FlyBase Gene Report: Hsap\HTT

General Information

Symbol

Hsap\HTT

Species

H. sapiens

Name

huntingtin

Annotation Symbol

Feature Type

engineered_foreign_gene

FlyBase ID

FBgn0025587

Gene Model Status

Not Applicable

Stock Availability

73 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

Htt, HD, hHTT, mHTT, HTTex1

Key Links

Foreign Gene Data

Foreign sequence; species == Homo sapiens; gene == HTT; HGNC:4851.

(FlyBase Curators, 1992-)

Function

Information on product gene function for non-D. melanogaster species is no longer provided by FlyBase.

Up-to-date information on gene product function can be found by searching UniProtKB for proteins or RNAcentral for non-coding RNAs.

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Sequence Ontology: Class of Gene

engineered_foreign_gene

Transcript Data

Annotated Transcripts

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Polypeptides with Identical Sequences

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Hsap\HTT using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Hsap\HTT in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Hsap\HTT

View exonic expression by tissue for Hsap\HTT

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 153 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Hsap\HTT

Transgenic constructs containing regulatory region of Hsap\HTT

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act.PU

lethal, with Scer\GAL4^elav-C155

lethal - all die before end of larval stage, with Scer\GAL4^da.G32

Hsap\HTT^90.Q120.UAS

lethal - all die before end of P-stage, with Scer\GAL4^da.G32

Hsap\HTT^108.Q120.UAS

lethal - all die before end of P-stage, with Scer\GAL4^elav-C155

Hsap\HTT^{Q138.UAS.mRFP1}

lethal - all die before end of pupal stage, with Scer\GAL4^elav-C155

Hsap\HTT^{Q138.UAS.mRFP1}

partially lethal, with Scer\GAL4^elav.PU

Hsap\HTT^Q93.ex1.UAS

partially lethal, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

partially lethal - majority die, with Scer\GAL4^elav.PU

Hsap\HTT^Q93.ex1.UAS

partially lethal - majority die, with Scer\GAL4^elav-C155

partially lethal - majority die, with Scer\GAL4^gcm.PU

Hsap\HTT^103Q.Ex1.UAS

partially lethal - majority die | heat sensitive, with Scer\GAL4^da.G32

viable, with Scer\GAL4^elav.PLu

viable, with Scer\GAL4^elav.PU

Hsap\HTT^{M8V.H82A.Q127.ex1p.UAS}

viable, with Scer\GAL4^elav-C155

viable, with Scer\GAL4^RapGAP1-OK6

Hsap\HTT^103Q.Ex1.UAS

viable, with Scer\GAL4^repo

Hsap\HTT^103Q.Ex1.UAS

Other Phenotypes

Allele

abnormal behavior, with Scer\GAL4^elav.PLu

Hsap\HTT^Q128.UAS

abnormal body size | adult stage, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

abnormal circadian behavior, with Scer\GAL4^repo

Hsap\HTT^103Q.Ex1.UAS

abnormal circadian rhythm | adult stage, with Scer\GAL4^P2.4.Pdf

abnormal courtship behavior, with Scer\GAL4^NP0021

Hsap\HTT^{Q72.ex1p.UAS.EGFP}

abnormal eye color, with Scer\GAL4^GMR.PF

abnormal eye color, with Scer\GAL4^GMR.PU

abnormal eye color | heat sensitive, with Scer\GAL4^GMR.PU

Hsap\HTT^{M8V.H82A.Q127.ex1p.UAS}

abnormal eye color | progressive, with Scer\GAL4^GMR.PU

Hsap\HTT^Q93.ex1.UAS

abnormal feeding behavior | adult stage, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

abnormal flight | conditional, with Scer\GAL4^C164

Hsap\HTT^128Q.FL.UAS

abnormal grooming behavior | adult stage, with Scer\GAL4^elav.PLu

Hsap\HTT^{Q138.UAS.mRFP1}

abnormal grooming behavior | adult stage | progressive, with Scer\GAL4^elav.PLu

Hsap\HTT^Q96.UAS.GFP

abnormal locomotor behavior, with Scer\GAL4^elav-C155

abnormal locomotor behavior, with Scer\GAL4^gcm.PU

Hsap\HTT^103Q.Ex1.UAS

abnormal locomotor behavior, with Scer\GAL4^repo

Hsap\HTT^Q93.ex1.UAS

abnormal locomotor behavior | adult stage, with Scer\GAL4^Appl.G1a

Hsap\HTT^128Q.FL.UAS

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PLu

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

abnormal locomotor behavior | adult stage, with Scer\GAL4^repo.PU

Hsap\HTT^Q93.ex1.UAS

abnormal locomotor behavior | adult stage, with Scer\GAL4^{repo.Switch.2301}

Hsap\HTT^Q128.UAS

abnormal locomotor behavior | adult stage, with Scer\GAL4^repo

Hsap\HTT^103Q.Ex1.UAS

abnormal locomotor behavior | adult stage | heat sensitive, with Scer\GAL4^elav.PU

Hsap\HTT^{M8V.H82A.Q127.ex1p.UAS}

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^elav.PLu

Hsap\HTT^Q96.UAS.GFP

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^elav.PU

Hsap\HTT^{128Q.1-336.UAS}

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^elav-C155

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^nrv2.PS

Hsap\HTT^{128Q.1-336.UAS}

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^nrv2.PU

Hsap\HTT^NT.128Q.UAS

abnormal locomotor behavior | conditional, with Scer\GAL4^C164

Hsap\HTT^128Q.FL.UAS

abnormal locomotor behavior | larval stage, with Scer\GAL4^elav-C155

Hsap\HTT^Q128.UAS

abnormal locomotor behavior | progressive, with Scer\GAL4^elav-C155

abnormal locomotor behavior | progressive, with Scer\GAL4^nSyb.PU

Hsap\HTT^{UAS.103Q.mCherry}

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^C164

Hsap\HTT^Q93.ex1.UAS

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

abnormal locomotor rhythm, with Scer\GAL4^109(2)80

Hsap\HTT^{152Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}

abnormal locomotor rhythm, with Scer\GAL4^Pdf.PU

Hsap\HTT^Q93.ex1.UAS

abnormal locomotor rhythm | adult stage, with Scer\GAL4^P2.4.Pdf

Hsap\HTT^Q128.UAS

abnormal memory | adult stage, with Scer\GAL4^elav.PU

Hsap\HTT^{128Q.1-208.UAS}

abnormal neuroanatomy

Hsap\HTT^GMR.Q120

abnormal neuroanatomy, with Hsap\HTT^Q20.ex1.UAS, Scer\GAL4^ninaE.PD

Hsap\HTT^Q93.ex1.UAS

abnormal neuroanatomy, with Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^ninaE.PD

Hsap\HTT^Q20.ex1.UAS

abnormal neuroanatomy, with Scer\GAL4^109(2)80

Hsap\HTT^{152Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}

abnormal neuroanatomy, with Scer\GAL4^elav.PU

Hsap\HTT^Q93.ex1.UAS

abnormal neuroanatomy, with Scer\GAL4^elav-C155

abnormal neuroanatomy, with Scer\GAL4^GMR.long

Hsap\HTT^103Q.Ex1.UAS

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

abnormal neuroanatomy, with Scer\GAL4^GMR.PU

Hsap\HTT^{128Q.1-336.UAS}

abnormal neuroanatomy, with Scer\GAL4^ninaE.PD

Hsap\HTT^Q93.ex1.UAS

abnormal neuroanatomy | adult stage, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR.PF

Hsap\HTT^Q128.UAS

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR.PU

abnormal neuroanatomy | adult stage, with Scer\GAL4^nSyb.PS

Hsap\HTT^128Q.FL.UAS

abnormal neuroanatomy | adult stage, with Scer\GAL4^P2.4.Pdf

abnormal neuroanatomy | adult stage, with Scer\GAL4^repo

Hsap\HTT^103Q.Ex1.UAS

abnormal neuroanatomy | adult stage | cell non-autonomous | progressive, with Scer\GAL4^Orco.PK

Hsap\HTT^{Q138.UAS.mRFP1}

abnormal neuroanatomy | adult stage | progressive

Hsap\HTT^GMR.Q120

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^elav.PLu

Hsap\HTT^Q128.UAS

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^GMR61G12

Hsap\HTT^{Q72.ex1.UAS.cWa}

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^GMR.PU

Hsap\HTT^Q93.ex1.UAS

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^Orco.PK

Hsap\HTT^{Q138.UAS.mRFP1}

abnormal neuroanatomy | chemical conditional, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

abnormal neuroanatomy | progressive

Hsap\HTT^GMR.Q120

abnormal neuroanatomy | progressive, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

abnormal neuroanatomy | progressive, with Scer\GAL4^GMR.PF

Hsap\HTT^Q93.ex1.UAS

abnormal neurophysiology, with Scer\GAL4^109(2)80

Hsap\HTT^{152Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}

abnormal neurophysiology, with Scer\GAL4^elav-C155

Hsap\HTT^128Q.FL.UAS

abnormal neurophysiology, with Scer\GAL4^GMR.PF

Hsap\HTT^Q128.UAS

abnormal neurophysiology | adult stage, with Scer\GAL4^repo.PU

Hsap\HTT^Q93.ex1.UAS

abnormal neurophysiology | heat sensitive

Hsap\HTT^Q128.hs

abnormal neurophysiology | progressive, with Scer\GAL4^GMR.PF

Hsap\HTT^Q93.ex1.UAS

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^elav-C155

abnormal oxidative stress response, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

abnormal phototaxis, with Scer\GAL4^GMR.PF

Hsap\HTT^Q93.ex1.UAS

abnormal sleep, with Scer\GAL4^elav.PU

abnormal visual behavior | adult stage | progressive, with Scer\GAL4^GMR.PU

Hsap\HTT^Q93.ex1.UAS

bang sensitive, with Scer\GAL4^repo.PU

Hsap\HTT^Q93.ex1.UAS

bang sensitive, with Scer\GAL4^repo

Hsap\HTT^Q93.ex1.UAS

bang sensitive | adult stage, with Scer\GAL4^repo.PU

Hsap\HTT^Q93.ex1.UAS

decreased cell number | adult stage, with Scer\GAL4^elav.PU

decreased cell number | adult stage, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

decreased cell number | adult stage, with Scer\GAL4^GMR.PU

Hsap\HTT^{145Q.UAS.Tag:MYC}

decreased cell number | adult stage, with Scer\GAL4^nSyb.PS

Hsap\HTT^128Q.FL.UAS

decreased cell number | adult stage, with Scer\GAL4^P2.4.Pdf

Hsap\HTT^Q128.UAS

decreased cell number | adult stage | progressive, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

decreased rate of adult locomotory behavior, with Scer\GAL4^repo

Hsap\HTT^{128Q.1-231.UAS}

decreased rate of adult locomotory behavior | progressive, with Scer\GAL4^elav-C155

Hsap\HTT^{128Q.1-231.UAS}

decreased rate of adult locomotory behavior | progressive, with Scer\GAL4^repo

Hsap\HTT^{128Q.1-231.UAS}

decreased rate of movement | adult stage, with Scer\GAL4^Eaat1.PR

Hsap\HTT^Q93.ex1.UAS

decreased rate of movement | adult stage, with Scer\GAL4^elav.PU

Hsap\HTT^{128Q.1-208.UAS}

increased cell death

Hsap\HTT^GMR.Q120

increased cell death, with Hsap\HTT^Q20.ex1.UAS, Scer\GAL4^ninaE.PD

Hsap\HTT^Q93.ex1.UAS

increased cell death, with Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^ninaE.PD

Hsap\HTT^Q20.ex1.UAS

increased cell death, with Scer\GAL4^179Y

Hsap\HTT^Q93.ex1.UAS

increased cell death, with Scer\GAL4^Appl.G1a

Hsap\HTT^Q93.ex1.UAS

increased cell death, with Scer\GAL4^elav.PU

Hsap\HTT^Q93.ex1.UAS

increased cell death, with Scer\GAL4^GMR.PF

Hsap\HTT^NT.128Q.UAS

increased cell death, with Scer\GAL4^ninaE.PD

Hsap\HTT^Q93.ex1.UAS

increased cell death | adult stage | cell non-autonomous | progressive, with Scer\GAL4^Orco.PK

Hsap\HTT^{Q138.UAS.mRFP1}

increased cell death | adult stage | progressive, with Scer\GAL4^Orco.PK

Hsap\HTT^{Q138.UAS.mRFP1}

increased cell death | larval stage, with Scer\GAL4^Appl.G1a

increased cell death | larval stage, with Scer\GAL4^GMR.PF

increased cell death | larval stage, with Scer\GAL4^rn-GAL4-5

Hsap\HTT^{96Q.UAS.Cerulean}

increased mortality, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

increased rate of movement, with Scer\GAL4^elav.PU

long lived | chemical conditional, with Scer\GAL4^elav-C155

Hsap\HTT^{Q138.UAS.mRFP1}

melanotic necrosis, with Hsap\HTT^{48Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}, Scer\GAL4^GMR.PF

Hsap\HTT^{152Q.Ex1.UAS.EGFP}

melanotic necrosis, with Hsap\HTT^{152Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}, Scer\GAL4^GMR.PF

Hsap\HTT^{152Q.Ex1.UAS.EGFP}

melanotic necrosis, with Hsap\HTT^{152Q.Ex1.UAS.EGFP}, Scer\GAL4^GMR.PF

melanotic necrosis, with Scer\GAL4^GMR.PF

short lived

Hsap\HTT^{Q46.ex1p.UAS.EGFP}

short lived, with Scer\GAL4^Appl.G1a

Hsap\HTT^128Q.FL.UAS

short lived, with Scer\GAL4^Appl.PU

short lived, with Scer\GAL4^C164

Hsap\HTT^128Q.FL.UAS

short lived, with Scer\GAL4^Eaat1.PR

Hsap\HTT^Q93.ex1.UAS

short lived, with Scer\GAL4^elav.PLu

short lived, with Scer\GAL4^elav.PU

short lived, with Scer\GAL4^elav-C155

short lived, with Scer\GAL4^gcm.PU

Hsap\HTT^103Q.Ex1.UAS

short lived, with Scer\GAL4^HCH.Hand

short lived, with Scer\GAL4^moody.PU

Hsap\HTT^{128Q.1-231.UAS}

short lived, with Scer\GAL4^nSyb.PS

Hsap\HTT^128Q.FL.UAS

short lived, with Scer\GAL4^nSyb.PU

Hsap\HTT^{UAS.103Q.mCherry}

short lived, with Scer\GAL4^RapGAP1-OK6

Hsap\HTT^103Q.Ex1.UAS

short lived, with Scer\GAL4^repo.PU

short lived, with Scer\GAL4^repo

short lived, with Scer\GAL4^Toll-6-D42

Hsap\HTT^{Q103.ex1p.UAS.EGFP}

short lived, with Scer\GAL4^unspecified

Hsap\HTT^Q128.UAS

short lived | calorie restriction conditional, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

short lived | heat sensitive, with Scer\GAL4^elav.PU

Hsap\HTT^{M8V.H82A.Q127.ex1p.UAS}

short lived | RU486 conditional, with Scer\GAL4^{repo.Switch.2301}

Hsap\HTT^Q128.UAS

some die during immature adult stage | recessive, with Scer\GAL4^elav-C155

Hsap\HTT^Q128.UAS

some die during pharate adult stage, with Scer\GAL4^elav-C155

some die during pupal stage, with Scer\GAL4^elav-C155

uncoordinated, with Scer\GAL4^109(2)80

Hsap\HTT^{152Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}

visible, with Scer\GAL4^GMR.PF

visible, with Scer\GAL4^GMR.PU

visible | adult stage, with Scer\GAL4^GMR.PF

Hsap\HTT^Q93.ex1.UAS

visible | adult stage, with Scer\GAL4^GMR.PU

visible | adult stage | progressive, with Scer\GAL4^GMR.PF

Hsap\HTT^Q93.ex1.UAS

visible | adult stage | progressive, with Scer\GAL4^GMR.PU

visible | dominant

visible | progressive, with Scer\GAL4^GMR.PF

Hsap\HTT^Q93.ex1.UAS

visible | progressive, with Scer\GAL4^GMR.PU

Hsap\HTT^Q93.ex1.UAS

wild-type

Hsap\HTT^GMR.Q2

Phenotype manifest in

Allele

adult antennal lobe, with Scer\GAL4^elav.PU

Hsap\HTT^Q93.ex1.UAS

adult cerebrum | cell non-autonomous | progressive, with Scer\GAL4^Orco.PK

Hsap\HTT^{Q138.UAS.mRFP1}

adult CNS glial cell, with Scer\GAL4^repo

Hsap\HTT^103Q.Ex1.UAS

adult heart, with Scer\GAL4^HCH.Hand

adult heart | RU486 conditional, with Scer\GAL4^{Hand.ΔVM.Switch}

adult heart muscle cell, with Scer\GAL4^HCH.Hand

adult median bundle, with Scer\GAL4^ey-OK107

Hsap\HTT^Q93.ex1.UAS

adult mushroom body, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

adult mushroom body, with Scer\GAL4^ey-OK107

Hsap\HTT^Q93.ex1.UAS

adult mushroom body alpha'-lobe, with Scer\GAL4^ey-OK107

Hsap\HTT^Q93.ex1.UAS

adult mushroom body beta'-lobe, with Scer\GAL4^ey-OK107

Hsap\HTT^Q93.ex1.UAS

adult mushroom body gamma-lobe, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

adult mushroom body gamma-lobe, with Scer\GAL4^ey-OK107

Hsap\HTT^Q93.ex1.UAS

adult neuromuscular junction | conditional, with Scer\GAL4^C164

Hsap\HTT^128Q.FL.UAS

adult optic lobe | cell non-autonomous | progressive, with Scer\GAL4^Orco.PK

Hsap\HTT^{Q138.UAS.mRFP1}

adult optic lobe neuron, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

adult ostium, with Scer\GAL4^HCH.Hand

adult s-LNv neuron, with Scer\GAL4^P2.4.Pdf

adult s-LNv neuron | adult stage

Hsap\HTT^Q128.UAS

adult s-LNv neuron | adult stage, with Scer\GAL4^GMR61G12

Hsap\HTT^{Q72.ex1.UAS.cWa}

axon, with Scer\GAL4^179Y

Hsap\HTT^Q93.ex1.UAS

axon, with Scer\GAL4^Appl.G1a

Hsap\HTT^Q93.ex1.UAS

axon, with Scer\GAL4^elav-C155

Hsap\HTT^{Q138.UAS.mRFP1}

axon | adult stage, with Scer\GAL4^GMR61G12

Hsap\HTT^{Q72.ex1.UAS.cWa}

axon | larval stage, with Scer\GAL4^Appl.G1a

Hsap\HTT^{Q138.UAS.mRFP1}

cardiac myofibril, with Scer\GAL4^HCH.Hand

dendrite, with Scer\GAL4^109(2)80

Hsap\HTT^{152Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}

dendrite | adult stage, with Scer\GAL4^GMR61G12

Hsap\HTT^{Q72.ex1.UAS.cWa}

dendrite | larval stage, with Scer\GAL4²²¹

Hsap\HTT^Q93.ex1.UAS

dendritic arborizing neuron, with Scer\GAL4^109(2)80

Hsap\HTT^{152Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}

dorsal longitudinal indirect flight muscle cell, with Scer\GAL4^repo.PU

Hsap\HTT^Q93.ex1.UAS

eye

Hsap\HTT^GMR.Q120

eye, with Hsap\HTT^{48Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}, Scer\GAL4^GMR.PF

Hsap\HTT^{152Q.Ex1.UAS.EGFP}

eye, with Hsap\HTT^{152Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}, Scer\GAL4^GMR.PF

Hsap\HTT^{152Q.Ex1.UAS.EGFP}

eye, with Hsap\HTT^{152Q.Ex1.UAS.EGFP}, Scer\GAL4^GMR.PF

eye, with Scer\GAL4^elav-C155

eye, with Scer\GAL4^GMR.long

Hsap\HTT^GMR.Q120

eye, with Scer\GAL4^GMR.PF

eye, with Scer\GAL4^GMR.PU

eye | adult stage, with Scer\GAL4^GMR.PU

eye | adult stage | progressive, with Scer\GAL4^GMR.PF

Hsap\HTT^Q93.ex1.UAS

eye | progressive

Hsap\HTT^GMR.Q120

eye | progressive, with Scer\GAL4^GMR.PF

Hsap\HTT^Q93.ex1.UAS

eye | progressive, with Scer\GAL4^GMR.PU

Hsap\HTT^Q93.ex1.UAS

eye | progressive | nutrition conditional, with Scer\GAL4^GMR.PU

Hsap\HTT^Q93.ex1.UAS

eye disc, with Scer\GAL4^GMR.PF

eye disc | larval stage, with Scer\GAL4^GMR.PU

Hsap\HTT^Q93.ex1.UAS

eye photoreceptor cell

Hsap\HTT^GMR.Q120

eye photoreceptor cell, with Scer\GAL4^elav.PU

Hsap\HTT^Q93.ex1.UAS

eye photoreceptor cell, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

eye photoreceptor cell, with Scer\GAL4^GMR.long

eye photoreceptor cell, with Scer\GAL4^GMR.PF

Hsap\HTT^Q128.UAS

eye photoreceptor cell, with Scer\GAL4^ninaE.PU

Hsap\HTT^{UAS.103Q.mCherry}

eye photoreceptor cell | adult stage, with Scer\GAL4^GMR.PU

Hsap\HTT^{128Q.1-336.UAS}

eye photoreceptor cell | adult stage | decreased number, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

eye photoreceptor cell | adult stage | decreased number, with Scer\GAL4^GMR.PU

Hsap\HTT^{145Q.UAS.Tag:MYC}

eye photoreceptor cell | adult stage | decreased number, with Scer\GAL4^nSyb.PS

Hsap\HTT^128Q.FL.UAS

eye photoreceptor cell | adult stage | progressive, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

eye photoreceptor cell | progressive

Hsap\HTT^GMR.Q120

fat body | larval stage, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

giant fiber neuron, with Scer\GAL4^repo.PU

Hsap\HTT^Q93.ex1.UAS

gnathal ganglion, with Scer\GAL4^ey-OK107

Hsap\HTT^Q93.ex1.UAS

imaginal disc

Hsap\HTT^{96Q.UAS.Cerulean}

indirect flight muscle motor neuron | conditional, with Scer\GAL4^C164

Hsap\HTT^128Q.FL.UAS

interommatidial bristle, with Scer\GAL4^GMR.PF

Hsap\HTT^Q128.UAS

interommatidial bristle, with Scer\GAL4^GMR.PU

Hsap\HTT^{128Q.1-336.UAS}

Kenyon cell, with Scer\GAL4^ey-OK107

Hsap\HTT^Q93.ex1.UAS

lamellar body, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

lamina, with Scer\GAL4^repo

Hsap\HTT^103Q.Ex1.UAS

larval dorsal multidendritic neuron ddaE | larval stage, with Scer\GAL4²²¹

Hsap\HTT^Q93.ex1.UAS

larval segmental nerve, with Scer\GAL4^Appl.G1a

microtubule | larval stage, with Scer\GAL4²²¹

Hsap\HTT^Q93.ex1.UAS

mitochondrion, with Scer\GAL4^elav.PU

Hsap\HTT^Q93.ex1.UAS

mitochondrion, with Scer\GAL4^HCH.Hand

Hsap\HTT^{Q46.ex1p.UAS.EGFP}

mitochondrion | larval stage, with Scer\GAL4^Appl.G1a

multivesicular body, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

neuromere, with Scer\GAL4^elav-C155

Hsap\HTT^{Q138.UAS.mRFP1}

neuron, with Scer\GAL4^elav-C155

Hsap\HTT^{Q138.UAS.mRFP1}

NMJ bouton, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

olfactory receptor neuron | adult stage, with Scer\GAL4^Orco.PK

Hsap\HTT^{Q138.UAS.mRFP1}

ommatidium

ommatidium, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

ommatidium, with Scer\GAL4^GMR.long

Hsap\HTT^GMR.Q120

ommatidium, with Scer\GAL4^GMR.PF

ommatidium, with Scer\GAL4^GMR.PU

ommatidium | adult stage, with Scer\GAL4^GMR.PF

Hsap\HTT^128Q.FL.UAS

ommatidium | adult stage, with Scer\GAL4^GMR.PU

Hsap\HTT^{145Q.UAS.Tag:MYC}

photoreceptor, with Scer\GAL4^elav-C155

photoreceptor, with Scer\GAL4^GMR.PU

Hsap\HTT^Q97.ex1.UAS

photoreceptor | adult stage, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

photoreceptor neuron

Hsap\HTT^GMR.Q120

photoreceptor neuron, with Hsap\HTT^Q20.ex1.UAS, Scer\GAL4^ninaE.PD

Hsap\HTT^Q93.ex1.UAS

photoreceptor neuron, with Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^ninaE.PD

Hsap\HTT^Q20.ex1.UAS

photoreceptor neuron, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

photoreceptor neuron, with Scer\GAL4^GMR.PF

Hsap\HTT^Q93.ex1.UAS

photoreceptor neuron, with Scer\GAL4^ninaE.PD

Hsap\HTT^Q93.ex1.UAS

photoreceptor neuron | adult stage, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

photoreceptor neuron | adult stage, with Scer\GAL4^repo

Hsap\HTT^103Q.Ex1.UAS

photoreceptor neuron | adult stage | progressive, with Scer\GAL4^GMR.PU

Hsap\HTT^NT.128Q.UAS

pigment cell, with Hsap\HTT^{48Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}, Scer\GAL4^GMR.PF

Hsap\HTT^{152Q.Ex1.UAS.EGFP}

pigment cell, with Hsap\HTT^{152Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}, Scer\GAL4^GMR.PF

Hsap\HTT^{152Q.Ex1.UAS.EGFP}

pigment cell, with Hsap\HTT^{152Q.Ex1.UAS.EGFP}, Scer\GAL4^GMR.PF

pigment cell, with Scer\GAL4^GMR.PF

pigment granule, with Scer\GAL4^GMR.PF

Hsap\HTT^Q93.ex1.UAS

retina

Hsap\HTT^GMR.Q120

retina, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

retina, with Scer\GAL4^GMR.PF

Hsap\HTT^NT.128Q.UAS

retina, with Scer\GAL4^GMR.PU

Hsap\HTT^{128Q.1-336.UAS}

retina, with Scer\GAL4^repo

Hsap\HTT^103Q.Ex1.UAS

retina | adult stage | progressive, with Scer\GAL4^GMR.PU

retina | progressive

Hsap\HTT^GMR.Q120

rhabdomere

rhabdomere, with Hsap\HTT^Q20.ex1.UAS, Scer\GAL4^ninaE.PD

Hsap\HTT^Q93.ex1.UAS

rhabdomere, with Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^ninaE.PD

Hsap\HTT^Q20.ex1.UAS

rhabdomere, with Scer\GAL4^elav.PU

Hsap\HTT^Q93.ex1.UAS

rhabdomere, with Scer\GAL4^elav-C155

rhabdomere, with Scer\GAL4^GMR.PF

Hsap\HTT^Q93.ex1.UAS

rhabdomere, with Scer\GAL4^GMR.PU

Hsap\HTT^Q93.ex1.UAS

rhabdomere, with Scer\GAL4^ninaE.PD

Hsap\HTT^Q93.ex1.UAS

rhabdomere | adult stage

Hsap\HTT^GMR.Q120

rhabdomere | adult stage, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

rhabdomere | adult stage, with Scer\GAL4^GMR.PF

Hsap\HTT^Q128.UAS

rhabdomere | conditional

Hsap\HTT^GMR.Q120

rhabdomere | decreased number, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

rhabdomere | progressive

Hsap\HTT^GMR.Q120

rhabdomere | progressive, with Scer\GAL4^elav.PLu

Hsap\HTT^Q128.UAS

rhabdomere | progressive, with Scer\GAL4^elav.PU

Hsap\HTT^Q93.ex1.UAS

rhabdomere | progressive, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

rhabdomere | progressive, with Scer\GAL4^GMR.PF

Hsap\HTT^GMR.Q120

rhabdomere | progressive, with Scer\GAL4^GMR.PU

Hsap\HTT^Q93.ex1.UAS

rhabdomere | progressive | nutrition conditional, with Scer\GAL4^GMR.PU

Hsap\HTT^Q93.ex1.UAS

rhabdomere of eye photoreceptor cell

Hsap\HTT^GMR.Q120

rhabdomere of eye photoreceptor cell, with Scer\GAL4^elav.PU

rhabdomere of eye photoreceptor cell | adult stage | conditional, with Scer\GAL4^GMR.PF

Hsap\HTT^128Q.FL.UAS

rhabdomere of eye photoreceptor cell | adult stage | progressive, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

rhabdomere of eye photoreceptor cell | adult stage | progressive, with Scer\GAL4^GMR.PU

Hsap\HTT^{72Q.UAS.Emerald}

rhabdomere of eye photoreceptor cell | progressive

Hsap\HTT^GMR.Q120

synaptic vesicle, with Scer\GAL4^elav-C155

Hsap\HTT^Q93.ex1.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (1)

htt

11 of 14

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Hsap\HTT. Refer to their site for version information.

Human Disease Associations

FlyBase Human Disease Model Reports

Huntington disease

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 70 )

Allele

Disease

Evidence

References

Hsap\HTT^{Q25.ex1p.UAS.EGFP}

model of Huntington's disease

CEA

(White et al., 2020)

Hsap\HTT^{Q46.ex1p.UAS.EGFP}

model of amyloidosis

CEA

(Melkani et al., 2013)

model of cardiomyopathy

CEA

(Melkani et al., 2013)

model of Huntington's disease

CEA

(Kim et al., 2017, Jimenez-Sanchez et al., 2015)

Hsap\HTT^{Q72.ex1p.UAS.EGFP}

model of amyloidosis

CEA

(Melkani et al., 2013)

model of cardiomyopathy

CEA

(Melkani et al., 2013)

model of Huntington's disease

CEA

(Swinter et al., 2023, Xu et al., 2019, Kim et al., 2017)

CEC

(Xiao and Qiu, 2019)

Hsap\HTT^Q0.UAS

DOES NOT model Huntington's disease

CEA

(Lee et al., 2004)

model of Huntington's disease

CEA

(Nitta et al., 2023)

Hsap\HTT^{Q103.ex1p.UAS.EGFP}

model of amyloidosis

CEA

(Melkani et al., 2013)

model of cardiomyopathy

CEA

(Melkani et al., 2013)

model of Huntington's disease

CEA

(Swinter et al., 2023, Xu et al., 2019, Kim et al., 2017)

Hsap\HTT^{152Q.Ex1.UAS.EGFP}

model of Huntington's disease

CEA with Hsap\HTT^{48Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}

(Doumanis et al., 2009)

Hsap\HTT^{48Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}

model of Huntington's disease

CEA with Hsap\HTT^{152Q.Ex1.UAS.EGFP}

(Doumanis et al., 2009)

Hsap\HTT^{Q15.UAS.mRFP1}

DOES NOT model Huntington's disease

CEA

(Weiss and Littleton, 2016)

model of Huntington's disease

CEA

(White et al., 2020)

Hsap\HTT^{Q138.UAS.mRFP1}

model of Huntington's disease

CEA

(Swinter et al., 2023, Huelsmeier et al., 2021, Tandon and Sarkar, 2021, Joag et al., 2020, Hansen et al., 2019, Raj and Sarkar, 2019, Zhu et al., 2019, Akbergenova and Littleton, 2017, Krench et al., 2016, Weiss and Littleton, 2016, Babcock and Ganetzky, 2015, Weiss et al., 2012)

Hsap\HTT^{Q138.UAS.EGFP,mRFP1}

model of Huntington's disease

CEA

(Singh et al., 2014)

Hsap\HTT^Q96.UAS.GFP

model of Huntington's disease

CEA

(Xie et al., 2021)

Hsap\HTT^{98Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}

model of Huntington's disease

CEA

(Doumanis et al., 2009)

Hsap\HTT^103Q.Ex1.UAS

model of Huntington's disease

CEA

(Shiraishi et al., 2014, Tamura et al., 2011)

Hsap\HTT^586.Q120.UAS

model of Huntington's disease

CEA

(Barbaro et al., 2015)

Hsap\HTT^552.Q120.UAS

model of Huntington's disease

CEA

(Barbaro et al., 2015)

Hsap\HTT^536.Q120.UAS

model of Huntington's disease

CEA

(Barbaro et al., 2015)

Hsap\HTT^513.Q120.UAS

model of Huntington's disease

CEA

(Barbaro et al., 2015)

Hsap\HTT^469.Q120.UAS

model of Huntington's disease

CEA

(Daldin et al., 2017, Barbaro et al., 2015)

Hsap\HTT^108.Q120.UAS

model of Huntington's disease

CEA

(Barbaro et al., 2015)

Hsap\HTT^90.Q120.UAS

model of Huntington's disease

CEA

(Farkas et al., 2023, Faragó et al., 2022, Chatterjee et al., 2021, Faragó et al., 2019, Barbaro et al., 2015)

Hsap\HTT^Q48.ex1p.UAS

model of Huntington's disease

CEA

(Iijima-Ando et al., 2005)

Hsap\HTT^{171aa.138Q.UAS.Tag:HA}

model of Huntington's disease

CEA

(Arribat et al., 2013, Mugat et al., 2008)

Hsap\HTT^{UAS.103Q.mCherry}

model of Huntington's disease

CEA

(Poças et al., 2015)

model of neurodegenerative disease

CEA with Hsap\SNCA^UAS.EGFP

(Poças et al., 2015)

Hsap\HTT^{25Q.UAS.Cerulean}

model of Huntington's disease

CEA

(Recasens-Alvarez et al., 2021)

Hsap\HTT^{96Q.UAS.Cerulean}

model of Huntington's disease

CEA

(Recasens-Alvarez et al., 2021)

Hsap\HTT^200Q.UAS

model of Huntington's disease

CEA

(Onur et al., 2021, Yao et al., 2015)

Hsap\HTT^Q25.FL.UAS

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^{Q25.S13A.S16A.FL.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^{Q25.S13D.S16D.FL.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^{Q120.S13A.S16A.FL.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^{Q120.S13D.S16D.FL.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^Q25.ex1.UAS

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^{Q25.S13A.S16A.ex1.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^{Q25.S13D.S16D.ex1.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^{Q120.S13A.S16A.ex1.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^{Q120.S13D.S16D.ex1.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^118.Q120.UAS

model of Huntington's disease

CEA

(Chongtham et al., 2020)

Hsap\HTT^{171.Q120.UAS.Tag:HA}

model of Huntington's disease

CEA

(Chongtham et al., 2020)

Hsap\HTT^{171.Q120.UAS.Tag:CALI(TC)}

model of Huntington's disease

CEA

(Chongtham et al., 2020)

Hsap\HTT^{Q97.ex1.UAS.cAa}

model of Huntington's disease

CEA

(Ast et al., 2018)

Hsap\HTT^{Q100.UAS.mRFP(Unk)}

model of Huntington's disease

CEA

(Bason et al., 2019)

Hsap\HTT^GMR.Q75

model of Huntington's disease

CEA

(Jackson et al., 1998)

Hsap\HTT^GMR.Q120

model of Huntington's disease

CEA

(Jimenez-Sanchez et al., 2015, Tamura et al., 2011, Underwood et al., 2010, Winslow et al., 2010, Wang et al., 2009, Ravikumar et al., 2008, Qi et al., 2007, Rusten et al., 2007, Hoshino et al., 2006, Jackson et al., 1998)

model of neurodegenerative disease

CEA

(Chan et al., 2000)

Hsap\HTT^Q93.ex1.UAS

model of Huntington's disease

CEA

(Aditi et al., 2022, Dhankhar et al., 2022, Nandi et al., 2022, Xu et al., 2022, Khyati et al., 2021, Singh and Agrawal, 2021, Delfino et al., 2020, Raj and Sarkar, 2019, Aron et al., 2018, Calpena et al., 2018, Dubey and Tapadia, 2018, Song et al., 2018, Zhang et al., 2018, Singh et al., 2017, Aditi et al., 2016, Breda et al., 2016, Chongtham and Agrawal, 2016, Ruetenik et al., 2016, Vicente Miranda et al., 2016, Besson et al., 2015, Varadarajan et al., 2015, Kumar et al., 2014, Maheshwari et al., 2014, Smith et al., 2014, O'Rourke et al., 2013, Xiao et al., 2013, Dupont et al., 2012, Steinert et al., 2012, Campesan et al., 2011, Maher et al., 2011, Sleiman et al., 2011, Besson et al., 2010, Luthi-Carter et al., 2010, Menzies et al., 2010, Zhang et al., 2009, McLear et al., 2008, Mugat et al., 2008, Slepko et al., 2006, Agrawal et al., 2005, Lievens et al., 2005, Wolfgang et al., 2005, Steffan et al., 2001)

model of neurodegenerative disease

CEA

(Richards et al., 2011, Mallik and Lakhotia, 2009, Liévens et al., 2008, Pallos et al., 2008, Wolfgang et al., 2005, Gunawardena et al., 2003, Steffan et al., 2001)

Hsap\HTT^Q128.UAS

model of Huntington's disease

CEA

(Dubey et al., 2024, Nitta et al., 2023, Martin et al., 2021, Xu et al., 2019, Coelho et al., 2018, Akbergenova and Littleton, 2017, Gregory et al., 2017, Prakash et al., 2017, Arribat et al., 2013, Gohil et al., 2011, Rana et al., 2010, Ryoo et al., 2007, Lee et al., 2004)

Hsap\HTT^Q97.ex1.UAS

model of Huntington's disease

CEA

(Huelsmeier et al., 2021, Steffan et al., 2004)

Hsap\HTT^NT.128Q.UAS

model of Huntington's disease

CEA

(Yao et al., 2015, Lu et al., 2013, Miller et al., 2012, Zhang et al., 2012, Al-Ramahi et al., 2007, Al-Ramahi et al., 2006)

Hsap\HTT^{Q108.ex1p.UAS}

model of Huntington's disease

CEA

(Iijima-Ando et al., 2005)

Hsap\HTT^128Q.FL.UAS

model of neurodegenerative disease

CEA

(Burr et al., 2014)

model of Huntington's disease

CEA

(Swinter et al., 2023, Bolshakova et al., 2022, Casale et al., 2022, Xu et al., 2022, Migazzi et al., 2021, Beaver et al., 2020, Hope et al., 2020, White et al., 2020, Di Cristo et al., 2019, Tuxworth et al., 2019, Yeh et al., 2018, Billes et al., 2016, Steinert et al., 2012, Wu et al., 2011, Gonzales and Yin, 2010, Romero et al., 2008)

Hsap\HTT^{128Q.1-208.UAS}

model of Huntington's disease

CEA

(Gonzales et al., 2016, Gonzales and Yin, 2010)

Hsap\HTT^{128Q.1-336.UAS}

model of Huntington's disease

CEA

(Stroedicke et al., 2015, Shirasaki et al., 2012, Kaltenbach et al., 2007)

Hsap\HTT^{Q25.ex1.UAS.GFP}

model of Huntington's disease

CEA with Hsap\HTT^{Q91.ex1.QUAS.mCherry}

(Donnelly et al., 2020)

Hsap\HTT^{Q91.ex1.QUAS.mCherry}

model of Huntington's disease

CEA

(Pearce et al., 2015)

CEA with Hsap\HTT^{Q25.ex1.UAS.GFP}

(Donnelly et al., 2020)

CEA with Hsap\HTT^{Q138.ex1-12.QUAS.mRFP1}

(Donnelly et al., 2020)

Hsap\HTT^{Q91.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Donnelly et al., 2020)

Hsap\HTT^Q120.FL.UAS

model of Huntington's disease

CEA

(Chatterjee et al., 2021, Chongtham et al., 2020)

Hsap\HTT^Q120.ex1.UAS

model of Huntington's disease

CEA

(Chongtham et al., 2020)

Hsap\HTT^{Q138.ex1-12.QUAS.mRFP1}

model of Huntington's disease

CEA

(Donnelly et al., 2020)

CEA with Hsap\HTT^{Q91.ex1.QUAS.mCherry}

(Donnelly et al., 2020)

Hsap\HTT^{Q97.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.T3D.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S13D.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S16D.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.T3A.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S13A.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S16A.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Branco-Santos et al., 2017)

Hsap\HTT^{Q72.ex1.UAS.cWa}

model of Huntington's disease

CEA

(Wen et al., 2020)

Hsap\HTT^{128Q.1-231.UAS}

model of Huntington's disease

CEA

(Hernandez et al., 2023, Reyes-Ortiz et al., 2023, Onur et al., 2021)

Hsap\HTT^{145Q.UAS.Tag:MYC}

model of Huntington's disease

CEA

(Xu et al., 2022)

Hsap\HTT^{Q46.ex1.UAS.IVS.EGFP}

model of Huntington's disease

CEA

(Drombosky et al., 2018)

Hsap\HTT^{Q97.ex1.UAS.IVS.EGFP}

model of Huntington's disease

CEA

(Drombosky et al., 2018)

Hsap\HTT^{ex1.βHP.UAS.IVS.mCh}

model of Huntington's disease

CEA

(Drombosky et al., 2018)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 42 )

Allele

Disease

Interaction

References

Hsap\HTT^{Q46.ex1p.UAS.EGFP}

model of Huntington's disease

is ameliorated by CalpA^KK104532

(Menzies et al., 2015)

is ameliorated by CalpA^NIG.7563R

(Menzies et al., 2015)

is ameliorated by CalpA^NIG.18152R

(Menzies et al., 2015)

Hsap\HTT^{Q72.ex1p.UAS.EGFP}

model of amyloidosis

is ameliorated by unc-45^+t

(Melkani et al., 2013)

model of cardiomyopathy

is ameliorated by unc-45^+t

(Melkani et al., 2013)

model of Huntington's disease

is ameliorated by EDTP^GL01215

(Xiao and Qiu, 2019)

is ameliorated by EDTP^HMS01577

(Xiao and Qiu, 2019)

is ameliorated by Fmr1^GL00075

(Xu et al., 2019)

is ameliorated by Fmr1^HMS00248

(Xu et al., 2019)

Hsap\HTT^Q0.UAS

ameliorates neurodegenerative disease

modeled by htt^RNAi.UAS

(Mugat et al., 2008)

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Mugat et al., 2008)

modeled by Hsap\HTT^{171aa.138Q.UAS.Tag:HA}

(Mugat et al., 2008)

Hsap\HTT^Q20.ex1.UAS

exacerbates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Slepko et al., 2006)

Hsap\HTT^{Q103.ex1p.UAS.EGFP}

model of Huntington's disease

is ameliorated by Fmr1^GL00075

(Xu et al., 2019)

is ameliorated by Fmr1^HMS00248

(Xu et al., 2019)

is ameliorated by EDTP^HMS01577

(Xiao et al., 2019)

Hsap\HTT^{Q15.UAS.mRFP1}

model of Huntington's disease

is exacerbated by Hip1^MI05905

(White et al., 2020)

Hsap\HTT^{Q138.UAS.mRFP1}

model of Huntington's disease

is ameliorated by orb2^UAS.A.EGFP

(Joag et al., 2020)

is ameliorated by orb2^UAS.B.EGFP

(Joag et al., 2020)

is exacerbated by orb2^RNAi.UAS.cUa

(Joag et al., 2020)

is ameliorated by Rab7^T22N.UAS

(Akbergenova and Littleton, 2017)

is ameliorated by Snx16^Δ1

(Akbergenova and Littleton, 2017)

is ameliorated by Snx16^Δ2

(Akbergenova and Littleton, 2017)

is ameliorated by gbb¹

(Akbergenova and Littleton, 2017)

is ameliorated by gbb²

(Akbergenova and Littleton, 2017)

is ameliorated by InR^UAS.Exel

(Tandon and Sarkar, 2021, Raj and Sarkar, 2019)

is ameliorated by Pi3K92E^CAAX.UAS

(Hansen et al., 2019)

is exacerbated by Pi3K92E^{D954A.UAS.Tag:MYC}

(Hansen et al., 2019)

is ameliorated by Nmnat^UAS.cZa

(Zhu et al., 2019)

is exacerbated by Nmnat^unspecified

(Zhu et al., 2019)

is ameliorated by Atx2^{KI.ΔcIDR-GFP}

(Huelsmeier et al., 2021)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Swinter et al., 2023)

is ameliorated by Lkb1^4A4-2

(Schulte et al., 2011)

Hsap\HTT^{Q138.UAS.EGFP,mRFP1}

model of Huntington's disease

is ameliorated by Myc^UAS.cZa

(Singh et al., 2014)

Hsap\HTT^Q96.UAS.GFP

model of Huntington's disease

is ameliorated by Rack1^KK109073

(Xie et al., 2021)

Hsap\HTT^{98Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}

model of Huntington's disease

is ameliorated by Nup160^GD11413

(Doumanis et al., 2009)

is ameliorated by kri^GD11686

(Doumanis et al., 2009)

Hsap\HTT^103Q.Ex1.UAS

model of Huntington's disease

is ameliorated by Irbp^KK101447

(Tamura et al., 2011)

model of neurodegenerative disease

is ameliorated by TER94^GS10258

(Fujita et al., 2013)

Hsap\HTT^90.Q120.UAS

model of Huntington's disease

is ameliorated by His3.3A^{K14Q.UAS.Tag:FLAG}

(Faragó et al., 2022)

is exacerbated by His3.3A^{K14R.UAS.Tag:FLAG}

(Faragó et al., 2022)

is exacerbated by His3.3A^{K27Q.UAS.Tag:FLAG}

(Faragó et al., 2022)

is exacerbated by His3.3A^{K27R.UAS.Tag:FLAG}

(Faragó et al., 2022)

is ameliorated by His3.3A^{K9M.UAS.Tag:FLAG}

(Faragó et al., 2022)

is exacerbated by His3.3A^{K9Q.UAS.Tag:FLAG}

(Faragó et al., 2022)

is exacerbated by His3.3A^{K9R.UAS.Tag:FLAG}

(Faragó et al., 2022)

is ameliorated by Yod1^UAS.Tag:FLAG

(Farkas et al., 2023)

is ameliorated by Hat1^Δ57

(Varga et al., 2019)

Hsap\HTT^Q48.ex1p.UAS

model of Huntington's disease

is ameliorated by Hsc70-4^K71S.UAS

(Iijima-Ando et al., 2005)

is ameliorated by Mmus\Prkaca^hs.PJ

(Iijima-Ando et al., 2005)

is exacerbated by CrebB^S162

(Iijima-Ando et al., 2005)

Hsap\HTT^{171aa.138Q.UAS.Tag:HA}

model of Huntington's disease

is ameliorated by en^UAS.cTa

(Mugat et al., 2008)

is ameliorated by en^VP16.UAS

(Mugat et al., 2008)

is exacerbated by htt^RNAi.UAS

(Mugat et al., 2008)

is ameliorated by ttk⁸⁰⁴

(Mugat et al., 2008)

is ameliorated by htt^{620aa.UAS.Tag:MYC}

(Mugat et al., 2008)

is ameliorated by Hsap\HTT^Q0.UAS

(Mugat et al., 2008)

is ameliorated by Hsap\HTT^P42.UAS.GFP

(Arribat et al., 2013)

Hsap\HTT^{72Q.UAS.Emerald}

model of neurodegenerative disease

is exacerbated by Tom40^GD5210

(Liu et al., 2018)

Hsap\HTT^200Q.UAS

model of Huntington's disease

is ameliorated by DopEcR^KK111211

(Yao et al., 2015)

Hsap\HTT^171.Q120.UAS

ameliorates Huntington's disease

modeled by Hsap\HTT^Q120.FL.UAS

(Chongtham et al., 2020)

Hsap\HTT^{Q97.ex1.UAS.cAa}

model of Huntington's disease

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Ast et al., 2018)

Hsap\HTT^{Q100.UAS.mRFP(Unk)}

model of Huntington's disease

is ameliorated by Hsap\DNAJB6^UAS.Tag:V5

(Bason et al., 2019)

is ameliorated by Hsap\DNAJB6^{lexAop.Tag:V5}

(Bason et al., 2019)

Hsap\HTT^GMR.Q120

model of Huntington's disease

is exacerbated by Rab5^UAS.EGFP

(Ravikumar et al., 2008)

is exacerbated by Hsap\SNCA^UAS.cFa

(Winslow et al., 2010)

is ameliorated by Hsap\YAP1^ΔC61.UAS

(Hoshino et al., 2006)

is exacerbated by Vps25^A3

(Rusten et al., 2007)

is exacerbated by Vps28^D2

(Rusten et al., 2007)

is exacerbated by shrb^G5

(Rusten et al., 2007)

is ameliorated by Irbp^KK101447

(Tamura et al., 2011)

is ameliorated by Atg1^{ninaE.Tag:MYC}

(Wang et al., 2009)

is ameliorated by Tsc1^UAS.cGa

(Wang et al., 2009)

is ameliorated by Atg1^{W.Scer\UAS.T:Hsap\MYC}

(Wang et al., 2009)

is ameliorated by gig^UAS.cTa

(Wang et al., 2009)

is ameliorated by QC^KK109667

(Jimenez-Sanchez et al., 2015)

is ameliorated by QC^GD6767

(Jimenez-Sanchez et al., 2015)

is ameliorated by isoQC^KK108983

(Jimenez-Sanchez et al., 2015)

is ameliorated by Hsap\HTT^GMR.Q120

(Takeuchi et al., 2015)

is ameliorated by DnaJ-1^UAS.cTa

(Takeuchi et al., 2015)

is exacerbated by Rnor\Hmgb1^UAS.cQa

(Qi et al., 2007)

is ameliorated by p53^5A-1-4

(Bae et al., 2005)

is exacerbated by Psa^NIG.1009R

(Menzies et al., 2010)

is ameliorated by Psa^GMR.Ex.PK

(Menzies et al., 2010)

is ameliorated by CalpA^KK104532

(Menzies et al., 2015)

is ameliorated by Hsap\ATXN3^{fl.Q27.UAS.Tag:MYC}

(Warrick et al., 2005)

is ameliorated by DnaJ-1^UAS.cKb

(Kuo et al., 2013)

model of neurodegenerative disease

is ameliorated by DnaJ-1^UAS.Tag:FLAG

(Chan et al., 2000)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Chan et al., 2000)

is ameliorated by Rpn11^UAS.cTa

(Tonoki et al., 2009)

is exacerbated by Rpn11^RNAi.UAS

(Tonoki et al., 2009)

is exacerbated by Trpml¹

(Venkatachalam et al., 2008)

ameliorates Huntington's disease

modeled by Hsap\HTT^GMR.Q120

(Takeuchi et al., 2015)

Hsap\HTT^Q93.ex1.UAS

model of Huntington's disease

is ameliorated by Sirt2^5B-2-35

(Luthi-Carter et al., 2010)

is ameliorated by Wnt2^O

(Dupont et al., 2012)

is exacerbated by sgg^UAS.cBa

(Dupont et al., 2012)

is exacerbated by sgg^S9A.UAS

(Dupont et al., 2012)

is ameliorated by arm³

(Dupont et al., 2012)

is ameliorated by arm^G0192

(Dupont et al., 2012)

is exacerbated by arm^{S10.UAS.Tag:MYC}

(Dupont et al., 2012)

is ameliorated by wg¹

(Dupont et al., 2012)

is ameliorated by wg^Sp-1

(Dupont et al., 2012)

is ameliorated by sgg^Y214F.UAS

(Dupont et al., 2012)

is ameliorated by Wnt2^I

(Dupont et al., 2012)

is ameliorated by Wnt2^RJ

(Dupont et al., 2012)

is ameliorated by pan³

(Dupont et al., 2012)

is ameliorated by pan²

(Dupont et al., 2012)

is ameliorated by Apc2^UAS.cUa

(Dupont et al., 2012)

is ameliorated by Axn^UAS.cUa

(Dupont et al., 2012)

is ameliorated by Zw^UAS.cLa

(Besson et al., 2015)

is ameliorated by Pfk^UAS.cTa

(Besson et al., 2015)

is ameliorated by Hsap\SLC2A3^UAS.cBa

(Besson et al., 2015)

is ameliorated by jp^UAS

(Calpena et al., 2018)

is exacerbated by jp^KK107921

(Calpena et al., 2018)

is ameliorated by Sirt1¹⁷

(Smith et al., 2014)

is exacerbated by Sirt1¹⁷

(Smith et al., 2014)

is ameliorated by htt^81aa.UAS

(Mugat et al., 2008)

is ameliorated by Hsap\HTT^Q0.UAS

(Mugat et al., 2008)

is ameliorated by cd¹

(Campesan et al., 2011)

is ameliorated by cn³

(Campesan et al., 2011)

is ameliorated by cn^KK101938

(Campesan et al., 2011)

is ameliorated by v^KK108195

(Campesan et al., 2011)

is ameliorated by v^36f

(Campesan et al., 2011)

is exacerbated by htt^98E2

(Zhang et al., 2009)

is exacerbated by Hsap\HTT^Q20.ex1.UAS

(Slepko et al., 2006)

is ameliorated by Hsap\HTT^{C4sFv.UAS.Tag:HA}

(Wolfgang et al., 2005)

is ameliorated by Zzzz\scFv^{C4.UAS.Tag:HA}

(McLear et al., 2008, Wolfgang et al., 2005)

is ameliorated by Bmcp^UAS.cBa

(Besson et al., 2010)

is ameliorated by Hsap\UCP2^UAS.cFa

(Besson et al., 2010)

is ameliorated by Glut1^UAS.cBa

(Besson et al., 2010)

is ameliorated by Ctr1B^NIG.7459R

(Xiao et al., 2013)

is ameliorated by ATP7^EY07895

(Xiao et al., 2013, Cao et al., 2008)

is exacerbated by ATP7^GD3322

(Xiao et al., 2013)

is ameliorated by Rab11^UAS.EGFP

(Steinert et al., 2012)

is ameliorated by Psa^UAS.cSa

(Menzies et al., 2010)

is exacerbated by Psa^NIG.1009R

(Menzies et al., 2010)

is ameliorated by mav^GL01025

(Varadarajan et al., 2015)

is exacerbated by Hsf^GD16368

(Maheshwari et al., 2014)

is ameliorated by Hsap\KYAT1^{IVS.10xUAS.GFP}

(Breda et al., 2016)

is exacerbated by v^36f

(Breda et al., 2016)

is ameliorated by InR^UAS.Exel

(Raj and Sarkar, 2019)

is ameliorated by Rab8^{Q67L.UASp.YFP}

(Delfino et al., 2020)

is exacerbated by Rab8^{T22N.UASp.YFP}

(Delfino et al., 2020)

is ameliorated by Rab8^UASp.YFP

(Delfino et al., 2020)

is exacerbated by Usp12-46^KK108313

(Aron et al., 2018)

is ameliorated by Usp12-46^UAS.cAa

(Aron et al., 2018)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(McLear et al., 2008)

is ameliorated by Su(var)2-10^zimp-2

(O'Rourke et al., 2013)

is ameliorated by srl^UAS.cTa

(Ruetenik et al., 2016)

is ameliorated by Sin3A⁰⁸²⁶⁹

(Steffan et al., 2001)

is exacerbated by E(z)⁶³

(Song et al., 2018)

is exacerbated by E(z)⁷³¹

(Song et al., 2018)

is exacerbated by gpp^X

(Song et al., 2018)

is ameliorated by trr¹

(Song et al., 2018)

is ameliorated by trr³

(Song et al., 2018)

is ameliorated by trx¹

(Song et al., 2018)

is ameliorated by Jarid2^MB00996

(Song et al., 2018)

is ameliorated by Kdm4A^KG04636

(Song et al., 2018)

is ameliorated by Set2^RNAi.UAS

(Song et al., 2018)

is ameliorated by Utx¹

(Song et al., 2018)

is ameliorated by Utx²

(Song et al., 2018)

is exacerbated by ash1²²

(Song et al., 2018)

is exacerbated by esc⁵

(Song et al., 2018)

is exacerbated by gpp^XXV

(Song et al., 2018)

is ameliorated by Kdm2^DG12810

(Song et al., 2018)

is ameliorated by Su(var)3-3^GD9296

(Song et al., 2018)

is exacerbated by Hsap\PPM1B^UAS.Tag:HA

(Nandi et al., 2022)

is ameliorated by Nil^HMC06011

(Nandi et al., 2022)

is exacerbated by Glo1^KK109109

(Vicente Miranda et al., 2016)

is exacerbated by Tpi^GD10138

(Vicente Miranda et al., 2016)

is ameliorated by Pink1^UAS.Tag:HA

(Khalil et al., 2015)

is exacerbated by Drp1^UAS.cDa

(Khalil et al., 2015)

is ameliorated by Glut1^d05758

(Vittori et al., 2014)

is exacerbated by Glut1^17J

(Vittori et al., 2014)

is exacerbated by Glut1^KK108683

(Vittori et al., 2014)

is exacerbated by Tl^EP1051

(Cao et al., 2008)

is ameliorated by svr^EP356

(Cao et al., 2008)

is ameliorated by g^EP514

(Cao et al., 2008)

is ameliorated by MESR4^EP386

(Cao et al., 2008)

is exacerbated by SNF4Aγ^EP3015b

(Cao et al., 2008)

is exacerbated by SNF4Aγ^KG10152

(Cao et al., 2008)

is ameliorated by mub^EP3108

(Cao et al., 2008)

is NOT ameliorated by Gcn5^UAS.cBa

(Bodai et al., 2012)

is exacerbated by Gcn5^E333st

(Bodai et al., 2012)

is exacerbated by nej³

(Bodai et al., 2012)

is NOT exacerbated by mof²

(Bodai et al., 2012)

is NOT exacerbated by enok²

(Bodai et al., 2012)

is ameliorated by Mmus\Gpx1^UAS.cMa

(Mason et al., 2013)

is ameliorated by Sumo^unspecified

(Steffan et al., 2004)

is exacerbated by Ubi-p63E^unspecified

(Steffan et al., 2004)

is ameliorated by Mmus\Bag1^UAS.Tag:FLAG

(Sroka et al., 2009)

is ameliorated by Kdm5¹⁰⁴²⁴

(Vashishtha et al., 2013)

is ameliorated by Hsap\HTT^{P42.UAS.Tag:MYC}

(Arribat et al., 2013)

is ameliorated by Hsap\HTT^P42.UAS.GFP

(Arribat et al., 2013)

model of neurodegenerative disease

is ameliorated by Hsap\HTT^{C4sFv.UAS.Tag:HA}

(Wolfgang et al., 2005)

is ameliorated by Zzzz\scFv^{C4.UAS.Tag:HA}

(Wolfgang et al., 2005)

is exacerbated by Khc⁹

(Gunawardena et al., 2003)

is ameliorated by lncRNA:Hsrω^RNAi.Sym.UAS

(Mallik and Lakhotia, 2009)

is ameliorated by Sirt1¹⁷

(Pallos et al., 2008)

is ameliorated by HDAC1^5-5

(Pallos et al., 2008)

is ameliorated by Sirt2^5B-2-35

(Pallos et al., 2008)

is ameliorated by Sin3A⁰⁸²⁶⁹

(Steffan et al., 2001)

is NOT ameliorated by rl^Sem.C.UAS

(Liévens et al., 2008)

is ameliorated by Tpr2^UAS.cKa

(Liévens et al., 2008)

is ameliorated by DnaJ-1^UAS.cKa

(Liévens et al., 2008)

is ameliorated by mrj^UAS.cFa

(Liévens et al., 2008)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Liévens et al., 2008)

is ameliorated by Akt^UAS.Exel

(Liévens et al., 2008)

is ameliorated by Rab11^UAS.EGFP

(Richards et al., 2011)

is ameliorated by DJ-1α^UAS.cMa

(Sajjad et al., 2014)

is exacerbated by Hsp110⁰⁰⁰⁸²

(Zhang et al., 2010)

is exacerbated by Hsp110^S064906

(Zhang et al., 2010)

is ameliorated by Hsp110^UAS.cZa

(Zhang et al., 2010)

is exacerbated by Hsp110^S031820

(Zhang et al., 2010)

is exacerbated by Hsp110^S004112

(Zhang et al., 2010)

is exacerbated by Nipped-A^NC116

(Zhang et al., 2010)

is exacerbated by Nipped-A^NC186

(Zhang et al., 2010)

is exacerbated by lncRNA:Hsrω⁰⁵²⁴¹

(Sengupta and Lakhotia, 2006)

is ameliorated by yki^UAS.cHa

(Dubey and Tapadia, 2018)

is exacerbated by yki^RNAi.UAS.cUa

(Dubey and Tapadia, 2018)

Hsap\HTT^Q128.UAS

exacerbates neurodegenerative disease

modeled by dsh^Q108.UAS

(Lee et al., 2004)

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Lee et al., 2004)

model of Huntington's disease

is ameliorated by Atx2^HMS01392

(Xu et al., 2019)

is ameliorated by Atx2^HMS02726

(Xu et al., 2019)

is ameliorated by Atx2^KK100423

(Xu et al., 2019)

is exacerbated by Atx2^UAS.Tag:FLAG

(Xu et al., 2019)

is ameliorated by CrebA^JF02189

(Xu et al., 2019)

is ameliorated by Fmr1^GL00075

(Xu et al., 2019)

is ameliorated by Fmr1^HMS00248

(Xu et al., 2019)

is ameliorated by Hsap\HTT^P42.UAS.GFP

(Arribat et al., 2013)

is ameliorated by Hsap\HTT^{P42.UAS.Tag:MYC}

(Arribat et al., 2013)

is ameliorated by Hsp110^UAS.cKa

(Martin et al., 2021)

is ameliorated by Hsp68^UAS.cUa

(Martin et al., 2021)

is ameliorated by InR^K1409A.UAS

(Martin et al., 2021)

is ameliorated by Itpr^JF01957

(Martin et al., 2021)

is ameliorated by Pten^UAS.cUa

(Martin et al., 2021)

is ameliorated by Pyk^GL00099

(Martin et al., 2021)

is exacerbated by Rab5^KK102895

(Martin et al., 2021)

is ameliorated by Rab5^UAS.EGFP

(Martin et al., 2021)

is ameliorated by SERCA^HMS02878

(Martin et al., 2021)

is ameliorated by SERCA^JF01948

(Martin et al., 2021)

is ameliorated by foxo^TM.UAS

(Martin et al., 2021)

is ameliorated by foxo^UAS.cUa

(Martin et al., 2021)

is ameliorated by kto^HMS01062

(Martin et al., 2021)

is ameliorated by CG42306^GD11667

(Martin et al., 2021)

is exacerbated by CrebB^JF02494

(Martin et al., 2021)

is ameliorated by Hsap\DNAJB1^UAS.cKa

(Martin et al., 2021)

is ameliorated by nej^GD8975

(Martin et al., 2021)

is ameliorated by nej^HMS01507

(Martin et al., 2021)

is ameliorated by nej^KK113191

(Martin et al., 2021)

is ameliorated by nej^RNAi.UAS.cSa

(Martin et al., 2021)

is ameliorated by pan^ΔN.UAS

(Martin et al., 2021)

is ameliorated by pygo^KK108114

(Martin et al., 2021)

is ameliorated by srl^EY05931

(Martin et al., 2021)

is ameliorated by rho-5^UAS.cZa

(Lee et al., 2015)

is exacerbated by rho-5^KO1

(Lee et al., 2015)

is ameliorated by Hsap\RHBDF1^UAS.cLa

(Lee et al., 2015)

is ameliorated by slmb^UAS.cGa

(Godin et al., 2010)

Hsap\HTT^Q97.ex1.UAS

model of Huntington's disease

is ameliorated by Atx2^{KI.ΔcIDR-GFP}

(Huelsmeier et al., 2021)

is exacerbated by Tbp^sI10

(Hsu et al., 2014)

is exacerbated by Tbp^UAS.cHa

(Hsu et al., 2014)

Hsap\HTT^NT.128Q.UAS

model of Huntington's disease

is ameliorated by S-Lap1^GD11904

(Lu et al., 2013)

is exacerbated by CG15445^KK104296

(Lu et al., 2013)

is ameliorated by Pvf1^d06222

(Lu et al., 2013)

is exacerbated by Pvf1^KG01713

(Lu et al., 2013)

is exacerbated by Sec61β⁰⁷²¹⁴

(Lu et al., 2013)

is exacerbated by Sec61γ^VDRC.cUa

(Lu et al., 2013)

is ameliorated by Hsap\NUB1^UAS.cLa

(Lu et al., 2013)

is ameliorated by Hsap\STUB1^UAS.cAa

(Al-Ramahi et al., 2006)

is ameliorated by Dgkε^GD1964

(Zhang et al., 2012)

is exacerbated by GAPcenA^f01044

(Yao et al., 2015)

is ameliorated by DopEcR^MI02790

(Yao et al., 2015)

is ameliorated by DopEcR^KK111211

(Yao et al., 2015)

is exacerbated by GAPcenA^KK101516

(Yao et al., 2015)

Hsap\HTT^128Q.FL.UAS

model of Huntington's disease

is ameliorated by Ca-α1D^X10

(Romero et al., 2008)

is ameliorated by Syx1A^Δ229

(Romero et al., 2008)

is ameliorated by αSnap^M4

(Romero et al., 2008)

is ameliorated by cac^HC129

(Romero et al., 2008)

is ameliorated by Rop^G27

(Romero et al., 2008)

is ameliorated by Hap40^ko3

(Xu et al., 2022)

is ameliorated by Tip60^UAS.cUa

(Beaver et al., 2020)

is ameliorated by nbs¹

(Tuxworth et al., 2019)

is ameliorated by Su(var)3-9^UAS.EGFP

(Casale et al., 2022)

is ameliorated by Su(var)205^UASp.cCa

(Casale et al., 2022)

is ameliorated by Hsap\PRMT6^UAS.cSa

(Migazzi et al., 2021)

is ameliorated by Rab4^{UAS.mRFP(Unk)}

(White et al., 2020)

Hsap\HTT^{128Q.1-208.UAS}

model of Huntington's disease

is ameliorated by Pka-C2^KK110127

(Gonzales et al., 2016)

is ameliorated by Pka-C1^KK108966

(Gonzales et al., 2016)

is ameliorated by Pka-R1^BDK.UAS

(Gonzales et al., 2016)

Hsap\HTT^{128Q.1-336.UAS}

model of Huntington's disease

is exacerbated by M6^EY07032

(Kaltenbach et al., 2007)

is ameliorated by arm³

(Kaltenbach et al., 2007)

is ameliorated by hts⁰¹¹⁰³

(Kaltenbach et al., 2007)

is exacerbated by Itpr^EY02522

(Kaltenbach et al., 2007)

is ameliorated by arm^G0192

(Kaltenbach et al., 2007)

is ameliorated by Gpdh1^n1-5

(Kaltenbach et al., 2007)

is ameliorated by ND-PDSW^k10101

(Kaltenbach et al., 2007)

is exacerbated by zip⁰²⁹⁵⁷

(Kaltenbach et al., 2007)

is exacerbated by Gαi^EY10355

(Kaltenbach et al., 2007)

is ameliorated by Gαi^KG01907

(Kaltenbach et al., 2007)

is ameliorated by Itpr⁰⁵⁶¹⁶

(Kaltenbach et al., 2007)

is exacerbated by Dhc64C^4-19

(Kaltenbach et al., 2007)

is exacerbated by Asph^KG09881

(Kaltenbach et al., 2007)

is exacerbated by LamC^k11904

(Kaltenbach et al., 2007)

is ameliorated by αSnap^I1

(Kaltenbach et al., 2007)

is ameliorated by αSnap^M4

(Kaltenbach et al., 2007)

is ameliorated by faf^EP381

(Kaltenbach et al., 2007)

is ameliorated by porin^k05123

(Kaltenbach et al., 2007)

is exacerbated by CLIP-190^KG07837

(Kaltenbach et al., 2007)

is ameliorated by Khc⁸

(Kaltenbach et al., 2007)

is exacerbated by Pgi²

(Kaltenbach et al., 2007)

is ameliorated by Eip75B^BG02576

(Kaltenbach et al., 2007)

is ameliorated by pnut^XP

(Kaltenbach et al., 2007)

is ameliorated by Rpt1^43Ed-1

(Kaltenbach et al., 2007)

is exacerbated by zip^IIX62

(Kaltenbach et al., 2007)

is exacerbated by shot³

(Kaltenbach et al., 2007)

is exacerbated by Asph^ZCL1605

(Kaltenbach et al., 2007)

is ameliorated by Eip75B^KG09026

(Kaltenbach et al., 2007)

is exacerbated by Pgi^nNC1

(Kaltenbach et al., 2007)

is exacerbated by CAP^KG00308

(Kaltenbach et al., 2007)

is ameliorated by Ca-Ma2d^KG00260

(Kaltenbach et al., 2007)

is exacerbated by faf^BX4

(Kaltenbach et al., 2007)

is exacerbated by Syx1A^EP3215

(Kaltenbach et al., 2007)

is exacerbated by crol⁰⁴⁴¹⁸

(Kaltenbach et al., 2007)

is ameliorated by arm^G0234

(Kaltenbach et al., 2007)

is exacerbated by shot^65-2

(Kaltenbach et al., 2007)

is exacerbated by Unc-76^G0423a

(Kaltenbach et al., 2007)

is exacerbated by 14-3-3ζ^EY06147

(Kaltenbach et al., 2007)

is exacerbated by CAP^BG02184

(Kaltenbach et al., 2007)

is ameliorated by pnut⁰²⁵⁰²

(Kaltenbach et al., 2007)

is ameliorated by Eip75B^KG00139

(Kaltenbach et al., 2007)

is ameliorated by M6^BG00390

(Kaltenbach et al., 2007)

is exacerbated by Src42A^KG02515

(Kaltenbach et al., 2007)

is exacerbated by Unc-76^G0310

(Kaltenbach et al., 2007)

is ameliorated by αSnap^G8

(Kaltenbach et al., 2007)

is ameliorated by Mef2^KG01211a

(Kaltenbach et al., 2007)

is exacerbated by Lac^BG01462

(Kaltenbach et al., 2007)

is ameliorated by Mef2^X1

(Kaltenbach et al., 2007)

is exacerbated by Rpt1^EP2153

(Kaltenbach et al., 2007)

is ameliorated by crol^EY08953

(Kaltenbach et al., 2007)

is ameliorated by Syx1A⁰⁶⁷³⁷

(Kaltenbach et al., 2007)

is ameliorated by Gpdh1^n1-4

(Kaltenbach et al., 2007)

is ameliorated by hts^k06121

(Kaltenbach et al., 2007)

is ameliorated by porin^f03616

(Kaltenbach et al., 2007)

is ameliorated by 14-3-3ε^j2B10

(Branco et al., 2008, Kaltenbach et al., 2007)

is ameliorated by hts^KG06777

(Kaltenbach et al., 2007)

is exacerbated by 14-3-3ε^UAS.cCa

(Branco et al., 2008, Kaltenbach et al., 2007)

is ameliorated by Chc^BG02593a

(Kaltenbach et al., 2007)

is ameliorated by Chc¹

(Kaltenbach et al., 2007)

is exacerbated by CLIP-190^KG06490

(Kaltenbach et al., 2007)

is ameliorated by αSnap^P2

(Kaltenbach et al., 2007)

is ameliorated by pnut^KG00478

(Kaltenbach et al., 2007)

is exacerbated by Dhc64C^KG08838

(Kaltenbach et al., 2007)

is ameliorated by arm²

(Kaltenbach et al., 2007)

is ameliorated by Chc^G0438

(Kaltenbach et al., 2007)

is ameliorated by Eip75B⁰⁷⁰⁴¹

(Kaltenbach et al., 2007)

is exacerbated by Ca-Ma2d^EY09750

(Kaltenbach et al., 2007)

is ameliorated by Khc^e02141

(Kaltenbach et al., 2007)

is exacerbated by Unc-76^G0333

(Kaltenbach et al., 2007)

is exacerbated by Lac^G00044

(Kaltenbach et al., 2007)

is ameliorated by αSnap^M3

(Kaltenbach et al., 2007)

is exacerbated by LamC^G00158

(Kaltenbach et al., 2007)

is exacerbated by Src42A^E1

(Kaltenbach et al., 2007)

is exacerbated by Src42A^k10108

(Kaltenbach et al., 2007)

is ameliorated by Rpt1⁰⁵⁶⁴³

(Kaltenbach et al., 2007)

is ameliorated by Syx1A^Δ229

(Kaltenbach et al., 2007)

is exacerbated by 14-3-3ζ^EY03325

(Kaltenbach et al., 2007)

is exacerbated by CCT1^c03987

(Shirasaki et al., 2012)

is exacerbated by CaMKII^GD9506

(Shirasaki et al., 2012)

is ameliorated by Hsp60A^EY01572

(Shirasaki et al., 2012)

is ameliorated by Hsp83⁰⁸⁴⁴⁵

(Shirasaki et al., 2012)

is exacerbated by ND-30^GD5910

(Shirasaki et al., 2012)

is exacerbated by 14-3-3ε^GD4108

(Shirasaki et al., 2012)

is ameliorated by ND-30^EY03664

(Shirasaki et al., 2012)

is ameliorated by Gαi^EY10355

(Shirasaki et al., 2012)

is exacerbated by 14-3-3ε^ex4

(Shirasaki et al., 2012)

is ameliorated by Vps35^GD11710

(Shirasaki et al., 2012)

is ameliorated by CG45062^GD2154

(Shirasaki et al., 2012)

is ameliorated by Mpcp2⁰⁰⁵⁶⁴

(Shirasaki et al., 2012)

is ameliorated by Hsp60C^GD12177

(Shirasaki et al., 2012)

is exacerbated by nrv2^k13315

(Shirasaki et al., 2012)

is exacerbated by 14-3-3ζ^GD16467

(Shirasaki et al., 2012)

is ameliorated by Hsap\CRMP1^UAS.Tag:MYC

(Stroedicke et al., 2015)

is ameliorated by CRMP^EY04380

(Stroedicke et al., 2015)

is ameliorated by DnaJ-1^EP411

(Branco et al., 2008)

is exacerbated by eff⁸

(Branco et al., 2008)

is ameliorated by Hsap\STUB1^UAS.cAa

(Branco et al., 2008)

is exacerbated by skd^L7062

(Branco et al., 2008)

is exacerbated by tara^EP3463

(Branco et al., 2008)

is exacerbated by cpo^EP3378

(Branco et al., 2008)

is ameliorated by Diap1^{UAS.cHa.Tag:MYC}

(Branco et al., 2008)

is ameliorated by pum^bem

(Branco et al., 2008)

is ameliorated by sov^KG00226

(Branco et al., 2008)

is ameliorated by Pi3K92E^UAS.Tag:MYC

(Branco et al., 2008)

is exacerbated by pum^EP3461

(Branco et al., 2008)

is ameliorated by 14-3-3ε^ex4

(Branco et al., 2008)

is exacerbated by RhoGAPp190^EP1357

(Branco et al., 2008)

is exacerbated by Diap1⁴

(Branco et al., 2008)

is ameliorated by Akt^UAS.Tag:HA

(Branco et al., 2008)

is exacerbated by Akt⁰⁴²²⁶

(Branco et al., 2008)

is exacerbated by mub^EP3623

(Branco et al., 2008)

is exacerbated by vib^EP651

(Branco et al., 2008)

is exacerbated by vib^EP513

(Branco et al., 2008)

is exacerbated by sov^EP1438

(Branco et al., 2008)

is exacerbated by Hsc70-3^K97S.UAS

(Branco et al., 2008)

is exacerbated by Hsap\STUB1^UAS.cAa

(Branco et al., 2008)

is exacerbated by Sin3A^dQ4

(Branco et al., 2008)

is exacerbated by Sirt1^EP2300

(Branco et al., 2008)

is ameliorated by sol^GD8164

(Miller et al., 2010)

is ameliorated by SppL^GD284

(Miller et al., 2010)

is ameliorated by Spp^RNAi.UAS

(Miller et al., 2010)

is ameliorated by CalpA^GD12275

(Miller et al., 2010)

is ameliorated by Mmp2^BG00958

(Miller et al., 2010)

is exacerbated by sol^EY02771

(Miller et al., 2010)

is ameliorated by SppL^EY06831

(Miller et al., 2010)

is ameliorated by gol^GD3528

(Miller et al., 2010)

is ameliorated by Mmp2⁰²³⁵³

(Miller et al., 2010)

Hsap\HTT^{Q91.ex1.QUAS.mCherry}

model of Huntington's disease

is exacerbated by Ced-12^GD4186

(Pearce et al., 2015)

is exacerbated by Crk^GD8583

(Pearce et al., 2015)

is exacerbated by Crk^KK108690

(Pearce et al., 2015)

is exacerbated by Rac1^GD17411

(Pearce et al., 2015)

is exacerbated by Shark^RNAi.UAS.WIZ

(Pearce et al., 2015)

is exacerbated by bsk^GD10555

(Pearce et al., 2015)

is exacerbated by drpr^Δ5

(Pearce et al., 2015)

is exacerbated by drpr^RNAi.UAS

(Pearce et al., 2015)

Hsap\HTT^Q120.FL.UAS

model of Huntington's disease

is ameliorated by Hsap\HTT^171.Q120.UAS

(Chongtham et al., 2020)

Hsap\HTT^{P42.UAS.Tag:MYC}

ameliorates Huntington's disease

modeled by Hsap\HTT^Q128.UAS

(Arribat et al., 2013)

modeled by Hsap\HTT^Q93.ex1.UAS

(Arribat et al., 2013)

Hsap\HTT^P42.UAS.GFP

ameliorates Huntington's disease

modeled by Hsap\HTT^{171aa.138Q.UAS.Tag:HA}

(Arribat et al., 2013)

modeled by Hsap\HTT^Q128.UAS

(Arribat et al., 2013)

modeled by Hsap\HTT^Q93.ex1.UAS

(Arribat et al., 2013)

Hsap\HTT^{Q97.ex1.UAS.mCherry}

model of Huntington's disease

is ameliorated by Pp1α-96A^HMS02477

(Branco-Santos et al., 2017)

is ameliorated by Pp1-87B^HMS00409

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.T3D.ex1.UAS.mCherry}

model of Huntington's disease

is exacerbated by Pp1α-96A^HMS02477

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S13D.ex1.UAS.mCherry}

model of Huntington's disease

is ameliorated by Pp1α-96A^HMS02477

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S16D.ex1.UAS.mCherry}

model of Huntington's disease

is ameliorated by Pp1α-96A^HMS02477

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S13A.ex1.UAS.mCherry}

model of Huntington's disease

is ameliorated by Pp1α-96A^HMS02477

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S16A.ex1.UAS.mCherry}

model of Huntington's disease

is ameliorated by Pp1α-96A^HMS02477

(Branco-Santos et al., 2017)

Hsap\HTT^{Q72.ex1.UAS.cWa}

model of Huntington's disease

is exacerbated by Hsap\MAPT^UAS.cWa

(Wen et al., 2020)

is ameliorated by tau^KO

(Wen et al., 2020)

Hsap\HTT^{128Q.1-231.UAS}

model of Huntington's disease

is ameliorated by NfI^JF02219

(Reyes-Ortiz et al., 2023)

is ameliorated by NfI^MI06280

(Reyes-Ortiz et al., 2023)

is ameliorated by Abl^UAS.cFa

(Onur et al., 2021)

is ameliorated by AnxB10^d03410

(Onur et al., 2021)

is ameliorated by CG43373^KK110535

(Onur et al., 2021)

is ameliorated by CG8916^GD3383

(Onur et al., 2021)

is ameliorated by CenG1A^MI06024

(Onur et al., 2021)

is exacerbated by Jra^NIG.2275R

(Onur et al., 2021)

is ameliorated by Nrx-1^MI02579

(Onur et al., 2021)

is exacerbated by Pkc53E^GD11984

(Onur et al., 2021)

is ameliorated by PlexA^NIG.11081R

(Onur et al., 2021)

is ameliorated by Pvr^GD75

(Onur et al., 2021)

is ameliorated by RhoBTB^VSH330130

(Onur et al., 2021)

is exacerbated by SH3PX1^NIG.6757R

(Onur et al., 2021)

is exacerbated by Snap25^NIG.17676R

(Onur et al., 2021)

is exacerbated by Spn42De^KK103216

(Onur et al., 2021)

is ameliorated by Sytβ^KK112599

(Onur et al., 2021)

is ameliorated by cora¹⁴

(Onur et al., 2021)

is ameliorated by dpn^GFP.FPTB

(Onur et al., 2021)

is ameliorated by ena^{UASp.B.mCherry}

(Onur et al., 2021)

is ameliorated by mGluR^NIG.11144R

(Onur et al., 2021)

is exacerbated by mahe^GD17235

(Onur et al., 2021)

is ameliorated by nmdyn-D7^GD13902

(Onur et al., 2021)

is ameliorated by sif^NIG.5406R

(Onur et al., 2021)

is ameliorated by trn^S064117

(Onur et al., 2021)

is exacerbated by tsr^N121

(Onur et al., 2021)

is ameliorated by vlc^k01109

(Onur et al., 2021)

is ameliorated by zld^GFP.FPTB

(Onur et al., 2021)

is ameliorated by Itgbn^HM05089

(Hernandez et al., 2023)

is ameliorated by Itgbn^HMJ23472

(Hernandez et al., 2023)

is ameliorated by if^HMC06096

(Hernandez et al., 2023)

is ameliorated by if^HMS01872

(Hernandez et al., 2023)

is ameliorated by if^JF02695

(Hernandez et al., 2023)

is ameliorated by if^MI12214

(Hernandez et al., 2023)

is ameliorated by if^WKO.P1-D4

(Hernandez et al., 2023)

is ameliorated by mew^HMS02849

(Hernandez et al., 2023)

is ameliorated by mew^JF02694

(Hernandez et al., 2023)

is ameliorated by mew^TKO.GS00808

(Hernandez et al., 2023)

is ameliorated by mys^HMS00043

(Hernandez et al., 2023)

is ameliorated by mys^JF02819

(Hernandez et al., 2023)

is ameliorated by scb^HMS01873

(Hernandez et al., 2023)

Hsap\HTT^{Q97.ex1.UAS.IVS.EGFP}

model of Huntington's disease

is ameliorated by Hsap\HTT^{ex1.βHP-P12.UAS.IVS.mCh}

(Drombosky et al., 2018)

is ameliorated by Hsap\HTT^{ex1.βHP-P2.UAS.IVS.mCh}

(Drombosky et al., 2018)

Hsap\HTT^{ex1.βHP-P2.UAS.IVS.mCh}

ameliorates Huntington's disease

modeled by Hsap\HTT^{Q97.ex1.UAS.IVS.EGFP}

(Drombosky et al., 2018)

Hsap\HTT^{ex1.βHP-P12.UAS.IVS.mCh}

ameliorates Huntington's disease

modeled by Hsap\HTT^{Q97.ex1.UAS.IVS.EGFP}

(Drombosky et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

htt

Hsap\HTT

(Rui et al., 2015, Mugat et al., 2008)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

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(data from AllianceMine provided by esyN)

Select Layout:

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Circle

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Legend:

Protein

RNA

Selected Interactor(s)

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Hsap\HTT - Hap40

anti tag coimmunoprecipitation, anti tag western blot

(Xu et al., 2022)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

Cytogenetic map

Sequence location

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (73)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

68417

w^*; P{UAS-HTT.ex1.Q97}3

68413

w^*; P{UAS-HTT.ex1.Q50}Y4

68418

w^*; P{UAS-HTT.ex1.Q93}4F1

68403

w^*; P{UAS-HTT.FL.Q120.His}2

68419

w^*; P{UAS-HTT.ex1.Q97.K6R}7

68423

w^*; P{UAS-HTT.ex1.Q97.3KR}2

68424

w^*; P{UAS-HTT.ex1.Q97.3KQ}3

56771

w^*; P{UAS-HTT.96Q.Cerulean}2

58360

w^*; P{UAS-HTT.25Q.Cerulean}2

68412

w^*; P{UAS-HTT.ex1.Q20}111F1L

68414

w^*; M{UAS-HTT.ex1.Q25}ZH-51D

68421

w^*; P{UAS-HTT.ex1.Q97.K15R}1

More stocks available...

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Expression of Hsap\YAP1 in vivo seems to play a protective role against the toxicity of mutant Hsap\HD in HD pathology.

(Hoshino et al., 2006)

A Drosophila model for Huntington's disease has been developed. The age of onset and severity of neuronal degeneration correlate with length of polyglutamine tract in the Hsap\HD protein, and nuclear accumulation of the Hsap\HD protein.

(Jackson et al., 1998)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (22)

Reported As

Symbol Synonym

APP

(Hu et al., 2014)

(HGNC Curators and FlyBase Curators, 2013-, McConoughey et al., 2010, Menzies et al., 2010, Bahadorani and Hilliker, 2008, Kaltenbach et al., 2007, Riley, 2006)

(Qurashi et al., 2012)

HTT

(Nitta et al., 2023, Tang and More, 2023, Nandi et al., 2022, Nayak and Mishra, 2022, Riccardi et al., 2022, Riccardi et al., 2022, Singh and Agrawal, 2022, Martin et al., 2021, Faragó et al., 2019, Lakra et al., 2019, Xu et al., 2019, Ast et al., 2018, Chen et al., 2018, Drombosky et al., 2018, Song et al., 2018, Vu et al., 2018, Branco-Santos et al., 2017, Fernius et al., 2017, Prakash et al., 2017, Krench et al., 2016, Quinti et al., 2016, Smalley et al., 2016, Vicente Miranda et al., 2016, Barbaro et al., 2015, El-Daher et al., 2015, Jimenez-Sanchez et al., 2015, McGurk et al., 2015, Menzies et al., 2015, Stroedicke et al., 2015, Varadarajan et al., 2015, Lu et al., 2014, Maheshwari et al., 2014, Quinn, 2014.7.18, Trujillo et al., 2014, Vittori et al., 2014, HGNC Curators and FlyBase Curators, 2013-, Lu et al., 2013, Ravikumar et al., 2008)

HTTN

(Al-Ramahi et al., 2018)

HTTex1

(Hervás et al., 2020, Ast et al., 2018)

Hsap\HD

Hsap\HTT

(Sousa et al., 2023, Bertapelle et al., 2022, Bhattacharjee et al., 2019, Coelho and Moreno, 2019, Kovács et al., 2017, Breda et al., 2016, Sameni et al., 2016, Jia et al., 2012)

Htt

(Barwell et al., 2023, Sharma et al., 2023, Zsindely et al., 2023, Benoit et al., 2022, Hegde and Srivastava, 2022, Tello et al., 2022, Joy et al., 2021, Subhan and Siddique, 2021, Bolus et al., 2020, Bono-Yagüe et al., 2020, Denton et al., 2020, Joag et al., 2020, Varga et al., 2020, Bason et al., 2019, Raj and Sarkar, 2019, Rodriguez-Fernandez et al., 2019, Zhu et al., 2019, Arabit et al., 2018, Coelho et al., 2018, Song et al., 2018, Yeh et al., 2018, Zhang et al., 2018, Akbergenova and Littleton, 2017, Daldin et al., 2017, Gregory et al., 2017, Raj and Sarkar, 2017, Singh et al., 2017, Sowade and Jahn, 2017, Chongtham and Agrawal, 2016, Lewis and Smith, 2016, Weiss and Littleton, 2016, Babcock and Ganetzky, 2015, Besson et al., 2015, Heidari et al., 2015, Jimenez-Sanchez et al., 2015, Menzies et al., 2015, Poças et al., 2015, Takeuchi et al., 2015, Yao et al., 2015, Hsu et al., 2014, Sajjad et al., 2014, Singh et al., 2014, Smith et al., 2014, Fujita et al., 2013, Fujita et al., 2013, Sinadinos et al., 2013, Bodai et al., 2012, Shirasaki et al., 2012, Sontag et al., 2012, Weiss et al., 2012, Zhang et al., 2012, Campesan et al., 2011, Gohil et al., 2011, Kirilly et al., 2011, Maher et al., 2011, Richards et al., 2011, Schulte et al., 2011, Tsoi et al., 2011, Wu et al., 2011, Gonzales and Yin, 2010, Luthi-Carter et al., 2010, Nisoli et al., 2010, Rana et al., 2010, Winslow et al., 2010, Wu et al., 2010, Branco et al., 2008, Fujikake et al., 2008, Liévens et al., 2008, Mugat et al., 2008, Pallos et al., 2008, Ravikumar et al., 2008, Al-Ramahi et al., 2007, Mahoney et al., 2007, Ryoo et al., 2007, Al-Ramahi et al., 2006, Boeddrich et al., 2006, Hoshino et al., 2006, Rujano et al., 2006, Lievens et al., 2005, Warrick et al., 2005, Kazantsev et al., 2002, Kazemi-Esfarjani and Benzer, 2002, Steffan et al., 2001)

Huntingtin

(Fernandez-Funez et al., 2001)

IT15

(HGNC Curators and FlyBase Curators, 2013-)

hHTT

(Ecovoiu et al., 2022, Billes et al., 2016, White et al., 2015)

hHtt

(Arribat et al., 2013, Mugat et al., 2008)

human Htt

(Schulte et al., 2011)

huntingtin

(Berger et al., 2006)

mHTT

(Jantrapirom et al., 2019, Lin et al., 2019)

mHtt

(Subhan and Siddique, 2021)

Name Synonyms

HUNTINGTIN

(McGurk et al., 2015)

Huntingtin

(Gohel et al., 2020, Chongtham and Agrawal, 2016, Sontag et al., 2012, Tamura et al., 2011, Wu et al., 2011, Lloyd and Taylor, 2010, Doumanis et al., 2009, Branco et al., 2008, Liévens et al., 2008, Mugat et al., 2008, Mclear et al., 2007, Iijima-Ando et al., 2005)

Huntington Disease

human HTT

(Al-Ramahi et al., 2017)

huntingtin (Huntington disease)

(HGNC Curators and FlyBase Curators, 2013-)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 7 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3064

Other crossreferences

Ensembl_Homo_sapiens -

ENSG00000197386

HUGO Gene Nomenclature Committee -

HTT; huntingtin

MARRVEL - MARRVEL (human gene)

Online Mendelian Inheritance in Man (OMIM) -

613004

Online Mendelian Inheritance in Man (OMIM) -

References (305)

Information on product gene function for non-D. melanogaster species is no longer provided by FlyBase.

NA

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