dRNaseZ, Juvenile hormone-inducible protein 1, tRNase Z, RNZ

(FlyBase, 2017-, Xie and Dubrovsky, 2015)

5'-3' DNA EXONUCLEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Aptx

aprataxin

(FlyBase, 2017-)

CG43345

(FlyBase, 2017-)

Gen

XPG-like endonuclease

mus324, DmGEN, BcDNA:GM10765

(FlyBase, 2017-)

Pld3

Phospholipase D family member 3

(FlyBase, 2017-)

Snm1

mus322

(FlyBase, 2017-)

tos

tosca

(FlyBase, 2017-)

5'-3' RNA EXONUCLEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cpsf73

Cleavage and polyadenylation specificity factor 73

CPSF-73

(FlyBase, 2017-)

pcm

pacman

XRN1, dXRN1

(FlyBase, 2017-)

Rai1

Rat1 Interacting Protein 1

dRai1

(FlyBase, 2017-)

Rat1

Rat1 5'-3' exoribonuclease

Xrn2

(FlyBase, 2017-)

A1 ASPARTIC ENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Bace

beta-site APP-cleaving enzyme

dBACE

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

cathD

cathepsin D

CTSD

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG5860

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG5863

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG6508

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG10104

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG17134

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG17283

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG31661

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG31926

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG31928

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG33128

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

Pgcl

Pepsinogen C-like

T2, pcl, pepsinogen-like, EG:EG0001.1, scβ

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

A22 ASPARTIC ENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Psn

Presenilin

PS, γ-secretase, Dps, dPsn, dPresenilin

(FlyBase, 2017-, Ponting et al., 2002, Rawlings and Barrett, 1996-)

Spp

Signal peptide peptidase

shanti, Signal peptide protease

(FlyBase, 2017-, Casso et al., 2012, Narayanan et al., 2007, Ponting et al., 2002, Rawlings and Barrett, 1996-)

SppL

Signal peptide peptidase-like

(FlyBase, 2017-, Casso et al., 2012, Narayanan et al., 2007, Ponting et al., 2002, Rawlings and Barrett, 1996-)

A28 ASPARTIC ENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

rngo

rings lost

(FlyBase, 2017-, Morawe et al., 2011, Rawlings and Barrett, 1996-)

ABCE ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

pix

pixie

ABCE1

(He et al., 2019, Dermauw and Van Leeuwen, 2014, Dean et al., 2001)

ABCF ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG1703

(He et al., 2019, Dermauw and Van Leeuwen, 2014, Dean et al., 2001)

CG9281

(He et al., 2019, Dermauw and Van Leeuwen, 2014, Dean et al., 2001)

CG9330

(He et al., 2019, Dermauw and Van Leeuwen, 2014, Dean et al., 2001)

ACID CARBON-CARBON HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Fumarylacetoacetase

l(3)64Al

(FlyBase, 2017-)

ACID PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Acph-1

Acid phosphatase 1

Acph

(Attrill and Antonazzo, 2013.6.25)

CG1637

(Pogson et al., 2014)

CG6656

(Attrill and Antonazzo, 2013.6.25)

CG9449

(Attrill and Antonazzo, 2013.6.25)

CG9451

(Attrill and Antonazzo, 2013.6.25)

CG9452

(Attrill and Antonazzo, 2013.6.25)

Mipp1

Multiple inositol polyphosphate phosphatase 1

(FlyBase, 2017-, Cheng and Andrew, 2015)

Mipp2

Multiple inositol polyphosphate phosphatase 2

l(1)G0050, l(1)G0303

(FlyBase, 2017-, Cheng and Andrew, 2015)

primo-1

(FlyBase, 2017-, Miller et al., 2000)

primo-2

(FlyBase, 2017-, Miller et al., 2000)

ACID SULFUR-NITROGEN HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Sgsh

N-sulfoglucosamine sulfohydrolase

(FlyBase, 2017-)

ACID TRIGLYCERIDE LIPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2772

(FlyBase, 2017-, Horne et al., 2009)

CG3635

(FlyBase, 2017-)

CG6753

(FlyBase, 2017-, Horne et al., 2009)

CG7329

(FlyBase, 2017-, Horne et al., 2009)

CG8093

(FlyBase, 2017-, Horne et al., 2009)

CG11406

(FlyBase, 2017-)

CG11598

(FlyBase, 2017-, Horne et al., 2009)

CG11600

(FlyBase, 2017-, Horne et al., 2009)

CG11608

(FlyBase, 2017-, Horne et al., 2009)

CG17097

anon-SAGE:Wang-018

(FlyBase, 2017-, Horne et al., 2009)

CG18284

(FlyBase, 2017-, Horne et al., 2009)

CG18301

(FlyBase, 2017-, Horne et al., 2009)

CG18302

(FlyBase, 2017-, Horne et al., 2009)

CG18530

(FlyBase, 2017-, Horne et al., 2009)

CG31089

(FlyBase, 2017-, Horne et al., 2009)

CG31091

(FlyBase, 2017-, Horne et al., 2009)

CG31871

(FlyBase, 2017-, Horne et al., 2009)

CG31872

(FlyBase, 2017-, Horne et al., 2009)

Lip1

Lipase 1

(FlyBase, 2017-, Horne et al., 2009)

Lip2

Lipase 2

dilp2

(FlyBase, 2017-, Horne et al., 2009)

Lip3

Lipase 3

(FlyBase, 2017-, Horne et al., 2009)

Lip4

Lipase 4

dLip4

(FlyBase, 2017-, Horne et al., 2009)

mag

magro

lipA

(FlyBase, 2017-, Horne et al., 2009)

ACTIN MATURATION PROTEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG33108

(FlyBase, 2017-)

ACYLGLYCEROL LIPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Hormone-sensitive lipase

dHSL, DmHSL

(FlyBase, 2017-)

Hydr1

α/β hydrolase 1

(FlyBase, 2017-)

Hydr2

α/β hydrolase2

anon-23Da, c24

(FlyBase, 2017-)

ACYLPHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Acyp

Acylphosphatase

AcPDro, BG:DS00180.1

(FlyBase, 2017-, Degl'Innocenti et al., 2003)

Acyp2

Acylphosphatase 2

AcPDro2

(FlyBase, 2017-, Degl'Innocenti et al., 2003)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

ADAM METALLOPROTEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Kul

Kuzbanian-like

ADAM10

(FlyBase, 2017-, Meyer et al., 2011, Rawlings and Barrett, 1996-)

kuz

kuzbanian

l(2)34Da, l(2)br38, BG:DS07660.3

(FlyBase, 2017-, Meyer et al., 2011, Rawlings and Barrett, 1996-)

Meltrin

Neu3, CT23341, DMeltrin

(FlyBase, 2017-, Meyer et al., 2011, Rawlings and Barrett, 1996-)

Tace

(FlyBase, 2017-, Meyer et al., 2011, Rawlings and Barrett, 1996-)

ADAM WITH THROMBOSPONDIN MOTIF

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

AdamTS-A

ADAM metallopeptidase with thrombospondin type 1 motif A

l(3)89Aa

(FlyBase, 2017-, Kim et al., 2016, Ismat et al., 2013, Meyer et al., 2011, Nicholson et al., 2005, Rawlings and Barrett, 1996-)

AdamTS-B

ADAM metallopeptidase with thrombospondin type 1 motif B

(FlyBase, 2017-, Kim et al., 2016, Ismat et al., 2013, Meyer et al., 2011, Nicholson et al., 2005, Rawlings and Barrett, 1996-)

sona

sol narae

Dimp

(FlyBase, 2017-, Kim et al., 2016, Meyer et al., 2011, Rawlings and Barrett, 1996-)

stl

stall

fs(2)A16

(FlyBase, 2017-, Kim et al., 2016, Ismat et al., 2013, Meyer et al., 2011, Rawlings and Barrett, 1996-)

ADENOSINE DEAMINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ada

Adenosine deaminase

(FlyBase, 2017-, Zurovec et al., 2002, Maier et al., 2001)

Adar

Adenosine deaminase acting on RNA

dADAR, EG:BACN35H14.1, hypnos-2

(FlyBase, 2017-)

Adat1

Adenosine deaminase, tRNA-specific 1

BG:DS00941.2, adat, dADAT1

(FlyBase, 2017-)

Adgf-A

Adenosine deaminase-related growth factor A

(FlyBase, 2017-, Zurovec et al., 2002, Maier et al., 2001)

Adgf-A2

Adenosine deaminase-related growth factor A2

MSI

(FlyBase, 2017-, Zurovec et al., 2002, Maier et al., 2001)

Adgf-B

Adenosine deaminase-related growth factor B

(FlyBase, 2017-, Zurovec et al., 2002, Maier et al., 2001)

Adgf-C

Adenosine deaminase-related growth factor C

(FlyBase, 2017-, Zurovec et al., 2002, Maier et al., 2001)

Adgf-D

Adenosine deaminase-related growth factor D

(FlyBase, 2017-, Zurovec et al., 2002, Maier et al., 2001)

CG5292

(FlyBase, 2017-)

CG10927

(FlyBase, 2017-)

ADP-RIBOSE DIPHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG4098

(FlyBase, 2017-)

CG8128

(FlyBase, 2017-)

spd-2

spindle defective 2

Spd2, DSpd-2, D-Spd2, DSpd2, Cep192

(FlyBase, 2017-)

ALKALINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Alp1

Alkaline phosphatase 1

Aph, Aph-1

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp2

Alkaline phosphatase 2

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp4

Alkaline phosphatase 4

Aph-4, l(3)07028

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp5

Alkaline phosphatase 5

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp6

Alkaline phosphatase 6

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp7

Alkaline phosphatase 7

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp8

Alkaline phosphatase 8

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp9

Alkaline phosphatase 9

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp10

Alkaline phosphatase 10

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp11

Alkaline phosphatase 11

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp12

Alkaline phosphatase 12

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

Alp13

Alkaline phosphatase 13

(Attrill and Antonazzo, 2013.6.25)

phu

phurba tashi

BEST:LD38109

(Li et al., 2022, Attrill and Antonazzo, 2013.6.25)

ALPHA,ALPHA-TREHALASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG6262

(Lombard et al., 2013)

Treh

Trehalase

TRE

(Yoshida et al., 2016, Lombard et al., 2013)

ALPHA-GALACTOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5731

(Lombard et al., 2013)

CG7997

(Lombard et al., 2013)

ALPHA-GLUCOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Agl

Glycogen debranching enzyme

(FlyBase, 2017-)

GCS2α

Glucosidase 2 α subunit

BcDNA:GH04962, α-glucosidase, clot#312

(FlyBase, 2017-)

Mal-A1

Maltase A1

LvpH, H, mal_A1, Larval visceral protein H

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-A2

Maltase A2

LvpD, mal_A2, D

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-A3

Maltase A3

LvpL, L, mal_A3

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-A4

Maltase A4

mal_A4

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-A5

Maltase A5

mal_A5

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-A6

Maltase A6

mal_A6

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-A7

Maltase A7

mal_A7

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-A8

Maltase A8

mal_A8

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-B1

Maltase B1

mal_B1

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

Mal-B2

Maltase B2

mal_B2

(Inomata et al., 2019, FlyBase, 2017-, Lombard et al., 2013, Gabriško and Janeček, 2011)

AMINOACYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

AMINOACYL-TRNA EDITING HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

AlaRS

Alanyl-tRNA synthetase

Aats-ala

(FlyBase, 2017-)

AlaRS-m

Alanyl-tRNA synthetase, mitochondrial

Dm mt AlaRS, Aats-ala-m, AlaS

(FlyBase, 2017-)

β-PheRS

Phenylalanyl-tRNA synthetase, β-subunit

(FlyBase, 2017-)

CG10802

(FlyBase, 2017-)

Dtd

D-aminoacyl-tRNA deacylase

DmDTD

(FlyBase, 2017-)

IleRS

Isoleucyl-tRNA synthetase

Aats-ile, l(3)00827

(FlyBase, 2017-)

IleRS-m

Isoleucyl-tRNA synthetase, mitochondrial

(FlyBase, 2017-)

LeuRS

Leucyl-tRNA synthetase

(FlyBase, 2017-)

LeuRS-m

Leucyl-tRNA synthetase, mitochondrial

Aats-leu, LeuRS

(FlyBase, 2017-)

ThrRS

Threonyl-tRNA synthetase

Aats-thr, l(2)k04203

(FlyBase, 2017-)

ValRS

Valyl-tRNA synthetase

l(2)03531, Aats-val, l(2)rI255

(FlyBase, 2017-)

ValRS-m

Valyl-tRNA synthetase, mitochondrial

(FlyBase, 2017-)

AMINOACYL-TRNA HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG1307

BG:DS00004.12

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Amy-d

Amylase distal

Amy, Amylase, α-amylase, alpha-amylase distal, AmyB

(FlyBase, 2017-, Lombard et al., 2013, Da Lage et al., 1996)

Amy-p

Amylase proximal

Amy, α-amylase, Amylase, alpha-amylase proximal, AmyA

(Feller et al., 2021, FlyBase, 2017-, Claisse et al., 2016, Lombard et al., 2013, Da Lage et al., 1996)

Amyrel

Amylase related

(Feller et al., 2021, FlyBase, 2017-, Claisse et al., 2016, Lombard et al., 2013)

ANGIOTENSIN-CONVERTING ENZYME-LIKE PEPTIDYL-DIPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Acer

Angiotensin-converting enzyme-related

l(2)k07704

(FlyBase, 2017-, Coates et al., 2000, Rawlings and Barrett, 1996-)

Ance

Angiotensin converting enzyme

Race, ACE, BG:DS08220.3

(FlyBase, 2017-, Coates et al., 2000, Rawlings and Barrett, 1996-)

ARF GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Arf1

ADP ribosylation factor 1

Arf79F, ADP ribosylation factor 79F, dArf1, ADP ribosylation factor at 79F, Arf

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arf4

ADP ribosylation factor 4

Arf102F, ADP ribosylation factor 102F

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arf6

ADP ribosylation factor 6

Arf51F, dArf6

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arfrp1

ADP-ribosylation factor related protein 1

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arl1

ADP ribosylation factor-like 1

Arf72A, arl, l(3)72Ae, Arflike at 72A

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arl2

ADP ribosylation factor-like 2

Arf84F, Arl84F, Q06849

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arl4

ADP ribosylation factor-like 4

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arl5

ADP-ribosylation factor-like 5

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arl6

ADP ribosylation factor-like 6

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Arl8

ADP ribosylation factor-like 8

Gie, GTPase indispensable for equal segregation of chromosomes

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

CG4789

(Rojas et al., 2012)

CG11356

(FlyBase, 2017-)

CG13692

(Zeledon et al., 2019)

CG17819

(Zeledon et al., 2019)

dnd

dead end

Arl3

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

Sar1

Secretion-associated Ras-related 1

l(3)05712, bro5

(Zeledon et al., 2019, Rojas et al., 2012, Colicelli, 2004, Pasqualato et al., 2002)

ARGONAUTE ENDORIBONUCLEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

AGO1

Argonaute-1

Ago-1, Argonaute, dAGO1, l(2)04845, MRE20

(FlyBase, 2017-, Azlan et al., 2016)

AGO2

Argonaute 2

Ago-2, dAgo2, Argonaute, DmAgo2

(FlyBase, 2017-, Azlan et al., 2016)

AGO3

Argonaute 3

Ago-3, BEST:LD15785

(FlyBase, 2017-, Azlan et al., 2016)

aub

aubergine

sting, stellate-interacting gene

(FlyBase, 2017-, Azlan et al., 2016)

piwi

P-element induced wimpy testis

(FlyBase, 2017-, Azlan et al., 2016)

ARYLESTERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Hmu

Hemomucin

(FlyBase, 2017-)

Ssl2

Strictosidine synthase-like 2

(FlyBase, 2017-)

ASPARAGINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5715

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG6696

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG6763

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG6974

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG7631

BG:BACR44L22.6

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG10280

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG11865

BG:BACR44L22.4

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG15253

BG:BACR44L22.3

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG15254

BG:BACR44L22.2

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG15255

BG:BACR44L22.1

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

Semp1

Seminal metalloprotease-1

BG:BACR44L22.8

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

tld

tolloid

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

tok

tolkin

tlr, tolloid-related 1, tlr-1, tldr-1, tolloid-related

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

ATG8 PROTEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Atg4a

Autophagy-related 4a

Atg4

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

Atg4b

Autophagy-related 4b

Atg4

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

ATP-DEPENDENT FE-S CLUSTER CHAPERONES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Nubp1

NUBP iron-sulfur cluster assembly factor 1

(Marelja et al., 2018, FlyBase, 2017-, Mandilaras and Missirlis, 2012)

Nubp2

NUBP iron-sulfur cluster assembly factor 2

(Marelja et al., 2018, FlyBase, 2017-, Mandilaras and Missirlis, 2012)

Nubpl

NUBP iron-sulfur cluster assembly factor, mitochondrial

(FlyBase, 2017-)

ATP-DEPENDENT METALLOENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Afg3l2

AFG3 like matrix AAA peptidase subunit 2

(FlyBase, 2017-, Juhola et al., 2000, Rawlings and Barrett, 1996-)

Spg7

Paraplegin

EG:100G10.7, anon-3Ba

(FlyBase, 2017-, Juhola et al., 2000, Rawlings and Barrett, 1996-)

YME1L

YME1 like ATPase

(FlyBase, 2017-, Juhola et al., 2000, Rawlings and Barrett, 1996-)

ATP-DEPENDENT SERINE ENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

ClpP

Caseinolytic protease proteolytic subunit

(Pareek et al., 2018, FlyBase, 2017-, Matsushima et al., 2017, Rawlings and Barrett, 1996-)

Lon

Lon protease

(Pareek et al., 2018, FlyBase, 2017-, Matsushima et al., 2017, Rawlings and Barrett, 1996-)

ATYPICAL HEAT SHOCK PROTEIN 70 CHAPERONES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Grp170

Grp170 co-chaperone

EG:25E8.1

(Ratheesh et al., 2012, Easton et al., 2000)

Hsp110

Heat shock protein 110

Hsc70Cb, dHsp110, Hsc70, l(3)70Ca, l(3)00082

(Ratheesh et al., 2012, Nikolaidis and Nei, 2004, Easton et al., 2000)

BETA-ALANYL-DOPAMINE/HISTAMINE HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

tan

(FlyBase, 2017-, True et al., 2005)

BETA-ASPARTYL PEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG7860

(FlyBase, 2017-)

BETA-GALACTOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ect3

Ectoderm-expressed 3

anon-87Ag

(Lombard et al., 2013)

Gal

β galactosidase

β-gal

(Lombard et al., 2013, Fuerst et al., 1987)

BETA-GLUCOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG9701

(FlyBase, 2017-, Lombard et al., 2013)

CG33090

BG:DS01068.2

(FlyBase, 2017-)

BETA-GLUCURONIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

βGlu

β glucuronidase

Glu

(FlyBase, 2017-, Lombard et al., 2013)

CG15117

(FlyBase, 2017-, Lombard et al., 2013)

BETA-MANNOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

β-Man

β-Mannosidase

(FlyBase, 2017-, Rosenbaum et al., 2014, Lombard et al., 2013)

BETA-N-ACETYLHEXOSAMINIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG7985

(Lombard et al., 2013)

fdl

fused lobes

β-N-acetyl-D-glucosaminidase, l(2)k17040, β-N-acetylglucosaminidase, GlcNAc'ase

(Lombard et al., 2013, Cattaneo et al., 2006, Leonard et al., 2006)

Hexo1

Hexosaminidase 1

β-N-acetyl-D-hexosaminidase, GlcNAc'ase

(Lombard et al., 2013, Cattaneo et al., 2006, Leonard et al., 2006)

Hexo2

Hexosaminidase 2

β-N-acetyl-D-hexosaminidase, GlcNAc'ase, β-N-acetyl-D-glucosaminidase

(Lombard et al., 2013, Cattaneo et al., 2006, Leonard et al., 2006)

BETA TUBULINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

βTub56D

β-Tubulin at 56D

β-tubulin, β1-tubulin, β1, β1 tubulin, tubulin

(Findeisen et al., 2014, Nielsen et al., 2010, Kollmar and Odronitz, 2006, Goldstein and Gunawardena, 2000)

βTub60D

β-Tubulin at 60D

β3-tubulin, β-tubulin, β3 tubulin, β3, Pin

(Findeisen et al., 2014, Nielsen et al., 2010, Kollmar and Odronitz, 2006, Goldstein and Gunawardena, 2000)

βTub65B

β-Tubulin at 65B

CT42364, Tub2B

(Findeisen et al., 2014, Kollmar and Odronitz, 2006, Goldstein and Gunawardena, 2000)

βTub85D

β-Tubulin at 85D

β-tubulin, β2-tubulin, β2 tubulin, B2t, β2

(Findeisen et al., 2014, Nielsen et al., 2010, Kollmar and Odronitz, 2006, Goldstein and Gunawardena, 2000)

βTub97EF

β-Tubulin at 97EF

β-tubulin, tubulin, β tubulin, βtubulin, βTub98C

(Findeisen et al., 2014, Nielsen et al., 2010, Kollmar and Odronitz, 2006, Goldstein and Gunawardena, 2000)

C1B CYSTEINE PEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG1440

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

C69 CYSTEINE EXOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG10098

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CALPAINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CalpA

Calpain-A

calpain

(Metwally et al., 2019, FlyBase, 2017-, Friedrich et al., 2004, Rawlings and Barrett, 1996-)

CalpB

Calpain-B

(Metwally et al., 2019, FlyBase, 2017-, Friedrich et al., 2004, Rawlings and Barrett, 1996-)

sol

small optic lobes

(Metwally et al., 2019, FlyBase, 2017-, Friedrich et al., 2004, Rawlings and Barrett, 1996-)

CARBOHYDRATE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5171

(FlyBase, 2017-)

Fbp

Fructose bisphosphatase

fructose-1,6-bisphosphatase

(FlyBase, 2017-)

G6P

Glucose-6-Phosphatase

G6pase

(FlyBase, 2017-)

Pfrx

6-phosphofructo-2-kinase

Pfk2

(FlyBase, 2017-)

Tps1

Trehalose-6-phosphate synthase 1

l(2)k08903, jf5, BcDNA:GH08860, trehalose synthase, trehalose-6-phosphate synthase

(FlyBase, 2017-)

CARBON-NITROGEN HYDROLASES OF CYCLIC AMIDES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Collapsin Response Mediator Protein

(FlyBase, 2017-)

rudimentary

Su(b), CAD, fs(1)M34

(FlyBase, 2017-)

CARBON-NITROGEN HYDROLASES OF LINEAR AMIDINES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

arg

arginase

EG:171D11.4, EG:65F1.3

(FlyBase, 2017-)

CG1764

(FlyBase, 2017-)

CARBON-SULFUR HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ahcy

Adenosylhomocysteinase

Ahcy13

(FlyBase, 2017-)

CARBOXYLESTERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

α-Est1

α-Esterase-1

αE1, A, Est1, DmαE1, fragment A

(FlyBase, 2017-, Birner-Gruenberger et al., 2012, Campbell et al., 2003)

α-Est2

α-Esterase-2

αE2, DmαE2

(FlyBase, 2017-, Birner-Gruenberger et al., 2012, Campbell et al., 2003)

α-Est3

α-Esterase-3

αE3, DmαE3, α-Ests

(FlyBase, 2017-, Birner-Gruenberger et al., 2012, Campbell et al., 2003)

α-Est4

α-Esterase-4

αE4, DmαE4

(FlyBase, 2017-, Birner-Gruenberger et al., 2012, Campbell et al., 2003)

α-Est5

α-Esterase-5

αE5, DmαE5, Est-C

(FlyBase, 2017-, Birner-Gruenberger et al., 2012, Campbell et al., 2003)

α-Est6

α-Esterase-6

αE6, Esterase-6, DmαE6

(FlyBase, 2017-, Birner-Gruenberger et al., 2012, Campbell et al., 2003)

α-Est7

α-Esterase-7

αE7, Est23, DmαE7, ali, alpha-Esterase-7

(FlyBase, 2017-, Birner-Gruenberger et al., 2012, Campbell et al., 2003)

α-Est8

α-Esterase-8

αE8, Est8, DmαE8

(FlyBase, 2017-, Birner-Gruenberger et al., 2012, Campbell et al., 2003)

α-Est9

α-Esterase-9

αE9, DmαE9, Dm_3R:18691

(FlyBase, 2017-, Birner-Gruenberger et al., 2012, Campbell et al., 2003)

α-Est10

α-Esterase-10

αE10, Esterase-10, DmαE10, α-Ests

(FlyBase, 2017-, Birner-Gruenberger et al., 2012, Campbell et al., 2003)

CG2059

(FlyBase, 2017-, Birner-Gruenberger et al., 2012)

CG3841

(FlyBase, 2017-)

CG4757

BcDNA:GH05741

(FlyBase, 2017-)

CG5355

(FlyBase, 2017-, Birner-Gruenberger et al., 2012)

CG6414

(FlyBase, 2017-)

CG14717

anon-SAGE:Wang-126

(FlyBase, 2017-)

clt

cricklet

(FlyBase, 2017-)

Est-6

Esterase 6

Est6, Est-D, Est

(FlyBase, 2017-, Birner-Gruenberger et al., 2012)

Est17

Esterase 17

Est-17

(FlyBase, 2017-)

Est-P

Esterase P

yEst-6, EstP, ΨEst-6, Est-7

(FlyBase, 2017-)

Est-Q

Esterase Q

(FlyBase, 2017-)

gas

gasoline

(FlyBase, 2017-)

Jhe

Juvenile hormone esterase

JH, JH esterase

(FlyBase, 2017-, Birner-Gruenberger et al., 2012)

Jhedup

Juvenile hormone esterase duplication

(FlyBase, 2017-)

puml

pummelig

CGI-58

(FlyBase, 2017-, Birner-Gruenberger et al., 2012)

CASPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Damm

Death associated molecule related to Mch2 caspase

Daydream, Death associated molecule related to Mch2

(FlyBase, 2017-, Xu et al., 2009, Harvey et al., 2001, Rawlings and Barrett, 1996-)

Dcp-1

Death caspase-1

Dcp1, caspase, caspase-1

(FlyBase, 2017-, Xu et al., 2009, Harvey et al., 2001, Rawlings and Barrett, 1996-)

Decay

Death executioner caspase related to Apopain/Yama

caspase-3, Caspase 3, Casp3, Cas3, CC3

(FlyBase, 2017-, Xu et al., 2009, Harvey et al., 2001, Rawlings and Barrett, 1996-)

Dredd

Death related ced-3/Nedd2-like caspase

Dcp-2/Dredd, Dcp-2, EG:115C2.9, Dcp2

(FlyBase, 2017-, Xu et al., 2009, Harvey et al., 2001, Rawlings and Barrett, 1996-)

Drice

Death related ICE-like caspase

Ice, caspase-3, caspase 3

(FlyBase, 2017-, Xu et al., 2009, Harvey et al., 2001, Rawlings and Barrett, 1996-)

Dronc

Death regulator Nedd2-like caspase

Nc, Nedd2-like caspase, caspase-9

(FlyBase, 2017-, Xu et al., 2009, Harvey et al., 2001, Rawlings and Barrett, 1996-)

Strica

Ser/Thr-rich caspase

dream, Strica/Dream, Dream/Strica

(FlyBase, 2017-, Xu et al., 2009, Harvey et al., 2001, Rawlings and Barrett, 1996-)

CATHEPSINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CtsB

Cathepsin B

CtsB1, Cathepsin B1

(FlyBase, 2017-, Kocks et al., 2003, Rawlings and Barrett, 1996-)

CtsF

Cathepsin F

(FlyBase, 2017-, Kumar et al., 2013, Kocks et al., 2003, Rawlings and Barrett, 1996-)

CtsK1

Cathepsin K1

26-29-p, 26-29kD-proteinase, l(3)s3635, 26/29kD-proteinase, anon-SAGE:Wang-123

(FlyBase, 2017-, Kumar et al., 2013, Kocks et al., 2003, Rawlings and Barrett, 1996-)

CtsK2

Cathepsin K2

(FlyBase, 2017-, Kumar et al., 2013, Kocks et al., 2003, Rawlings and Barrett, 1996-)

CtsL1

Cathepsin L1

Cp1, Cathepsin L, Dcp-1, Dcp1, CTSL

(FlyBase, 2017-, Kumar et al., 2013, Kocks et al., 2003, Rawlings and Barrett, 1996-)

CtsL2

Cathepsin L2

(FlyBase, 2017-, Kumar et al., 2013, Kocks et al., 2003, Rawlings and Barrett, 1996-)

CtsL3

Cathepsin L3

(FlyBase, 2017-, Kumar et al., 2013, Kocks et al., 2003, Rawlings and Barrett, 1996-)

CtsL4

Cathepsin L4

(FlyBase, 2017-, Kumar et al., 2013, Kocks et al., 2003, Rawlings and Barrett, 1996-)

CDC25 FAMILY PROTEIN PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

stg

string

cdc25, cdc25^string, l(3)01235, Cdc25^stg, stg^cdc25

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

twe

twine

Cdc25, twn, mat(2)synHB5, l(2)35Fh, mat(2)syn^HB5

(Hatzihristidis et al., 2015, Morrison et al., 2000)

CHAPERONIN CONTAINING TCP-1 COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CCT1

Chaperonin containing TCP1 subunit 1

T-cp1, Tcp1-like, Tcp1, T-cpl, TCP1α

(Monzo et al., 2010)

CCT2

Chaperonin containing TCP1 subunit 2

(Monzo et al., 2010)

CCT3

Chaperonin containing TCP1 subunit 3

Cctgamma, Cctγ, Y, Cctg, vine

(Monzo et al., 2010)

CCT4

Chaperonin containing TCP1 subunit 4

(Monzo et al., 2010)

CCT5

Chaperonin containing TCP1 subunit 5

l(2)06444, T-complex Chaperonin 5

(Monzo et al., 2010)

CCT6

Chaperonin containing TCP1 subunit 6

Tcp-1zeta, l(1)G0057, Tcp-1ζ, lethal (1) G0022, T-cp1ζ

(Monzo et al., 2010)

CCT7

Chaperonin containing TCP1 subunit 7

Tcp-1eta, Tcp-1η

(Monzo et al., 2010)

CCT8

Chaperonin containing TCP1 subunit 8

(Monzo et al., 2010)

CHITINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cht2

Chitinase 2

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht4

Chitinase 4

DmCHT4

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht5

Chitinase 5

DmCHT5

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht6

Chitinase 6

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht7

Chitinase 7

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht8

Chitinase 8

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht9

Chitinase 9

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht10

Chitinase 10

Cht3, chitinase-3, Cht1, Chitinase 3, DmCHT10

(Behr and Riedel, 2020, Pesch et al., 2016, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht11

Chitinase 11

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Cht12

Chitinase 12

(Behr and Riedel, 2020, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

CHITIN DEACETYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cda5

Chitin deacetylase-like 5

(Naba et al., 2019.7.9, Dixit et al., 2008)

Cda9

Chitin deacetylase-like 9

(Naba et al., 2019.7.9, Dixit et al., 2008)

ChLD3

Chitin and LDLR binding deacetylase 3

(Naba et al., 2019.7.9, Dixit et al., 2008)

serp

serpentine

l(3)76BDk

(Naba et al., 2019.7.9, Dixit et al., 2008)

CLASS II APURINIC OR APYRIMIDINIC ENDONUCLEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG6171

(FlyBase, 2017-, Kanno et al., 2007)

RpLP0

Ribosomal protein LP0

RpP0, AP3, PO, LP0, Ape

(FlyBase, 2017-)

Rrp1

Recombination repair protein 1

APEX1

(FlyBase, 2017-, Nugent et al., 1993)

COA HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

3-hydroxyisobutyryl-CoA hydrolase

(FlyBase, 2017-)

iPLA2-VIA

calcium-independent phospholipase A2 VIA

PLA2G6

(FlyBase, 2017-)

CROSSOVER JUNCTION DNA ENDONUCLEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Gen

XPG-like endonuclease

mus324, DmGEN, BcDNA:GM10765

(Bellendir et al., 2017, FlyBase, 2017-)

mus81

EG:BACR7A4.16

(FlyBase, 2017-)

slx1

nuclease slx1

(FlyBase, 2017-)

CTD FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG8584

(Burroughs et al., 2006)

CG12078

(Burroughs et al., 2006)

Dullard

l(1)G0269, ddd

(Burroughs et al., 2006)

Fcp1

TFIIF-interacting CTD phosphatase

(Burroughs et al., 2006)

hzg

herzog

(Burroughs et al., 2006)

ttm2

tiny tim 2

(Burroughs et al., 2006)

ttm3

tiny tim 3

(Pan and Zhang, 2009)

ttm50

tiny tim 50

EG:95B7.3, Gp99

(Burroughs et al., 2006)

Ublcp1

Ubiquitin-like domain-containing C-terminal domain phosphatase 1

BcDNA:LD21504

(Burroughs et al., 2006)

CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

dnc

dunce

PDE4, EG:96G10.7, fs(1)M42, EG:140G11.4

(FlyBase, 2017-, Day, 2005)

Pde1c

Phosphodiesterase 1c

(FlyBase, 2017-, Day, 2005)

Pde6

Phosphodiesterase 6

PDE5/6

(FlyBase, 2017-, Day, 2005)

Pde8

Phosphodiesterase 8

(FlyBase, 2017-, Day, 2005)

Pde9

Phosphodiesterase 9

(FlyBase, 2017-, Day, 2005)

Pde11

Phosphodiesterase 11

(FlyBase, 2017-, Day, 2005)

prune

EG:152A3.5

(FlyBase, 2017-)

CYSTEINE-TYPE DENEDDYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Den1

Deneddylase 1

(FlyBase, 2017-, Chan et al., 2008, Rawlings and Barrett, 1996-)

CYSTEINE-TYPE OTU DEUBIQUITINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG4968

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

CG7857

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Duba

Deubiquitinating enzyme A

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

trbd

trabid

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Yod1

Yod1 deubiquitinase

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

CYTIDINE DEAMINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG8349

(FlyBase, 2017-)

CG8353

(FlyBase, 2017-)

CG8360

(FlyBase, 2017-)

CYTOSOLIC PROTEIN TYROSINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG14297

(Hatzihristidis et al., 2015, Morrison et al., 2000)

csw

corkscrew

E(sev)1A, EG:BACN25G24.2, l(1)csw, l(1)2Db, l(1)G0170

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000, Walchli et al., 2000)

primo-1

(Lee et al., 2020, Morrison et al., 2000)

primo-2

(Morrison et al., 2000)

Ptp61F

Protein tyrosine phosphatase 61F

DPTP61F, protein tyrosine phosphatase

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000, Walchli et al., 2000)

PTP-ER

Protein tyrosine phosphatase-ERK/Enhancer of Ras1

ER2-5

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000)

Ptpmeg

Protein tyrosine phosphatase Meg

Meg

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000, Walchli et al., 2000)

Ptpmeg2

Protein tyrosine phosphatase Meg2

l(1)G0232

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000, Walchli et al., 2000)

DEOXYRIBONUCLEASES I

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Dcr-1

Dicer-1

Dicer, Dcr1

(FlyBase, 2017-)

Dcr-2

Dicer-2

Dcr2, Dicer, dmDcr-2, dcr

(FlyBase, 2017-)

DEOXYRIBONUCLEASES II

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

DNaseII

Deoxyribonuclease II

DNase1, dDNase II

(FlyBase, 2017-, Seong et al., 2006)

DESUMOYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG32110

(FlyBase, 2017-, Berdnik et al., 2012, Rawlings and Barrett, 1996-)

pira

pirate

(FlyBase, 2017-, Berdnik et al., 2012, Rawlings and Barrett, 1996-)

Ulp1

DmUlp1

(FlyBase, 2017-, Berdnik et al., 2012, Rawlings and Barrett, 1996-)

velo

veloren

verloren

(FlyBase, 2017-, Berdnik et al., 2012, Rawlings and Barrett, 1996-)

DEUFMYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ufsp1

UFM1 specific peptidase 1

(FlyBase, 2017-, Kang et al., 2007, Rawlings and Barrett, 1996-)

Ufsp2

UFM1 specific peptidase 2

(FlyBase, 2017-, Kang et al., 2007, Rawlings and Barrett, 1996-)

DINUCLEOTIDE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG8128

(FlyBase, 2017-)

DIPEPTIDYL PEPTIDASES IV

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG3744

(FlyBase, 2017-, Chihara et al., 2005, Rawlings and Barrett, 1996-)

CG11034

(FlyBase, 2017-, Chihara et al., 2005, Rawlings and Barrett, 1996-)

CG17684

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

Dpp10

Dipeptidyl peptidase 10

(FlyBase, 2017-, Chihara et al., 2005, Rawlings and Barrett, 1996-)

ome

omega

(FlyBase, 2017-, Chihara et al., 2005, Rawlings and Barrett, 1996-)

DISLOCASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG4701

BG:DS06874.3

(FlyBase, 2017-)

CG6230

BcDNA:GH06032

(FlyBase, 2017-)

nmd

no mitochondrial derivative

l(2)08774, Msp1

(FlyBase, 2017-)

DNA N-GLYCOSYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Nthl1

Nth-like DNA glycosylase 1

(FlyBase, 2017-)

Ogg1

8-oxoguanine DNA glycosylase

(FlyBase, 2017-)

RpS3

Ribosomal protein S3

M(3)95A, M(3)w, S3, M(3R)w, Minute

(FlyBase, 2017-)

Smug

Single-strand-selective monofunctional uracil-DNA glycosylase

SMUG1

(FlyBase, 2017-)

Tdg

Thymine DNA glycosylase

Thd1, MUG, G/T-mismatch-specific-thymine-DNA-glycosylase

(FlyBase, 2017-)

DUAL SPECIFICITY PROTEIN PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cdc14

Cell division cycle 14

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

CG3632

(Hatzihristidis et al., 2015, Morrison et al., 2000)

CG7378

MKP-like

(Hatzihristidis et al., 2015, Morrison et al., 2000)

CG10089

(Hatzihristidis et al., 2015, Morrison et al., 2000)

CG13197

(Hatzihristidis et al., 2015, Morrison et al., 2000)

CG15528

(Hatzihristidis et al., 2015, Morrison et al., 2000)

EDTP

Egg-derived tyrosine phosphatase

(Hatzihristidis et al., 2015)

Mkp

MAP kinase-specific phosphatase

DMKP

(Hatzihristidis et al., 2015)

Mkp3

Mitogen-activated protein kinase phosphatase 3

DMKP-3, MAP Kinase Phosphatase 3

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

MKP-4

MAPK Phosphatase 4

MAPK

(Hatzihristidis et al., 2015, Morrison et al., 2000)

mtm

myotubularin

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

Mtmr6

Myotubularin related protein 6

BcDNA:GH04637

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

PRL-1

PRL-1 phosphatase

BG:DS07473.3, PRL

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

Pten

Phosphatase and tensin homolog

dPTEN

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

PTPMT1

Protein tyrosine phosphatase, mitochondrial 1

Plip

(Hatzihristidis et al., 2015, Morrison et al., 2000)

puc

puckered

hrt, l(3)84Eh, vco, hearty

(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)

ssh

slingshot

l(3)01207, Mkph, MKP

(Hatzihristidis et al., 2015, Morrison et al., 2000)

DYNAMIN-LIKE GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Drp1

Dynamin related protein 1

dynamin-2, l(2)ND2, l(2)ND3, noodle, Drp-1

(FlyBase, 2017-)

Opa1

Optic atrophy 1

dOpa1, Opa1-like, optic atrophy 1-like, l(2)s3475

(FlyBase, 2017-)

shi

shibire

dynamin, shibere, Dyn

(FlyBase, 2017-)

ENDO-ALPHA MANNOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG14015

(FlyBase, 2017-, Lombard et al., 2013)

ENDOPLASMIC RETICULUM CLASS I ALPHA-MANNOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

α-Man-Ib

α-Mannosidase class I b

(Lombard et al., 2013, Nemčovičová et al., 2013, Mortimer et al., 2012)

EPOXIDE HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG10602

(FlyBase, 2017-)

Jheh1

Juvenile hormone epoxide hydrolase 1

Jheh, JH, EH, epoxide hydrolase

(Borovsky et al., 2022, FlyBase, 2017-, Guio et al., 2014)

Jheh2

Juvenile hormone epoxide hydrolase 2

epoxide hydrolase, EH

(Borovsky et al., 2022, FlyBase, 2017-, Guio et al., 2014)

Jheh3

Juvenile hormone epoxide hydrolase 3

EH, epoxide hydrolase

(Borovsky et al., 2022, FlyBase, 2017-, Guio et al., 2014)

ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Edem1

ER degradation enhancer, mannosidase alpha-like 1

EG:86E4.2

(Jang et al., 2015, Rosenbaum et al., 2014, Lombard et al., 2013)

Edem2

ER degradation enhancer, mannosidase alpha-like 2

(Jang et al., 2015, Rosenbaum et al., 2014, Lombard et al., 2013)

EYA FAMILY PROTEIN TYROSINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

eya

eyes absent

cli, clift, ey-2

(Hatzihristidis et al., 2015, Burroughs et al., 2006)

FATTY ACID AMIDE HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Dna2

DNA replication helicase/nuclease 2

mus-109, mus109, mus(1)109

(FlyBase, 2017-)

Fen1

Flap endonuclease 1

EG:EG0003.3

(FlyBase, 2017-, Barclay et al., 2014)

Gen

XPG-like endonuclease

mus324, DmGEN, BcDNA:GM10765

(Bellendir et al., 2017, FlyBase, 2017-, Barclay et al., 2014)

mus81

EG:BACR7A4.16

(Bellendir et al., 2017, FlyBase, 2017-, Barclay et al., 2014)

mus201

mutagen-sensitive 201

mus(2)201, mus-201, ESTS:55A11T, XPG, DmXPG

(FlyBase, 2017-)

slx1

nuclease slx1

(FlyBase, 2017-)

tos

tosca

(FlyBase, 2017-)

GAMMA-GLUTAMYL HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

l(3)72Dp

lethal (3) 72Dp

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

l(3)72Dr

lethal (3) 72Dr

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

GAMMA-GLUTAMYL TRANSPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG1492

(FlyBase, 2017-, Walker et al., 2006, Rawlings and Barrett, 1996-)

CG4829

(FlyBase, 2017-, Walker et al., 2006, Rawlings and Barrett, 1996-)

CG17636

EG:23E12.1

(FlyBase, 2017-, Walker et al., 2006, Rawlings and Barrett, 1996-)

Ggt-1

γ-glutamyl transpeptidase

(FlyBase, 2017-, Walker et al., 2006, Rawlings and Barrett, 1996-)

GLUCONOLACTONASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

regucalcin

(FlyBase, 2017-, Arboleda-Bustos and Segarra, 2011)

smp-30

Senescence marker protein-30

Dca, cold acclimation, Drosophila cold acclimation gene

(FlyBase, 2017-, Arboleda-Bustos and Segarra, 2011)

GLUCOSYLCERAMIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG33090

BG:DS01068.2

(FlyBase, 2017-)

Gba1a

Glucocerebrosidase 1a

dGBA1a

(Maor et al., 2016, Lombard et al., 2013, Maor et al., 2013)

Gba1b

Glucocerebrosidase 1b

dGBA1b

(Maor et al., 2016, Lombard et al., 2013, Maor et al., 2013)

GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

GOLGI CLASS I ALPHA-MANNOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

α-Man-Ia

α-Mannosidase class I a

alpha-Man-I, mas-1, α-Man-I, mas1, alpha-mannosidase

(Lombard et al., 2013, Nemčovičová et al., 2013, Mortimer et al., 2012)

α-Man-Ic

α-Mannosidase class I c

(Lombard et al., 2013, Nemčovičová et al., 2013, Mortimer et al., 2012)

GOLGI CLASS II ALPHA-MANNOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

α-Man-IIa

α-Mannosidase class II a

dGMII, α-Man-II, GMII, alpha-Man-II, Golgi α-mannosidase II

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

α-Man-IIb

α-Mannosidase class II b

α-mannosidase-IIb, ManII, alpha-mannosidase, ManIIb, Man'ase

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

GPI-ANCHOR TRANSAMIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

PIG-K

Phosphatidylinositol glycan anchor biosynthesis class K

EG:133E12.3

(Kawaguchi et al., 2019, FlyBase, 2017-, Rawlings and Barrett, 1996-)

HAD FAMILY NON-PROTEIN PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

aay

astray

(Burroughs et al., 2006)

CG2680

EG:100G10.4

(Cao et al., 2009, Burroughs et al., 2006)

CG5171

(FlyBase, 2017-)

CG5567

(Cao et al., 2009, Burroughs et al., 2006)

CG5577

(Burroughs et al., 2006)

CG10352

(Cao et al., 2009)

CG11291

(Cao et al., 2009)

CG12237

(Burroughs et al., 2006)

CG14212

(Burroughs et al., 2006)

CG15739

(Burroughs et al., 2006)

CG15771

(Burroughs et al., 2006)

CG17294

(Cao et al., 2009, Burroughs et al., 2006)

CG32487

(Cao et al., 2009, Burroughs et al., 2006)

CG32488

(Cao et al., 2009, Burroughs et al., 2006)

cN-IIIB

cytosolic 5'-nucleotidase IIIB

cytosolic nucleotidase III-like, cNIII-like

(Burroughs et al., 2006)

Enoph

Enolase-phosphatase

(Burroughs et al., 2006)

Nt5a

5' nucleotidase A

(Burroughs et al., 2006)

Nt5b

5' nucleotidase B

(Burroughs et al., 2006)

Nt5c

5' nucleotidase C

(Burroughs et al., 2006)

PNKP

Polynucleotide kinase 3'-phosphatase

(Burroughs et al., 2006)

Tps1

Trehalose-6-phosphate synthase 1

l(2)k08903, jf5, BcDNA:GH08860, trehalose synthase, trehalose-6-phosphate synthase

(Burroughs et al., 2006)

HEAT SHOCK PROTEIN 60 CHAPERONINS - GROUP I

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Hsp60A

Heat shock protein 60A

Hsp60, l(1)BP5, heat shock protein 60, Hsp 60, 12

(Morrow et al., 2016, Arya et al., 2007, Sarkar and Lakhotia, 2005)

Hsp60B

Heat shock protein 60B

ms(2)21D, Hsp64, Heat shock protein 60 related

(Morrow et al., 2016, Arya et al., 2007, Sarkar and Lakhotia, 2005)

Hsp60C

Heat shock protein 60C

Hsp64

(Morrow et al., 2016, Arya et al., 2007, Sarkar and Lakhotia, 2005)

Hsp60D

Heat shock protein 60D

(Morrow et al., 2016, Arya et al., 2007, Sarkar and Lakhotia, 2005)

HEAT SHOCK PROTEIN 70 CHAPERONES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG7182

(FlyBase, 2017-)

Hsc70-1

Heat shock protein 70 cognate 1

Hsc70, Heat shock protein cognate 1, Hsc1

(Kaneko, 2022, Ratheesh et al., 2012)

Hsc70-2

Heat shock protein 70 cognate 2

Hsc70, Heat shock protein cognate 2, hsc2, Hsc70.2

(Kaneko, 2022, Ratheesh et al., 2012, Nikolaidis and Nei, 2004)

Hsc70-3

Heat shock protein 70 cognate 3

BiP, Hsc3, Hsc70, Grp78, Hsc-70-3

(Kaneko, 2022, Ratheesh et al., 2012, Nikolaidis and Nei, 2004)

Hsc70-4

Heat shock protein 70 cognate 4

Hsc4, Hsc70, Heat shock protein cognate 4, BAP74, scattered

(Kaneko, 2022, Ratheesh et al., 2012, Nikolaidis and Nei, 2004)

Hsc70-5

Heat shock protein 70 cognate 5

Hsc5, Hsc70, Heat shock protein cognate 5, l(2)k04907, Heat shock 70 kDa protein cognate 5

(Kaneko, 2022, Ratheesh et al., 2012, Nikolaidis and Nei, 2004)

Hsp68

Heat shock protein 68

(Kaneko, 2022, Ratheesh et al., 2012)

Hsp70Aa

Heat shock protein 70 Aa

hsp70, Hsp70A, hsp-70, hsp70 87A, heat-shock protein 70

(Kaneko, 2022, Nikolaidis and Nei, 2004)

Hsp70Ab

Heat shock protein 70 Ab

hsp70, Hsp70A, hsp-70, heat-shock protein 70

(Kaneko, 2022, Ratheesh et al., 2012, Nikolaidis and Nei, 2004)

Hsp70Ba

Heat shock protein 70 Ba

hsp70, Hsp70B, hsp-70, hsp70 87C, heat-shock protein 70

(Kaneko, 2022, Ratheesh et al., 2012, Takahashi et al., 2010, Nikolaidis and Nei, 2004)

Hsp70Bb

Heat shock protein 70 Bb

hsp70, Hsp70B, hsp-70, heat-shock protein 70, Hsp70Bc

(Kaneko, 2022, Ratheesh et al., 2012, Takahashi et al., 2010, Nikolaidis and Nei, 2004)

Hsp70Bbb

Heat shock protein 70 Bbb

Hsp70, heat-shock protein 70, hsp70B

(Kaneko, 2022, Ratheesh et al., 2012, Takahashi et al., 2010)

Hsp70Bc

Heat shock protein 70 Bc

hsp70, Hsp70B, heat-shock protein 70, hsp-70

(Kaneko, 2022, Takahashi et al., 2010, Nikolaidis and Nei, 2004)

HEAT SHOCK PROTEIN 90 CHAPERONES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Gp93

Glycoprotein 93

Hsp90, dGRP94

(Pantzartzi et al., 2013, Chen et al., 2006)

Hsp83

Heat shock protein 83

Hsp90, hsp82, l(3)j5C2, E(sev)3A, E(sina)2

(Pantzartzi et al., 2013, Chen et al., 2006)

Trap1

(Pantzartzi et al., 2013, Chen et al., 2006)

HEAT SHOCK PROTEIN 100 CHAPERONES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

ClpX

Caseinolytic protease chaperone subunit

(Raut et al., 2017)

HETEROTRIMERIC G-PROTEIN ALPHA SUBUNITS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG17760

(Im et al., 2015, Krishnan et al., 2015, Colicelli, 2004)

CG30054

(Im et al., 2015, Krishnan et al., 2015, Colicelli, 2004)

cta

concertina

Gα, conc, Gα_12/13

(Im et al., 2015, Krishnan et al., 2015, Boto et al., 2010, Katanayeva et al., 2010, Colicelli, 2004)

Gαf

G protein alpha subunit f

Gα73B, Galpha73B, Gfα, Gf

(Im et al., 2015, Krishnan et al., 2015, Boto et al., 2010, Katanayeva et al., 2010, Colicelli, 2004)

Gαi

G protein alpha subunit i

G-iα65A, Gα_i, G-ialpha65A, Giα, Gai

(Krishnan et al., 2015, Boto et al., 2010, Katanayeva et al., 2010, Colicelli, 2004)

Gαo

G protein alpha subunit o

G-oα47A, G-oalpha47A, Go, Goα, Gα_o

(Im et al., 2015, Krishnan et al., 2015, Boto et al., 2010, Katanayeva et al., 2010, Colicelli, 2004)

Gαq

G protein alpha subunit q

dgq, Gqα, Gq, Gα49B, Galpha49B

(Im et al., 2015, Krishnan et al., 2015, Boto et al., 2010, Katanayeva et al., 2010, Colicelli, 2004)

Gαs

G protein alpha subunit s

Gα_s, Gs, dgs, Gsα, G-sα60A

(Im et al., 2015, Krishnan et al., 2015, Boto et al., 2010, Katanayeva et al., 2010, Colicelli, 2004)

JAMM DEUBIQUITINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2224

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

CG4751

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012)

eIF3f1

eukaryotic translation initiation factor 3 subunit f1

eIF3-S5

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

eIF3f2

eukaryotic translation initiation factor 3 subunit f2

eIF3f

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Zhang et al., 2012, Rawlings and Barrett, 1996-)

eIF3h

eukaryotic translation initiation factor 3 subunit h

eIF-3p40, l(2)k09003, Eukaryotic initiation factor 3 p40 subunit

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Rpn11

Regulatory particle non-ATPase 11

p37B, S13, 37B, DmS13

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

JOSEPHIN DEUBIQUITINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Josd

Josephin domain containing

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

L,D-CARBOXYPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

PGRP-SA

Peptidoglycan recognition protein SA

seml, semmelweis

(FlyBase, 2017-)

LEUCYL AMINOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Dip-B

Dipeptidase B

DipB

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

grsm

granny smith

BcDNA:LD41548

(Laurinyecz et al., 2019, FlyBase, 2017-, Dorus et al., 2011, Rawlings and Barrett, 1996-)

LIPID PHOSPHATE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG11425

(Garcia-Murillas et al., 2006, Renault et al., 2002, Morrison et al., 2000)

CG11426

LPP

(Garcia-Murillas et al., 2006, Renault et al., 2002, Morrison et al., 2000)

CG11437

(Garcia-Murillas et al., 2006, Renault et al., 2002, Morrison et al., 2000)

CG11438

(Garcia-Murillas et al., 2006, Renault et al., 2002, Morrison et al., 2000)

CG12746

(Renault et al., 2002, Morrison et al., 2000)

CG31717

(FlyBase, 2017-)

laza

lazaro

(Garcia-Murillas et al., 2006, Renault et al., 2002, Morrison et al., 2000)

Lpin

Lipin

dLipin, DmLpin, DmLipin, EP2431

(Valente et al., 2010)

wun

wunen

l(2)k16806

(Garcia-Murillas et al., 2006, Renault et al., 2002, Morrison et al., 2000)

wun2

wunen-2

wun-2, N14, Tunen, Pap2G

(Garcia-Murillas et al., 2006, Renault et al., 2002, Morrison et al., 2000)

LYSOPHOSPHOLIPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Apt1

Acyl-protein thioesterase 1

(FlyBase, 2017-)

CG5412

(FlyBase, 2017-)

CG7365

(FlyBase, 2017-)

CG11029

(FlyBase, 2017-, Horne et al., 2009)

CG15111

(FlyBase, 2017-)

sws

swiss cheese

olfE

(FlyBase, 2017-)

LYSOSOMAL CLASS II ALPHA-MANNOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

LManI

Lysosomal α-mannosidase I

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

LManII

Lysosomal α-mannosidase II

LM408, BcDNA:GH02419, lysosomal α-mannosidase, dLM

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

LManIII

Lysosomal α-mannosidase III

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

LManIV

Lysosomal α-mannosidase IV

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

LManV

Lysosomal α-mannosidase V

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

LManVI

Lysosomal α-mannosidase VI

(Rosenbaum et al., 2014, Lombard et al., 2013, Nemčovičová et al., 2013)

LYSOZYMES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG6421

EG:EG0003.8

(Lombard et al., 2013)

CG6426

n(2)k04810

(Lombard et al., 2013)

CG6429

(Lombard et al., 2013)

CG6435

(FlyBase, 2017-)

CG7798

(Lombard et al., 2013, Li et al., 2005)

CG8492

(Lombard et al., 2013)

CG11159

(Lombard et al., 2013, Li et al., 2005)

CG14823

(FlyBase, 2017-)

CG16756

(Lombard et al., 2013, Li et al., 2005)

CG16799

(Lombard et al., 2013, Li et al., 2005)

CG30062

(Lombard et al., 2013)

LysB

Lysozyme B

(Lombard et al., 2013, Li et al., 2005, Regel et al., 1998, Hultmark, 1996, Daffre et al., 1994)

LysD

Lysozyme D

(Lombard et al., 2013, Li et al., 2005, Regel et al., 1998, Hultmark, 1996, Daffre et al., 1994)

LysE

Lysozyme E

(Lombard et al., 2013, Li et al., 2005, Regel et al., 1998, Hultmark, 1996, Daffre et al., 1994)

LysP

Lysozyme P

(Lombard et al., 2013, Li et al., 2005, Regel et al., 1998, Hultmark, 1996, Daffre et al., 1994)

LysS

Lysozyme S

(Lombard et al., 2013, Li et al., 2005, Regel et al., 1998, Hultmark, 1996, Daffre et al., 1994)

LysX

Lysozyme X

(Lombard et al., 2013, Li et al., 2005, Regel et al., 1998, Hultmark, 1996, Daffre et al., 1994)

M1 METALLOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG3502

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG5849

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG7653

BG:DS00365.1

(Li et al., 2022, FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG8773

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG8774

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG10602

(FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG11951

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG31198

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG31233

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG31343

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG31445

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG32473

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG42335

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

CG46339

sda, slamdance

(Li et al., 2022, FlyBase, 2017-, Rawlings and Barrett, 1996-)

Psa

Puromycin sensitive aminopeptidase

dPsa, l(3)06226

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

SP1029

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

superdeath

Suppressor of ER stress-induced death

(Li et al., 2022, FlyBase, 2017-, Schulz et al., 2001, Rawlings and Barrett, 1996-)

M3 METALLOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG7791

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M8 METALLOENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Invadolysin

IX-14, l(3)IX-14

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M14 METALLOCARBOXYPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2915

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG3097

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG3108

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG4017

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG4408

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG4678

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG7025

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG8539

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG8560

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG8562

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG8563

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG8564

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG12374

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG14820

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG17633

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG18417

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG18585

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG31019

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG32379

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

Nna1

Nna1 carboxypeptidase

NnaD

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

svr

silver

EG:171D11.3, CPD, slv

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M16 METALLOENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG3107

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG8728

(FlyBase, 2017-)

CG10588

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

Ide

Insulin degrading metalloproteinase

dIDE

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

Nrd1

Nardilysin

dNRD1

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

UQCR-C1

Ubiquinol-cytochrome c reductase core protein 1

(Rawlings and Barrett, 1996-)

M19 METALLODIPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG6154

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG42750

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG44837

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M20 METALLOEXOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cndp2

Cytosolic non-specific dipeptidase 2

Dip-A, anon-41Fb

(Andreyeva et al., 2019, FlyBase, 2017-, Rawlings and Barrett, 1996-)

M24B METALLOEXOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

ApepP

Aminopeptidase P

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG9581

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

Dip-C

Dipeptidase C

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M28 METALLOEXOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG9416

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG10051

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG10062

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG10073

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG10081

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG11961

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG13160

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG30043

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG30047

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG30049

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG33012

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M49 METALLODIPEPTIDYL-PEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

DppIII

Dipeptidyl aminopeptidase III

Dipeptidyl-peptidase III

(FlyBase, 2017-, Mazzocco et al., 2003, Rawlings and Barrett, 1996-)

M76 METALLOENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5131

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M79 METALLOENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Sras

severas

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

M100 METALLOENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

maternal haploid

fs(1)1182, fs(1)A1182

(FlyBase, 2017-, Tang et al., 2017, Delabaere et al., 2014)

MATRIX METALLOPROTEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Mmp1

Matrix metalloproteinase 1

MMP-1, dMMP1, matrix metalloprotease 1, l(2)k04809, Dm1-MMP

(FlyBase, 2017-, LaFever et al., 2017, Small and Crawford, 2016, Meyer et al., 2011, Rawlings and Barrett, 1996-)

Mmp2

Matrix metalloproteinase 2

l(2)02353, Dm2-MMP, dmmp2

(FlyBase, 2017-, LaFever et al., 2017, Small and Crawford, 2016, Meyer et al., 2011, Rawlings and Barrett, 1996-)

METALLO-TYPE DENEDDYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CSN5

COP9 signalosome subunit 5

DCH5, l(3)L4032, Jab1, l(3)89Cf, COP9 complex homolog subunit 5

(FlyBase, 2017-, Wei et al., 2008, Doronkin et al., 2003, Cope et al., 2002, Rawlings and Barrett, 1996-)

METHIONYL AMINOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5188

(FlyBase, 2017-, Giglione et al., 2000, Rawlings and Barrett, 1996-)

CG13630

(FlyBase, 2017-, Giglione et al., 2000, Rawlings and Barrett, 1996-)

und

uninitiated

p67

(FlyBase, 2017-, Giglione et al., 2000, Rawlings and Barrett, 1996-)

MINDY DEUBIQUITINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG7332

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG14142

(FlyBase, 2017-)

MITOFUSINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

fzo

fuzzy onions

(Noguchi et al., 2011, Deng et al., 2008, Hwa et al., 2002)

Marf

Mitochondrial assembly regulatory factor

dMfn, Mfn, mitofusin, Mfn2

(Sandoval et al., 2014, Deng et al., 2008, Hwa et al., 2002)

MUTL ATPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Mlh1

dmlh1

(FlyBase, 2017-, Marti et al., 2002, Sekelsky et al., 2000)

Pms2

dmlh2

(FlyBase, 2017-, Marti et al., 2002, Sekelsky et al., 2000)

MUTS ATPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Msh6

(FlyBase, 2017-, Marti et al., 2002, Sekelsky et al., 2000)

spel1

spellchecker1

Msh2, spel, BG:DS01068.9

(FlyBase, 2017-, Marti et al., 2002, Sekelsky et al., 2000)

N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG17065

(Lombard et al., 2013)

N-ACETYLGLUCOSAMINE-6-SULFATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG18278

(FlyBase, 2017-)

CG30059

(FlyBase, 2017-)

Sulf1

Sulfated

Neu5

(FlyBase, 2017-)

N-ACETYLGLUCOSAMINYLPHOSPHATIDYLINOSITOL DEACETYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

PIG-L

Phosphatidylinositol glycan anchor biosynthesis class L

(FlyBase, 2017-)

N-ACETYLMURAMOYL-L-ALANINE AMIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

PGRP-LB

Peptidoglycan recognition protein LB

(FlyBase, 2017-, Zaidman-Rémy et al., 2011, Mellroth et al., 2003)

PGRP-SB1

Peptidoglycan recognition protein SB1

PGRP-SB, PGRP SB1

(FlyBase, 2017-, Zaidman-Rémy et al., 2011, Mellroth et al., 2003)

PGRP-SB2

Peptidoglycan recognition protein SB2

PGRP-SB

(FlyBase, 2017-, Zaidman-Rémy et al., 2011, Mellroth et al., 2003)

PGRP-SC1a

Peptidoglycan recognition protein SC1a

PGRP-SC1, PGRP-SC, picky

(FlyBase, 2017-, Zaidman-Rémy et al., 2011, Mellroth et al., 2003)

PGRP-SC1b

Peptidoglycan recognition protein SC1b

PGRP-SC1, PGRP-SC, SC1B

(FlyBase, 2017-, Zaidman-Rémy et al., 2011, Mellroth et al., 2003)

PGRP-SC2

Peptidoglycan recognition protein SC2

PGRP-SC, Peptidoglycan-recognition protein-SC2 precursor

(FlyBase, 2017-, Zaidman-Rémy et al., 2011, Mellroth et al., 2003)

NAD+ NUCLEOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Sarm

Sterile alpha and Armadillo motif

Ect4, dsarm, SARM1, Edis, Ectoderm-expressed 4

(FlyBase, 2017-)

NEPRILYSINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Nep1

Neprilysin 1

dNEP1

(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nep2

Neprilysin 2

dNEP2

(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nep3

Neprilysin 3

dNEP3

(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nep4

Neprilysin 4

(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nep5

Neprilysin 5

(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nep6

Neprilysin 6

(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nep7

Neprilysin 7

(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

N-ETHYLMALEIMIDE-SENSITIVE FACTORS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG31495

(FlyBase, 2017-)

comt

comatose

dNSF1, NSF, com, NSF1, dNSF-1

(FlyBase, 2017-, Golby et al., 2001)

Nsf2

N-ethylmaleimide-sensitive factor 2

dNSF2, dNSF-2, lotus, NEM-sensitive fusion protein 2, urd

(FlyBase, 2017-, Golby et al., 2001)

NEUTRAL TRIGLYCERIDE LIPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG1986

(FlyBase, 2017-, Horne et al., 2009)

CG4267

(FlyBase, 2017-, Horne et al., 2009)

CG4582

(FlyBase, 2017-)

CG5162

(FlyBase, 2017-, Horne et al., 2009)

CG5665

(FlyBase, 2017-, Horne et al., 2009)

CG5966

(FlyBase, 2017-, Horne et al., 2009)

CG6271

(FlyBase, 2017-, Horne et al., 2009)

CG6277

(FlyBase, 2017-, Horne et al., 2009)

CG6283

(FlyBase, 2017-, Horne et al., 2009)

CG6295

(FlyBase, 2017-, Horne et al., 2009)

CG6296

(FlyBase, 2017-, Horne et al., 2009)

CG6431

chr2L_10724193_10724543.0

(FlyBase, 2017-, Horne et al., 2009)

CG6472

(FlyBase, 2017-, Horne et al., 2009)

CG6675

(FlyBase, 2017-, Horne et al., 2009)

CG6847

(FlyBase, 2017-, Horne et al., 2009)

CG7367

(FlyBase, 2017-, Horne et al., 2009)

CG10163

(FlyBase, 2017-, Horne et al., 2009)

CG10357

(FlyBase, 2017-, Horne et al., 2009)

CG13282

(FlyBase, 2017-, Horne et al., 2009)

CG13562

(FlyBase, 2017-, Horne et al., 2009)

CG17191

(FlyBase, 2017-, Horne et al., 2009)

CG17192

(FlyBase, 2017-, Horne et al., 2009)

CG17292

(FlyBase, 2017-, Horne et al., 2009)

CG18258

anon-SAGE:Wang-051

(FlyBase, 2017-, Horne et al., 2009)

CG18641

(FlyBase, 2017-, Horne et al., 2009)

CG34447

(FlyBase, 2017-, Horne et al., 2009)

CG34448

(FlyBase, 2017-, Horne et al., 2009)

sxe2

sex-specific enzyme 2

(FlyBase, 2017-, Horne et al., 2009)

NUCLEOSIDE DIPHOSPHATE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5276

(FlyBase, 2017-, Fenckova et al., 2011)

CG10898

(FlyBase, 2017-)

CG12567

(FlyBase, 2017-)

CG42249

(FlyBase, 2017-, Fenckova et al., 2011)

NTPase

(FlyBase, 2017-)

NUCLEOSIDE TRIPHOSPHATE DIPHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG8891

(FlyBase, 2017-)

CG9515

(FlyBase, 2017-)

dUTPase

Deoxyuridine triphosphatase

BcDNA:LD08534, UTPase, anon-SAGE:Wang-077

(FlyBase, 2017-)

NUCLEOTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

cytosolic 5'-nucleotidase IIIB

cytosolic nucleotidase III-like, cNIII-like

(FlyBase, 2017-)

Nt5a

5' nucleotidase A

(Singgih et al., 2021, FlyBase, 2017-)

Nt5b

5' nucleotidase B

(Singgih et al., 2021, FlyBase, 2017-)

Nt5c

5' nucleotidase C

(Singgih et al., 2021, FlyBase, 2017-)

NT5E-2

Ecto-5'-nucleotidase 2

(FlyBase, 2017-)

veil

NT5E-1

(FlyBase, 2017-)

PALMITOYL-(PROTEIN) HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Apt1

Acyl-protein thioesterase 1

(FlyBase, 2017-, Bannan et al., 2008)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Palmitoyl-protein thioesterase 1

(FlyBase, 2017-, Bannan et al., 2008)

Ppt2

Palmitoyl-protein Thioesterase 2

PPT-2

(FlyBase, 2017-, Bannan et al., 2008)

PEPTIDE DEFORMYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG31278

(FlyBase, 2017-)

CG31373

(FlyBase, 2017-)

PHOSPHATIDYLINOSITOL PHOSPHATE AND INOSITOL PHOSPHATE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

5PtaseI

Inositol polyphosphate-5-phosphatase type I

(Allen et al., 2020, Seeds et al., 2004, Morrison et al., 2000)

CG3632

(Allen et al., 2020, Balakrishnan et al., 2015, Morrison et al., 2000)

CG6707

(Allen et al., 2020, Balakrishnan et al., 2015)

CG6805

(Allen et al., 2020, Seeds et al., 2004)

CG9389

(Allen et al., 2020, Morrison et al., 2000)

CG9391

(Allen et al., 2020, Morrison et al., 2000)

CG9784

lincRNA.S9473

(Allen et al., 2020, Balakrishnan et al., 2015, Seeds et al., 2004)

CG17026

(Allen et al., 2020, Morrison et al., 2000)

CG17027

(Allen et al., 2020, Morrison et al., 2000)

CG17028

(Allen et al., 2020, Morrison et al., 2000)

CG17029

(Allen et al., 2020, Morrison et al., 2000)

CG42271

(Allen et al., 2020, Balakrishnan et al., 2015)

EDTP

Egg-derived tyrosine phosphatase

(Allen et al., 2020)

FIG4

FIG4 phosphoinositide 5-phosphatase

dFIG4

(Allen et al., 2020, Balakrishnan et al., 2015)

INPP5E

Inositol polyphosphate 5-phosphatase E

pharbin-like

(Allen et al., 2020, Balakrishnan et al., 2015, Seeds et al., 2004, Morrison et al., 2000)

Ipp

Inositol polyphosphate 1-phosphatase

(Allen et al., 2020, Acharya et al., 1998)

Mipp1

Multiple inositol polyphosphate phosphatase 1

(Allen et al., 2020, Chi et al., 1999)

Mipp2

Multiple inositol polyphosphate phosphatase 2

l(1)G0050, l(1)G0303

(Allen et al., 2020, Chi et al., 1999)

mtm

myotubularin

(Allen et al., 2020, Balakrishnan et al., 2015, Morrison et al., 2000)

Mtmr6

Myotubularin related protein 6

BcDNA:GH04637

(Allen et al., 2020, Balakrishnan et al., 2015, Morrison et al., 2000)

Ocrl

Oculocerebrorenal syndrome of Lowe

dOCRL, EG:86E4.5

(Allen et al., 2020, Balakrishnan et al., 2015)

Pten

Phosphatase and tensin homolog

dPTEN

(Allen et al., 2020, Pagliarini et al., 2004)

PTPMT1

Protein tyrosine phosphatase, mitochondrial 1

Plip

(Allen et al., 2020, Balakrishnan et al., 2015, Pagliarini et al., 2004, Morrison et al., 2000)

Sac1

Sac1 phosphatase

impatent

(Allen et al., 2020, Balakrishnan et al., 2015)

sp3

spermathreecae

(Allen et al., 2020, Balakrishnan et al., 2015)

Synj

Synaptojanin

(Allen et al., 2020, Balakrishnan et al., 2015, Seeds et al., 2004, Morrison et al., 2000)

PHOSPHOLIPASE A2 ENZYMES - CALCIUM INDEPENDENT

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG7365

(FlyBase, 2017-)

CG11029

(FlyBase, 2017-, Horne et al., 2009)

iPLA2-VIA

calcium-independent phospholipase A2 VIA

PLA2G6

(Ben-David et al., 2015, Renault et al., 2002)

PHOSPHOLIPASE A2 ENZYMES - SECRETED

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG3009

(Ben-David et al., 2015, Renault et al., 2002)

CG14507

(Ben-David et al., 2015, Renault et al., 2002)

CG30503

(Ben-David et al., 2015, Renault et al., 2002)

CG42237

C133

(Ben-David et al., 2015, Renault et al., 2002)

GIIIspla2

Phospholipase A2 group III

(Ben-David et al., 2015, Renault et al., 2002)

GXIVsPLA2

(Ben-David et al., 2015, Renault et al., 2002)

sPLA2

secretory Phospholipase A2

(Ben-David et al., 2015, Renault et al., 2002)

PHOSPHOLIPASES A1

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

PAPLA1

Phosphatidic Acid Phospholipase A1

(FlyBase, 2017-, Gáliková et al., 2017, Kunduri et al., 2014)

PHOSPHOLIPASES C

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

norpA

no receptor potential A

PLC, PLCβ, phospholipase C, PLC-β, MRE18

(FlyBase, 2017-, Balakrishnan et al., 2015)

Plc21C

Phospholipase C at 21C

PLC, plc21, plc-21

(FlyBase, 2017-, Balakrishnan et al., 2015)

small wing

PLCγ, PLC, PLC-γ, phospholipase Cγ

(FlyBase, 2017-, Balakrishnan et al., 2015)

PPM FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

alph

alphabet

SK3-1, pp2c99B

(Morrison et al., 2000)

CG7115

BcDNA:LD21794

(Morrison et al., 2000)

CG10376

(Morrison et al., 2000)

CG10417

(Morrison et al., 2000)

CG12091

(Hudson et al., 2007)

CG15035

(Hudson et al., 2007)

CG17598

(Morrison et al., 2000)

CG17746

(Morrison et al., 2000)

fig

fos intronic gene

(Hudson et al., 2007)

Mppe

Metallophosphoesterase

dmppe

(Cao et al., 2011)

Nil

Nilkantha

(Morrison et al., 2000)

Pdp

Pyruvate dehydrogenase phosphatase

(Morrison et al., 2000)

Phlpp

PH domain leucine-rich repeat protein phosphatase

(Morrison et al., 2000)

Pp2C1

Protein phosphatase 2C

PP2C, dpp2c1

(Morrison et al., 2000)

Ppm1

(Morrison et al., 2000)

PPPDE DEUBIQUITINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG7222

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG12231

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CanA1

Calcineurin A1

calcineurin, CaN, PP2B 21EF

(Miskei et al., 2011, Morrison et al., 2000)

CanA-14F

Calcineurin A at 14F

MRE12, Calcineurin

(Miskei et al., 2011, Morrison et al., 2000)

CG11597

PP4-like

(Miskei et al., 2011, Morrison et al., 2000)

flw

flapwing

PP1β9C, PP1, PP1β, PP1 9C, PP1c

(Miskei et al., 2011, Morrison et al., 2000)

mts

microtubule star

PP2A, PP2A-C, PP2Ac, PP2A catalytic subunit, protein phosphatase 2A

(Miskei et al., 2011, Morrison et al., 2000)

Pp1-13C

Protein phosphatase 1 at 13C

PP1α13C, PP1, PP1 13C, PP1c, 13C

(Miskei et al., 2011, Morrison et al., 2000)

Pp1-87B

Protein phosphatase 1 at 87B

Su(var)3-6, PP1α87B, PP1, PP1 87B, Su-var(3)6

(Miskei et al., 2011, Morrison et al., 2000)

Pp1α-96A

Protein phosphatase 1α at 96A

PP1α96A, Pp1-96A, PP1, PP1 96A, PP1c

(Miskei et al., 2011, Morrison et al., 2000)

Pp1-Y1

Protein phosphatase 1, Y-linked 1

(Miskei et al., 2011)

Pp1-Y2

Protein phosphatase 1, Y-linked 2

Pp1Y2

(Miskei et al., 2011)

Pp2B-14D

Protein phosphatase 2B at 14D

CnnA14D, canA, calcineurin, PP2B 14D, CaN

(Miskei et al., 2011, Morrison et al., 2000)

Pp4-19C

Protein phosphatase 19C

PP4, PP4c

(Miskei et al., 2011, Morrison et al., 2000)

PpD3

Protein phosphatase D3

PP5, Pp5-85E

(Miskei et al., 2011, Morrison et al., 2000)

PpD5

Protein phosphatase D5

(Miskei et al., 2011, Morrison et al., 2000)

PpD6

Protein phosphatase D6

PP1-like

(Miskei et al., 2011, Morrison et al., 2000)

PpN58A

Protein phosphatase N at 58A

PPN 58A

(Miskei et al., 2011, Morrison et al., 2000)

PpV

Protein phosphatase V

(Miskei et al., 2011, Morrison et al., 2000)

PpY-55A

Protein phosphatase Y at 55A

PPY, PPY 55A

(Miskei et al., 2011, Morrison et al., 2000)

rdgC

retinal degeneration C

(Miskei et al., 2011, Morrison et al., 2000)

PROPROTEIN CONVERTASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

amon

amontillado

PC2, dPC2, Ppp

(Tao et al., 2019, FlyBase, 2017-, Rawlings and Barrett, 1996-)

Fur1

Furin 1

Dfur1, dKLIP-1, Dfurin1, Furin, l(3)rL205

(Tao et al., 2019, FlyBase, 2017-, Rawlings and Barrett, 1996-)

Fur2

Furin 2

Dfur2, Dfurin2, furin

(Tao et al., 2019, FlyBase, 2017-, Rawlings and Barrett, 1996-)

S1P

Site-1 protease

dS1P

(Tao et al., 2019, FlyBase, 2017-, Rawlings and Barrett, 1996-)

PROTEASOME ENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Prosβ1

Proteasome β1 subunit

l(2)05070, β1, lethal (2) 05070

(FlyBase, 2017-, Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosβ2

Proteasome β2 subunit

DTS7, β2, beta2_dm, l(3)DTS7, Beta-2

(FlyBase, 2017-, Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosβ2R1

Proteasome β2 subunit-related 1

(FlyBase, 2017-, Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosβ2R2

Proteasome β2 subunit-related 2

(FlyBase, 2017-, Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosβ5

Proteasome β5 subunit

β5, dβ5

(FlyBase, 2017-, Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosβ5R1

Proteasome β5 subunit-related 1

Prosβ5R

(FlyBase, 2017-, Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosβ5R2

Proteasome β5 subunit-related 2

(FlyBase, 2017-, Belote and Zhong, 2009, Rawlings and Barrett, 1996-)

PROTEIN ADP-RIBOSYL HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2909

(Zhang et al., 2024)

CG3568

(Zhang et al., 2024)

Parg

Poly(ADP-ribose) glycohydrolase

(Fontana et al., 2023, FlyBase, 2017-)

Targ1

Terminal ADP-ribose protein glycohydrolase 1

(Fontana et al., 2023, FlyBase, 2017-)

Targ2

Terminal ADP-ribose protein glycohydrolase 2

(Fontana et al., 2023, FlyBase, 2017-)

Targ3

Terminal ADP-ribose protein glycohydrolase 3

(Fontana et al., 2023, FlyBase, 2017-)

PROTEIN ARGININE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Argp

Arginine phosphatase

(Lee et al., 2020, Fuhrmann et al., 2013)

PROTEIN HISTIDINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG18662

(FlyBase, 2017-)

janA

janus A

janus, Y

(FlyBase, 2017-)

janB

janus B

janus

(FlyBase, 2017-)

ocn

ocnus

BcDNA:GH02250

(FlyBase, 2017-)

PYROGLUTAMYTL-PEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG32147

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

RAB GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Rab1

Rab-protein 1, omt, omelette, dRab1, DmRab1

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab2

Drab2, Rab-protein 2, DmRab2

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab3

drab3, dm-Rab3, DmRab3, Rab3A

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab4

Rab-protein 4, DmRab4

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab5

DRab5, l(2)k08232, Rab-protein 5, DmRab5

(Fu et al., 2017, Zhang et al., 2007, Colicelli, 2004)

Rab6

l(2)08323, wrt, warthog, DmRab6

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab7

DmRab7, DRab7, Rab-protein 7

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab8

l(3)76BDu, DmRab8, dm-Rab8

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab9

DmRab9

(Zhang et al., 2007)

Rab9D

Rab at 9D

(Fu et al., 2017, Zhang et al., 2007, Colicelli, 2004)

Rab9Db

Rab at 9Db

(Fu et al., 2017, Zhang et al., 2007, Colicelli, 2004)

Rab9E

Rab at 9E

(Fu et al., 2017, Zhang et al., 2007)

Rab9Fa

Rab at 9Fa

DmRabX3

(Fu et al., 2017, Zhang et al., 2007)

Rab9Fb

Rab at 9Fb

DmRabX3, RabX3

(Zhang et al., 2007, Colicelli, 2004)

Rab10

Rab-protein 10, DRab10, DmRab10

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab11

l(3)j2D1, Drab11, Rab-protein 11, DmRab11, l(3)93Bi

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab14

BG:DS01068.7, ESTS:57H4T, DmRab14

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab18

Rab-RP4, DmRab18, Rab-related protein 4

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab19

Rab-RP3, DmRab19

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab21

DmRab21

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab23

DmRab23

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab26

DmRab26

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab27

EG:80H7.4, DmRab27, dm-Rab27

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab30

DmRab30

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab32

ltd, lightoid, Rab-RP1, RabRP1, DmRab32

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab35

dRab35, DmRab35

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab39

DmRab39

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

Rab40

DmRab40

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

RabX1

chrw, chrowded, DmRabX1

(Fu et al., 2017, Zhang et al., 2007, Colicelli, 2004)

RabX2

DmRabX2

(Zhang et al., 2007, Colicelli, 2004)

RabX4

DmRabX4

(Fu et al., 2017, Zhang et al., 2007, Colicelli, 2004)

RabX5

DmRabX5

(Fu et al., 2017, Rojas et al., 2012, Zhang et al., 2007, Colicelli, 2004)

RabX6

DmRabX6

(Fu et al., 2017, Zhang et al., 2007, Colicelli, 2004)

RAD51-LIKE ATPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Rad51D

Rad51 recombinase D

Rad51C

(FlyBase, 2017-, Sekelsky, 2017, Sekelsky et al., 2000)

spn-A

spindle A

spnA, Rad51, DmRad51, DMR

(FlyBase, 2017-, Sekelsky, 2017, Sekelsky et al., 2000)

spn-B

spindle B

spnB, XRCC3

(FlyBase, 2017-, Sekelsky, 2017, Sekelsky et al., 2000)

spn-D

spindle D

spnD

(FlyBase, 2017-, Sekelsky, 2017)

Xrcc2

X-ray repair cross complementing 2

Rad51D

(FlyBase, 2017-, Sekelsky, 2017, Sekelsky et al., 2000)

RAN GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ran

l(1)G0075, Ran GTPase

(Rojas et al., 2012, Tracy et al., 2010, Koizumi et al., 2001)

Ran-like

(Tracy et al., 2010, Colicelli, 2004, Koizumi et al., 2001)

RAS GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5160

(Diez et al., 2011, Colicelli, 2004)

CG8500

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

CG8519

(Diez et al., 2011, Colicelli, 2004)

CG8641

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

CG13375

EG:BACR37P7.8

(Diez et al., 2011, Colicelli, 2004)

CG14669

(Rojas et al., 2012)

CG30158

(Diez et al., 2011)

CG42541

(Diez et al., 2011)

Rala

Ras-like protein A

Ral, dRal, Ras-related protein, l(1)G0174, l(1)G0373

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

Rap1

Rap1 GTPase

R, Roughened, Dras3, Rap, l(3)62Bf

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

Rap2l

Ras-associated protein 2-like

Rap21

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

Ras64B

Ras oncogene at 64B

Ras, Ras2, Dras2, Dmras64B, ras-2

(Diez et al., 2011, Colicelli, 2004)

Ras85D

Ras oncogene at 85D

Ras, Ras1, Dras1, RasV12, dRas

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

Rheb

Ras homolog enriched in brain

dRheb, Ras homologue enriched in brain

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

Ric

Ras-related protein interacting with calmodulin

(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)

RAS-RELATED GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

RagA-B

Ras-related GTP binding A/B

RagA, dRagB

(Kim et al., 2008)

RagC-D

Ras-related GTP binding C/D

RagC, dRagC

(Kim et al., 2008)

RECEPTOR PROTEIN TYROSINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG42327

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000)

Lar

Leukocyte-antigen-related-like

Dlar, bypass

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000)

Ptp4E

Protein tyrosine phosphatase 4E

DPTP4E

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000)

Ptp10D

Protein tyrosine phosphatase 10D

DPTP10D

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000, Walchli et al., 2000)

Ptp52F

Protein tyrosine phosphatase 52F

DPTP52F

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000)

Ptp69D

Protein tyrosine phosphatase 69D

DPTP69D, DPTP

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000)

Ptp99A

Protein tyrosine phosphatase 99A

DPTP99A

(Hatzihristidis et al., 2015, Andersen et al., 2004, Morrison et al., 2000, Walchli et al., 2000)

RFC COMPLEX ATPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG8142

(FlyBase, 2017-, Tsuchiya et al., 2007, Krause et al., 2001)

cutlet

(FlyBase, 2017-, Tsuchiya et al., 2007)

elg1

enhanced level of genomic instability 1

(FlyBase, 2017-, Tsuchiya et al., 2007)

Gnf1

Germ line transcription factor 1

rfc1, RfC140, RFC

(FlyBase, 2017-, Tsuchiya et al., 2007, Krause et al., 2001)

Rad17

(FlyBase, 2017-, Tsuchiya et al., 2007, Krause et al., 2001)

RfC3

Replication factor C subunit 3

(FlyBase, 2017-, Tsuchiya et al., 2007, Krause et al., 2001)

RfC4

Replication factor C subunit 4

RfC40, l(3)e20, l(3)64Ai, DmRFC4

(FlyBase, 2017-, Tsuchiya et al., 2007, Krause et al., 2001)

RfC38

Replication factor C 38kD subunit

BcDNA:LD06837

(FlyBase, 2017-, Tsuchiya et al., 2007, Krause et al., 2001)

RGK GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Rgk1

Rad, Gem/Kir family member 1

(Puhl et al., 2014, Diez et al., 2011, Colicelli, 2004)

Rgk2

Rad, Gem/Kir family member 2

(Puhl et al., 2014, Diez et al., 2011)

Rgk3

Rad, Gem/Kir family member 3

(Puhl et al., 2014, Diez et al., 2011)

RHO GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cdc42

Cell division cycle 42

Dcdc42, DmCDC42

(Neisch et al., 2013, Rojas et al., 2012, Colicelli, 2004)

Miro

Mitochondrial Rho

dmiro

(Rojas et al., 2012, Colicelli, 2004)

Mtl

Mig-2-like

Rac, Rac GTPase

(Neisch et al., 2013, Colicelli, 2004)

Rac1

Rac, Drac1, Drac, Rac GTPase, D-Rac1

(Neisch et al., 2013, Rojas et al., 2012, Colicelli, 2004)

Rac2

Rac, Rac1, Drac2, Rac GTPase, DRacB

(Neisch et al., 2013, Rojas et al., 2012, Colicelli, 2004)

Rho1

RhoA, Rho, Rho GTPase, DrhoA, Rho kinase

(Neisch et al., 2013, Rojas et al., 2012, Colicelli, 2004)

RhoBTB

Rho-related BTB domain containing

RhoGTPase, RhoX

(Neisch et al., 2013, Rojas et al., 2012, Colicelli, 2004)

RhoL

Rho-like

Mes1, Drac3, DRhoL

(Neisch et al., 2013, Colicelli, 2004)

RhoU

(Neisch et al., 2013, Colicelli, 2004)

RHOMBOID PROTEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

rho

rhomboid

ve, Rho1, rhomboid-1, rho-1, veinlet

(FlyBase, 2017-, Urban et al., 2002, Guichard et al., 2000, Wasserman et al., 2000, Rawlings and Barrett, 1996-)

rho-4

rhomboid-4

rho4, DmRho4

(FlyBase, 2017-, Urban et al., 2002, Guichard et al., 2000, Wasserman et al., 2000, Rawlings and Barrett, 1996-)

rho-6

rhomboid-6

rho6

(FlyBase, 2017-, Urban et al., 2002, Wasserman et al., 2000)

rho-7

rhomboid-7

(FlyBase, 2017-, Urban et al., 2002, Guichard et al., 2000, Wasserman et al., 2000, Rawlings and Barrett, 1996-)

roughoid

rhomboid-3, rho3, rho-3, rhomboid 3, rhomboid3

(FlyBase, 2017-, Urban et al., 2002, Guichard et al., 2000, Wasserman et al., 2000, Rawlings and Barrett, 1996-)

stet

stem cell tumor

rhomboid-2, rho-2, brho

(FlyBase, 2017-, Urban et al., 2002, Guichard et al., 2000, Wasserman et al., 2000, Rawlings and Barrett, 1996-)

RIBONUCLEASES III

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Dcr-1

Dicer-1

Dicer, Dcr1

(FlyBase, 2017-, Lee et al., 2004, Bernstein et al., 2001)

Dcr-2

Dicer-2

Dcr2, Dicer, dmDcr-2, dcr

(FlyBase, 2017-, Lim et al., 2008, Lee et al., 2004)

drosha

(FlyBase, 2017-)

RIBONUCLEASE T2S

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

RNaseX25

Ribonuclease X25

DmRNase-X25, RNase X25

(FlyBase, 2017-)

RIBONUCLEOSIDE HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5418

(FlyBase, 2017-)

CG11158

(FlyBase, 2017-)

CG12177

(FlyBase, 2017-)

RNA DECAPPING ENZYMES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

DCP2

Decapping protein 2

dDcp2, l(3)tb

(FlyBase, 2017-)

Dcps

Decapping enzyme, scavenger

(FlyBase, 2017-)

Rai1

Rat1 Interacting Protein 1

dRai1

(FlyBase, 2017-)

RNA-DNA HYBRID RIBONUCLEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG13690

(FlyBase, 2017-)

Fen1

Flap endonuclease 1

EG:EG0003.3

(FlyBase, 2017-)

rnh1

ribonuclease H1

RNase H1, l(2)k07624, l(2)43F1-5

(FlyBase, 2017-, Filippov et al., 1997)

RNA LARIAT DEBRANCHING ENZYMES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

ldbr

lariat debranching enzyme

(FlyBase, 2017-)

RPD3/HDA1 LYSINE DEACETYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

HDAC1

Histone deacetylase 1

Rpd3, dHDAC1, dRPD3, HDAC, Su(var)326

(Feller et al., 2015, Pandey et al., 2002)

HDAC3

Histone deacetylase 3

dHDAC3, HDAC

(Feller et al., 2015, Pandey et al., 2002)

HDAC4

Histone deacetylase 4

dHDAC4, HDAC4a, HDAC

(Feller et al., 2015, Pandey et al., 2002)

HDAC6

Histone deacetylase 6

dHDAC6, HDAC2, HDAC, dHDAC2

(Feller et al., 2015, Pandey et al., 2002)

HDAC11

Histone deacetylase 11

HDACX

(Feller et al., 2015, Pandey et al., 2002)

S1A SERINE PROTEASES - CHYMOTRYPSIN-LIKE

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG3916

SP154

(Cao and Jiang, 2018)

CG4053

SP185

(Cao and Jiang, 2018)

CG4815

SP189

(Cao and Jiang, 2018)

CG5246

SP96

(Cao and Jiang, 2018)

CG5255

SP141

(Cao and Jiang, 2018)

CG5909

(Cao and Jiang, 2018)

CG6462

SP127

(Cao and Jiang, 2018)

CG6592

lincRNA.S4213, SP105

(Cao and Jiang, 2018)

CG7142

SP132

(Cao and Jiang, 2018)

CG7542

SP71

(Cao and Jiang, 2018)

CG8329

SP170

(Cao and Jiang, 2018)

CG9649

SP55

(Cao and Jiang, 2018)

CG10041

SP178

(Cao and Jiang, 2018)

CG10469

SP123

(Cao and Jiang, 2018)

CG10472

SP78

(Cao and Jiang, 2018)

CG10477

SP51

(Cao and Jiang, 2018)

CG11664

EG:BACR7A4.3, SP193

(Cao and Jiang, 2018)

CG11911

SP103

(Cao and Jiang, 2018)

CG11912

SP140

(Cao and Jiang, 2018)

CG12256

SP133

(Cao and Jiang, 2018)

CG12951

SP87

(Cao and Jiang, 2018)

CG14227

(Cao and Jiang, 2018)

CG14892

SP175

(Cao and Jiang, 2018)

CG16749

SP91

(Cao and Jiang, 2018)

CG17234

SP113

(Cao and Jiang, 2018)

CG17404

SP149

(Cao and Jiang, 2018)

CG17475

SP131

(Cao and Jiang, 2018)

CG18179

SP152

(Cao and Jiang, 2018)

CG18636

(Cao and Jiang, 2018)

CG30098

(Cao and Jiang, 2018)

CG30283

SP37

(Cao and Jiang, 2018)

CG30287

(Cao and Jiang, 2018)

CG31220

(Cao and Jiang, 2018)

CG31265

(Cao and Jiang, 2018)

CG31269

(Cao and Jiang, 2018)

CG32523

SP50

(Cao and Jiang, 2018)

CG32808

EG:80H7.1

(Cao and Jiang, 2018)

CG33226

(Cao and Jiang, 2018)

CG33459

(Cao and Jiang, 2018)

CG34458

SP118

(Cao and Jiang, 2018)

CG43335

(Cao and Jiang, 2018)

CG43336

(Cao and Jiang, 2018)

gastrulation-defective

fs(1)M18, fs(1)gd, fs(1)573, SP186

(Cao and Jiang, 2018)

Jon25Biii

Jonah 25Biii

SP177, Jon25B

(Cao and Jiang, 2018)

Jon44E

Jonah 44E

SP100

(Cao and Jiang, 2018)

Jon65Ai

Jonah 65Ai

Jon65A, SP145

(Cao and Jiang, 2018)

Jon65Aii

Jonah 65Aii

Jon65A, SP153

(Cao and Jiang, 2018)

Jon65Aiv

Jonah 65Aiv

Jon65A, BEST:GH23808, SP117

(Cao and Jiang, 2018)

Jon66Cii

Jonah 66Cii

Jonah 66C, Jon66C, SP165

(Cao and Jiang, 2018)

Jon74E

Jonah 74E

SP85

(Cao and Jiang, 2018)

Jon99Cii

Jonah 99Cii

Ser99Da, Jon99C, Jon99Cβ, Ser1, SP122

(Cao and Jiang, 2018)

Jon99Ciii

Jonah 99Ciii

Ser99Db, Ser2, Jon99Cβ, Jon99C, Serine protease 5

(Cao and Jiang, 2018)

Jon99Fi

Jonah 99Fi

Jon99F

(Cao and Jiang, 2018)

Jon99Fii

Jonah 99Fii

Jon99F, SP135

(Cao and Jiang, 2018)

modSP

modular serine protease

W, X, Ser89E, SP53

(Cao and Jiang, 2018)

Phae1

Phaedra 1

SP134

(Cao and Jiang, 2018)

Phae2

Phaedra 2

SP147

(Cao and Jiang, 2018)

Send1

Spermathecal endopeptidase 1

SP163

(Cao and Jiang, 2018)

Send2

Spermathecal endopeptidase 2

BG:DS01068.10

(Cao and Jiang, 2018)

Sp212

Serine-peptidase 212

(Cao and Jiang, 2018)

yip7

yippee interacting protein 7

Machete, SP116

(Cao and Jiang, 2018)

S1A SERINE PROTEASES - ELASTASE-LIKE

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG1304

SP46

(Cao and Jiang, 2018)

CG8952

SP52

(Cao and Jiang, 2018)

CG9631

SP60, BcDNA:GH08420

(Cao and Jiang, 2018)

CG9676

SP99

(Cao and Jiang, 2018)

CG17477

(Cao and Jiang, 2018)

CG18180

SP151

(Cao and Jiang, 2018)

CG33458

(Cao and Jiang, 2018)

CG33461

(Cao and Jiang, 2018)

CG33462

(Cao and Jiang, 2018)

Jon25Bi

Jonah 25Bi

Ser4, Jon25B, SP137

(Cao and Jiang, 2018)

Jon25Bii

Jonah 25Bii

SP112, Jon25B

(Cao and Jiang, 2018)

Jon65Aiii

Jonah 65Aiii

Jon65A, SP98

(Cao and Jiang, 2018)

Jon66Ci

Jonah 66Ci

SP171, Jon66C, Jonah 66C

(Cao and Jiang, 2018)

Jon99Ci

Jonah 99Ci

Ser99Dc, Jon99C, Jon99Cβi, SP150, SER3

(Cao and Jiang, 2018)

Ser6

Serine protease 6

SP47

(Cao and Jiang, 2018)

S1A SERINE PROTEASES - TRYPSIN-LIKE

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

αTry

αTrypsin

alpha, SP102, Try

(Cao and Jiang, 2018)

βTry

βTrypsin

SP119, Try

(Cao and Jiang, 2018)

CG1299

SP18

(Cao and Jiang, 2018)

CG1773

SP74

(Cao and Jiang, 2018)

CG3355

SP21

(Cao and Jiang, 2018)

CG3650

SP159

(Cao and Jiang, 2018)

CG3700

(Cao and Jiang, 2018)

CG3795

EG:9D2.4, SP160

(Cao and Jiang, 2018)

CG4613

SP40

(Cao and Jiang, 2018)

CG4914

SP39

(Cao and Jiang, 2018)

CG4927

(Cao and Jiang, 2018)

CG6041

SP86

(Cao and Jiang, 2018)

CG6048

SP108

(Cao and Jiang, 2018)

CG6865

SP63

(Cao and Jiang, 2018)

CG7432

(Cao and Jiang, 2018)

CG7829

SP136

(Cao and Jiang, 2018)

CG8170

(Cao and Jiang, 2018)

CG8172

(Cao and Jiang, 2018)

CG8299

SP65

(Cao and Jiang, 2018)

CG8870

(Cao and Jiang, 2018)

CG9294

SP20

(Cao and Jiang, 2018)

CG9372

(Cao and Jiang, 2018)

CG9733

pro-phenoloxidase AE, SP10, proAE

(Cao and Jiang, 2018)

CG9737

(Cao and Jiang, 2018)

CG10232

(Cao and Jiang, 2018)

CG10405

SP155

(Cao and Jiang, 2018)

CG10587

SP167

(Cao and Jiang, 2018)

CG10663

SP30

(Cao and Jiang, 2018)

CG10764

SP77

(Cao and Jiang, 2018)

CG11037

SP191

(Cao and Jiang, 2018)

CG11192

SP82

(Cao and Jiang, 2018)

CG11313

(Cao and Jiang, 2018)

CG11529

SP84

(Cao and Jiang, 2018)

CG11668

(Cao and Jiang, 2018)

CG11670

SP27

(Cao and Jiang, 2018)

CG11836

SP23

(Cao and Jiang, 2018)

CG11841

SP45

(Cao and Jiang, 2018)

CG11842

SP68

(Cao and Jiang, 2018)

CG11843

SP43

(Cao and Jiang, 2018)

CG12133

SP15

(Cao and Jiang, 2018)

CG13430

SP70

(Cao and Jiang, 2018)

CG13744

(Cao and Jiang, 2018)

CG14642

SP29

(Cao and Jiang, 2018)

CG14760

SP120

(Cao and Jiang, 2018)

CG14780

SP95, EG:80H7.3

(Cao and Jiang, 2018)

CG16710

(Cao and Jiang, 2018)

CG16998

SP104

(Cao and Jiang, 2018)

CG17239

SP138

(Cao and Jiang, 2018)

CG17571

38C.22, anon-38C.22, SP83

(Cao and Jiang, 2018)

CG18735

SP22

(Cao and Jiang, 2018)

CG18754

(Cao and Jiang, 2018)

CG30002

(Cao and Jiang, 2018)

CG30025

(Cao and Jiang, 2018)

CG30031

(Cao and Jiang, 2018)

CG30082

(Cao and Jiang, 2018)

CG30083

(Cao and Jiang, 2018)

CG30087

(Cao and Jiang, 2018)

CG30088

(Cao and Jiang, 2018)

CG30091

SP49

(Cao and Jiang, 2018)

CG30187

(Cao and Jiang, 2018)

CG30286

(Cao and Jiang, 2018)

CG30288

(Cao and Jiang, 2018)

CG30289

(Cao and Jiang, 2018)

CG30371

(Cao and Jiang, 2018)

CG30375

(Cao and Jiang, 2018)

CG30414

SP62

(Cao and Jiang, 2018)

CG31219

(Cao and Jiang, 2018)

CG31681

(Cao and Jiang, 2018)

CG31954

SP107

(Cao and Jiang, 2018)

CG32260

(Cao and Jiang, 2018)

CG32269

(Cao and Jiang, 2018)

CG32270

(Cao and Jiang, 2018)

CG32271

(Cao and Jiang, 2018)

CG32277

(Cao and Jiang, 2018)

CG32374

(Cao and Jiang, 2018)

CG32376

(Cao and Jiang, 2018)

CG32755

(Cao and Jiang, 2018)

CG33159

(Cao and Jiang, 2018)

CG33160

(Cao and Jiang, 2018)

CG34290

(Cao and Jiang, 2018)

CG34409

(Cao and Jiang, 2018)

CG43110

MB7.chr2R.pasa.4777

(Cao and Jiang, 2018)

CG43742

(Cao and Jiang, 2018)

Corin

SP75

(Cao and Jiang, 2018)

δTry

δTrypsin

(Cao and Jiang, 2018)

easter

(Cao and Jiang, 2018)

εTry

εTrypsin

epsilonTrypsin, SP88, Try

(Cao and Jiang, 2018)

Erasp

Endoplasmic reticulum stress-associated serine protease

(Cao and Jiang, 2018)

ηTry

ηTrypsin

SP57

(Cao and Jiang, 2018)

flz

filzig

lint, lumens interrupted

(Cao and Jiang, 2018)

γTry

γTrypsin

(Cao and Jiang, 2018)

grass

Gram-positive Specific Serine protease

c-SP1

(Cao and Jiang, 2018)

Hayan

(Cao and Jiang, 2018)

ιTry

ιTrypsin

SP129

(Cao and Jiang, 2018)

l(2)k05911

lethal (2) k05911

(Cao and Jiang, 2018)

λTry

SP76

(Cao and Jiang, 2018)

MP1

Melanization Protease 1

BEST:GH02921

(Cao and Jiang, 2018)

ndl

nudel

SP89

(Cao and Jiang, 2018)

Notopleural

(Cao and Jiang, 2018)

psh

persephone

(Cao and Jiang, 2018)

Stubble

sbd, Sb-sbd, stubbloid, Stubble-stubbloid

(Cao and Jiang, 2018)

Sems

Seminase

SP168

(Cao and Jiang, 2018)

Ser7

SP#2

(Cao and Jiang, 2018)

Ser8

SP90, SP#3

(Cao and Jiang, 2018)

Ser12

Serine protease 12

SP92

(Cao and Jiang, 2018)

snk

snake

(Cao and Jiang, 2018)

Sp7

Serine protease 7

MP2, PAE1, Melanization Protease 2

(Cao and Jiang, 2018)

SPE

Spatzle-Processing Enzyme

c-SP4

(Cao and Jiang, 2018)

spirit

Serine Protease Immune Response Integrator

c-SP33

(Cao and Jiang, 2018)

teq

Tequila

graal, SP72

(Cao and Jiang, 2018)

θTry

θTrypsin

SP139

(Cao and Jiang, 2018)

tpr

tracheal-prostasin

SP17

(Cao and Jiang, 2018)

Try29F

Trypsin 29F

SP106

(Cao and Jiang, 2018)

ζTry

ζTrypsin

SP110

(Cao and Jiang, 2018)

S1C SERINE PEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG3589

(Rawlings and Barrett, 1996-)

HtrA2

HTRA2-related serine protease

omi, dOmi, DmHtrA2

(Rawlings and Barrett, 1996-)

S9A SERINE OLIGOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2528

lincRNA.224

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG5355

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

S10 SERINE CARBOXYPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG4572

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG31821

BG:DS00365.3

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG31823

BG:DS00365.3

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG32483

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

hiro

highroad

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

S26 SERINE ENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG9240

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG11110

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

twr

twisted bristles roughened eye

Spase18-21, Spase 18/21-subunit, Spase18/21, BG:DS00004.11, l(3)05614

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

S28 SERINE EXOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2493

38C.55

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG3734

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG3739

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG9953

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG11626

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG18493

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

S51 SERINE DIPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2200

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

S81 SERINE ISOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG6435

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

CG14823

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

SEPARASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Sse

Separase

l(3)SG14

(FlyBase, 2017-, Jager et al., 2001, Rawlings and Barrett, 1996-)

SEPTINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

pnut

peanut

dSEPT7, septin

(Shuman and Momany, 2021, O'Neill and Clark, 2016, Pan et al., 2007, Goldstein and Gunawardena, 2000)

Septin1

Septin 1

Sep1, septin, iby, dSEPT1

(Shuman and Momany, 2021, O'Neill and Clark, 2016, Pan et al., 2007, Goldstein and Gunawardena, 2000)

Septin2

Septin 2

Sep2, septin

(Shuman and Momany, 2021, O'Neill and Clark, 2016, Pan et al., 2007, Goldstein and Gunawardena, 2000)

Septin4

Septin 4

Sep4, septin, dSEPT4

(Shuman and Momany, 2021, O'Neill and Clark, 2016, Pan et al., 2007, Goldstein and Gunawardena, 2000)

Septin5

Septin 5

Sep5, septin

(Shuman and Momany, 2021, O'Neill and Clark, 2016, Pan et al., 2007, Goldstein and Gunawardena, 2000)

SERINE-TYPE OTU DEUBIQUITINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG3251

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Louis et al., 2015, Zhang et al., 2012, Rawlings and Barrett, 1996-)

otu

ovarian tumor

fs(1)231, K, fs(1)M101

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Louis et al., 2015, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

SIGNAL RECOGNITION PARTICLE GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Srp54k

Signal recognition particle 54k

l(3)01418, Srp54

(FlyBase, 2017-)

SrpRα

Signal recognition particle receptor α

Gtp-bp, GTP-binding protein

(FlyBase, 2017-)

SrpRβ

Signal recognition particle receptor β

l(3)rK561, l(3)rL537

(FlyBase, 2017-)

SINGLE-STRANDED DNA ENDODEOXYRIBONUCLEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Endonuclease G

(FlyBase, 2017-)

mei-9

meiotic 9

mei9, mus110

(FlyBase, 2017-)

mre11

meiotic recombination 11

(FlyBase, 2017-)

Sid

Stress induced DNase

(FlyBase, 2017-)

Tengl1

Testis EndoG-Like 1

(FlyBase, 2017-)

Tengl2

Testis EndoG-Like 2

(FlyBase, 2017-)

Tengl3

Testis EndoG-Like 3

(FlyBase, 2017-)

Tengl4

Testis EndoG-Like 4

(FlyBase, 2017-)

SIRTUIN LYSINE DEACETYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Sirt1

Sirtuin 1

Sir2, dSir2

(Feller et al., 2015, Pandey et al., 2002, Frye, 2000)

Sirt2

Sirtuin 2

Sir2, dsirt2, sirtuin

(Feller et al., 2015, Frye, 2000)

Sirt4

Sirtuin 4

(Feller et al., 2015, Pandey et al., 2002, Frye, 2000)

Sirt6

Sirtuin 6

(Feller et al., 2015, Pandey et al., 2002, Frye, 2000)

Sirt7

Sirtuin 7

(Feller et al., 2015, Pandey et al., 2002, Frye, 2000)

SITE 2 PEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

S2P

site-2 protease

dS2P

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

SNF2-LIKE CHROMATIN REMODELERS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

brm

brahma

l(3)72Aa, dBRM

(FlyBase, 2017-, Schneiderman et al., 2009)

CG4049

Arip4

(FlyBase, 2017-, Schneiderman et al., 2009)

CG7376

(FlyBase, 2017-, Schneiderman et al., 2009)

CG10445

(FlyBase, 2017-, Schneiderman et al., 2009)

Chd1

Chromodomain-helicase-DNA-binding protein 1

CHD-1, Chromodomain-helicase-DNA-binding protein, dCHD1

(FlyBase, 2017-, Schneiderman et al., 2009)

Chd3

(FlyBase, 2017-, Schneiderman et al., 2009)

dom

domino

DOM-A

(FlyBase, 2017-, Schneiderman et al., 2009)

Etl1

(FlyBase, 2017-, Schneiderman et al., 2009)

Hel89B

Helicase 89B

BTAF1, Mot1, 89B helicase

(FlyBase, 2017-, Schneiderman et al., 2009)

Ino80

INO80 complex subunit

Tel, Telomere elongation, dIno80

(FlyBase, 2017-, Schneiderman et al., 2009)

Iswi

Imitation SWI

NURF, CHRAC, ACF, dISWI, dNURF

(FlyBase, 2017-, Schneiderman et al., 2009)

kis

kismet

l(2)k16510, KIS-L, EP474

(FlyBase, 2017-, Schneiderman et al., 2009)

lds

lodestar

factor 2, Horka, Negative transcription elongation factor 2

(FlyBase, 2017-, Schneiderman et al., 2009)

Mi-2

dMi-2, Pha, dMi2, PHD-containing ATPase, l(3)L1243

(FlyBase, 2017-, Schneiderman et al., 2009)

okr

okra

rad54, DmRAD54

(FlyBase, 2017-, Schneiderman et al., 2009)

XNP

dATRX, dXNP

(FlyBase, 2017-, Schneiderman et al., 2009)

SPHINGOMYELINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Asm

Acid sphingomyelinase

aSMase

(Chen et al., 2022, FlyBase, 2017-, Renault et al., 2002)

CG15533

aSMase

(Chen et al., 2022, FlyBase, 2017-, Renault et al., 2002)

CG15534

aSMase, αSmase

(Chen et al., 2022, FlyBase, 2017-, Renault et al., 2002)

nSMase

neutral sphingomyelinase

(Chen et al., 2022, FlyBase, 2017-, Renault et al., 2002)

STE24 METALLOENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

ste24a

prenyl protease type I

(FlyBase, 2017-, Adolphsen et al., 2012, Rawlings and Barrett, 1996-)

ste24b

ste24b prenyl protease type I

(FlyBase, 2017-, Adolphsen et al., 2012, Rawlings and Barrett, 1996-)

ste24c

ste24c prenyl protease type I

(FlyBase, 2017-, Adolphsen et al., 2012, Rawlings and Barrett, 1996-)

STRUCTURAL MAINTENANCE OF CHROMOSOMES GENE FAMILY

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

glu

gluon

SMC4, DmSMC4, l(2)k08819

(Carter and Sjögren, 2012, Harvey et al., 2002)

SMC1

Structural maintenance of chromosomes 1

cohesin, DmSMC1

(Carter and Sjögren, 2012, Harvey et al., 2002)

SMC2

Structural maintenance of chromosomes 2

DmSMC2

(Carter and Sjögren, 2012, Harvey et al., 2002)

SMC3

Structural maintenance of chromosomes 3

Cap

(Carter and Sjögren, 2012, Harvey et al., 2002)

SMC5

Structural maintenance of chromosomes 5

(Carter and Sjögren, 2012, Harvey et al., 2002)

SMC6

Structural maintenance of chromosomes 6

jnj, HU- or caffeine-sensitive 95E, java no jive, huc95E

(Carter and Sjögren, 2012, Harvey et al., 2002)

TASPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Tasp1

Taspase 1

l(3)72Dl

(FlyBase, 2017-, Wünsch et al., 2015, Hsieh et al., 2003, Rawlings and Barrett, 1996-)

TRANSLATIONAL GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG4849

eEF2

(FlyBase, 2017-)

CG33158

(FlyBase, 2017-)

eEF1α1

eukaryotic translation elongation factor 1 alpha 1

Ef1alpha48D, EF-1α, Ef1α48D, EF1α, Elongation factor 1α48D

(FlyBase, 2017-)

eEF1α2

eukaryotic translation elongation factor 1 alpha 2

Ef1alpha100E, EF-1α, F2, Ef1α100E, EF1α

(FlyBase, 2017-)

eEF2

eukaryotic translation elongation factor 2

Ef2b, EF2, Elongation factor 2b, Elongation factor 2

(FlyBase, 2017-)

eEFSec

eukaryotic translation elongation factor, selenocysteine-specific

EfSec

(FlyBase, 2017-)

eIF2γ

eukaryotic translation initiation factor 2 subunit gamma

eIF-2γ, eIF-2gamma, eIF2G, eIF-2G

(FlyBase, 2017-)

eIF5B

eukaryotic translation initiation factor 5B

cIF2, dIF2, IF2, eukaryotic initiation factor 5B, cytoplasmic Initiation Factor 2

(FlyBase, 2017-)

eRF3

eukaryotic translation release factor 3

Elf, delf, Dsup35

(FlyBase, 2017-)

Gtpbp1

GTP binding protein 1

Dgp-1

(FlyBase, 2017-)

Gtpbp2

GTP binding protein 2

CG 2017, GP-1 related

(FlyBase, 2017-)

HBS1

(FlyBase, 2017-)

mEFG1

mitochondrial translation elongation factor G 1

ico, iconoclast, l(2)27Ea, G

(FlyBase, 2017-)

mEFTu1

mitochondrial translation elongation factor Tu 1

EfTuM, Elongation factor Tu mitochondrial, l(3)L4569

(FlyBase, 2017-)

mEFTu2

mitochondrial translation elongation factor Tu 2

(FlyBase, 2017-)

mIF2

mitochondrial translation initiation factor 2

(FlyBase, 2017-)

mRRF2

mitochondrial ribosome recycling factor 2

EF-G2

(FlyBase, 2017-)

waw

waclaw

(FlyBase, 2017-)

TRIPEPTIDYL PEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

TppII

Tripeptidyl-peptidase II

TPP II, dTPP II, dTPPII

(Tao et al., 2019, FlyBase, 2017-, Rawlings and Barrett, 1996-)

TRNA-INTRON ENDONUCLEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Tsen2

tRNA splicing endonuclease subunit 2

(Schmidt et al., 2019, FlyBase, 2017-)

Tsen34

tRNA splicing endonuclease subunit 34

(Schmidt et al., 2019, FlyBase, 2017-)

UCH DEUBIQUITINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

caly

calypso

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Uch

Ubiquitin carboxy-terminal hydrolase

dUCH, ubiquitin carboxyl terminal hydrolase, UCH-D

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Uch-L5

Ubiquitin carboxy-terminal hydrolase L5

Uch-L3, p37A, UCHL5, Ubiquitin C-terminal hydrolase

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Uch-L5R

Uch-L5-related

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

UDP-SUGAR DIPHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG42813

(FlyBase, 2017-)

CG42814

(FlyBase, 2017-)

UNCLASSIFIED ACID ANHYDRIDE HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Aps

Aps pyrophosphatase

(FlyBase, 2017-)

CG10194

NUDT19

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Diadenosine tetraphosphatase

Apf

(FlyBase, 2017-)

Fitm

Fat storage inducing transmembrane protein

(FlyBase, 2017-)

mRNA-cap

mRNA-capping-enzyme

(Hatzihristidis et al., 2015, Morrison et al., 2000)

NitFhit

Nitrilase and fragile histidine triad fusion protein

(FlyBase, 2017-)

Nurf-38

Nucleosome remodeling factor - 38kD

NURF, NURF38, dNURF, p38, l(2)k16102

(FlyBase, 2017-)

prune

EG:152A3.5

(FlyBase, 2017-)

UNCLASSIFIED ATPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ak6

Adenylate kinase 6

(FlyBase, 2017-)

Bcs1

Bcs1 chaperone

(FlyBase, 2017-)

bor

belphegor

denuded, CP89BC, dATAD3A

(FlyBase, 2017-)

c12.2

(FlyBase, 2017-)

Cdc6

Cell division cycle 6

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Coenzyme Q8

(FlyBase, 2017-)

Dcr-2

Dicer-2

Dcr2, Dicer, dmDcr-2, dcr

(FlyBase, 2017-)

Ku80

BG:DS09217.6

(FlyBase, 2017-)

Ns1

Nucleostemin 1

(FlyBase, 2017-)

Orc1

Origin recognition complex subunit 1

DmORC1, ORC, sat

(FlyBase, 2017-)

Orc4

Origin recognition complex subunit 4

ORC, DmORC4

(FlyBase, 2017-)

Orc5

Origin recognition complex subunit 5

l(2)34Df, DmORC5, l(2)br39, ORC, BG:DS00941.8

(FlyBase, 2017-)

pch2

pachytene checkpoint 2

(FlyBase, 2017-)

Pex1

Peroxin 1

l(3)70Da, l(3)s4868, l(3)02402, l(3)S084807, lethal (3) 70Da

(FlyBase, 2017-)

Pex6

Peroxin 6

(FlyBase, 2017-)

rad50

(FlyBase, 2017-)

sick

sickie

Dm_2L:104545

(FlyBase, 2017-)

smid

smallminded

l(3)j6B8

(FlyBase, 2017-)

TER94

Transitional endoplasmic reticulum 94

VCP, dVCP, p97, l(2)03775, Valosin-containing protein

(FlyBase, 2017-)

Torsin

torp4a, dtorsin, DTor

(FlyBase, 2017-)

Vps4

Vacuolar protein sorting 4

BcDNA:GH02678, dvps4

(FlyBase, 2017-)

UNCLASSIFIED CARBON-NITROGEN HYDROLASES (NON-PEPTIDASE)

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG11089

(FlyBase, 2017-)

Nmdmc

NAD-dependent methylenetetrahydrofolate dehydrogenase

DNMDMC

(FlyBase, 2017-)

Punch

GTPCH, GTP cyclohydrolase, GTP cyclohydrolase I, GCH1, unpigmented

(FlyBase, 2017-)

pug

pugilist

pugD, MTHFD

(FlyBase, 2017-)

UNCLASSIFIED CARBON-NITROGEN HYDROLASES OF LINEAR AMIDES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Btnd

Biotinidase

(FlyBase, 2017-)

bwa

brain washing

Dacer, 38B.6

(FlyBase, 2017-)

CDase

Ceramidase

slab

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

BP1006

(FlyBase, 2017-)

DJ-1α

DJ-1, DJ-1A

(FlyBase, 2017-)

dj-1β

DJ-1, DJ-1b

(FlyBase, 2017-)

GLS

Glutaminase

(FlyBase, 2017-)

HINT1

histidine triad nucleotide binding protein 1

(FlyBase, 2017-)

KFase

Kynurenine formamidase

(FlyBase, 2017-)

Naam

Nicotinamide amidase

D-NAAM

(FlyBase, 2017-)

Nadsyn

NAD synthetase

(FlyBase, 2017-)

NitFhit

Nitrilase and fragile histidine triad fusion protein

(FlyBase, 2017-)

Ntan1

N-terminal amidohydrolase 1

SP2637

(FlyBase, 2017-)

Pngl

PNGase-like

PNGase, dNGLY1

(FlyBase, 2017-)

pyd3

βAS

(FlyBase, 2017-)

tun

tungus

(FlyBase, 2017-)

UNCLASSIFIED CARBOXYLIC ESTER HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ace

Acetylcholine esterase

AChE, acetylcholinesterase, DmAChE

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

wf, wingful, l(3)72CDf, l(3)72Da

(FlyBase, 2017-)

PGAP1

Post-GPI attachment to proteins 1

(FlyBase, 2017-)

Pgls

6-phosphogluconolactonase

(FlyBase, 2017-)

sfl

sulfateless

NDST, lincRNA.S4253

(FlyBase, 2017-)

UNCLASSIFIED DEAMINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

AMPdeam

AMP deaminase

(FlyBase, 2017-)

CG6951

(FlyBase, 2017-)

DhpD

Dihydropterin deaminase

(FlyBase, 2017-)

Oscillin

(FlyBase, 2017-)

UK114

BG:DS07851.3, DUK114

(FlyBase, 2017-)

UNCLASSIFIED DNA ENDONUCLEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG7139

BcDNA:LD21293

(FlyBase, 2017-)

CG8679

(FlyBase, 2017-)

CG42391

(FlyBase, 2017-)

Drep4

DNA fragmentation factor-related protein 4

dCAD, Rep4, CAD

(FlyBase, 2017-)

UNCLASSIFIED ESTER BOND HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

falten

(FlyBase, 2017-)

kraken

(FlyBase, 2017-)

lama

lamina ancestor

(FlyBase, 2017-)

meep

(FlyBase, 2017-)

Mesh1

Metazoan SpoT homolog-1

(FlyBase, 2017-)

PGAP3

Post-GPI attachment to proteins 3

(FlyBase, 2017-)

UNCLASSIFIED ETHER HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG7582

(FlyBase, 2017-)

UNCLASSIFIED GLUCOSIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG16965

(FlyBase, 2017-, Lombard et al., 2013)

GCS1

Glucosidase 1

(FlyBase, 2017-, Lombard et al., 2013)

UNCLASSIFIED GTPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

128up

upstream of RpIII128

(FlyBase, 2017-)

atl

atlastin

D-atlastin, dAtl

(FlyBase, 2017-)

CenG1A

Centaurin gamma 1A

BG:DS08220.1

(FlyBase, 2017-)

CG2656

(FlyBase, 2017-)

CG3704

EG:BACR7A4.17

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Guanylyl cyclase at 88E

Gyc-88E

(FlyBase, 2017-)

Non1

Novel nucleolar protein 1

BcDNA:LD23830

(FlyBase, 2017-)

RecQ5

RecQ5 helicase

RECQE, Q1, DQ1, RECQ5/QE

(FlyBase, 2017-)

Scp2

Sarcoplasmic calcium-binding protein 2

Calexcitin, JHDK, dSCP2

(FlyBase, 2017-)

Tsr1

Tsr1 ribosome assembly factor

(FlyBase, 2017-)

UNCLASSIFIED NUCLEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Dead-box-1

(FlyBase, 2017-)

egl

egalitarian

(FlyBase, 2017-)

mms4

Methyl methanesulfonate sensitivity 4

(FlyBase, 2017-)

prage

prg, EG:137E7.1, EG:131F2.2

(FlyBase, 2017-)

Rad9

(FlyBase, 2017-)

Tudor-SN

Tudor staphylococcal nuclease

TSN

(FlyBase, 2017-)

UNCLASSIFIED O-GLYCOSYL HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Agbe

1,4-Alpha-glucan branching enzyme

(FlyBase, 2017-)

CG33080

(FlyBase, 2017-)

ENGase

Endo-beta-N-acetylglucosaminidase

(FlyBase, 2017-, Lombard et al., 2013)

Fuca

α-L-fucosidase

(FlyBase, 2017-)

Idua

alpha-L-iduronidase

(FlyBase, 2017-, Lombard et al., 2013)

Naglu

N-acetyl-alpha-glucosaminidase

ESTS:172F5T

(FlyBase, 2017-, Lombard et al., 2013)

Oga

O-GlcNAcase

GlcNAcase

(FlyBase, 2017-, Lombard et al., 2013)

Parg

Poly(ADP-ribose) glycohydrolase

(FlyBase, 2017-)

tobi

target of brain insulin

(FlyBase, 2017-)

UNCLASSIFIED PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2921

(FlyBase, 2017-)

CG4161

BG:DS03023.2

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(Attrill and Antonazzo, 2013.6.25)

CG31924

(FlyBase, 2017-)

curled

nocturnin, nocturin

(FlyBase, 2017-)

Epp

Ecdysteroid phosphate phosphatase

(FlyBase, 2017-)

Gs1l

GS1-like

(FlyBase, 2017-)

UNCLASSIFIED PHOSPHORIC DIESTER HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5895

(FlyBase, 2017-)

CG6962

(FlyBase, 2017-)

CG10747

38B.13

(FlyBase, 2017-)

CG14883

(FlyBase, 2017-)

CG32052

BEST:HL01355, aSMase

(FlyBase, 2017-)

Fic

Fic domain-containing protein

(FlyBase, 2017-)

gkt

glaikit

Tdp1, anon-23Db, c22

(FlyBase, 2017-)

Mpped

Metallophosphoesterase domain containing

(FlyBase, 2017-)

PGAP5

Post-GPI attachment to proteins 5

(FlyBase, 2017-)

PLCXD

Phosphatidylinositol-specific phospholipase C X domain containing

(FlyBase, 2017-)

Pld

Phospholipase D

dPLD, MitoPLD

(FlyBase, 2017-)

Rrp1

Recombination repair protein 1

APEX1

(FlyBase, 2017-)

zuc

zucchini

MitoPLD

(FlyBase, 2017-)

UNCLASSIFIED PROTEIN SERINE/THREONINE PHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG34183

(FlyBase, 2017-)

Pgam5

Phosphoglycerate mutase 5

EG:63B12.4, dPGAM5

(Imai et al., 2010)

Pgam5-2

Phosphoglycerate mutase 5-2

(Imai et al., 2010)

Ssu72

Ssu72 CTD phosphatase

(Zhang et al., 2011)

UNCLASSIFIED RNA ENDONUCLEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Arlr

Age-related lipid regulator

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Clipper

CPSF30, c6a

(FlyBase, 2017-)

Cpsf73

Cleavage and polyadenylation specificity factor 73

CPSF-73

(FlyBase, 2017-)

Dis3

dDis3, Tazman

(FlyBase, 2017-)

EndoG

Endonuclease G

(FlyBase, 2017-)

EndoU

Endoribonuclease U-specific

dendoU

(FlyBase, 2017-)

IntS11

Integrator 11

(FlyBase, 2017-)

Ire1

Inositol-requiring enzyme-1

ire-1, Ire1α, Ire

(FlyBase, 2017-)

mldr

mulder

(FlyBase, 2017-)

pelo

pelota

(FlyBase, 2017-)

Regnase-1

Regnase 1

(FlyBase, 2017-)

RNASEK

Ribonuclease kappa

l(2)NC110

(FlyBase, 2017-)

RNaseMRP:RNA

Ribonuclease MRP RNA

MRP RNA, snmRNA:342, RNase MRP

(FlyBase, 2017-)

RNaseP:RNA

Ribonuclease P RNA

RNase P RNA

(FlyBase, 2017-)

Rtc1

(FlyBase, 2017-)

Sid

Stress induced DNase

(FlyBase, 2017-)

Smg6

(FlyBase, 2017-)

Swt1

Swt1 RNA endoribonuclease

(FlyBase, 2017-)

Tengl1

Testis EndoG-Like 1

(FlyBase, 2017-)

Tengl2

Testis EndoG-Like 2

(FlyBase, 2017-)

Tengl3

Testis EndoG-Like 3

(FlyBase, 2017-)

Tengl4

Testis EndoG-Like 4

(FlyBase, 2017-)

Trax

Translin associated factor X

(FlyBase, 2017-)

zuc

zucchini

MitoPLD

(FlyBase, 2017-)

UNCLASSIFIED SULFURIC ESTER HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Iduronate 2-sulfatase

(FlyBase, 2017-)

UNCLASSIFIED THIOLESTER HYDROLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG4390

(FlyBase, 2017-)

tzn

tenzing norgay

(FlyBase, 2017-)

UNCLASSIFIED TRIGLYCERIDE LIPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

bmm

brummer

ATGL, DmATGL

(FlyBase, 2017-, Horne et al., 2009)

dob

doppelganger von brummer

(FlyBase, 2017-)

Hsl

Hormone-sensitive lipase

dHSL, DmHSL

(FlyBase, 2017-, Horne et al., 2009)

inaE

inactivation no afterpotential E

diacylglycerol lipase, DAGL

(FlyBase, 2017-, Horne et al., 2009)

USP DEUBIQUITINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CYLD

Cylindromatosis

dCYLD

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

DUBAI

Deubiquitinating apoptotic inhibitor

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

faf

fat facets

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

not

non-stop

l(3)02069

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

puf

puffyeye

Usp34

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

scny

scrawny

dUSP36, Usp36, mule, l(3)02331, emperor's thumb

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Usp1

Ubiquitin specific protease 1

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Usp2

Ubiquitin specific protease 2

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Usp5

Ubiquitin specific protease 5

leon, DmUSP5

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Usp7

Ubiquitin-specific protease 7

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Usp8

Ubiquitin specific protease 8

Ubpy

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Usp10

Ubiquitin specific protease 10

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Usp12-46

Ubiquitin-specific protease 12/46

Usp12

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Usp14

Ubiquitin specific protease 14

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Usp15-31

Ubiquitin specific protease 15/31

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Usp16-45

Ubiquitin specific protease 16/45

Usp45

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Usp20-33

Ubiquitin specific protease 20/33

Usp33

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Usp30

Ubiquitin specific protease 30

dUSP30

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Usp32

Ubiquitin specific protease 32

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

Usp47

Ubiquitin specific protease 47

Ubp64E, E(var)3-64E, Ubp64, D-UBP-64E

(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)

VANINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG32750

(FlyBase, 2017-, Logan-Garbisch et al., 2014)

CG32751

(FlyBase, 2017-, Logan-Garbisch et al., 2014)

vanin-like

(FlyBase, 2017-, Logan-Garbisch et al., 2014)

VIRAL TEGUMENT-LIKE DEUBIQUITINASES